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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December-2015 Volume 12 Issue 6

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Brain mechanisms of sympathetic activation in heart failure: Roles of the renin‑angiotensin system, nitric oxide and pro‑inflammatory cytokines (Review)

Bin Xu, Hongli Li
Pages: 7823-7829
Published online on: 13 October 2015

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Article Open Access

MicroRNA-519 enhances HL60 human acute myeloid leukemia cell line proliferation by reducing the expression level of RNA-binding protein human antigen R Retraction in /10.3892/mmr.2024.13335

Kebin Huang, Bingwei Dong, Yueyue Wang, Tao Tian, Biying Zhang
Pages: 7830-7836
Published online on: 20 October 2015

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Article Open Access

Increased cyclooxygenase-2 and nuclear factor-κB/p65 expression in mouse hippocampi after systemic administration of tetanus toxin

Bing Chun Yan, Yong Hwan Jeon, Joon Ha Park, In Hye Kim, Jeong‑Hwi Cho, Ji Hyeon Ahn, Bai Hui Chen, Hyun‑Jin Tae, Jae‑Chul Lee, Ji Yun Ahn, Dong Won Kim, Jun Hwi Cho, Moo‑Ho Won, Seongkweon Hong
Pages: 7837-7844
Published online on: 26 October 2015

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Article Open Access

Effect of Hath1 on the proliferation and apoptosis of cutaneous squamous cell carcinoma in vitro

Zuolin Ying, Xiaojie Li, Hong Dang, Feng Wang, Xiaoyan Xu
Pages: 7845-7850
Published online on: 21 October 2015

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Article Open Access

Further insight into molecular mechanism underlying thoracic spinal cord injury using bioinformatics methods

Weiguo Wang, Rongjun Liu, Zhanwang Xu, Xiufeng Niu, Zhaohu Mao, Qingxi Meng, Xuecheng Cao
Pages: 7851-7858
Published online on: 14 October 2015

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Article Open Access

Role of the Toll‑like receptor 3 signaling pathway in the neuroprotective effect of sevoflurane pre‑conditioning during cardiopulmonary bypass in rats

Jin Zhou, Nan Zhou, Xiao‑Ning Wu, Hui‑Juan Cao, Ying-Jie Sun, Tie‑Zheng Zhang, Ke‑Yan Chen, Dong‑Mei Yu
Pages: 7859-7868
Published online on: 09 October 2015

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Article Open Access

Inhibition of integrin β1 decreases the malignancy of ovarian cancer cells and potentiates anticancer therapy via the FAK/STAT1 signaling pathway

Lei Zhang, Wen Zou
Pages: 7869-7876
Published online on: 14 October 2015

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Article Open Access

Novel insights into a treatment for aplastic anemia based on the advanced proliferation of bone marrow‑derived mesenchymal stem cells induced by fibroblast growth factor 1

Shayi Jiang, Min Xia, Jingwei Yang, Jingbo Shao, Xuelian Liao, Jiashi Zhu, Hui Jiang
Pages: 7877-7882
Published online on: 09 October 2015

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Article Open Access

NADPH oxidase 3‑associated oxidative stress and caspase 3‑dependent apoptosis in the cochleae of D‑galactose‑induced aged rats Corrigendum in /10.3892/mmr.2015.4590

Zhengde Du, Shuo Li, Lin Liu, Qiong Yang, Hongwei Zhang, Chunsheng Gao
Pages: 7883-7890
Published online on: 13 October 2015

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Article Open Access

Identification of key genes associated with the human abdominal aortic aneurysm based on the gene expression profile

Xudong Chen, Chengfei Zheng, Yunjun He, Lu Tian, Jianhui Li, Donglin Li, Wei Jin, Ming Li, Shusen Zheng
Pages: 7891-7898
Published online on: 15 October 2015

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Article Open Access

Modulation of fatty acid metabolism is involved in the alleviation of isoproterenol-induced rat heart failure by fenofibrate

