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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December-2015 Volume 12 Issue 6

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Journal Metrics

Impact Factor: 3.5

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Brain mechanisms of sympathetic activation in heart failure: Roles of the renin‑angiotensin system, nitric oxide and pro‑inflammatory cytokines (Review)

Bin Xu, Hongli Li
Pages: 7823-7829
Published online on: 13 October 2015

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Article Open Access

MicroRNA-519 enhances HL60 human acute myeloid leukemia cell line proliferation by reducing the expression level of RNA-binding protein human antigen R Retraction in /10.3892/mmr.2024.13335

Kebin Huang, Bingwei Dong, Yueyue Wang, Tao Tian, Biying Zhang
Pages: 7830-7836
Published online on: 20 October 2015

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Article Open Access

Increased cyclooxygenase-2 and nuclear factor-κB/p65 expression in mouse hippocampi after systemic administration of tetanus toxin

Bing Chun Yan, Yong Hwan Jeon, Joon Ha Park, In Hye Kim, Jeong‑Hwi Cho, Ji Hyeon Ahn, Bai Hui Chen, Hyun‑Jin Tae, Jae‑Chul Lee, Ji Yun Ahn, Dong Won Kim, Jun Hwi Cho, Moo‑Ho Won, Seongkweon Hong
Pages: 7837-7844
Published online on: 26 October 2015

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Article Open Access

Effect of Hath1 on the proliferation and apoptosis of cutaneous squamous cell carcinoma in vitro

Zuolin Ying, Xiaojie Li, Hong Dang, Feng Wang, Xiaoyan Xu
Pages: 7845-7850
Published online on: 21 October 2015

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Article Open Access

Further insight into molecular mechanism underlying thoracic spinal cord injury using bioinformatics methods

Weiguo Wang, Rongjun Liu, Zhanwang Xu, Xiufeng Niu, Zhaohu Mao, Qingxi Meng, Xuecheng Cao
Pages: 7851-7858
Published online on: 14 October 2015

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Article Open Access

Role of the Toll‑like receptor 3 signaling pathway in the neuroprotective effect of sevoflurane pre‑conditioning during cardiopulmonary bypass in rats

Jin Zhou, Nan Zhou, Xiao‑Ning Wu, Hui‑Juan Cao, Ying-Jie Sun, Tie‑Zheng Zhang, Ke‑Yan Chen, Dong‑Mei Yu
Pages: 7859-7868
Published online on: 09 October 2015

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Article Open Access

Inhibition of integrin β1 decreases the malignancy of ovarian cancer cells and potentiates anticancer therapy via the FAK/STAT1 signaling pathway

Lei Zhang, Wen Zou
Pages: 7869-7876
Published online on: 14 October 2015

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Article Open Access

Novel insights into a treatment for aplastic anemia based on the advanced proliferation of bone marrow‑derived mesenchymal stem cells induced by fibroblast growth factor 1

Shayi Jiang, Min Xia, Jingwei Yang, Jingbo Shao, Xuelian Liao, Jiashi Zhu, Hui Jiang
Pages: 7877-7882
Published online on: 09 October 2015

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Article Open Access

NADPH oxidase 3‑associated oxidative stress and caspase 3‑dependent apoptosis in the cochleae of D‑galactose‑induced aged rats Corrigendum in /10.3892/mmr.2015.4590

Zhengde Du, Shuo Li, Lin Liu, Qiong Yang, Hongwei Zhang, Chunsheng Gao
Pages: 7883-7890
Published online on: 13 October 2015

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Article Open Access

Identification of key genes associated with the human abdominal aortic aneurysm based on the gene expression profile

Xudong Chen, Chengfei Zheng, Yunjun He, Lu Tian, Jianhui Li, Donglin Li, Wei Jin, Ming Li, Shusen Zheng
Pages: 7891-7898
Published online on: 15 October 2015

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Article Open Access

Modulation of fatty acid metabolism is involved in the alleviation of isoproterenol-induced rat heart failure by fenofibrate

Ping Li, Shike Luo, Chunji Pan, Xiaoshu Cheng
Pages: 7899-7906
Published online on: 21 October 2015

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Article Open Access

Upregulation of fractalkine contributes to the proliferative response of prostate cancer cells to hypoxia via promoting the G1/S phase transition

Jiebing Tang, Yuanyuan Chen, Rongjun Cui, Dong Li, Lijie Xiao, Ping Lin, Yandan Du, Hui Sun, Xiaoguang Yu, Xiulan Zheng
Pages: 7907-7914
Published online on: 13 October 2015

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Article Open Access

Co‑expression of the carbamoyl‑phosphate synthase 1 gene and its long non‑coding RNA correlates with poor prognosis of patients with intrahepatic cholangiocarcinoma

Sen‑Lin Ma, Ai‑Jun Li, Zhao‑Yang Hu, Fu‑Sheng Shang, Meng‑Chao Wu
Pages: 7915-7926
Published online on: 13 October 2015

