Inhibition of varicella‑zoster virus replication by an ethanol extract of Lysimachia mauritiana

Bae,Sohee; Song,Yoon‑Jae

doi:10.3892/mmr.2017.6444

June-2017 Volume 15 Issue 6

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June-2017 Volume 15 Issue 6

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Article

Inhibition of varicella‑zoster virus replication by an ethanol extract of Lysimachia mauritiana

Authors:
- Sohee Bae
- Yoon‑Jae Song
View Affiliations / Copyright

Affiliations: Department of Life Science, Gachon University, Seongnam‑Si, Kyeonggi‑Do 461‑701, Republic of Korea
Pages: 3847-3851
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Published online on: April 7, 2017

https://doi.org/10.3892/mmr.2017.6444
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Abstract

Varicella‑zoster virus (VZV), a ubiquitous human α‑herpesvirus, is the causative agent of chickenpox and shingles. In the present study, we investigated the antiviral activity of a 70% ethanol extract of Lysimachia mauritiana (LME) against VZV. LME strongly interfered with the replication of both laboratory and clinical strains of VZV without affecting the viability of MRC‑5 cells. Moreover, LME treatment suppressed the expression of an essential viral transactivator, immediate‑early 62 protein (IE62), in addition to other lytic genes in the later phases of viral replication. The finding that LME exerts potent inhibitory effects on VZV gene expression and replication supports its potential utility as a therapeutic anti‑viral agent.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Inhibition of varicella‑zoster virus replication by an ethanol extract of Lysimachia mauritiana

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