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Article Open Access

Identification of potential gene targets in systemic vasculitis using DNA microarray analysis

  • Authors:
    • Yiwen Feng
    • Miao Zheng
    • Shujie Gan
    • Lei Zhang
    • Zhong Wan
    • Yanping Zhang
    • Qin Qian
    • Jingdong Tang
  • View Affiliations / Copyright

    Affiliations: Vascular Surgery Department, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, P.R. China
    Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3665-3673
    |
    Published online on: April 11, 2017
       https://doi.org/10.3892/mmr.2017.6455
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Abstract

The present study aimed to identify the involvement of critical genes in systemic vasculitis, to gain an improved understanding of the molecular circuity and to investigate novel potential gene targets for systemic vasculitis treatment. The dual‑color cDNA microarray data of GSE16945, consisting of peripheral mononuclear blood cell specimens from 13 patients with systemic vasculitis and 16 healthy controls, was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were screened in systemic vasculitis compared with controls using BRB ArrayTools, followed by the construction of a protein‑protein interaction (PPI) network using the clusterProfiler package, and significant functional interaction (FI) module selection. Furthermore, transcriptional factors (TFs) among the identified DEGs were predicted and a transcriptional regulation network was constructed. A total of 173 up- and 93 downregulated genes were identified, which were mainly associated with immune response pathways. FBJ murine osteosarcoma viral oncogene homolog (FOS), ubiquitin B (UBB), signal transducer and activator of transcription 1 (STAT1) and MX dynamin‑like GTPase 1 (MX1) were identified as hub proteins in the PPI network. Furthermore, UBB, FOS, and STAT1 were hub proteins in the three identified FI modules, respectively. In total, nine TFs were predicted among the DEGs. Of the DEGs that were predicted to be TFs, STAT1, v‑maf avian musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB) and tyrosine 3‑monooxygenase/tryptophan 5‑monooxygenase activation protein Z (YWHAZ), which interacted with each other, were identified to regulate further DEGs as target genes. Various genes, including FOS, UBB, MX1, STAT1, MAFB, and YWHAZ may be potential targets useful for the treatment of systemic vasculitis.
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1 

de Souza AWS: Autoantibodies in systemic vasculitis. Front Immunol. 6:1842015.PubMed/NCBI

2 

Stagnaro C, Cioffi E, Talarico R and Rossa A Della: Systemic vasculitides: A critical digest of the most recent literature. Clin Exp Rheumatol. 33(2 Suppl 89): S145–S154. 2015.PubMed/NCBI

3 

Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, Flores-Suarez LF, Gross WL, Guillevin L, Hagen EC, et al: 2012 revised international chapel hill consensus conference nomenclature of vasculitides. Arthritis Rheumatism. 65:1–11. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Yang JJ, Preston GA, Alcorta DA, Waga I, Munger WE, Hogan SL, Sekura SB, Phillips BD, Thomas RP, Jennette JC and Falk RJ: Expression profile of leukocyte genes activated by anti-neutrophil cytoplasmic autoantibodies (ANCA). Kidney Int. 62:1638–1649. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Wagner EF: Bone development and inflammatory disease is regulated by AP-1 (Fos/Jun). Annals Rheum Dis. 69:i86–i88. 2010. View Article : Google Scholar

6 

Ordonez L, Bernard I, L'Faqihi-Olive FE, Tervaert JW, Damoiseaux J and Saoudi A: CD45RC isoform expression identifies functionally distinct T cell subsets differentially distributed between healthy individuals and AAV patients. PLoS One. 4:e52872009. View Article : Google Scholar : PubMed/NCBI

7 

Kobayashi S, Ito A, Okuzaki D, Onda H, Yabuta N, Nagamori I, Suzuki K, Hashimoto H and Nojima H: Expression profiling of PBMC-based diagnostic gene markers isolated from vasculitis patients. DNA Res. 15:253–265. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Okuzaki D, Fukushima T, Tougan T, Ishii T, Kobayashi S, Yoshizaki K, Akita T and Nojima H: Genopal™: A novel hollow fibre array for focused microarray analysis. DNA Res. 17:369–379. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Simon R, Lam A, Li MC, Ngan M, Menenzes S and Zhao Y: Analysis of gene expression data using BRB-array tools. Cancer Inform. 3:11–17. 2007.PubMed/NCBI

10 

Zhao Y and Simon R: BRB-ArrayTools Data Archive for human cancer gene expression: A unique and efficient data sharing resource. Cancer Inform. 6:9–15. 2008.PubMed/NCBI

11 

Ihaka R and Gentleman R: R: A language for data analysis and graphics. J Computational and graphical statistics. 5:299–314. 1996. View Article : Google Scholar

12 

Yu G, Wang LG, Han Y and He QY: ClusterProfiler: An R package for comparing biological themes among gene clusters. Omics. 16:284–287. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Reiner-Benaim A: FDR control by the BH procedure for Two-Sided Correlated Tests with implications to gene expression Data Analysis. Biom J. 49:107–126. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Benjamini Y and Hochberg Y: Controlling the false discovery rate: A practical and powerful approach to multiple testing. J Royal Statistical Soc. 57:289–300. 1995.