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Article Open Access

Changes in the immunohistochemical localization of the glycine receptor in the superior olivary complex of adult circling mice

Young‑Bok Yoo, Dhiraj Maskey, Myeung Ju Kim
Pages: 7927-7932
Published online on: 13 October 2015

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Article Open Access

Protection against ischemia/reperfusion‑induced renal injury by co‑treatment with erythropoietin and sodium selenite

Lu Liu, Chao Liu, Lan Hou, Juan Lv, Fang Wu, Xuefei Yang, Shuting Ren, Wenjun Ji, Meng Wang, Lina Chen
Pages: 7933-7940
Published online on: 09 October 2015

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Article Open Access

Atorvastatin protects endothelial colony‑forming cells against H2O2‑induced oxidative damage by regulating the expression of annexin A2

Da‑Wei Li, Ji‑Hua Li, Ying‑Di Wang, Guang‑Ren Li
Pages: 7941-7948
Published online on: 13 October 2015

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Article Open Access

Isolation and characteristics of CD133‑/A2B5+ and CD133‑/A2B5‑ cells from the SHG139s cell line

Yong Han, Hangzhou Wang, Yulun Huang, Zhe Cheng, Ting Sun, Guilin Chen, Xueshun Xie, Youxin Zhou, Ziwei Du
Pages: 7949-7956
Published online on: 15 October 2015

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Article Open Access

Novel hydroxybutyl chitosan nanoparticles for siRNA delivery targeting tissue factor inhibits proliferation and induces apoptosis in human vascular smooth muscle cells

Kang Wan, Jian Li, Dan Li, Junhua Ge, Yunlong Wang, Xuexun Li, Yongfang Guo, Junjie Guo, Min Leng, Pan Wang, Yi An
Pages: 7957-7962
Published online on: 21 October 2015

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Article Open Access

Cannabinoid WIN55, 212-2 induces cell cycle arrest and inhibits the proliferation and migration of human BEL7402 hepatocellular carcinoma cells Corrigendum in /mmr/13/1/1054

Dacai Xu, Jianglin Wang, Zhenkang Zhou, Zhiwei He, Qing Zhao
Pages: 7963-7970
Published online on: 23 October 2015

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Article Open Access

Knockdown of eukaryotic translation initiation factor 4E suppresses cell growth and invasion, and induces apoptosis and cell cycle arrest in a human lung adenocarcinoma cell line Corrigendum in /10.3892/mmr.2016.4930

Baofu Chen, Bo Zhang, Lilong Xia, Jian Zhang, Yu Chen, Quanteng Hu, Chengchu Zhu
Pages: 7971-7978
Published online on: 21 October 2015

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Article Open Access

Involvement of epithelial-to-mesenchymal transition and associated transforming growth factor-β/Smad signaling in paraquat-induced pulmonary fibrosis

Ying‑Ying Han, Peng Shen, Wen‑Xiu Chang
Pages: 7979-7984
Published online on: 19 October 2015

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Article Open Access

Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury Retraction in /10.3892/mmr.2026.13883

Zeqi Zhong, Yuan Tao, Hui Yang
Pages: 7985-7991
Published online on: 13 October 2015

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Article Open Access

Suppression of A549 cell proliferation and metastasis by calycosin via inhibition of the PKC‑α/ERK1/2 pathway: An in vitro investigation Corrigendum in /10.3892/mmr.2016.4976

Xu‑Dong Cheng, Jun‑Fei Gu, Jia‑Rui Yuan, Liang Feng, Xiao‑Bin Jia
Pages: 7992-8002
Published online on: 15 October 2015

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Article Open Access

Forkhead box C1 induces epithelial‑mesenchymal transition and is a potential therapeutic target in nasopharyngeal carcinoma

Lei Ou‑Yang, Sheng‑Jun Xiao, Peng Liu, Shi‑Jang Yi, Xiao‑Ling Zhang, Shi Ou‑Yang, Sheng‑Kui Tan, Xun Lei
Pages: 8003-8009
Published online on: 12 October 2015

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Article Open Access

Inhibitory effects of fasudil on renal interstitial fibrosis induced by unilateral ureteral obstruction

Itsuko Baba, Yasuhiro Egi, Hiroyuki Utsumi, Tetsuhiro Kakimoto, Kazuo Suzuki
Pages: 8010-8020
Published online on: 21 October 2015

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Article Open Access

Profile of differentially expressed miRNAs in high-grade serous carcinoma and clear cell ovarian carcinoma, and the expression of miR-510 in ovarian carcinoma

Xinchen Zhang, Gordon Guo, Guang Wang, Jinyao Zhao, Bo Wang, Xiaotang Yu, Yanfang Ding
Pages: 8021-8031
Published online on: 26 October 2015

