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Article Open Access

Palmitate impairs angiogenesis via suppression of cathepsin activity

  • Authors:
    • Jin Zhang
    • Ying Shan
    • Yong Li
    • Xinping Luo
    • Haiming Shi
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3644-3650
    |
    Published online on: April 12, 2017
       https://doi.org/10.3892/mmr.2017.6463
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Abstract

Angiogenesis requires the interaction of multiple variable factors to promote endothelial cell adhesion, migration and survival. Palmitate, a free fatty acid, exhibits an anti‑angiogenic effect via interference with endothelial cell function, whereas cysteine proteases are important in protein turnover and are termed positive modulators of neovascularization. However, the association between these two factors regarding the regulation of human endothelial cell function remains to be elucidated. By using cell counting kit‑8, the Transwell method and an annexin V‑fluorescein isothiocyanate/propidium iodide apoptosis detection kit, the present study reported that high levels of palmitate result in a significant decrease in endothelial cell proliferation and invasion, and induced cell apoptosis; cathepsin L and S inhibitors may suppress palmitate‑induced apoptosis. Conversely, the results of the cathepsin L and S activity assay and reverse-transcription-quantitative polymerase chain reaction indicated that palmitate inhibited cathepsin‑induced endothelial cell invasion, partially via suppressing the expression and activity of cathepsin L and S. The findings of the present study suggested that the potent anti‑angiogenic properties of palmitate may be mediated by cysteine proteases.
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View References

1 

Binet F and Sapieha P: ER stress and angiogenesis. Cell Metab. 22:560–575. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Pourrajab F, Zarch A Vakili, Hekmatimoghaddam S and Zare-Khormizi MR: MicroRNAs; easy and potent targets in optimizing therapeutic methods in reparative angiogenesis. J Cell Mol Med. 19:2702–2714. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Urbich C, Heeschen C, Aicher A, Sasaki K, Bruhl T, Farhadi MR, Vajkoczy P, Hofmann WK, Peters C, Pennacchio LA, et al: Cathepsin L is required for endothelial progenitor cell-induced neovascularization. Nat Med. 11:206–213. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Shi GP, Sukhova GK, Kuzuya M, Ye Q, Du J, Zhang Y, Pan JH, Lu ML, Cheng XW, Iguchi A, et al: Deficiency of the cysteine protease cathepsin S impairs microvessel growth. Circ Res. 92:493–500. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Conus S and Simon HU: Cathepsins: Key modulators of cell death and inflammatory responses. Biochem Pharmacol. 76:1374–1382. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Droga-Mazovec G, Bojic L, Petelin A, Ivanova S, Romih R, Repnik U, Salvesen GS, Stoka V, Turk V and Turk B: Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues. J Biol Chem. 283:19140–19150. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Zheng X, Chu F, Mirkin BL, Sudha T, Mousa SA and Rebbaa A: Role of the proteolytic hierarchy between cathepsin Lcathepsin D and caspase-3 in regulation of cellular susceptibility to apoptosis and autophagy. Biochim Biophys Acta. 1783:2294–2300. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Shulman GI: Cellular mechanisms of insulin resistance. J Clin Invest. 106:171–176. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Boden G and Shulman GI: Free fatty acids in obesity and type 2 diabetes: Defining their role in the development of insulin resistance and beta-cell dysfunction. Eur J Clin Invest. 32 Suppl 3:S14–S23. 2002. View Article : Google Scholar

10 

Listenberger LL, Ory DS and Schaffer JE: Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J Biol Chem. 276:14890–14895. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Listenberger LL, Han X, Lewis SE, Cases S, RV Jr, Ory DS Farese and Schaffer JE: Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci USA. 100:pp. 3077–3082. 2003; View Article : Google Scholar : PubMed/NCBI

12 

Paumen MB, Ishida Y, Muramatsu M, Yamamoto M and Honjo T: Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. J Biol Chem. 272:3324–3329. 1997. View Article : Google Scholar : PubMed/NCBI

13 

Cnop M, Hannaert JC, Hoorens A, Eizirik DL and Pipeleers DG: Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation. Diabetes. 50:1771–1777. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Ostrander DB, Sparagna GC, Amoscato AA, McMillin JB and Dowhan W: Decreased cardiolipin synthesis corresponds with cytochrome c release in palmitate-induced cardiomyocyte apoptosis. J Biol Chem. 276:38061–38067. 2001.PubMed/NCBI

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Pinter E, Mahooti S, Wang Y, Imhof BA and Madri JA: Hyperglycemia-induced vasculopathy in the murine vitelline vasculature: Correlation with PECAM-1/CD31 tyrosine phosphorylation state. Am J Pathol. 154:1367–1379. 1999. View Article : Google Scholar : PubMed/NCBI