Ping Li, Shike Luo, Chunji Pan, Xiaoshu Cheng
Pages: 7899-7906
Published online on: 21 October 2015

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Article Open Access

Upregulation of fractalkine contributes to the proliferative response of prostate cancer cells to hypoxia via promoting the G1/S phase transition

Jiebing Tang, Yuanyuan Chen, Rongjun Cui, Dong Li, Lijie Xiao, Ping Lin, Yandan Du, Hui Sun, Xiaoguang Yu, Xiulan Zheng
Pages: 7907-7914
Published online on: 13 October 2015

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Article Open Access

Co‑expression of the carbamoyl‑phosphate synthase 1 gene and its long non‑coding RNA correlates with poor prognosis of patients with intrahepatic cholangiocarcinoma

Sen‑Lin Ma, Ai‑Jun Li, Zhao‑Yang Hu, Fu‑Sheng Shang, Meng‑Chao Wu
Pages: 7915-7926
Published online on: 13 October 2015

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Article Open Access

Changes in the immunohistochemical localization of the glycine receptor in the superior olivary complex of adult circling mice

Young‑Bok Yoo, Dhiraj Maskey, Myeung Ju Kim
Pages: 7927-7932
Published online on: 13 October 2015

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Article Open Access

Protection against ischemia/reperfusion‑induced renal injury by co‑treatment with erythropoietin and sodium selenite

Lu Liu, Chao Liu, Lan Hou, Juan Lv, Fang Wu, Xuefei Yang, Shuting Ren, Wenjun Ji, Meng Wang, Lina Chen
Pages: 7933-7940
Published online on: 09 October 2015

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Article Open Access

Atorvastatin protects endothelial colony‑forming cells against H2O2‑induced oxidative damage by regulating the expression of annexin A2

Da‑Wei Li, Ji‑Hua Li, Ying‑Di Wang, Guang‑Ren Li
Pages: 7941-7948
Published online on: 13 October 2015

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Article Open Access

Isolation and characteristics of CD133‑/A2B5+ and CD133‑/A2B5‑ cells from the SHG139s cell line

Yong Han, Hangzhou Wang, Yulun Huang, Zhe Cheng, Ting Sun, Guilin Chen, Xueshun Xie, Youxin Zhou, Ziwei Du
Pages: 7949-7956
Published online on: 15 October 2015

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Article Open Access

Novel hydroxybutyl chitosan nanoparticles for siRNA delivery targeting tissue factor inhibits proliferation and induces apoptosis in human vascular smooth muscle cells

Kang Wan, Jian Li, Dan Li, Junhua Ge, Yunlong Wang, Xuexun Li, Yongfang Guo, Junjie Guo, Min Leng, Pan Wang, Yi An
Pages: 7957-7962
Published online on: 21 October 2015

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Article Open Access

Cannabinoid WIN55, 212-2 induces cell cycle arrest and inhibits the proliferation and migration of human BEL7402 hepatocellular carcinoma cells Corrigendum in /mmr/13/1/1054

Dacai Xu, Jianglin Wang, Zhenkang Zhou, Zhiwei He, Qing Zhao
Pages: 7963-7970
Published online on: 23 October 2015

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Article Open Access

Knockdown of eukaryotic translation initiation factor 4E suppresses cell growth and invasion, and induces apoptosis and cell cycle arrest in a human lung adenocarcinoma cell line Corrigendum in /10.3892/mmr.2016.4930

Baofu Chen, Bo Zhang, Lilong Xia, Jian Zhang, Yu Chen, Quanteng Hu, Chengchu Zhu
Pages: 7971-7978
Published online on: 21 October 2015

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Article Open Access

Involvement of epithelial-to-mesenchymal transition and associated transforming growth factor-β/Smad signaling in paraquat-induced pulmonary fibrosis

Ying‑Ying Han, Peng Shen, Wen‑Xiu Chang
Pages: 7979-7984
Published online on: 19 October 2015