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Article Open Access

Cerebralcare Granule® attenuates cognitive impairment in rats continuously overexpressing microRNA-30e

Yong Xu, Zhifen Liu, Xi Song, Kerang Zhang, Xingrong Li, Jianhong Li, Xu Yan, Yuan Li, Zhongchen Xie, Hui Zhang
Pages: 8032-8040
Published online on: 22 October 2015

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Article Open Access

Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway Corrigendum in /10.3892/mmr.2016.4972

Wei Zhao, Mingshu Lu, Qiwen Zhang
Pages: 8041-8047
Published online on: 21 October 2015

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Article Open Access

Substance P enhances the activation of AMPK and cellular lipid accumulation in 3T3‑L1 cells in response to high levels of glucose

Maria Jose Dubon, Yeji Byeon, Ki‑Sook Park
Pages: 8048-8054
Published online on: 16 October 2015

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Article Open Access

Adipose differentiation-related protein is not involved in hypoxia inducible factor-1-induced lipid accumulation under hypoxia

Guomin Shen, Ning Ning, Xingsheng Zhao, Xi Liu, Guangyu Wang, Tianzhen Wang, Ran Zhao, Chao Yang, Dongmei Wang, Pingyuan Gong, Yan Shen, Yongjian Sun, Xiao Zhao, Yinji Jin, Weiwei Yang, Yan He, Lei Zhang, Xiaoming Jin, Xiaobo Li
Pages: 8055-8061
Published online on: 26 October 2015

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Article

Anti-cancer effects of 2-oxoquinoline derivatives on the HCT116 and LoVo human colon cancer cell lines

Feng-Qi Fang, Hui-Shu Guo, Jie Zhang, Li-Ying Ban, Ji-Wei Liu, Pei-Yao Yu
Pages: 8062-8070
Published online on: 16 October 2015

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Article

Determination of the mechanism of action of repetitive halothane exposure on rat brain tissues using a combined method of microarray gene expression profiling and bioinformatics analysis

Jiansheng Wang, Xiaojun Yang, Huan Xiao, Jianqiang Kong, Miao Bing
Pages: 8071-8076
Published online on: 21 October 2015

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Article

Toll‑like receptor 9 agonist stimulation enables osteogenic differentiation without altering the immune status of umbilical cord mesenchymal stem cells

Yongfeng Yang, Yanwen Wang, Li Li, Ji Bao, Fei Chen, Li Zhang
Pages: 8077-8084
Published online on: 13 October 2015

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Article

Substance P prevents 1-methyl-4-phenylpyridinium-induced cytotoxicity through inhibition of apoptosis via neurokinin-1 receptors in MES23.5 cells

Shuang‑Yan Wang, Lei Chen, Yan Xue, Yu‑Jun Xia
Pages: 8085-8092
Published online on: 21 October 2015

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Article

Dexamethasone protects normal human liver cells from apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand by upregulating the expression of P-glycoproteins

Bo Zhao, Gui‑Juan Xie, Rui‑Feng Li, Qing Chen, Xu‑Qing Zhang
Pages: 8093-8100
Published online on: 21 October 2015

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Article

Inhibition of pro‑collagen I expression by oxymatrine in hepatic stellate cells is mediated via nuclear translocation of Y‑box binding protein 1

Meiling Du, Jun Zhang, Diannan Xu, Wenshuai Li, Jie Liu, Fei Liu
Pages: 8101-8106
Published online on: 12 October 2015

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Article

Identification of candidate target genes for human peripheral arterial disease using weighted gene co‑expression network analysis

De‑Xin Yin, Hao‑Min Zhao, Da‑Jun Sun, Jian Yao, Da‑Yong Ding
Pages: 8107-8112
Published online on: 15 October 2015

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Article

Dynamic expression of miR-206-3p during mouse skin development is independent of keratinocyte differentiation

Yuan Mu, Hong Zhou, Wei‑Jiang Wu, Li‑Chao Hu, Hong‑Bing Chen
Pages: 8113-8120
Published online on: 20 October 2015

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Article

MicroRNA‑200a suppresses epithelial‑to‑mesenchymal transition in rat hepatic stellate cells via GLI family zinc finger 2

Fujun Yu, Yihu Zheng, Weilong Hong, Bicheng Chen, Peihong Dong, Jianjian Zheng
Pages: 8121-8128
Published online on: 16 October 2015

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Article

Clinical significance of STAT3 and MAPK phosphorylation, and the protein expression of cyclin D1 in skin squamous cell carcinoma tissues

Jian Wu, Wen‑Ying Lu, Lei‑Lei Cui
Pages: 8129-8134
Published online on: 21 October 2015

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Article

Recombinant human PDCD5 exhibits an antitumor role in hepatocellular carcinoma cells via clathrin‑dependent endocytosis