17 

Ciapaite J, Van Bezu J, Van Eikenhorst G, Bakker SJ, Teerlink T, Diamant M, Heine RJ, Krab K, Westerhoff HV and Schalkwijk CG: Palmitate and oleate have distinct effects on the inflammatory phenotype of human endothelial cells. Biochim Biophys Acta. 1771:147–154. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Urbich C, Dernbach E, Rössig L, Zeiher AM and Dimmeler S: High glucose reduces cathepsin L activity and impairs invasion of circulating progenitor cells. J Mol Cell Cardiol. 45:429–436. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Shimabukuro M, Zhou YT, Levi M and Unger RH: Fatty acid-induced beta cell apoptosis: A link between obesity and diabetes. Proc Natl Acad Sci USA. 95:pp. 2498–2502. 1998; View Article : Google Scholar : PubMed/NCBI

20 

Chiu HC, Kovacs A, Ford DA, Hsu FF, Garcia R, Herrero P, Saffitz JE and Schaffer JE: A novel mouse model of lipotoxic cardiomyopathy. J Clin Invest. 107:813–822. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Gudz TI, Tserng KY and Hoppel CL: Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. J Biol Chem. 272:24154–24158. 1997. View Article : Google Scholar : PubMed/NCBI

22 

Vafeiadou K, Weech M, Sharma V, Yaqoob P, Todd S, Williams CM, Jackson KG and Lovegrove JA: A review of the evidence for the effects of total dietary fat, saturated, monounsaturated and n-6 polyunsaturated fatty acids on vascular function, endothelial progenitor cells and microparticles. Br J Nutr. 107:303–324. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Zhang CL, Lyngmo V and Nordøy A: The effects of saturated fatty acids on endothelial cells. Thromb Res. 65:65–75. 1992. View Article : Google Scholar : PubMed/NCBI

24 

Artwohl M, Roden M, Waldhäusl W, Freudenthaler A and Baumgartner-Parzer SM: Free fatty acids trigger apoptosis and inhibit cell cycle progression in human vascular endothelial cells. FASEB J. 18:146–148. 2004.PubMed/NCBI

25 

Yu H, Yang Z, Ding X, Wang Y and Han Y: Correlation between the different chain lengths of free fatty acid oxidation and ability of trophoblastic invasion. Chin Med J (Engl). 127:3378–3382. 2014.PubMed/NCBI

26 

Dimmeler S, Haendeler J, Galle J and Zeiher AM: Oxidized low-density lipoprotein induces apoptosis of human endothelial cells by activation of CPP32-like proteases. A mechanistic clue to the ‘response to injury’ hypothesis. Circulation. 95:1760–1763. 1997. View Article : Google Scholar : PubMed/NCBI

27 

Sata M and Walsh K: Oxidized LDL activates fas-mediated endothelial cell apoptosis. J Clin Invest. 102:1682–1689. 1998. View Article : Google Scholar : PubMed/NCBI

28 

Raymond MA, Désormeaux A, Laplante P, Vigneault N, Filep JG, Landry K, Pshezhetsky AV and Hébert MJ: Apoptosis of endothelial cells triggers a caspase-dependent anti-apoptotic paracrine loop active on VSMC. FASEB J. 18:705–707. 2004.PubMed/NCBI

29 

Laplante P, Raymond MA, Gagnon G, Vigneault N, Sasseville AM, Langelier Y, Bernard M, Raymond Y and Hébert MJ: Novel fibrogenic pathways are activated in response to endothelial apoptosis: Implications in the pathophysiology of systemic sclerosis. J Immunol. 174:5740–5749. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Li D, Yang B and Mehta JL: Ox-LDL induces apoptosis in human coronary artery endothelial cells: Role of PKC, PTK, bcl-2, and Fas. Am J Physiol. 275:H568–H576. 1998.PubMed/NCBI

31 

Choy JC, Granville DJ, Hunt DW and McManus BM: Endothelial cell apoptosis: Biochemical characteristics and potential implications for atherosclerosis. J Mol Cell Cardiol. 33:1673–1690. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Cirman T, Oresić K, Mazovec GD, Turk V, Reed JC, Myers RM, Salvesen GS and Turk B: Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins. J Biol Chem. 279:3578–3587. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Heinrich M, Neumeyer J, Jakob M, Hallas C, Tchikov V, Winoto-Morbach S, Wickel M, Schneider-Brachert W, Trauzold A, Hethke A and Schütze S: Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and −3 activation. Cell Death Differ. 11:550–563. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Stoka V, Turk B, Schendel SL, Kim TH, Cirman T, Snipas SJ, Ellerby LM, Bredesen D, Freeze H, Abrahamson M, et al: Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route. J Biol Chem. 276:3149–3157. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Guicciardi ME, Leist M and Gores GJ: Lysosomes in cell death. Oncogene. 23:2881–2890. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Schotte P, Van Criekinge W, Van de Craen M, Van Loo G, Desmedt M, Grooten J, Cornelissen M, De Ridder L, Vandekerckhove J, Fiers W, et al: Cathepsin B-mediated activation of the proinflammatory caspase-11. Biochem Biophys Res Commun. 251:379–387. 1998. View Article : Google Scholar : PubMed/NCBI

