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Article

Decreased microRNA-132 and its function in human non-small cell lung cancer

Retraction in: /10.3892/mmr.2021.12161
  • Authors:
    • Xiyu Liu
    • Song Yan
    • Changyan Pei
    • Youbin Cui
  • View Affiliations / Copyright

    Affiliations: Department of Chest Surgery, The First Bethune Hospital of Jilin University, Changchun, Jilin 130000, P.R. China, Department of Chest Surgery, The Cancer Hospital of Jilin Province, Changchun, Jilin 130000, P.R. China, Department of Medical Administration, Jilin Province People's Hospital, Changchun, Jilin 130000, P.R. China
  • Pages: 3601-3608
    |
    Published online on: January 19, 2015
       https://doi.org/10.3892/mmr.2015.3222
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Abstract

MicroRNA‑132 (miR‑132) has been shown to be dysregulated in certain types of human malignancies and is associated with tumor progression. However, its function in non‑small cell lung cancer (NSCLC) and whether it is differentially expressed in this disease, remain unclear. Thus, the aim of the present study was to investigate the effects of miR‑132 on NSCLC tumorigenesis and progression. Using reverse transcription‑quantitative polymerase chain reaction, miR‑132 expression was detected in NSCLC cell lines and primary tumor tissues. The association between miR‑132 expression, and clinicopathological factors and prognosis was assessed using statistical analysis. An MTT assay, flow cytometry, Transwell invasion assays and scratch migration assays were conducted in order to examine the proliferation, apoptosis, invasion and migration of NSCLC cells that had been transfected with miR‑132 mimics or inhibitors. The results showed that miR‑132 expression levels were significantly downregulated in NSCLC cells compared with that in corresponding non‑cancerous lung tissues (P<0.001). In addition, reduced miR‑132 expression was significantly associated with lymph node metastasis (P=0.003), an advanced tumor‑node‑metastasis stage (P<0.001) and shorter overall survival (P<0.001). Multivariate regression analysis confirmed that downregulation of miR‑132 was an independent predictor of prognosis. Furthermore, transfection of miR‑132 mimics into the NSCLC cells reduced cell proliferation, invasion and migration, and promoted cell apoptosis. These findings indicate that miR‑132 may be a novel diagnostic and prognostic marker, as well as a potential target for molecular therapy in NSCLC.
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1 

Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin. 60:277–300. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Verdecchia A, Francisci S, Brenner H, et al: Recent cancer survival in Europe: a 2000-02 period analysis of EUROCARE-4 data. Lancet Oncol. 8:784–796. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Osman A: MicroRNAs in health and disease - basic science and clinical applications. Clinical laboratory. 58:393–402. 2012.

4 

Zhao G, Cai C, Yang T, et al: MicroRNA-221 induces cell survival and cisplatin resistance through PI3K/Akt pathway in human osteosarcoma. PLoS One. 8:e539062013. View Article : Google Scholar : PubMed/NCBI

5 

Mendell JT and Olson EN: MicroRNAs in stress signaling and human disease. Cell. 148:1172–1187. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Zhang B, Pan X, Cobb GP and Anderson TA: microRNAs as oncogenes and tumor suppressors. Dev Biol. 302:1–12. 2007. View Article : Google Scholar

8 

Dieckmann KP, Spiekermann M, Balks T, et al: MicroRNAs miR-371-3 in serum as diagnostic tools in the management of testicular germ cell tumours. Br J Cancer. 107:1754–1760. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Takahashi M, Cuatrecasas M, Balaguer F, et al: The clinical significance of MiR-148a as a predictive biomarker in patients with advanced colorectal cancer. PLoS One. 7:e466842012. View Article : Google Scholar : PubMed/NCBI

10 

Meng W, Ye Z, Cui R, et al: MicroRNA-31 predicts the presence of lymph node metastases and survival in patients with lung adenocarcinoma. Clin Cancer Res. 19:5423–5433. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Liu XH, Lu KH, Wang KM, et al: MicroRNA-196a promotes non-small cell lung cancer cell proliferation and invasion through targeting HOXA5. BMC Cancer. 12:3482012. View Article : Google Scholar : PubMed/NCBI

12 

Li Y, Jiang Q, Xia N, Yang H and Hu C: Decreased expression of microRNA-375 in nonsmall cell lung cancer and its clinical significance. J Int Med Res. 40:1662–1669. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Wang XC, Wang W, Zhang ZB, Zhao J, Tan XG and Luo JC: Overexpression of miRNA-21 promotes radiation-resistance of non-small cell lung cancer. Radiat Oncol. 8:1462013. View Article : Google Scholar : PubMed/NCBI