Da‑Zhi Fu, Ying Cheng, Hui He, Hai‑Yang Liu, Yong‑Feng Liu
Pages: 8135-8140
Published online on: 26 October 2015

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Article

Pro‑angiogenic microRNA‑296 upregulates vascular endothelial growth factor and downregulates Notch1 following cerebral ischemic injury

Jie Feng, Tianxiang Huang, Qing Huang, Hua Chen, Yu Li, Wei He, Gui‑Bin Wang, Le Zhang, Jian Xia, Ning Zhang, Yunhai Liu
Pages: 8141-8147
Published online on: 13 October 2015

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Article

Procyanidin B2 inhibits high glucose‑induced epithelial‑mesenchymal transition in HK‑2 human renal proximal tubular epithelial cells

Dandan Li, Tingbao Zhao, Jianzhong Meng, Ying Jing, Fengyu Jia, Ping He
Pages: 8148-8154
Published online on: 15 October 2015

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Article

Effects of Wenyangbushen formula on the expression of VEGF, OPG, RANK and RANKL in rabbits with steroid-induced femoral head avascular necrosis

Hong‑Mei Song, Ying‑Chen Wei, Nan Li, Bin Wu, Na Xie, Kun‑Mu Zhang, Shi‑Zhong Wang, He‑Ming Wang
Pages: 8155-8161
Published online on: 23 October 2015

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Article

Contactin‑associated protein‑like 2 expression in SH‑SY5Y cells is upregulated by a FOXP2 mutant with a shortened poly‑glutamine tract

Yunjing Zhao, Xiaoliang Liu, Hongwei Sun, Yueping Wang, Wenzhu Yang, Hongwei Ma
Pages: 8162-8168
Published online on: 23 October 2015

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Article

Obestatin stimulates differentiation and regulates lipolysis and leptin secretion in rat preadipocytes

Tatiana Wojciechowicz, Marek Skrzypski, Paweł A. Kołodziejski, Dawid Szczepankiewicz, Ewa Pruszyńska‑Oszmałek, Przemysław Kaczmarek, Mathias Z. Strowski, Krzysztof W. Nowak
Pages: 8169-8175
Published online on: 22 October 2015

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Article

Mitochondrial COI/tRNASer(UCN) G7444A mutation may be associated with aminoglycoside-induced and non-syndromic hearing impairment

Qi Liu, Ping Liu, Yu Ding, Xue‑Jun Dong, Zong‑Xin Wang, Yan‑Er Qian, Qing Wang, Guo‑Can Yang
Pages: 8176-8178
Published online on: 26 October 2015

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Article

Screening and analysis of mutation hot-spots in deafness-associated genes among adolescents with hearing loss

Hong Jiang, Qizhen Liu, Lihong Chen
Pages: 8179-8184
Published online on: 23 October 2015

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Article

Enhanced antitumor effect of cisplatin in human oral squamous cell carcinoma cells by tumor suppressor GRIM‑19

Minghe Li, Zhihong Li, Jia Li, Liou Jin, Chengxue Jin, Chengmin Han, Xin Ji, Fei Sun
Pages: 8185-8192
Published online on: 09 October 2015

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Article

Candesartan ameliorates acute myocardial infarction in rats through inducible nitric oxide synthase, nuclear factor‑κB, monocyte chemoattractant protein‑1, activator protein‑1 and restoration of heat shock protein 72

Xuefeng Lin, Min Wu, Bo Liu, Junkui Wang, Gongchang Guan, Aiqun Ma, Yong Zhang
Pages: 8193-8200
Published online on: 13 October 2015

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Article

DNA methylation inhibitor, decitabine, promotes MGC803 gastric cancer cell migration and invasion via the upregulation of NEDD4‑1

Dong Li, Chun‑Yan Xu, Rong‑Jun Cui, Jie‑Bing Tang, Hui Sun, Zheng‑Kai Yang, Jing‑Yi Bu, Ping Lin, Ning Huang, Yan‑Dan Du, Xiao‑Guang Yu
Pages: 8201-8208
Published online on: 09 October 2015

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Article

Effect of the one‑carbon unit cycle on overall DNA methylation in children with Down's syndrome

Cui Song, Jingyi He, Jie Chen, Youxue Liu, Feng Xiong, Yutian Wang, Tingyu Li
Pages: 8209-8214
Published online on: 13 October 2015

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Article

Anti-inflammatory effects of 1,25-dihydroxyvitamin D3 in monocytes cultured in serum from patients with type 2 diabetes mellitus and diabetic nephropathy with uremia via Toll-like receptor 4 and nuclear factor-κB p65

Mengxue Yang, Jie Xu, Jie Yu, Bo Yang, Hua Gan, Sicheng Li, Xianwen Li
Pages: 8215-8222
Published online on: 23 October 2015

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Article

Co-treatment of THP-1 cells with naringenin and curcumin induces cell cycle arrest and apoptosis via numerous pathways