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Article Open Access

Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury

Zeqi Zhong, Yuan Tao, Hui Yang
Pages: 7985-7991
Published online on: 13 October 2015

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Article Open Access

Suppression of A549 cell proliferation and metastasis by calycosin via inhibition of the PKC‑α/ERK1/2 pathway: An in vitro investigation Corrigendum in /10.3892/mmr.2016.4976

Xu‑Dong Cheng, Jun‑Fei Gu, Jia‑Rui Yuan, Liang Feng, Xiao‑Bin Jia
Pages: 7992-8002
Published online on: 15 October 2015

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Article Open Access

Forkhead box C1 induces epithelial‑mesenchymal transition and is a potential therapeutic target in nasopharyngeal carcinoma

Lei Ou‑Yang, Sheng‑Jun Xiao, Peng Liu, Shi‑Jang Yi, Xiao‑Ling Zhang, Shi Ou‑Yang, Sheng‑Kui Tan, Xun Lei
Pages: 8003-8009
Published online on: 12 October 2015

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Article Open Access

Inhibitory effects of fasudil on renal interstitial fibrosis induced by unilateral ureteral obstruction

Itsuko Baba, Yasuhiro Egi, Hiroyuki Utsumi, Tetsuhiro Kakimoto, Kazuo Suzuki
Pages: 8010-8020
Published online on: 21 October 2015

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Article Open Access

Profile of differentially expressed miRNAs in high-grade serous carcinoma and clear cell ovarian carcinoma, and the expression of miR-510 in ovarian carcinoma

Xinchen Zhang, Gordon Guo, Guang Wang, Jinyao Zhao, Bo Wang, Xiaotang Yu, Yanfang Ding
Pages: 8021-8031
Published online on: 26 October 2015

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Article Open Access

Cerebralcare Granule® attenuates cognitive impairment in rats continuously overexpressing microRNA-30e

Yong Xu, Zhifen Liu, Xi Song, Kerang Zhang, Xingrong Li, Jianhong Li, Xu Yan, Yuan Li, Zhongchen Xie, Hui Zhang
Pages: 8032-8040
Published online on: 22 October 2015

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Article Open Access

Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway Corrigendum in /10.3892/mmr.2016.4972

Wei Zhao, Mingshu Lu, Qiwen Zhang
Pages: 8041-8047
Published online on: 21 October 2015

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Article Open Access

Substance P enhances the activation of AMPK and cellular lipid accumulation in 3T3‑L1 cells in response to high levels of glucose

Maria Jose Dubon, Yeji Byeon, Ki‑Sook Park
Pages: 8048-8054
Published online on: 16 October 2015

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Article Open Access

Adipose differentiation-related protein is not involved in hypoxia inducible factor-1-induced lipid accumulation under hypoxia

Guomin Shen, Ning Ning, Xingsheng Zhao, Xi Liu, Guangyu Wang, Tianzhen Wang, Ran Zhao, Chao Yang, Dongmei Wang, Pingyuan Gong, Yan Shen, Yongjian Sun, Xiao Zhao, Yinji Jin, Weiwei Yang, Yan He, Lei Zhang, Xiaoming Jin, Xiaobo Li
Pages: 8055-8061
Published online on: 26 October 2015

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Article

Anti-cancer effects of 2-oxoquinoline derivatives on the HCT116 and LoVo human colon cancer cell lines

Feng-Qi Fang, Hui-Shu Guo, Jie Zhang, Li-Ying Ban, Ji-Wei Liu, Pei-Yao Yu
Pages: 8062-8070
Published online on: 16 October 2015

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Article

Determination of the mechanism of action of repetitive halothane exposure on rat brain tissues using a combined method of microarray gene expression profiling and bioinformatics analysis

Jiansheng Wang, Xiaojun Yang, Huan Xiao, Jianqiang Kong, Miao Bing
Pages: 8071-8076
Published online on: 21 October 2015

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Article

Toll‑like receptor 9 agonist stimulation enables osteogenic differentiation without altering the immune status of umbilical cord mesenchymal stem cells