14 

Bian HB, Pan X, Yang JS, Wang ZX and De W: Upregulation of microRNA-451 increases cisplatin sensitivity of non-small cell lung cancer cell line (A549). J Exp Clin Cancer Res. 30:202011. View Article : Google Scholar : PubMed/NCBI

15 

Wong TS, Liu XB, Wong BY, Ng RW, Yuen AP and Wei WI: Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue. Clin Cancer Res. 14:2588–2592. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Yang L, Belaguli N and Berger DH: MicroRNA and colorectal cancer. World J Surg. 33:638–646. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Park JK, Henry JC, Jiang J, et al: miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor. Biochem Biophys Res Commun. 406:518–523. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Anand S, Majeti BK, Acevedo LM, et al: MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis. Nat Med. 16:909–914. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Calin GA, Liu CG, Sevignani C, et al: MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. Proc Natl Acad Sci USA. 101:11755–11760. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Wei X, Tan C, Tang C, et al: Epigenetic repression of miR-132 expression by the hepatitis B virus × protein in hepatitis B virus-related hepatocellular carcinoma. Cell Signal. 25:1037–1043. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Formosa A, Lena AM, Markert EK, et al: DNA methylation silences miR-132 in prostate cancer. Oncogene. 32:127–134. 2013. View Article : Google Scholar

22 

Li S, Meng H, Zhou F, et al: MicroRNA-132 is frequently down-regulated in ductal carcinoma in situ (DCIS) of breast and acts as a tumor suppressor by inhibiting cell proliferation. Pathol Res Pract. 209:179–183. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Yang J, Gao T, Tang J, Cai H, Lin L and Fu S: Loss of microRNA-132 predicts poor prognosis in patients with primary osteosarcoma. Mol Cell Biochem. 381:9–15. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Groome PA1, Bolejack V, Crowley JJ, et al; IASLC International Staging Committee; Cancer Research and Biostatistics; Observers to the Committee; Participating Institutions. The IASLC Lung Cancer Staging Project: validation of the proposals for revision of the T, N, and M descriptors and consequent stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours. J Thorac Oncol. 2:694–705. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Wanet A, Tacheny A, Arnould T and Renard P: miR-212/132 expression and functions: within and beyond the neuronal compartment. Nucleic Acids Res. 40:4742–4753. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Brennecke J, Stark A, Russell RB and Cohen SM: Principles of microRNA-target recognition. PLoS Biol. 3:e852005. View Article : Google Scholar : PubMed/NCBI

27 

Krek A, Grun D, Poy MN, et al: Combinatorial microRNA target predictions. Nat Genet. 37:495–500. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu X, Yan S, Pei C and Cui Y: Decreased microRNA-132 and its function in human non-small cell lung cancer Retraction in /10.3892/mmr.2021.12161. Mol Med Rep 11: 3601-3608, 2015.
APA
Liu, X., Yan, S., Pei, C., & Cui, Y. (2015). Decreased microRNA-132 and its function in human non-small cell lung cancer Retraction in /10.3892/mmr.2021.12161. Molecular Medicine Reports, 11, 3601-3608. https://doi.org/10.3892/mmr.2015.3222
MLA
Liu, X., Yan, S., Pei, C., Cui, Y."Decreased microRNA-132 and its function in human non-small cell lung cancer Retraction in /10.3892/mmr.2021.12161". Molecular Medicine Reports 11.5 (2015): 3601-3608.
Chicago
Liu, X., Yan, S., Pei, C., Cui, Y."Decreased microRNA-132 and its function in human non-small cell lung cancer Retraction in /10.3892/mmr.2021.12161". Molecular Medicine Reports 11, no. 5 (2015): 3601-3608. https://doi.org/10.3892/mmr.2015.3222
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Yan S, Pei C and Cui Y: Decreased microRNA-132 and its function in human non-small cell lung cancer Retraction in /10.3892/mmr.2021.12161. Mol Med Rep 11: 3601-3608, 2015.
APA
Liu, X., Yan, S., Pei, C., & Cui, Y. (2015). Decreased microRNA-132 and its function in human non-small cell lung cancer Retraction in /10.3892/mmr.2021.12161. Molecular Medicine Reports, 11, 3601-3608. https://doi.org/10.3892/mmr.2015.3222
MLA
Liu, X., Yan, S., Pei, C., Cui, Y."Decreased microRNA-132 and its function in human non-small cell lung cancer Retraction in /10.3892/mmr.2021.12161". Molecular Medicine Reports 11.5 (2015): 3601-3608.
Chicago
Liu, X., Yan, S., Pei, C., Cui, Y."Decreased microRNA-132 and its function in human non-small cell lung cancer Retraction in /10.3892/mmr.2021.12161". Molecular Medicine Reports 11, no. 5 (2015): 3601-3608. https://doi.org/10.3892/mmr.2015.3222
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