Dunyun Shi, Yun Xu, Xin Du, Xuhong Chen, Xiaoli Zhang, Jin Lou, Ming Li, Jiacai Zhuo
Pages: 8223-8228
Published online on: 23 October 2015

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Article

CXC195 induces apoptosis and endoplastic reticulum stress in human hepatocellular carcinoma cells by inhibiting the PI3K/Akt/mTOR signaling pathway

Xiao‑Liang Chen, Jian‑Ping Fu, Jun Shi, Ping Wan, Hong Cao, Zhi‑Mou Tang
Pages: 8229-8236
Published online on: 23 October 2015

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Article

Effects of simvastatin on the osteogenic differentiation and immunomodulation of bone marrow mesenchymal stem cells

Jianyi Niu, Gang Ding, Li Zhang
Pages: 8237-8240
Published online on: 23 October 2015

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Article

Toll-like receptor-2 and -4 are associated with hyperlipidemia

Ya‑Jun Zhu, Chao Wang, Guangyao Song, Sha‑Sha Zang, Yi‑Xuan Liu, Ling Li
Pages: 8241-8246
Published online on: 21 October 2015

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Article

Sorafenib inhibits cancer side population cells by targeting c‑Jun N‑terminal kinase signaling

Jong Bin Kim, Minjong Lee, Seo‑Young Park, Seulki Lee, Hye Ri Kim, Hyo‑Suk Lee, Jung‑Hwan Yoon, Yoon Jun Kim
Pages: 8247-8252
Published online on: 09 October 2015

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Mammalian target of rapamycin/p70 ribosomal S6 protein kinase signaling is altered by sevoflurane and/or surgery in aged rats

Yongzhe Liu, Li Ma, Linbo Jiao, Minglong Gao, Wenzhi Guo, Lin Chen, Ningling Pan, Yaqun Ma
Pages: 8253-8260
Published online on: 14 October 2015

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MicroRNA-101 inhibits proliferation of pulmonary microvascular endothelial cells in a rat model of hepatopulmonary syndrome by targeting the JAK2/STAT3 signaling pathway

Liguo Wang, Liwei Zhuang, Haifang Rong, Yuening Guo, Xiaohua Ling, Ruifeng Wang, Xin Yu, Wei Zhang
Pages: 8261-8267
Published online on: 22 October 2015

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Complementary DNA cloning of the pear 1-aminocyclopropane-1-carboxylic acid oxidase gene and agrobacterium-mediated anti-sense genetic transformation

Jing Qi, Zhen Dong, Yu‑Xing Zhang
Pages: 8268-8274
Published online on: 07 October 2015

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Phosphoinositide 3-kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells Retraction in /10.3892/mmr.2025.13739

Li‑Xia Peng, Ping Zhao, Hong‑Sheng Zhao, Er Pan, Bin‑Bin Yang, Qin Li
Pages: 8275-8281
Published online on: 15 October 2015

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MicroRNA‑1 suppresses cardiac hypertrophy by targeting nuclear factor of activated T cells cytoplasmic 3

Honglei Yin, Lihua Zhao, Shaoli Zhang, Yan Zhang, Suyang Lei
Pages: 8282-8288
Published online on: 14 October 2015

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Effect of lipopolysaccharide on angiotensin II type 1 receptor expression and function in human pulmonary microvascular endothelial cells

Hong‑Peng Li, Hai‑Bo Qiu, Hai‑Qin Wang
Pages: 8289-8293
Published online on: 23 October 2015

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Asiaticoside attenuates the effects of spinal cord injury through antioxidant and anti‑inflammatory effects, and inhibition of the p38‑MAPK mechanism

Yang Luo, Changfeng Fu, Zhenyu Wang, Zhuo Zhang, Hongxia Wang, Yi Liu
Pages: 8294-8300
Published online on: 09 October 2015

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Effects of diazoxide on Aβ1-42-induced expression of the NR2B subunit in cultured cholinergic neurons

Jin Zhu, Qingxi Fu, Chunfeng Xia, Guozhao Ma
Pages: 8301-8305
Published online on: 21 October 2015

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Protective effects of camel milk against pathogenicity induced by Escherichia coli and Staphylococcus aureus in Wistar rats

Mohamed Mohamed Soliman, Magdy Yassin Hassan, Salama Abdel‑Hafiz Mostafa, Hussein Abdel‑Maksoud Ali, Osama Moseilhy Saleh
Pages: 8306-8312
Published online on: 26 October 2015

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Small‑sized gold nanoparticles inhibit the proliferation and invasion of SW579 cells

Qingqing Zhang, Yongmei Ma, Shufang Yang, Bangkui Xu, Xiaoqiang Fei
Pages: 8313-8319
Published online on: 13 October 2015

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In vivo knockdown of CXCR4 using jetPEI/CXCR4 shRNA nanoparticles inhibits the pulmonary metastatic potential of B16‑F10 melanoma cells

