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Troxerutin protects against diabetic cardiomyopathy through NF‑κB/AKT/IRS1 in a rat model of type 2 diabetes

  • Authors:
    • Yongzhi Yu
    • Guanzhong Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Linzi District People's Hospital, Zibo, Shandong 255400, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3473-3478
    |
    Published online on: April 11, 2017
       https://doi.org/10.3892/mmr.2017.6456
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Abstract

Troxerutin is a bioflavonoid, which can be used to treat venous disorders, thrombosis and cerebrovascular diseases. Recent studies have demonstrated that it may also be used to prevent edemas. However, it is not known whether troxerutin protects against the cardiomyopathic complications of diabetes. In the present study, a rat model of type 2 diabetes was used to investigate the potential for troxerutin to protect against diabetic cardiomyopathy, through changes to nuclear factor‑κB (NF‑κB) expression. Troxerutin administration significantly reduced heart rate, blood pressure, blood glucose and plasma triglyceride levels across all measured time points. Furthermore, troxerutin significantly reduced reactive oxygen species levels, NF‑κB protein expression, and suppressed the phosphorylated forms of AKT, insulin receptor substrate 1 (IRS1) and c‑Jun N‑terminal kinase (JNK). These results suggested that troxerutin protects against cardiomyopathy via alterations in NF‑κB, AKT and IRS1 signaling, in a rat model of type 2 diabetes.
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1 

Fukuda T, Fukui M, Tanaka M, Senmaru T, Iwase H, Yamazaki M, Aoi W, Inui T, Nakamura N and Marunaka Y: Effect of Brazilian green propolis in patients with type 2 diabetes: A double-blind randomized placebo-controlled study. Biomed Rep. 3:355–360. 2015.PubMed/NCBI

2 

Han L, Tang L, Wang C, Chen Z, Zhang T, Chen S, Liu S, Peng X, Mai Y and Duan S: Fat mass and obesity-associated gene rs11642015 polymorphism is significantly associated with prediabetes and type 2 diabetes subsequent to adjustment for body mass index. Biomed Rep. 2:681–686. 2014.PubMed/NCBI

3 

Staimez LR, Weber MB, Narayan KM and Oza-Frank R: A systematic review of overweight, obesity, and type 2 diabetes among Asian American subgroups. Curr Diabetes Rev. 9:312–331. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Yamada Y, Matsui K, Takeuchi I, Oguri M and Fujimaki T: Association of genetic variants of the α-kinase 1 gene with type 2 diabetes mellitus in a longitudinal population-based genetic epidemiological study. Biomed Rep. 3:347–354. 2015.PubMed/NCBI

5 

Knabl J, Hüttenbrenner R, Hutter S, Günthner-Biller M, Riedel C, Hiden U, Kainer F, Desoye G and Jeschke U: Gestational diabetes mellitus upregulates vitamin D receptor in extravillous trophoblasts and fetoplacental endothelial cells. Reprod Sci. 22:358–366. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Nicolucci A, Cercone S, Chiriatti A, Muscas F and Gensini G: A Randomized trial on home telemonitoring for the management of metabolic and cardiovascular risk in patients with type 2 diabetes. Diabetes Technol Ther. 17:563–570. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Gu Y, Warren J, Walker N and Kennelly J: Gender differences in cardiovascular disease risk management for Pacific Islanders in primary care. Qual Prim Care. 21:275–285. 2013.PubMed/NCBI

