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Review Open Access

Structural and evolutionary divergence of aquaporins in parasites (Review)

  • Authors:
    • Zi‑Xin Ni
    • Jian‑Min Cui
    • Nian‑Zhang Zhang
    • Bao‑Quan Fu
  • View Affiliations / Copyright

    Affiliations: College of Veterinary Medicine, China Agricultural University, Beijing 100083, P.R. China, State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, P.R. China
    Copyright: © Ni et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3943-3948
    |
    Published online on: April 25, 2017
       https://doi.org/10.3892/mmr.2017.6505
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Abstract

Aquaporins are ubiquitous proteins that belong to the major intrinsic protein family. Previous studies have indicated that aquaporins are involved in multiple physiological processes in parasites, such as nutrient absorption and end product efflux, and thus, would be promising pharmacological agents in the fight against parasite infection. In the present paper, the authors analyzed the evolutionary relationship of parasitic aquaporins by re‑constructing of a phylogenic tree using neighbor‑joining and maximum likelihood methods. In addition, the authors discussed the variation of the conserved functional sites impacting on the transportation of water molecules. The protein was concluded to be a potential drug target in parasites.
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1 

Mehlhorn H: Encyclopedia of parasitology I. 3rd. Springer; 2008, View Article : Google Scholar

2 

Ramasamy R: Zoonotic malaria-global overview and research and policy needs. Front Public Health. 2:1232014. View Article : Google Scholar :

3 

Halonen SK and Weiss LM: Toxoplasmosis. Handb Clin Neurol. 114:125–145. 2013. View Article : Google Scholar :

4 

Pace D: Leishmaniasis. J Infect. 69 Suppl 1:S10–S18. 2014. View Article : Google Scholar

5 

Robinson MW and Dalton JP: Zoonotic helminth infections with particular emphasis on fasciolosis and other trematodiases. Philos Trans R Soc Lond B Biol Sci. 364:2763–2776. 2009. View Article : Google Scholar :

6 

Kirk K: Channels and transporters as drug targets in the Plasmodium-infected erythrocyte. Acta Trop. 89:285–298. 2004. View Article : Google Scholar

7 

Sibley LD: How apicomplexan parasites move in and out of cells. Curr Opin Biotechnol. 21:592–598. 2010. View Article : Google Scholar :

8 

Gomes D, Agasse A, Thiébaud P, Delrot S, Gerós H and Chaumont F: Aquaporins are multifunctional water and solute transporters highly divergent in living organisms. Biochim Biophys Acta. 1788:1213–1228. 2009. View Article : Google Scholar

9 

Shiels A: Focus on molecules: Major intrinsic protein. Exp Eye Res. 101:107–108. 2012. View Article : Google Scholar

10 

Castro-Borges W, Simpson DM, Dowle A, Curwen RS, Thomas-Oates J, Beynon RJ and Wilson RA: Abundance of tegument surface proteins in the human blood fluke Schistosoma mansoni determined by QconCAT proteomics. J Proteomics. 74:1519–1533. 2011. View Article : Google Scholar

11 

Fujiyoshi Y, Mitsuoka K, de Groot BL, Philippsen A, Grubmüller H, Agre P and Engel A: Structure and function of water channels. Curr Opin Struct Biol. 12:509–515. 2002. View Article : Google Scholar

12 

Sui H, Han BG, Lee JK, Walian P and Jap BK: Structural basis of water-specific transport through the AQP1 water channel. Nature. 414:872–878. 2001. View Article : Google Scholar

13 

Campbell EM, Ball A, Hoppler S and Bowman AS: Invertebrate aquaporin: A review. J Comp Physiol B. 178:935–955. 2008. View Article : Google Scholar

14 

Liu Z, Shen J, Carbrey JM, Mukhopadhyay R, Agre P and Rosen BP: Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. Proc Natl Acad Sci USA. 99:pp. 6053–6058. 2002; View Article : Google Scholar :

15 

Yakata K, Hiroaki Y, Ishibashi K, Sohara E, Sasaki S, Mitsuoka K and Fujiyoshi Y: Aquaporin-11 containing a divergent NPA motif has normal water channel activity. Biochim Biophys Acta. 1768:688–693. 2006. View Article : Google Scholar

16 

Itoh T, Rai T, Kuwahara M, Ko SB, Uchida S, Sasaki S and Ishibashi K: Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells. Biochem Biophys Res Commun. 330:832–838. 2005. View Article : Google Scholar

17 

Yue C, Cao H, Wang L, Zhou Y, Hao X, Zeng J, Wang X and Yang Y: Molecular cloning and expression analysis of tea plant aquaporin (AQP) gene family. Plant Physiol Biochem. 83:65–76. 2014. View Article : Google Scholar

18 

Geadkaew A, von Bülow J, Beitz E, Grams SV, Viyanant V and Grams R: Functional analysis of novel aquaporins from Fasciola gigantica. Mol Biochem Parasitol. 175:144–153. 2011. View Article : Google Scholar