Nayara Delgado André, Viviane Aline Oliveira Silva, Carolina Batista Ariza, Maria Angelica Ehara Watanabe, Fernando Luiz De Lucca
Pages: 8320-8326
Published online on: 26 October 2015

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Correction Open Access

[Corrigendum] Effects of rotigaptide (ZP123) on connexin43 remodeling in canine ventricular fibrillation

Guo-Ying Su, Jing Wang, Zhen-Xing Xu, Xiao-Jun Qiao, Jing-Quan Zhong, Yun Zhang
Pages: 8327-8327
Published online on: 23 October 2015

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[Corrigendum] Effects of miR-19b knockdown on the cardiac differentiation of P19 mouse embryonic carcinoma cells

Xuehua Liu, Liming Yang, Huiyan Wang, Guofeng Xu, Shasha Zhu, Mengmeng Li, Xiaoshan Hu, Jingai Zhu, Chun Zhu, Jing Xu, Shuping Han, Zhangbin Yu
Pages: 8328-8328
Published online on: 23 October 2015

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[Corrigendum] Lentivirus vector-mediated gene transduction of CNGRC peptide in rat adipose stem cells

Du Meng, Rui Liu, Li Pei, Lei Hou, Qian Ning, Qing Yu, Lu Feng, Xinhan Zhao
Pages: 8329-8329
Published online on: 23 October 2015

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Journal Cover
July-2026 Volume 34 Issue 1

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Impact Factor: 3.5

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Regulatory mechanisms and therapeutic potential of N6-methyladenosine modification in retinal diseases (Review)

Wenyao Zhang, Jinying Chen, Jingxiang Zhong
Article Number: 213
Published online on: 29 May 2026

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Epigenetic orchestration of scar formation: Therapeutic potential of targeting DNA methylation and non‑coding RNAs in cutaneous fibrosis (Review)

Jinshun Li, Weiyun Liu, Jin Yang, Yanan Li
Article Number: 212
Published online on: 29 May 2026

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Elucidating the multitarget neuroprotective mechanisms of protocatechuic acid in neurological disorders (Review)

Xiaoyan Xue, Yongchang Lai, Shasha Song, Liping Wu, Lifang Wang
Article Number: 211
Published online on: 29 May 2026

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[Retracted] Piperine depresses the migration progression via downregulating the Akt/mTOR/MMP‑9 signaling pathway in DU145 cells

Yuan Zeng, Ying Yang
Article Number: 210
Published online on: 27 May 2026

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FOSL2 drives transcriptional activation of super‑enhancer-regulated DYNC1H1 to promote hypoxia‑induced oral squamous cell carcinoma progression

Linyu Jin, Jing Zhang, Wenjing Wang, Nan Zhang, Yang Liu, Alin Tian, Weiwei Yin, Yongle Qiu
Article Number: 209
Published online on: 25 May 2026

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Targeting lipophagy in atherosclerosis: Molecular mechanisms, pathogenesis and therapeutic interventions (Review)

Songhua Nan, Chaojie Peng, Xue Meng, Jingnan Jia, Fangfang Zhao, Yinglin Cui
Article Number: 208
Published online on: 22 May 2026

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Mechanisms of pruritus and advances in traditional Chinese medicine therapy (Review)

Hailing Zhang, Yongji Li, Yuan Liu, Danyi Feng, Letao Zhao, Ran Chen, Xiwu Zhang, Jinjin Dou
Article Number: 207
Published online on: 22 May 2026

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Reprogramming of the hepatic ubiquitin‑immune axis: A unifying mechanism in liver disease progression (Review)

Yadi Ju, Xiaodan Chong, Weichen Ning, Yan Shi, Yangyang Li, Yihai Shi
Article Number: 206
Published online on: 22 May 2026

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Role of the PI3K/AKT signaling pathway in regulating gene expression in rheumatoid arthritis (Review)

Chengzhi Cong, Yuan Wang, Jian Liu, Chao Jin
Article Number: 205
Published online on: 21 May 2026

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Biomarkers of radioresistance in lung cancer: Current insights and future directions (Review)

Fatima Zohra Attouahri, Imane Chaoui, Abdelilah Laraqui, Mohamed Rida Tagajdid, Mohammed Oukabli, Mohammed El Marjany, Meriem Khyatti, Mohammed Attaleb, Mouna Ababou, Khalid Ennibi, Khaoula Errafii, Mohammed El Mzibri
Article Number: 204
Published online on: 21 May 2026

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Epigenetic research methods and animal models for intervertebral disc degeneration (Review)

Xinliang Cui, Li Zeng, Wei Zhang, Leimin Xi, Rui Wang, Diff Jia, Safa, Haoyu Feng, Huidong Jia
Article Number: 203
Published online on: 21 May 2026

