Role of adenovirus-mediated retinoblastoma 94 in the treatment of human non-small cell lung cancer

Liu,Fang; Li,Qingbao; Zhang,Ping; Chen,Fang; Cheng,Yufeng

doi:10.3892/mmr.2015.3227

May-2015 Volume 11 Issue 5

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May-2015 Volume 11 Issue 5

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Article Open Access

Role of adenovirus-mediated retinoblastoma 94 in the treatment of human non-small cell lung cancer

Authors:
- Fang Liu
- Qingbao Li
- Ping Zhang
- Fang Chen
- Yufeng Cheng
View Affiliations / Copyright

Affiliations: Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China, Department of Cardiac Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Oncology, The People's Hospital of Binzhou City, Binzhou, Shandong 256610, P.R. China, Department of Ultrasonography, The Second Hospital Affiliated to Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250001, P.R. China

Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
Pages: 3349-3353
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Published online on: January 20, 2015

https://doi.org/10.3892/mmr.2015.3227
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Abstract

Non‑small cell lung cancer (NSCLC) remains the leading cause of cancer‑related mortality despite the fact that great advances have been made in therapeutic treatment methods. Therefore, in the present study, the role of adenovirus-mediated retinoblastoma 94 (Ad‑RB94) gene therapy in NSCLC was investigated. Following treatment with Ad‑RB94, the proportion of A549 cells in the G2/M phase was increased. In the mouse xenograft model, the overexpression of RB94 inhibited the tumor growth compared with the control group and the Ad‑LacZ-treated group. In the transplanted tumors, the overexpression of RB94 induced the apoptosis of tumors as well as an increase in the mRNA levels of cyclinB1. In conclusion, the results of the present study suggested that RB94 may effectively inhibit NSCLC tumor cell growth by inducing G2/M cell cycle arrest and apoptosis, indicating that RB94 may be a promising candidate for adjuvant therapy with radiation or chemotherapy in NSCLC.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Role of adenovirus-mediated retinoblastoma 94 in the treatment of human non-small cell lung cancer

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