Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
June-2017 Volume 15 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2017 Volume 15 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Preliminary analysis of the association between methylation of the ACE2 promoter and essential hypertension

  • Authors:
    • Rui Fan
    • Shu‑Qi Mao
    • Tian‑Lun Gu
    • Fa‑De Zhong
    • Min‑Li Gong
    • Ling‑Mei Hao
    • Feng‑Ying Yin
    • Chang‑Zheng Dong
    • Li‑Na Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Preventive Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China, The Central Blood Station of Ningbo, Ningbo, Zhejiang 315099, P.R. China, Clinical Laboratory, The Seventh Hospital of Ningbo, Ningbo, Zhejiang 315202, P.R. China, Clinical Laboratory, The First Hospital of Ningbo, Zhejiang 315010, P.R. China
  • Pages: 3905-3911
    |
    Published online on: April 11, 2017
       https://doi.org/10.3892/mmr.2017.6460
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate whether methylation of the angiotensin I converting enzyme 2 (ACE2) promoter increases the risk of essential hypertension (EH). A total of 96 patients with EH were recruited and 96 sex‑ and age‑matched healthy controls. Methylation of 5 CpG dinucleotides in the ACE2 promoter was quantified using bisulfite pyrosequencing. Logistic regression and multiple linear regression were used to adjust for confounding factors and the generalized multifactor dimensionality reduction (GMDR) method was applied to investigate high‑order interactions. Methylation of CpG4 (adjusted P=0.020) and CpG5 (adjusted P=0.036) was significantly higher in patients with EH, with frequency 97.56±5.65% and 12.75±4.15% in EH individuals and 95.73±9.11% and 11.47±3.67% in healthy controls. GMDR detected significant interaction among the 5 CpG sites (odds ratio=7.33, adjusted P=0.01). Furthermore, receiver operating characteristic curves identified that CpG5 methylation was a significant predictor of EH. Notably, CpG2 methylation was significantly higher in males than in females (adjusted P=0.018). Conversely, CpG5 methylation was significantly lower in males (adjusted P=0.032). These results indicated that aberrant methylation of the ACE2 promoter may be associated with EH risk. In addition, sex may significantly influence ACE2 methylation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Li D, Lv J, Liu F, Liu P, Yang X, Feng Y, Chen G and Hao M: Hypertension burden and control in mainland China: Analysis of nationwide data 2003–2012. Int J Cardiol. 184:637–644. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK and He J: Global burden of hypertension: Analysis of worldwide data. Lancet. 365:217–223. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Pausova Z, Tremblay J and Hamet P: Gene-environment interactions in hypertension. Curr Hypertens Rep. 1:42–50. 1999. View Article : Google Scholar : PubMed/NCBI

4 

Zhu X, Chang YP, Yan D, Weder A, Cooper R, Luke A, Kan D and Chakravarti A: Associations between hypertension and genes in the renin-angiotensin system. Hypertension. 41:1027–1034. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, et al: A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1–9. Circ Res. 87:E1–E9. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G and Turner AJ: A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem. 275:33238–33243. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Tallant EA and Clark MA: Molecular mechanisms of inhibition of vascular growth by angiotensin-(1–7). Hypertension. 42:574–579. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Yagil Y and Yagil C: Hypothesis: ACE2 modulates blood pressure in the mammalian organism. Hypertension. 41:871–873. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Lu N, Yang Y, Wang Y, Liu Y, Fu G, Chen D, Dai H, Fan X, Hui R and Zheng Y: ACE2 gene polymorphism and essential hypertension: An updated meta-analysis involving 11,051 subjects. Mol Biol Rep. 39:6581–6589. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Patel SK, Wai B, Ord M, MacIsaac RJ, Grant S, Velkoska E, Panagiotopoulos S, Jerums G, Srivastava PM and Burrell LM: Association of ACE2 genetic variants with blood pressure, left ventricular mass, and cardiac function in Caucasians with type 2 diabetes. Am J Hypertens. 25:216–222. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Razin A, Webb C, Szyf M, Yisraeli J, Rosenthal A, Naveh-Many T, Sciaky-Gallili N and Cedar H: Variations in DNA methylation during mouse cell differentiation in vivo and in vitro. Proc Natl Acad Sci USA. 81:pp. 2275–2279. 1984; View Article : Google Scholar : PubMed/NCBI

