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Article

Mitochondrial transcription factor A (TFAM) is upregulated in glioma

  • Authors:
    • Hyunji Lee
    • Jisoo Park
    • Quangdon Tran
    • Dohoon Kim
    • Youngeun Hong
    • Hyeonjeong Cho
    • So Hee Kwon
    • Derek Brazil
    • Seon‑Hwan Kim
    • Jongsun Park
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology and Medical Science, Metabolic Diseases and Cell Signaling Laboratory, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea, College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, Republic of Korea, Centre for Experimental Medicine, Queen's University Belfast, Belfast, BT9 7BL, Northern Ireland, Department of Neurosurgery, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea
  • Pages: 3781-3786
    |
    Published online on: April 12, 2017
       https://doi.org/10.3892/mmr.2017.6467
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Abstract

Mitochondrial transcription factor A (TFAM), which was initially discovered as a transcription factor for mitochondrial DNA, has known to be critical for the regulation of mitochondrial DNA. However the possible involvement of TFAM in cancer is largely unknown. In this study, we have provided some evidence that TFAM may have a potential role in brain tumor. Western blot analysis with anti‑TFAM antibody indicated that TFAM is overexpressed in glioblastoma cell lines including U87MG and U251MG. Transcriptome profiling of U87MG and U251MG cells by using deep‑sequencing revealed that TFAM transcripts were upregulated in these cells compared to its of cerebral cortex. Confocal microscopic analysis of U251MG cells with anti‑TFAM antibody showed that TFAM is located to the dot‑like structure close to nucleus, probably mitochondria and endosome. Immunohistochemical analysis of glioma tissue specimens indicated that TFAM is highly upregulated. Bioinformatical analysis with Rembrandt knowledgebase also supported that TFAM mRNA is upregulated in glioma patients. Taken together, the results presented in this study obviously provided the evidence that TFAM was upregulated in glioma cell line and glioma tissue specimens. Therefore TFAM may be a novel diagnostic marker and therapeutic target for glioma and other cancer.
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1 

Friedmann-Morvinski D, Bushong EA, Ke E, Soda Y, Marumoto T, Singer O, Ellisman MH and Verma IM: Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice. Science. 338:1080–1084. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Arshad A Arif: S.H: EGFR and PTEN gene mutation status in glioblastoma patients and their prognostic impact on patient's survival. J Carcinog Muta. 6:2015.

3 

Virk SM, Gibson RM, Quinones-Mateu ME and Barnholtz-Sloan JS: Identification of variants in primary and recurrent glioblastoma using a cancer-specific gene panel and whole exome sequencing. PLoS One. 10:e01241782015. View Article : Google Scholar : PubMed/NCBI

4 

Bergers G and Benjamin LE: Tumorigenesis and the angiogenic switch. Nat Rev Cancer. 3:401–410. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Wesseling P, Ruiter DJ and Burger PC: Angiogenesis in brain tumors; pathobiological and clinical aspects. J Neurooncol. 32:253–265. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Jain RK, di Tomaso E, Duda DG, Loeffler JS, Sorensen AG and Batchelor TT: Angiogenesis in brain tumours. Nat Rev Neurosci. 8:610–622. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Das S and Marsden PA: Angiogenesis in glioblastoma. N Engl J Med. 369:1561–1563. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Carmeliet P and Jain RK: Molecular mechanisms and clinical applications of angiogenesis. Nature. 473:298–307. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Norden AD, Drappatz J and Wen PY: Novel anti-angiogenic therapies for malignant gliomas. Lancet Neurol. 7:1152–1160. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Chinot OL, Macdonald DR, Abrey LE, Zahlmann G, Kerloëguen Y and Cloughesy TF: Response assessment criteria for glioblastoma: Practical adaptation and implementation in clinical trials of antiangiogenic therapy. Curr Neurol Neurosci Rep. 13:3472013. View Article : Google Scholar : PubMed/NCBI

11 

Chinot OL, Wick W, Mason W, Henriksson R, Saran F, Nishikawa R, Carpentier AF, Hoang-Xuan K, Kavan P, Cernea D, et al: Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma. N Engl J Med. 370:709–722. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Gilbert MR, Dignam JJ, Armstrong TS, Wefel JS, Blumenthal DT, Vogelbaum MA, Colman H, Chakravarti A, Pugh S, Won M, et al: A randomized trial of bevacizumab for newly diagnosed glioblastoma. N Engl J Med. 370:699–708. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Ekstrand MI, Falkenberg M, Rantanen A, Park CB, Gaspari M, Hultenby K, Rustin P, Gustafsson CM and Larsson NG: Mitochondrial transcription factor A regulates mtDNA copy number in mammals. Hum Mol Genet. 13:935–944. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Picca A and Lezza AM: Regulation of mitochondrial biogenesis through TFAM-mitochondrial DNA interactions: Useful insights from aging and calorie restriction studies. Mitochondrion. 25:67–75. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Cheng Z and Ristow M: Mitochondria and metabolic homeostasis. Antioxidants & redox signaling. 19:240–242. 2013. View Article : Google Scholar

