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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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December-2015 Volume 12 Issue 6

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Effect of the one‑carbon unit cycle on overall DNA methylation in children with Down's syndrome

  • Authors:
    • Cui Song
    • Jingyi He
    • Jie Chen
    • Youxue Liu
    • Feng Xiong
    • Yutian Wang
    • Tingyu Li

  • View Affiliations / Copyright

    Affiliations: Children Nutrition Research Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, CSTC2009 CA5002, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China, Institute of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China
  • Pages: 8209-8214
    |
    Published online on: October 13, 2015
       https://doi.org/10.3892/mmr.2015.4439
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Abstract

DNA methylation is a major epigenetic mechanism regulating gene expression. In order to analyze the impact of the one‑carbon unit cycle on the overall level of DNA methylation in children with Down's syndrome (DS), the levels of indicators associated with the one‑carbon unit cycle, including folic acid (FA), vitamin B12 (VB12) and homocysteine (Hcy), and the overall DNA methylation level of DS and healthy controls (HCs) were determined in the present study. A total of 36 DS children and 40 age‑ and gender‑matched HCs were included in the present study to determine the levels of FA, VB12, Hcy and overall DNA methylation. The effect of the one‑carbon unit cycle on the overall level of DNA methylation within the DS group was analyzed. The results demonstrated that the level of VB12 was decreased (P=0.008), while the Hcy level was increased (P=0.000) in DS patients compared with the HCs. FA and VB12 levels decreased with increasing age in DS patients (P<0.05). DNA hypermethylation and hypomethylation were observed in DS patients with VB12 deficiency and hyperhomocysteinemia, respectively (P=0.031, P=0.021). Abnormalities in the one‑carbon unit cycle tend to worsen with increasing age in DS children. Thus, one‑carbon unit cycle‑associated alterations in DNA methylation may be important in the neuropathological alterations observed in DS.

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Copy and paste a formatted citation
Spandidos Publications style
Song C, He J, Chen J, Liu Y, Xiong F, Wang Y and Li T: Effect of the one‑carbon unit cycle on overall DNA methylation in children with Down's syndrome. Mol Med Rep 12: 8209-8214, 2015.
APA
Song, C., He, J., Chen, J., Liu, Y., Xiong, F., Wang, Y., & Li, T. (2015). Effect of the one‑carbon unit cycle on overall DNA methylation in children with Down's syndrome. Molecular Medicine Reports, 12, 8209-8214. https://doi.org/10.3892/mmr.2015.4439
MLA
Song, C., He, J., Chen, J., Liu, Y., Xiong, F., Wang, Y., Li, T."Effect of the one‑carbon unit cycle on overall DNA methylation in children with Down's syndrome". Molecular Medicine Reports 12.6 (2015): 8209-8214.
Chicago
Song, C., He, J., Chen, J., Liu, Y., Xiong, F., Wang, Y., Li, T."Effect of the one‑carbon unit cycle on overall DNA methylation in children with Down's syndrome". Molecular Medicine Reports 12, no. 6 (2015): 8209-8214. https://doi.org/10.3892/mmr.2015.4439
Copy and paste a formatted citation
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Spandidos Publications style
Song C, He J, Chen J, Liu Y, Xiong F, Wang Y and Li T: Effect of the one‑carbon unit cycle on overall DNA methylation in children with Down's syndrome. Mol Med Rep 12: 8209-8214, 2015.
APA
Song, C., He, J., Chen, J., Liu, Y., Xiong, F., Wang, Y., & Li, T. (2015). Effect of the one‑carbon unit cycle on overall DNA methylation in children with Down's syndrome. Molecular Medicine Reports, 12, 8209-8214. https://doi.org/10.3892/mmr.2015.4439
MLA
Song, C., He, J., Chen, J., Liu, Y., Xiong, F., Wang, Y., Li, T."Effect of the one‑carbon unit cycle on overall DNA methylation in children with Down's syndrome". Molecular Medicine Reports 12.6 (2015): 8209-8214.
Chicago
Song, C., He, J., Chen, J., Liu, Y., Xiong, F., Wang, Y., Li, T."Effect of the one‑carbon unit cycle on overall DNA methylation in children with Down's syndrome". Molecular Medicine Reports 12, no. 6 (2015): 8209-8214. https://doi.org/10.3892/mmr.2015.4439
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