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ZBTB16 upregulation maintains copper homeostasis to support esophageal tumor progression

Jingyi Wang, Bin Yang, Shengzu Peng, Bin Yang
Article Number: 202
Published online on: 21 May 2026

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[Corrigendum] MicroRNA‑1 promotes cartilage matrix synthesis and regulates chondrocyte differentiation via post‑​transcriptional suppression of Ihh expression  

Taoyu Chen, Xianda Che, Pengfei Han, Jiangong Lu, Chunfang Wang, Bin Liang, Ziqi Hou, Xiaochun Wei, Lei Wei, Pengcui Li
Article Number: 201
Published online on: 20 May 2026

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Estrogen deficiency as a common driver and integrative mechanism in osteoporosis‑osteoarthritis comorbidity (Review)

Jian Cheng, Xiaodong Wu, Lu Zhao, Shuai Jiang, Wenjie Zhao, Weishuai Zhang
Article Number: 200
Published online on: 20 May 2026

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Role of RNA 5‑methylcytosine modification in cancer: Insights from coding and non‑coding RNAs (Review)

Qin Jiang, Yi Gong, Mimi Zhai, Tenglong Tang, Sushun Liu
Article Number: 199
Published online on: 20 May 2026

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m6A modification in skeletal system diseases (Review)

Xi Xie, Chen Li, Haotian Zheng, Guang Gan, Xi Gao
Article Number: 198
Published online on: 19 May 2026

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Dynamic regulation of the ‘mitochondria‑immune axis’ in myocardial infarction: Molecular mechanisms driving macrophage polarization through energy metabolism disorders (Review)

Yu Zhang, Hao Feng, Qin Wu, Shuxian Yang, Yundong Jiang, Houping Xu, Li Dong, Xiaolin Li, Hui Chen, Gang Luo
Article Number: 197
Published online on: 19 May 2026

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[Retracted] Homeobox B9 facilitates hypertrophic scar formation via activating the mitogen‑activated protein kinase signaling pathway

Qun Xie, Dandan Liu, Mosheng Yu, Xiaowei Wu, Yueqiang Zhao, Qiang Hu, Qi Wang
Article Number: 196
Published online on: 18 May 2026

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Polysaccharides: Natural candidates for targeting immunometabolic regulation in hepatocellular carcinoma (Review)

Changmei Wu, Jinjin Dou, Xiwu Zhang
Article Number: 195
Published online on: 18 May 2026

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NF‑κB signaling drives Th17‑mediated lacrimal gland injury and tear dysfunction in a murine model of primary Sjögren's syndrome

Jiajun Xie, Huina Zhang, Wenyue Shen, Juan Ye
Article Number: 194
Published online on: 18 May 2026

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POSTN(+) fibroblasts and SPP1(+) macrophages in scar formation: A review of mechanisms and therapeutic targets (Review)

Haotian Wu, Xianglin Dong
Article Number: 193
Published online on: 15 May 2026

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Emerging role of DYRK1A as a target in cardiovascular diseases (Review)

Liqing Yu, Qionghong Cheng, Jun Wu
Article Number: 192
Published online on: 15 May 2026

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[Retracted] Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 inflammasome activation via SIRT1

Peng Zou, Xiaoxiao Liu, Gang Li, Yangang Wang
Article Number: 191
Published online on: 05 May 2026

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Gut microbiota and its metabolites: Key factors of drug resistance in the treatment of advanced prostate cancer (Review)

Jingheng Song, Hongguo Cui, Peisen Yang, Yankai Xu, Yuanyuan Liu, Gang Zhang, Yangyang Liu, Aimin Tian, Jizhong Che, Hui Sun, Zhengchao Zhang
Article Number: 190
Published online on: 04 May 2026

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Cepharanthine inhibits lysosomes and induces apoptosis in triple‑negative breast cancer cells

Juan Li, Siqin Zhou, Yu Wang, Guanghan Ou, Danli Yang, Liwen Shen
Article Number: 189
Published online on: 04 May 2026

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Applications of humanized mice in Mycobacterium tuberculosis infections (Review)

Binghua Han, Fang Liu, Jinzhao Long, Jiongjiong Wang, Yange Cui, Haiyan Yang
Article Number: 188
Published online on: 04 May 2026

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Research progress on neutrophil extracellular traps in sepsis‑induced coagulopathy (Review)

Jiandong Hu, Mengli Jin, Zhihua Cao, Binbin Zheng, Yuan Zheng, Hao Shen
Article Number: 187
Published online on: 04 May 2026

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Multifaceted regulatory role of proline‑ and glutamine-rich splicing factor in tumors (Review)

Shilin Zhang, Zhenhua Li, Li Fu
Article Number: 186
Published online on: 04 May 2026

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Effects of ALDH2 gene expression on the oxidative stress‑mediated NF‑κB/mTOR pathway in ketamine‑induced cystitis