Yongfeng Yang, Yanwen Wang, Li Li, Ji Bao, Fei Chen, Li Zhang
Pages: 8077-8084
Published online on: 13 October 2015

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Article

Substance P prevents 1-methyl-4-phenylpyridinium-induced cytotoxicity through inhibition of apoptosis via neurokinin-1 receptors in MES23.5 cells

Shuang‑Yan Wang, Lei Chen, Yan Xue, Yu‑Jun Xia
Pages: 8085-8092
Published online on: 21 October 2015

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Article

Dexamethasone protects normal human liver cells from apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand by upregulating the expression of P-glycoproteins

Bo Zhao, Gui‑Juan Xie, Rui‑Feng Li, Qing Chen, Xu‑Qing Zhang
Pages: 8093-8100
Published online on: 21 October 2015

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Article

Inhibition of pro‑collagen I expression by oxymatrine in hepatic stellate cells is mediated via nuclear translocation of Y‑box binding protein 1

Meiling Du, Jun Zhang, Diannan Xu, Wenshuai Li, Jie Liu, Fei Liu
Pages: 8101-8106
Published online on: 12 October 2015

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Article

Identification of candidate target genes for human peripheral arterial disease using weighted gene co‑expression network analysis

De‑Xin Yin, Hao‑Min Zhao, Da‑Jun Sun, Jian Yao, Da‑Yong Ding
Pages: 8107-8112
Published online on: 15 October 2015

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Article

Dynamic expression of miR-206-3p during mouse skin development is independent of keratinocyte differentiation

Yuan Mu, Hong Zhou, Wei‑Jiang Wu, Li‑Chao Hu, Hong‑Bing Chen
Pages: 8113-8120
Published online on: 20 October 2015

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Article

MicroRNA‑200a suppresses epithelial‑to‑mesenchymal transition in rat hepatic stellate cells via GLI family zinc finger 2

Fujun Yu, Yihu Zheng, Weilong Hong, Bicheng Chen, Peihong Dong, Jianjian Zheng
Pages: 8121-8128
Published online on: 16 October 2015

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Article

Clinical significance of STAT3 and MAPK phosphorylation, and the protein expression of cyclin D1 in skin squamous cell carcinoma tissues

Jian Wu, Wen‑Ying Lu, Lei‑Lei Cui
Pages: 8129-8134
Published online on: 21 October 2015

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Article

Recombinant human PDCD5 exhibits an antitumor role in hepatocellular carcinoma cells via clathrin‑dependent endocytosis

Da‑Zhi Fu, Ying Cheng, Hui He, Hai‑Yang Liu, Yong‑Feng Liu
Pages: 8135-8140
Published online on: 26 October 2015

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Article

Pro‑angiogenic microRNA‑296 upregulates vascular endothelial growth factor and downregulates Notch1 following cerebral ischemic injury

Jie Feng, Tianxiang Huang, Qing Huang, Hua Chen, Yu Li, Wei He, Gui‑Bin Wang, Le Zhang, Jian Xia, Ning Zhang, Yunhai Liu
Pages: 8141-8147
Published online on: 13 October 2015

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Article

Procyanidin B2 inhibits high glucose‑induced epithelial‑mesenchymal transition in HK‑2 human renal proximal tubular epithelial cells

Dandan Li, Tingbao Zhao, Jianzhong Meng, Ying Jing, Fengyu Jia, Ping He
Pages: 8148-8154
Published online on: 15 October 2015

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Article

Effects of Wenyangbushen formula on the expression of VEGF, OPG, RANK and RANKL in rabbits with steroid-induced femoral head avascular necrosis

Hong‑Mei Song, Ying‑Chen Wei, Nan Li, Bin Wu, Na Xie, Kun‑Mu Zhang, Shi‑Zhong Wang, He‑Ming Wang
Pages: 8155-8161
Published online on: 23 October 2015

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Article

Contactin‑associated protein‑like 2 expression in SH‑SY5Y cells is upregulated by a FOXP2 mutant with a shortened poly‑glutamine tract