16 

Kim AY, Kwak JH, Je NK, Lee YH and Jung YS: Epithelial-mesenchymal transition is associated with acquired resistance to 5-fluorocuracil in HT-29 colon cancer cells. Toxicol Res. 31:151–156. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Li Y, Park J, Piao L, Kong G, Kim Y, Park KA, Zhang T, Hong J, Hur GM, Seok JH, et al: PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage. Cell Signal. 25:74–84. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Kim IS, Yang SY, Han JH, Jung SH, Park HS and Myung CS: Differential gene expression in GPR40-overexpressing pancreatic β-cells treated with linoleic acid. Korean J Physiol Pharmacol. 19:141–149. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Bioinformatics UG: 2015, Human genome sequencing consortium. http://genome.ucsc.eduApril 17–2016

20 

Kim D and Salzberg S: 2015, TopHat 2.1.0 release 6/29/2015. https://ccb.jhu.edu/software/tophat/index.shtml

21 

Na CH, Hong JH, Kim WS, Shanta SR, Bang JY, Park D, Kim HK and Kim KP: Identification of protein markers specific for papillary renal cell carcinoma using imaging mass spectrometry. Mol Cells. 38:624–629. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Jiang J, Yang J, Wang Z, Wu G and Liu F: TFAM is directly regulated by miR-23b in glioma. Oncol Rep. 30:2105–2110. 2013.PubMed/NCBI

23 

Chargari C, Moncharmont C, Lévy A, Guy JB, Bertrand G, Guilbert M, Rousseau C, Védrine L, Alphonse G, Toillon RA, et al: Cancer stem cells, cornerstone of radioresistance and perspectives for radiosensitization: Glioblastoma as an example. Bull Cancer. 99:1153–1160. 2012.(In French). PubMed/NCBI

24 

Yoshida T, Azuma H, Aihara K, Fujimura M, Akaike M, Mitsui T and Matsumoto T: Vascular smooth muscle cell proliferation is dependent upon upregulation of mitochondrial transcription factor A (mtTFA) expression in injured rat carotid artery. Atherosclerosis. 178:39–47. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Kim AJ, Jee HJ, Song N, Kim M, Jeong SY and Yun J: p21 (WAF1/C1P1) deficiency induces mitochondrial dysfunction in HCT116 colon cancer cells. Biochem Biophys Res Commun. 430:653–658. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Guo J, Zheng L and Liu W, Wang X, Wang Z, Wang Z, French AJ, Kang D, Chen L, Thibodeau SN and Liu W: Frequent truncating mutation of TFAM induces mitochondrial DNA depletion and apoptotic resistance in microsatellite-unstable colorectal cancer. Cancer Res. 71:2978–2987. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lee H, Park J, Tran Q, Kim D, Hong Y, Cho H, Kwon SH, Brazil D, Kim SH, Park J, Park J, et al: Mitochondrial transcription factor A (TFAM) is upregulated in glioma. Mol Med Rep 15: 3781-3786, 2017.
APA
Lee, H., Park, J., Tran, Q., Kim, D., Hong, Y., Cho, H. ... Park, J. (2017). Mitochondrial transcription factor A (TFAM) is upregulated in glioma. Molecular Medicine Reports, 15, 3781-3786. https://doi.org/10.3892/mmr.2017.6467
MLA
Lee, H., Park, J., Tran, Q., Kim, D., Hong, Y., Cho, H., Kwon, S. H., Brazil, D., Kim, S., Park, J."Mitochondrial transcription factor A (TFAM) is upregulated in glioma". Molecular Medicine Reports 15.6 (2017): 3781-3786.
Chicago
Lee, H., Park, J., Tran, Q., Kim, D., Hong, Y., Cho, H., Kwon, S. H., Brazil, D., Kim, S., Park, J."Mitochondrial transcription factor A (TFAM) is upregulated in glioma". Molecular Medicine Reports 15, no. 6 (2017): 3781-3786. https://doi.org/10.3892/mmr.2017.6467
Copy and paste a formatted citation
x
Spandidos Publications style
Lee H, Park J, Tran Q, Kim D, Hong Y, Cho H, Kwon SH, Brazil D, Kim SH, Park J, Park J, et al: Mitochondrial transcription factor A (TFAM) is upregulated in glioma. Mol Med Rep 15: 3781-3786, 2017.
APA
Lee, H., Park, J., Tran, Q., Kim, D., Hong, Y., Cho, H. ... Park, J. (2017). Mitochondrial transcription factor A (TFAM) is upregulated in glioma. Molecular Medicine Reports, 15, 3781-3786. https://doi.org/10.3892/mmr.2017.6467
MLA
Lee, H., Park, J., Tran, Q., Kim, D., Hong, Y., Cho, H., Kwon, S. H., Brazil, D., Kim, S., Park, J."Mitochondrial transcription factor A (TFAM) is upregulated in glioma". Molecular Medicine Reports 15.6 (2017): 3781-3786.
Chicago
Lee, H., Park, J., Tran, Q., Kim, D., Hong, Y., Cho, H., Kwon, S. H., Brazil, D., Kim, S., Park, J."Mitochondrial transcription factor A (TFAM) is upregulated in glioma". Molecular Medicine Reports 15, no. 6 (2017): 3781-3786. https://doi.org/10.3892/mmr.2017.6467
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