Xiao Jian Xi, Yong Yao, Peng Gu, Min Hao Zhang
Article Number: 185
Published online on: 04 May 2026

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[Retracted] Rosiglitazone exerts neuroprotective effects via the suppression of neuronal autophagy and apoptosis in the cortex following traumatic brain injury

Junchao Yao, Kebin Zheng, Xiang Zhang
Article Number: 184
Published online on: 29 April 2026

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Journal Cover
August-2026 Volume 34 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Growth pattern and molecular biological analysis of primary meningioma cell cultures under different conditions

Stefan Linsler, Anna-Lena Moroldo, Walter Schulz‑schaeffer, Ralf Ketter, Joachim Oertel, Steffi Urbschat
Article Number: 228
Published online on: 12 June 2026

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Melatonin alleviates mitochondrial damage by regulating SIRT3‑mediated mitochondrial dynamics in granulosa cells under PCOS‑like conditions

Congcong Xie, Zehao Liu, Tong Chen, Hui Lu, Xiujia Zhang, Wenbo Yu, Jiaxin Zhang, Dandan Shang, Xueying Wang
Article Number: 227
Published online on: 11 June 2026

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Strontium‑based metal‑organic framework/alendronate‑silk fibroin hydrogels promote tendon‑bone interface healing

Tao Yang, Hanji Zhang, Mingjun Li, Yiming Ren, Yunbo Sun, Weiyu Hou, Mengqiang Tian
Article Number: 226
Published online on: 11 June 2026

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[Retracted] Tripterygium glycoside suppresses epithelial‑to‑­­ mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway

Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He
Article Number: 225
Published online on: 08 June 2026

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Gut microbiota‑derived metabolites in cardiovascular disease: Focus on trimethylamine N‑oxide, short‑chain fatty acids and bile acids (Review)

Meizhu Gao, Zhenming Hao, Yiling Li, Weixue Liu, Fubao Zhang
Article Number: 224
Published online on: 08 June 2026

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Fucoxanthin alleviates chondrocyte inflammation and osteoarthritis by modulating the JAK2/STAT3 signaling pathway

Miradj Siddick Adam, Huangming Zhuang, Xunshan Ren, Yuelong Zhang, Panghu Zhou
Article Number: 223
Published online on: 08 June 2026

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Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer

Huaiyong Li, Lili Liu, Qingzhu Yang, Yao Li, Yongli Song, Jing Jiang, Zhenzhong Wu, Weiwei Zhang, Baisong Lou
Article Number: 222
Published online on: 08 June 2026

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Molecular mechanisms of iron metabolism and ferroptosis in cardiovascular diseases and intervention strategies targeting natural products (Review)

Liangqing Ge, Tianqing Zhang, Jiangbiao Yu, Sijie Xiao, Yu Zhou, Li Luo
Article Number: 221
Published online on: 05 June 2026

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[Corrigendum] Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis

Ruiqiao Guan, Zhihao Li, Xiaohong Dai, Wei Zou, Xueping Yu, Hao Liu, Qiuxin Chen, Wei Teng, Peng Liu, Xiaoying Liu, Shanshan Dong
Article Number: 220
Published online on: 03 June 2026

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LINC01117 promotes the malignant proliferation of lung adenocarcinoma by increasing HOXD8 mRNA stability

Lizhong Zeng, Jie Shi, Cai Zhang, Yujiao Dong, Yang Chen, Qiuhong Zhang, Long Zhang, Shuanying Yang
Article Number: 219
Published online on: 03 June 2026

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Targeting regulatory T cells in the prostate cancer microenvironment: From mechanisms to therapeutics (Review)

Hua Luo
Article Number: 218
Published online on: 03 June 2026

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Dapagliflozin alleviates heart failure with preserved ejection fraction potentially by regulating the AIM2/caspase‑1/GSDMD pathway and attenuating pyroptosis

Sailiang Ding, Hao Yang, Ting Lu, Yibin Luo, Liang Xu, Xianghui Zeng
Article Number: 217
Published online on: 03 June 2026

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[Retracted] Carnosic acid alleviates brain injury through NF‑κB‑regulated inflammation and Caspase‑3‑associated apoptosis in high fat‑induced mouse models

Yong Liu, Yan Zhang, Ming Hu, Yu-Hu Li, Xing-Hua Cao
Article Number: 216
Published online on: 02 June 2026

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SIRT1/AMPK/PGC1α pathway in ischemic stroke: Elucidating neuroprotective strategies (Review)

Irum Naz Abbasi, Nashwa Amin, Qiaolu Xu, Azhar Badry Hussain, Fei Wu, Xia Yuan, Yang Yang, Suhong Ye, Marong Fang, Yihua Jiang
Article Number: 215
Published online on: 02 June 2026

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Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review)

Yinhuan Wang, Jiefang Guan
Article Number: 214
Published online on: 29 May 2026

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