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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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August-2015 Volume 12 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Neurotoxicity of cerebro-spinal fluid from patients with Parkinson's disease on mesencephalic primary cultures as an in vitro model of dopaminergic neurons

  • Authors:
    • Ping Kong
    • Ben‑Shu Zhang
    • Ping Lei
    • Xiao‑Dong Kong
    • Shi‑Shuang Zhang
    • Dai Li
    • Yun Zhang

  • View Affiliations / Copyright

    Affiliations: Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin 300192, P.R. China, Department of Neurology, Tianjin Medical University General Hospital, Tianjin 300192, P.R. China
  • Pages: 2217-2224
    |
    Published online on: March 31, 2015
       https://doi.org/10.3892/mmr.2015.3575
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Abstract

Parkinson's disease is a degenerative disorder of the central nervous system. In spite of extensive research, neither the cause nor the mechanisms have been firmly established thus far. One assumption is that certain toxic substances may exist in the cerebro‑spinal fluid (CSF) of Parkinson's disease patients. To confirm the neurotoxicity of CSF and study the potential correlation between neurotoxicity and the severity of Parkinson's disease, CSF was added to cultured cells. By observation of cell morphology, changes in the levels of lactate dehydrogenase, the ratio of tyrosine hydroxylase‑positive cells, and the expression of tyrosine hydroxylase mRNA and protein, the differences between the two groups were shown. The created in vitro model of dopaminergic neurons using primary culture of mouse embryonic mesencephalic tissue is suitable for the study of neurotoxicity. The observations of the present study indicated that CSF from Parkinson's disease patients contains factors that can cause specific injury to cultured dopaminergic neurons. However, no obvious correlation was found between the neurotoxicity of CSF and the severity of Parkinson's disease.

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Copy and paste a formatted citation
Spandidos Publications style
Kong P, Zhang BS, Lei P, Kong XD, Zhang SS, Li D and Zhang Y: Neurotoxicity of cerebro-spinal fluid from patients with Parkinson's disease on mesencephalic primary cultures as an in vitro model of dopaminergic neurons. Mol Med Rep 12: 2217-2224, 2015.
APA
Kong, P., Zhang, B., Lei, P., Kong, X., Zhang, S., Li, D., & Zhang, Y. (2015). Neurotoxicity of cerebro-spinal fluid from patients with Parkinson's disease on mesencephalic primary cultures as an in vitro model of dopaminergic neurons. Molecular Medicine Reports, 12, 2217-2224. https://doi.org/10.3892/mmr.2015.3575
MLA
Kong, P., Zhang, B., Lei, P., Kong, X., Zhang, S., Li, D., Zhang, Y."Neurotoxicity of cerebro-spinal fluid from patients with Parkinson's disease on mesencephalic primary cultures as an in vitro model of dopaminergic neurons". Molecular Medicine Reports 12.2 (2015): 2217-2224.
Chicago
Kong, P., Zhang, B., Lei, P., Kong, X., Zhang, S., Li, D., Zhang, Y."Neurotoxicity of cerebro-spinal fluid from patients with Parkinson's disease on mesencephalic primary cultures as an in vitro model of dopaminergic neurons". Molecular Medicine Reports 12, no. 2 (2015): 2217-2224. https://doi.org/10.3892/mmr.2015.3575
Copy and paste a formatted citation
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Spandidos Publications style
Kong P, Zhang BS, Lei P, Kong XD, Zhang SS, Li D and Zhang Y: Neurotoxicity of cerebro-spinal fluid from patients with Parkinson's disease on mesencephalic primary cultures as an in vitro model of dopaminergic neurons. Mol Med Rep 12: 2217-2224, 2015.
APA
Kong, P., Zhang, B., Lei, P., Kong, X., Zhang, S., Li, D., & Zhang, Y. (2015). Neurotoxicity of cerebro-spinal fluid from patients with Parkinson's disease on mesencephalic primary cultures as an in vitro model of dopaminergic neurons. Molecular Medicine Reports, 12, 2217-2224. https://doi.org/10.3892/mmr.2015.3575
MLA
Kong, P., Zhang, B., Lei, P., Kong, X., Zhang, S., Li, D., Zhang, Y."Neurotoxicity of cerebro-spinal fluid from patients with Parkinson's disease on mesencephalic primary cultures as an in vitro model of dopaminergic neurons". Molecular Medicine Reports 12.2 (2015): 2217-2224.
Chicago
Kong, P., Zhang, B., Lei, P., Kong, X., Zhang, S., Li, D., Zhang, Y."Neurotoxicity of cerebro-spinal fluid from patients with Parkinson's disease on mesencephalic primary cultures as an in vitro model of dopaminergic neurons". Molecular Medicine Reports 12, no. 2 (2015): 2217-2224. https://doi.org/10.3892/mmr.2015.3575
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