8 

Saisho Y: Glycemic variability and oxidative stress: A link between diabetes and cardiovascular disease? Int J Mol Sci. 15:18381–18406. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Geetha R, Radika MK, Priyadarshini E, Bhavani K and Anuradha CV: Troxerutin reverses fibrotic changes in the myocardium of high-fat high-fructose diet-fed mice. Mol Cell Biochem. 407:263–279. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Lu J, Wu DM, Zheng YL, Hu B, Cheng W, Zhang ZF and Li MQ: Troxerutin counteracts domoic acid-induced memory deficits in mice by inhibiting CCAAT/enhancer binding protein β-mediated inflammatory response and oxidative stress. J Immunol. 190:3466–3479. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Schmeck-Lindenau HJ, Naser-Hijazi B, Becker EW, Henneicke-von Zepelin HH and Schnitker J: Safety aspects of a coumarin-troxerutin combination regarding liver function in a double-blind placebo-controlled study. Int J Clin Pharmacol Ther. 41:193–199. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Zhang ZF, Shan Q, Zhuang J, Zhang YQ, Wang X, Fan SH, Lu J, Wu DM, Hu B and Zheng YL: Troxerutin inhibits 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47)-induced hepatocyte apoptosis by restoring proteasome function. Toxicol Lett. 233:246–257. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Yu X, Zhang Q, Cui W, Zeng Z, Yang W, Zhang C, Zhao H, Gao W, Wang X and Luo D: Low molecular weight fucoidan alleviates cardiac dysfunction in diabetic Goto-Kakizaki rats by reducing oxidative stress and cardiomyocyte apoptosis. J Diabetes Res. 2014:4209292014. View Article : Google Scholar : PubMed/NCBI

14 

Patel BM, Raghunathan S and Porwal U: Cardioprotective effects of magnesium valproate in type 2 diabetes mellitus. Eur J Pharmacol. 728:128–134. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Stolen TO, Høydal MA, Kemi OJ, Catalucci D, Ceci M, Aasum E, Larsen T, Rolim N, Condorelli G, Smith GL and Wisløff U: Interval training normalizes cardiomyocyte function, diastolic Ca2+ control and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy. Circ Res. 105:527–536. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Tan HW, Xing SS, Bi XP, Li L, Gong HP, Zhong M, Zhang Y and Zhang W: Felodipine attenuates vascular inflammation in a fructose-induced rat model of metabolic syndrome via the inhibition of NF-kappaB activation. Acta Pharmacol Sin. 29:1051–1059. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Asare Y, Shagdarsuren E, Schmid JA, Tilstam PV, Grommes J, El Bounkari O, Schütz AK, Weber C, de Winther MP, Noels H and Bernhagen J: Endothelial CSN5 impairs NF-κB activation and monocyte adhesion to endothelial cells and is highly expressed in human atherosclerotic lesions. Thromb Haemost. 110:141–152. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Hattori Y, Suzuki K, Tomizawa A, Hirama N, Okayasu T, Hattori S, Satoh H, Akimoto K and Kasai K: Cilostazol inhibits cytokine-induced nuclear factor-kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells. Cardiovasc Res. 81:133–139. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Wang H, Bei Y, Lu Y, Sun W, Liu Q, Wang Y, Cao Y, Chen P, Xiao J and Kong X: Exercise prevents cardiac injury and improves mitochondrial biogenesis in advanced diabetic cardiomyopathy with PGC-1α and Akt activation. Cell Physiol Biochem. 35:2159–2168. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Yu W, Wu J, Cai F, Xiang J, Zha W, Fan D, Guo S, Ming Z and Liu C: Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats. PLoS One. 7:e520132012. View Article : Google Scholar : PubMed/NCBI

21 

Lu Z, Ballou LM, Jiang YP, Cohen IS and Lin RZ: Restoration of defective L-type Ca2+ current in cardiac myocytes of type 2 diabetic db/db mice by Akt and PKC-i. J Cardiovasc Pharmacol. 58:439–445. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Lu J, Wu DM, Hu B, Zheng YL, Zhang ZF and Wang YJ: NGF-Dependent activation of TrkA pathway: A mechanism for the neuroprotective effect of troxerutin in D-galactose-treated mice. Brain Pathol. 20:952–965. 2010.PubMed/NCBI