15 

Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A, Lin J, Minguez P, Bork P, von Mering C and Jensen LJ: STRING v9.1: Protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res. 41:D808–D815. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Yu J and Finley RL: Combining multiple positive training sets to generate confidence scores for protein-protein interactions. Bioinformatics. 25:105–111. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Csardi G and Nepusz T: The igraph software package for complex network research. Inter Journal Complex Systems. 1695:1–9. 2006.

19 

Wu G, Dawson E, Duong A, Haw R and Stein L: ReactomeFIViz: A Cytoscape app for pathway and network-based data analysis. F1000Res. 3:1462014.PubMed/NCBI

20 

Tan PK, Downey TJ, Spitznagel EL Jr, Xu P, Fu D, Dimitrov DS, Lempicki RA, Raaka BM and Cam MC: Evaluation of gene expression measurements from commercial microarray platforms. Nucleic Acids Res. 31:5676–5684. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Van Dongen SM: Graph clustering by flow simulation. 2001.

22 

Huang ZX, Tian HY, Hu ZF, Zhou YB, Zhao J and Yao KT: GenCLiP: A software program for clustering gene lists by literature profiling and constructing gene co-occurrence networks related to custom keywords. BMC bioinformatics. 9:3082008. View Article : Google Scholar : PubMed/NCBI

23 

Matys V, Fricke E, Geffers R, Gössling E, Haubrock M, Hehl R, Hornischer K, Karas D, Kel AE, Kel-Margoulis OV, et al: TRANSFAC: Transcriptional regulation, from patterns to profiles. Nucleic Acids Res. 31:374–378. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Song KH, Kim YH and Kim BY: Sho-saiko-to, a traditional herbal medicine, regulates gene expression and biological function by way of microRNAs in primary mouse hepatocytes. BMC Complement Altern Med. 14:142014. View Article : Google Scholar : PubMed/NCBI

25 

Nicolle R, Radvanyi F and Elati M: CoRegNet: Reconstruction and integrated analysis of co-regulatory networks. Bioinformatics. 31:3066–3068. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Kawai T, Sato S, Ishii KJ, Coban C, Hemmi H, Yamamoto M, Terai K, Matsuda M, Inoue J, Uematsu S, et al: Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol. 5:1061–1068. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Dillon S, Agrawal A, Van Dyke T, Landreth G, McCauley L, Koh A, Maliszewski C, Akira S and Pulendran B: A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells. J Immunol. 172:4733–4743. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Wagner EF and Eferl R: Fos/AP-1 proteins in bone and the immune system. Immunol Rev. 208:126–140. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Tadema H, Abdulahad WH, Stegeman CA, Kallenberg CG and Heeringa P: Increased expression of Toll-like receptors by monocytes and natural killer cells in ANCA-associated vasculitis. PLoS One. 6:e243152011. View Article : Google Scholar : PubMed/NCBI

30 

Oh C, Park S, Lee EK and Yoo YJ: Downregulation of ubiquitin level via knockdown of polyubiquitin gene Ubb as potential cancer therapeutic intervention. Sci Rep. 3:26232013. View Article : Google Scholar : PubMed/NCBI

31 

Le Bras S, Loyer N and Le Borgne R: The multiple facets of ubiquitination in the regulation of notch signaling pathway. Traffic. 12:149–161. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Piggott K, Deng J, Warrington K, Younge B, Kubo JT, Desai M, Goronzy JJ and Weyand CM: Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitisclinical perspective. Circulation. 123:309–318. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Verhelst J, Parthoens E, Schepens B, Fiers W and Saelens X: Interferon-inducible protein Mx1 inhibits influenza virus by interfering with functional viral ribonucleoprotein complex assembly. J Virol. 86:13445–13455. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Vassilopoulos D and Calabrese LH: Hepatitis C virus infection and vasculitis: Implications of antiviral and immunosuppressive therapies. Arthritis Rheum. 46:585–597. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Ramana CV, Chatterjee-Kishore M, Nguyen H and Stark GR: Complex roles of Stat1 in regulating gene expression. Oncogene. 19:2619–2627. 2000. View Article : Google Scholar : PubMed/NCBI