12 

Deaton AM and Bird A: CpG islands and the regulation of transcription. Genes Dev. 25:1010–1022. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Bogdarina I, Welham S, King PJ, Burns SP and Clark AJ: Epigenetic modification of the renin-angiotensin system in the fetal programming of hypertension. Circ Res. 100:520–526. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Rangel M, dos Santos JC, Ortiz PH, Hirata M, Jasiulionis MG, Araujo RC, Ierardi DF and Mdo C Franco: Modification of epigenetic patterns in low birth weight children: Importance of hypomethylation of the ACE gene promoter. PLoS One. 9:e1061382014. View Article : Google Scholar : PubMed/NCBI

15 

Wang F, Demura M, Cheng Y, Zhu A, Karashima S, Yoneda T, Demura Y, Maeda Y, Namiki M, Ono K, et al: Dynamic CCAAT/enhancer binding protein-associated changes of DNA methylation in the angiotensinogen gene. Hypertension. 63:281–288. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Fan R, Mao S, Zhong F, Gong M, Yin F, Hao L and Zhang L: Association of AGTR1 promoter methylation levels with essential hypertension risk: A matched case-control study. Cytogenet Genome Res. 147:95–102. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Zhang LN, Liu PP, Wang L, Yuan F, Xu L, Xin Y, Fei LJ, Zhong QL, Huang Y, Xu L, et al: Lower ADD1 gene promoter DNA methylation increases the risk of essential hypertension. PLoS One. 8:e634552013. View Article : Google Scholar : PubMed/NCBI

18 

Fan R, Wang WJ, Zhong QL, Duan SW, Xu XT, Hao LM, Zhao J and Zhang LN: Aberrant methylation of the GCK gene body is associated with the risk of essential hypertension. Mol Med Rep. 12:2390–2394. 2015.PubMed/NCBI

19 

European Society of Hypertension-European Society of Cardiology Guidelines Committee, . 2003 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. J Hypertens. 21:1011–1053. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Perloff D, Grim C, Flack J, Frohlich ED, Hill M, McDonald M and Morgenstern BZ: Human blood pressure determination by sphygmomanometry. Circulation. 88:2460–2470. 1993. View Article : Google Scholar : PubMed/NCBI

21 

Bassil CF, Huang Z and Murphy SK: Bisulfite pyrosequencing. Methods Mol Biol. 1049:95–107. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Li LC and Dahiya R: MethPrimer: Designing primers for methylation PCRs. Bioinformatics. 18:1427–1431. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Mikeska T, Felsberg J, Hewitt CA and Dobrovic A: Analysing DNA methylation using bisulphite pyrosequencing. Methods Mol Biol. 791:33–53. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Lou XY, Chen GB, Yan L, Ma JZ, Zhu J, Elston RC and Li MD: A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Am J Hum Genet. 80:1125–1137. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Pei F, Wang X, Yue R, Chen C, Huang J, Huang J, Li X and Zeng C: Differential expression and DNA methylation of angiotensin type 1A receptors in vascular tissues during genetic hypertension development. Mol Cell Biochem. 402:1–8. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Jiang D, Zheng D, Wang L, Huang Y, Liu H, Xu L, Liao Q, Liu P, Shi X, Wang Z, et al: Elevated PLA2G7 gene promoter methylation as a gender-specific marker of aging increases the risk of coronary heart disease in females. PLoS One. 8:e597522013. View Article : Google Scholar : PubMed/NCBI

27 

Berletch JB, Yang F, Xu J, Carrel L and Disteche CM: Genes that escape from X inactivation. Hum Genet. 130:237–245. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Hellman A and Chess A: Gene body-specific methylation on the active X chromosome. Science. 315:1141–1143. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Carrel L and Willard HF: X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature. 434:400–404. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Sebag IA, Gillis MA, Calderone A, Kasneci A, Meilleur M, Haddad R, Noiles W, Patel B and Chalifour LE: Sex hormone control of left ventricular structure/function: Mechanistic insights using echocardiography, expression, and DNA methylation analyses in adult mice. Am J Physiol Heart Circ Physiol. 301:H1706–H1715. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Christensen BC, Houseman EA, Marsit CJ, Zheng S, Wrensch MR, Wiemels JL, Nelson HH, Karagas MR, Padbury JF, Bueno R, et al: Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet. 5:e10006022009. View Article : Google Scholar : PubMed/NCBI

32 

Breitling LP, Yang R, Korn B, Burwinkel B and Brenner H: Tobacco-smoking-related differential DNA methylation: 27K discovery and replication. Am J Hum Genet. 88:450–457. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Philibert RA, Plume JM, Gibbons FX, Brody GH and Beach SR: The impact of recent alcohol use on genome wide DNA methylation signatures. Front Genet. 3:542012. View Article : Google Scholar : PubMed/NCBI

