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Associations of maternal PLA2G4C and PLA2G4D polymorphisms with the risk of spontaneous preterm birth in a Chinese population

  • Authors:
    • Guang‑Jian Liu
    • Jian‑Rong He
    • Ya‑Shu Kuang
    • Xue‑Jiao Fan
    • Wei‑Dong Li
    • Jin‑Hua Lu
    • Xiao‑Yan Xia
    • Xiao‑Dan Liu
    • Nian‑Nian Chen
    • Wei‑Bi Mai
    • Hui‑Min Xia
    • Xiu Qiu
  • View Affiliations / Copyright

    Affiliations: Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, P.R. China, Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3607-3614
    |
    Published online on: April 12, 2017
       https://doi.org/10.3892/mmr.2017.6475
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Abstract

Preterm birth is the leading cause of mortality and morbidity in infants. Its etiology is multifactorial with genes and immune homeostasis. The authors investigated whether prostaglandin (PG) synthesis related single nucleotide polymorphisms (SNPs) PLA2G4C rs1366442 and PLA2G4D rs4924618 were associated with the risk of spontaneous preterm birth (SPTB) in a Chinese population of 114 cases of SPTB and 250 controls of term delivery. The risk associations were determined by odds ratios (ORs) and their 95% confidence intervals (CIs) calculated using multivariate logistic regression. Homology modeling was performed to elucidate potential mechanism of the SNP function. The maternal AT/TT genotype of PLA2G4D rs4924618 was associated with a reduced risk of SPTB (OR, 0.61; 95% CI, 0.37‑0.99), while no significant association between PLA2G4C rs1366442 and SPTB risk was identified. Structure and sequence analysis revealed that the amino acid substitution introduced by this SNP located at the conserved central core of the catalytic domain of cytosolic phospholipase A2 δ and was close to the active site. These findings suggested that the polymorphism of PLA2G4D rs4924618 may have a protective influence on the SPTB susceptibility in a Chinese population, supporting a role for genetics in the association between PG synthesis and preterm birth.
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Copy and paste a formatted citation
Spandidos Publications style
Liu GJ, He JR, Kuang YS, Fan XJ, Li WD, Lu JH, Xia XY, Liu XD, Chen NN, Mai WB, Mai WB, et al: Associations of maternal PLA2G4C and PLA2G4D polymorphisms with the risk of spontaneous preterm birth in a Chinese population. Mol Med Rep 15: 3607-3614, 2017.
APA
Liu, G., He, J., Kuang, Y., Fan, X., Li, W., Lu, J. ... Qiu, X. (2017). Associations of maternal PLA2G4C and PLA2G4D polymorphisms with the risk of spontaneous preterm birth in a Chinese population. Molecular Medicine Reports, 15, 3607-3614. https://doi.org/10.3892/mmr.2017.6475
MLA
Liu, G., He, J., Kuang, Y., Fan, X., Li, W., Lu, J., Xia, X., Liu, X., Chen, N., Mai, W., Xia, H., Qiu, X."Associations of maternal PLA2G4C and PLA2G4D polymorphisms with the risk of spontaneous preterm birth in a Chinese population". Molecular Medicine Reports 15.6 (2017): 3607-3614.
Chicago
Liu, G., He, J., Kuang, Y., Fan, X., Li, W., Lu, J., Xia, X., Liu, X., Chen, N., Mai, W., Xia, H., Qiu, X."Associations of maternal PLA2G4C and PLA2G4D polymorphisms with the risk of spontaneous preterm birth in a Chinese population". Molecular Medicine Reports 15, no. 6 (2017): 3607-3614. https://doi.org/10.3892/mmr.2017.6475
Copy and paste a formatted citation
x
Spandidos Publications style
Liu GJ, He JR, Kuang YS, Fan XJ, Li WD, Lu JH, Xia XY, Liu XD, Chen NN, Mai WB, Mai WB, et al: Associations of maternal PLA2G4C and PLA2G4D polymorphisms with the risk of spontaneous preterm birth in a Chinese population. Mol Med Rep 15: 3607-3614, 2017.
APA
Liu, G., He, J., Kuang, Y., Fan, X., Li, W., Lu, J. ... Qiu, X. (2017). Associations of maternal PLA2G4C and PLA2G4D polymorphisms with the risk of spontaneous preterm birth in a Chinese population. Molecular Medicine Reports, 15, 3607-3614. https://doi.org/10.3892/mmr.2017.6475
MLA
Liu, G., He, J., Kuang, Y., Fan, X., Li, W., Lu, J., Xia, X., Liu, X., Chen, N., Mai, W., Xia, H., Qiu, X."Associations of maternal PLA2G4C and PLA2G4D polymorphisms with the risk of spontaneous preterm birth in a Chinese population". Molecular Medicine Reports 15.6 (2017): 3607-3614.
Chicago
Liu, G., He, J., Kuang, Y., Fan, X., Li, W., Lu, J., Xia, X., Liu, X., Chen, N., Mai, W., Xia, H., Qiu, X."Associations of maternal PLA2G4C and PLA2G4D polymorphisms with the risk of spontaneous preterm birth in a Chinese population". Molecular Medicine Reports 15, no. 6 (2017): 3607-3614. https://doi.org/10.3892/mmr.2017.6475
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