Yunjing Zhao, Xiaoliang Liu, Hongwei Sun, Yueping Wang, Wenzhu Yang, Hongwei Ma
Pages: 8162-8168
Published online on: 23 October 2015

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Article

Obestatin stimulates differentiation and regulates lipolysis and leptin secretion in rat preadipocytes

Tatiana Wojciechowicz, Marek Skrzypski, Paweł A. Kołodziejski, Dawid Szczepankiewicz, Ewa Pruszyńska‑Oszmałek, Przemysław Kaczmarek, Mathias Z. Strowski, Krzysztof W. Nowak
Pages: 8169-8175
Published online on: 22 October 2015

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Article

Mitochondrial COI/tRNASer(UCN) G7444A mutation may be associated with aminoglycoside-induced and non-syndromic hearing impairment

Qi Liu, Ping Liu, Yu Ding, Xue‑Jun Dong, Zong‑Xin Wang, Yan‑Er Qian, Qing Wang, Guo‑Can Yang
Pages: 8176-8178
Published online on: 26 October 2015

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Article

Screening and analysis of mutation hot-spots in deafness-associated genes among adolescents with hearing loss

Hong Jiang, Qizhen Liu, Lihong Chen
Pages: 8179-8184
Published online on: 23 October 2015

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Article

Enhanced antitumor effect of cisplatin in human oral squamous cell carcinoma cells by tumor suppressor GRIM‑19

Minghe Li, Zhihong Li, Jia Li, Liou Jin, Chengxue Jin, Chengmin Han, Xin Ji, Fei Sun
Pages: 8185-8192
Published online on: 09 October 2015

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Article

Candesartan ameliorates acute myocardial infarction in rats through inducible nitric oxide synthase, nuclear factor‑κB, monocyte chemoattractant protein‑1, activator protein‑1 and restoration of heat shock protein 72

Xuefeng Lin, Min Wu, Bo Liu, Junkui Wang, Gongchang Guan, Aiqun Ma, Yong Zhang
Pages: 8193-8200
Published online on: 13 October 2015

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Article

DNA methylation inhibitor, decitabine, promotes MGC803 gastric cancer cell migration and invasion via the upregulation of NEDD4‑1

Dong Li, Chun‑Yan Xu, Rong‑Jun Cui, Jie‑Bing Tang, Hui Sun, Zheng‑Kai Yang, Jing‑Yi Bu, Ping Lin, Ning Huang, Yan‑Dan Du, Xiao‑Guang Yu
Pages: 8201-8208
Published online on: 09 October 2015

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Article

Effect of the one‑carbon unit cycle on overall DNA methylation in children with Down's syndrome

Cui Song, Jingyi He, Jie Chen, Youxue Liu, Feng Xiong, Yutian Wang, Tingyu Li
Pages: 8209-8214
Published online on: 13 October 2015

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Article

Anti-inflammatory effects of 1,25-dihydroxyvitamin D3 in monocytes cultured in serum from patients with type 2 diabetes mellitus and diabetic nephropathy with uremia via Toll-like receptor 4 and nuclear factor-κB p65

Mengxue Yang, Jie Xu, Jie Yu, Bo Yang, Hua Gan, Sicheng Li, Xianwen Li
Pages: 8215-8222
Published online on: 23 October 2015

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Article

Co-treatment of THP-1 cells with naringenin and curcumin induces cell cycle arrest and apoptosis via numerous pathways

Dunyun Shi, Yun Xu, Xin Du, Xuhong Chen, Xiaoli Zhang, Jin Lou, Ming Li, Jiacai Zhuo
Pages: 8223-8228
Published online on: 23 October 2015

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Article

CXC195 induces apoptosis and endoplastic reticulum stress in human hepatocellular carcinoma cells by inhibiting the PI3K/Akt/mTOR signaling pathway