34 

Ronn T, Volkov P, Davegårdh C, Dayeh T, Hall E, Olsson AH, Nilsson E, Tornberg A, Nitert M Dekker, Eriksson KF, et al: A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue. PLoS Genet. 9:e10035722013. View Article : Google Scholar : PubMed/NCBI

35 

Alexeeff SE, Baccarelli AA, Halonen J, Coull BA, Wright RO, Tarantini L, Bollati V, Sparrow D, Vokonas P and Schwartz J: Association between blood pressure and DNA methylation of retrotransposons and pro-inflammatory genes. Int J Epidemiol. 42:270–280. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Ishida K, Kobayashi T, Ito S, Komatsu Y, Yokoyama T, Okada M, Abe A, Murasawa A and Yoshie H: Interleukin-6 gene promoter methylation in rheumatoid arthritis and chronic periodontitis. J Periodontol. 83:917–925. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Pogribny IP, Pogribna M, Christman JK and James SJ: Single-site methylation within the p53 promoter region reduces gene expression in a reporter gene construct: Possible in vivo relevance during tumorigenesis. Cancer Res. 60:588–594. 2000.PubMed/NCBI

38 

Zou B, Chim CS, Zeng H, Leung SY, Yang Y, Tu SP, Lin MC, Wang J, He H, Jiang SH, et al: Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers. Gastroenterology. 131:1835–1843. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Fan S and Zhang X: CpG island methylation pattern in different human tissues and its correlation with gene expression. Biochem Biophys Res Commun. 383:421–425. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Mirza S, Sharma G, Parshad R, Srivastava A, Gupta SD and Ralhan R: Clinical significance of promoter hypermethylation of ERβ and RARβ2 in tumor and serum DNA in Indian breast cancer patients. Ann Surg Oncol. 19:3107–3115. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Fan R, Mao SQ, Gu TL, Zhong FD, Gong ML, Hao LM, Yin FY, Dong CZ and Zhang LN: Preliminary analysis of the association between methylation of the ACE2 promoter and essential hypertension. Mol Med Rep 15: 3905-3911, 2017.
APA
Fan, R., Mao, S., Gu, T., Zhong, F., Gong, M., Hao, L. ... Zhang, L. (2017). Preliminary analysis of the association between methylation of the ACE2 promoter and essential hypertension. Molecular Medicine Reports, 15, 3905-3911. https://doi.org/10.3892/mmr.2017.6460
MLA
Fan, R., Mao, S., Gu, T., Zhong, F., Gong, M., Hao, L., Yin, F., Dong, C., Zhang, L."Preliminary analysis of the association between methylation of the ACE2 promoter and essential hypertension". Molecular Medicine Reports 15.6 (2017): 3905-3911.
Chicago
Fan, R., Mao, S., Gu, T., Zhong, F., Gong, M., Hao, L., Yin, F., Dong, C., Zhang, L."Preliminary analysis of the association between methylation of the ACE2 promoter and essential hypertension". Molecular Medicine Reports 15, no. 6 (2017): 3905-3911. https://doi.org/10.3892/mmr.2017.6460
Copy and paste a formatted citation
x
Spandidos Publications style
Fan R, Mao SQ, Gu TL, Zhong FD, Gong ML, Hao LM, Yin FY, Dong CZ and Zhang LN: Preliminary analysis of the association between methylation of the ACE2 promoter and essential hypertension. Mol Med Rep 15: 3905-3911, 2017.
APA
Fan, R., Mao, S., Gu, T., Zhong, F., Gong, M., Hao, L. ... Zhang, L. (2017). Preliminary analysis of the association between methylation of the ACE2 promoter and essential hypertension. Molecular Medicine Reports, 15, 3905-3911. https://doi.org/10.3892/mmr.2017.6460
MLA
Fan, R., Mao, S., Gu, T., Zhong, F., Gong, M., Hao, L., Yin, F., Dong, C., Zhang, L."Preliminary analysis of the association between methylation of the ACE2 promoter and essential hypertension". Molecular Medicine Reports 15.6 (2017): 3905-3911.
Chicago
Fan, R., Mao, S., Gu, T., Zhong, F., Gong, M., Hao, L., Yin, F., Dong, C., Zhang, L."Preliminary analysis of the association between methylation of the ACE2 promoter and essential hypertension". Molecular Medicine Reports 15, no. 6 (2017): 3905-3911. https://doi.org/10.3892/mmr.2017.6460
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team