36 

Kawazoe Y, Naka T, Fujimoto M, Kohzaki H, Morita Y, Narazaki M, Okumura K, Saitoh H, Nakagawa R, Uchiyama Y, et al: Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation. J Exp Med. 193:263–270. 2001. View Article : Google Scholar : PubMed/NCBI

37 

Klampfer L: Signal transducers and activators of transcription (STATs): Novel targets of chemopreventive and chemotherapeutic drugs. Curr Cancer Drug Targets. 6:107–121. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Lin W, Choe WH, Hiasa Y, Kamegaya Y, Blackard JT, Schmidt EV and Chung RT: Hepatitis C virus expression suppresses interferon signaling by degrading STAT1. Gastroenterology. 128:1034–1041. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Chan AT, Flossmann O, Mukhtyar C, Jayne D and Luqmani RA: The role of biologic therapies in the management of systemic vasculitis. Autoimmu Rev. 5:273–278. 2006. View Article : Google Scholar

40 

Aida Y, Sato-Nishiwaki M, Abe S, Kishi H, Nunomiya K, Yamauchi K, lnoue S and Shibata Y: MafB suppresses acute inflammatory responses in lipopolysaccharide-stimulated lung injury in mice. Am J Respir Crit Care Med. 185:A13402012.

41 

Nishimura Y, Komatsu S, Ichikawa D, Nagata H, Hirajima S, Takeshita H, Kawaguchi T, Arita T, Konishi H, Kashimoto K, et al: Overexpression of YWHAZ relates to tumor cell proliferation and malignant outcome of gastric carcinoma. Br J Cancer. 108:1324–1331. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Kaganoi J, Watanabe G, Okabe M, Nagatani S, Kawabe A, Shimada Y, Imamura M and Sakai Y: STAT1 activation-induced apoptosis of esophageal squamous cell carcinoma cells in vivo. Ann Surg Oncol. 14:1405–1415. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Jamin C, Duguuguabe G, Okabe M, et al: STAT1 activation-induced apoptosis of esophageal squamous cell carcinoma cells in vivo. Annals of Surgical Oncology. 14:1405–1415. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Feng Y, Zheng M, Gan S, Zhang L, Wan Z, Zhang Y, Qian Q and Tang J: Identification of potential gene targets in systemic vasculitis using DNA microarray analysis. Mol Med Rep 15: 3665-3673, 2017.
APA
Feng, Y., Zheng, M., Gan, S., Zhang, L., Wan, Z., Zhang, Y. ... Tang, J. (2017). Identification of potential gene targets in systemic vasculitis using DNA microarray analysis. Molecular Medicine Reports, 15, 3665-3673. https://doi.org/10.3892/mmr.2017.6455
MLA
Feng, Y., Zheng, M., Gan, S., Zhang, L., Wan, Z., Zhang, Y., Qian, Q., Tang, J."Identification of potential gene targets in systemic vasculitis using DNA microarray analysis". Molecular Medicine Reports 15.6 (2017): 3665-3673.
Chicago
Feng, Y., Zheng, M., Gan, S., Zhang, L., Wan, Z., Zhang, Y., Qian, Q., Tang, J."Identification of potential gene targets in systemic vasculitis using DNA microarray analysis". Molecular Medicine Reports 15, no. 6 (2017): 3665-3673. https://doi.org/10.3892/mmr.2017.6455
Copy and paste a formatted citation
x
Spandidos Publications style
Feng Y, Zheng M, Gan S, Zhang L, Wan Z, Zhang Y, Qian Q and Tang J: Identification of potential gene targets in systemic vasculitis using DNA microarray analysis. Mol Med Rep 15: 3665-3673, 2017.
APA
Feng, Y., Zheng, M., Gan, S., Zhang, L., Wan, Z., Zhang, Y. ... Tang, J. (2017). Identification of potential gene targets in systemic vasculitis using DNA microarray analysis. Molecular Medicine Reports, 15, 3665-3673. https://doi.org/10.3892/mmr.2017.6455
MLA
Feng, Y., Zheng, M., Gan, S., Zhang, L., Wan, Z., Zhang, Y., Qian, Q., Tang, J."Identification of potential gene targets in systemic vasculitis using DNA microarray analysis". Molecular Medicine Reports 15.6 (2017): 3665-3673.
Chicago
Feng, Y., Zheng, M., Gan, S., Zhang, L., Wan, Z., Zhang, Y., Qian, Q., Tang, J."Identification of potential gene targets in systemic vasculitis using DNA microarray analysis". Molecular Medicine Reports 15, no. 6 (2017): 3665-3673. https://doi.org/10.3892/mmr.2017.6455
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