Xiao‑Liang Chen, Jian‑Ping Fu, Jun Shi, Ping Wan, Hong Cao, Zhi‑Mou Tang
Pages: 8229-8236
Published online on: 23 October 2015

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Article

Effects of simvastatin on the osteogenic differentiation and immunomodulation of bone marrow mesenchymal stem cells

Jianyi Niu, Gang Ding, Li Zhang
Pages: 8237-8240
Published online on: 23 October 2015

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Article

Toll-like receptor-2 and -4 are associated with hyperlipidemia

Ya‑Jun Zhu, Chao Wang, Guangyao Song, Sha‑Sha Zang, Yi‑Xuan Liu, Ling Li
Pages: 8241-8246
Published online on: 21 October 2015

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Article

Sorafenib inhibits cancer side population cells by targeting c‑Jun N‑terminal kinase signaling

Jong Bin Kim, Minjong Lee, Seo‑Young Park, Seulki Lee, Hye Ri Kim, Hyo‑Suk Lee, Jung‑Hwan Yoon, Yoon Jun Kim
Pages: 8247-8252
Published online on: 09 October 2015

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Mammalian target of rapamycin/p70 ribosomal S6 protein kinase signaling is altered by sevoflurane and/or surgery in aged rats

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Liguo Wang, Liwei Zhuang, Haifang Rong, Yuening Guo, Xiaohua Ling, Ruifeng Wang, Xin Yu, Wei Zhang
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Complementary DNA cloning of the pear 1-aminocyclopropane-1-carboxylic acid oxidase gene and agrobacterium-mediated anti-sense genetic transformation

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Li‑Xia Peng, Ping Zhao, Hong‑Sheng Zhao, Er Pan, Bin‑Bin Yang, Qin Li
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MicroRNA‑1 suppresses cardiac hypertrophy by targeting nuclear factor of activated T cells cytoplasmic 3

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Effect of lipopolysaccharide on angiotensin II type 1 receptor expression and function in human pulmonary microvascular endothelial cells

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Asiaticoside attenuates the effects of spinal cord injury through antioxidant and anti‑inflammatory effects, and inhibition of the p38‑MAPK mechanism

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Effects of diazoxide on Aβ1-42-induced expression of the NR2B subunit in cultured cholinergic neurons

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Protective effects of camel milk against pathogenicity induced by Escherichia coli and Staphylococcus aureus in Wistar rats

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Small‑sized gold nanoparticles inhibit the proliferation and invasion of SW579 cells

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In vivo knockdown of CXCR4 using jetPEI/CXCR4 shRNA nanoparticles inhibits the pulmonary metastatic potential of B16‑F10 melanoma cells

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[Corrigendum] Effects of rotigaptide (ZP123) on connexin43 remodeling in canine ventricular fibrillation

Guo-Ying Su, Jing Wang, Zhen-Xing Xu, Xiao-Jun Qiao, Jing-Quan Zhong, Yun Zhang
Pages: 8327-8327
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[Corrigendum] Effects of miR-19b knockdown on the cardiac differentiation of P19 mouse embryonic carcinoma cells

Xuehua Liu, Liming Yang, Huiyan Wang, Guofeng Xu, Shasha Zhu, Mengmeng Li, Xiaoshan Hu, Jingai Zhu, Chun Zhu, Jing Xu, Shuping Han, Zhangbin Yu
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[Corrigendum] Lentivirus vector-mediated gene transduction of CNGRC peptide in rat adipose stem cells

Du Meng, Rui Liu, Li Pei, Lei Hou, Qian Ning, Qing Yu, Lu Feng, Xinhan Zhao
Pages: 8329-8329
Published online on: 23 October 2015

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January-2026 Volume 33 Issue 1

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CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

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SCImago Journal Rank (SJR): 0.841

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Article Number: 50
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Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
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Published online on: 12 November 2025

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
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Published online on: 12 November 2025

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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
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Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
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Diabetic keratopathy and nuclear proteins (Review)

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
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Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
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Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

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Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

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Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
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Published online on: 31 October 2025

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Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 33 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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