37 

Vancompernolle K, Van Herreweghe F, Pynaert G, Van de Craen M, De Vos K, Totty N, Sterling A, Fiers W, Vandenabeele P and Grooten J: Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity. FEBS Lett. 438:150–158. 1998. View Article : Google Scholar : PubMed/NCBI

38 

Ishisaka R, Utsumi T, Kanno T, Arita K, Katunuma N, Akiyama J and Utsumi K: Participation of a cathepsin L-type protease in the activation of caspase-3. Cell Struct Funct. 24:465–470. 1999. View Article : Google Scholar : PubMed/NCBI

39 

Ishisaka R, Kanno T, Akiyama J, Yoshioka T, Utsumi K and Utsumi T: Activation of caspase-3 by lysosomal cysteine proteases and its role in 2,2′-azobis-(2-amidinopropane)dihydrochloride (AAPH)-induced apoptosis in HL-60 cells. J Biochem. 129:35–41. 2001. View Article : Google Scholar : PubMed/NCBI

40 

Tsai JY, Lee MJ, Dah-Tsyr Chang M and Huang H: The effect of catalase on migration and invasion of lung cancer cells by regulating the activities of cathepsin S, L, and K. Exp Cell Res. 323:28–40. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Zhang Q, Han M, Wang W, Song Y, Chen G, Wang Z and Liang Z: Downregulation of cathepsin L suppresses cancer invasion and migration by inhibiting transforming growth factor-β-mediated epithelial-mesenchymal transition. Oncol Rep. 33:1851–1859. 2015.PubMed/NCBI

42 

Burden RE, Gormley JA, Jaquin TJ, Small DM, Quinn DJ, Hegarty SM, Ward C, Walker B, Johnston JA, Olwill SA and Scott CJ: Antibody-mediated inhibition of cathepsin S blocks colorectal tumor invasion and angiogenesis. Clin Cancer Res. 15:6042–6051. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Li X, Cheng XW, Hu L, Wu H, Guo-Ping, Hao CN, Jiang H, Zhu E, Huang Z, Inoue A, et al: Cathepsin S activity controls ischemia-induced neovascularization in mice. Int J Cardiol. 183:198–208. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Shan Y, Li Y, Luo X and Shi H: Palmitate impairs angiogenesis via suppression of cathepsin activity. Mol Med Rep 15: 3644-3650, 2017.
APA
Zhang, J., Shan, Y., Li, Y., Luo, X., & Shi, H. (2017). Palmitate impairs angiogenesis via suppression of cathepsin activity. Molecular Medicine Reports, 15, 3644-3650. https://doi.org/10.3892/mmr.2017.6463
MLA
Zhang, J., Shan, Y., Li, Y., Luo, X., Shi, H."Palmitate impairs angiogenesis via suppression of cathepsin activity". Molecular Medicine Reports 15.6 (2017): 3644-3650.
Chicago
Zhang, J., Shan, Y., Li, Y., Luo, X., Shi, H."Palmitate impairs angiogenesis via suppression of cathepsin activity". Molecular Medicine Reports 15, no. 6 (2017): 3644-3650. https://doi.org/10.3892/mmr.2017.6463
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Shan Y, Li Y, Luo X and Shi H: Palmitate impairs angiogenesis via suppression of cathepsin activity. Mol Med Rep 15: 3644-3650, 2017.
APA
Zhang, J., Shan, Y., Li, Y., Luo, X., & Shi, H. (2017). Palmitate impairs angiogenesis via suppression of cathepsin activity. Molecular Medicine Reports, 15, 3644-3650. https://doi.org/10.3892/mmr.2017.6463
MLA
Zhang, J., Shan, Y., Li, Y., Luo, X., Shi, H."Palmitate impairs angiogenesis via suppression of cathepsin activity". Molecular Medicine Reports 15.6 (2017): 3644-3650.
Chicago
Zhang, J., Shan, Y., Li, Y., Luo, X., Shi, H."Palmitate impairs angiogenesis via suppression of cathepsin activity". Molecular Medicine Reports 15, no. 6 (2017): 3644-3650. https://doi.org/10.3892/mmr.2017.6463
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