23 

Lakshmanan AP, Harima M, Sukumaran V, Soetikno V, Thandavarayan RA, Suzuki K, Kodama M, Nagata M, Takagi R and Watanabe K: Modulation of AT-1R/AMPK-MAPK cascade plays crucial role for the pathogenesis of diabetic cardiomyopathy in transgenic type 2 diabetic (Spontaneous Diabetic Torii) rats. Biochem Pharmacol. 83:653–660. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Reinking BE, Wedemeyer EW, Weiss RM, Segar JL and Scholz TD: Cardiomyopathy in offspring of diabetic rats is associated with activation of the MAPK and apoptotic pathways. Cardiovasc Diabetol. 8:432009. View Article : Google Scholar : PubMed/NCBI

25 

Gonzalez AB, Young L, Doll JA, Morgan GM, Crawford SE and Plunkett BA: Elevated neonatal insulin-like growth factor I is associated with fetal hypertrophic cardiomyopathy in diabetic women. Am J Obstet Gynecol. 211:290 e1–e7. 2014. View Article : Google Scholar

26 

Sampath S and Karundevi B: Effect of troxerutin on insulin signaling molecules in the gastrocnemius muscle of high fat and sucrose-induced type-2 diabetic adult male rat. Mol Cell Biochem. 395:11–27. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Pan Y, Wang Y, Zhao Y, Peng K, Li W, Wang Y, Zhang J, Zhou S, Liu Q, Li X, et al: Inhibition of JNK phosphorylation by a novel curcumin analog prevents high glucose-induced inflammation and apoptosis in cardiomyocytes and the development of diabetic cardiomyopathy. Diabetes. 63:3497–3511. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Kuo WW, Wang WJ, Tsai CY, Way CL, Hsu HH and Chen LM: Diallyl trisufide (DATS) suppresses high glucose-induced cardiomyocyte apoptosis by inhibiting JNK/NFκB signaling via attenuating ROS generation. Int J Cardiol. 168:270–280. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yu Y and Zheng G: Troxerutin protects against diabetic cardiomyopathy through NF‑κB/AKT/IRS1 in a rat model of type 2 diabetes. Mol Med Rep 15: 3473-3478, 2017.
APA
Yu, Y., & Zheng, G. (2017). Troxerutin protects against diabetic cardiomyopathy through NF‑κB/AKT/IRS1 in a rat model of type 2 diabetes. Molecular Medicine Reports, 15, 3473-3478. https://doi.org/10.3892/mmr.2017.6456
MLA
Yu, Y., Zheng, G."Troxerutin protects against diabetic cardiomyopathy through NF‑κB/AKT/IRS1 in a rat model of type 2 diabetes". Molecular Medicine Reports 15.6 (2017): 3473-3478.
Chicago
Yu, Y., Zheng, G."Troxerutin protects against diabetic cardiomyopathy through NF‑κB/AKT/IRS1 in a rat model of type 2 diabetes". Molecular Medicine Reports 15, no. 6 (2017): 3473-3478. https://doi.org/10.3892/mmr.2017.6456
Copy and paste a formatted citation
x
Spandidos Publications style
Yu Y and Zheng G: Troxerutin protects against diabetic cardiomyopathy through NF‑κB/AKT/IRS1 in a rat model of type 2 diabetes. Mol Med Rep 15: 3473-3478, 2017.
APA
Yu, Y., & Zheng, G. (2017). Troxerutin protects against diabetic cardiomyopathy through NF‑κB/AKT/IRS1 in a rat model of type 2 diabetes. Molecular Medicine Reports, 15, 3473-3478. https://doi.org/10.3892/mmr.2017.6456
MLA
Yu, Y., Zheng, G."Troxerutin protects against diabetic cardiomyopathy through NF‑κB/AKT/IRS1 in a rat model of type 2 diabetes". Molecular Medicine Reports 15.6 (2017): 3473-3478.
Chicago
Yu, Y., Zheng, G."Troxerutin protects against diabetic cardiomyopathy through NF‑κB/AKT/IRS1 in a rat model of type 2 diabetes". Molecular Medicine Reports 15, no. 6 (2017): 3473-3478. https://doi.org/10.3892/mmr.2017.6456
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