19 

Pavlovic-Djuranovic S, Schultz JE and Beitz E: A single aquaporin gene encodes a water/glycerol/urea facilitator in Toxoplasma gondii with similarity to plant tonoplast intrinsic proteins. FEBS Lett. 555:500–504. 2003. View Article : Google Scholar

20 

Murata K, Mitsuoka K, Hirai T, Walz T, Agre P, Heymann JB, Engel A and Fujiyoshi Y: Structural determinants of water permeation through aquaporin-1. Nature. 407:599–605. 2000. View Article : Google Scholar

21 

Herrera M and Garvin JL: Aquaporins as gas channels. Pflugers Arch. 462:623–630. 2011. View Article : Google Scholar

22 

Stroud RM, Savage D, Miercke LJ, Lee JK, Khademi S and Harries W: Selectivity and conductance among the glycerol and water conducting aquaporin family of channels. FEBS Lett. 555:79–84. 2003. View Article : Google Scholar

23 

Beitz E, Wu B, Holm LM, Schultz JE and Zeuthen T: Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia, and protons. Proc Natl Acad Sci USA. 103:pp. 269–274. 2006; View Article : Google Scholar :

24 

Baker N, Glover L, Munday JC, Andrés D Aguinaga, Barrett MP, de Koning HP and Horn D: Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes. Proc Natl Acad Sci USA. 109:pp. 10996–1001. 2012; View Article : Google Scholar :

25 

Preston GM, Jung JS, Guggino WB and Agre P: The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel. J Biol Chem. 268:17–20. 1993.

26 

Ishibashi K, Kuwahara M, Gu Y, Tanaka Y, Marumo F and Sasaki S: Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol. Biochem Biophys Res Commun. 244:268–274. 1998. View Article : Google Scholar

27 

Froger A, Tallur B, Thomas D and Delamarche C: Prediction of functional residues in water channels and related proteins. Protein Sci. 7:1458–1468. 1998. View Article : Google Scholar :

28 

Chakrabarti N, Tajkhorshid E, Roux B and Pomès R: Molecular basis of proton blockage in aquaporins. Structure. 12:65–74. 2004. View Article : Google Scholar

29 

Wree D, Wu B, Zeuthen T and Beitz E: Requirement for asparagine in the aquaporin NPA sequence signature motifs for cation exclusion. FEBS J. 278:740–748. 2011. View Article : Google Scholar

30 

Uzcategui NL, Szallies A, Pavlovic-Djuranovic S, Palmada M, Figarella K, Boehmer C, Lang F, Beitz E and Duszenko M: Cloning, heterologous expression, and characterization of three aquaglyceroporins from Trypanosoma brucei. J Biol Chem. 279:42669–42676. 2004. View Article : Google Scholar

31 

Hansen M, Kun JF, Schultz JE and Beitz E: A Single, bi-functional aquaglyceroporin in blood-stage Plasmodium falciparum malaria parasites. J Biol Chem. 277:4874–4882. 2002. View Article : Google Scholar

32 

Geadkaew A, von Bülow J, Beitz E, Tesana S, Grams S Vichasri and Grams R: Bi-functionality of Opisthorchis viverrini aquaporins. Biochimie. 108:149–159. 2015. View Article : Google Scholar

33 

Huber VJ, Tsujita M and Nakada T: Aquaporins in drug discovery and pharmacotherapy. Mol Aspects Med. 33:691–703. 2012. View Article : Google Scholar

34 

Beitz E: Aquaporin Water and solute channels from malaria parasites and other pathogenic protozoa. ChemMedChem. 1:587–592. 2006. View Article : Google Scholar

35 

Munday JC, Eze AA, Baker N, Glover L, Clucas C, Andrés D Aguinaga, Natto MJ, Teka IA, McDonald J, Lee RS, et al: Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. J Antimicrob Chemother. 69:651–663. 2014. View Article : Google Scholar

36 

Faghiri Z and Skelly PJ: The role of tegumental aquaporin from the human parasitic worm, Schistosoma mansoni, in osmoregulation and drug uptake. FASEB J. 23:2780–2789. 2009. View Article : Google Scholar :

37 

Gourbal B, Sonuc N, Bhattacharjee H, Legare D, Sundar S, Ouellette M, Rosen BP and Mukhopadhyay R: Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin. J Biol Chem. 279:31010–31017. 2004. View Article : Google Scholar

38 

Braschi S, Curwen RS, Ashton PD, Verjovski-Almeida S and Wilson A: The tegument surface membranes of the human blood parasite Schistoma mansoni: A proteomic analysis after differential extraction. Proteomics. 6:1471–1482. 2006. View Article : Google Scholar

39 

Faghiri Z, Camargo SM, Huggel K, Forster IC, Ndegwa D, Verrey F and Skelly PJ: The tegument of the human parasitic worm Schistosoma mansoni as an excretory organ: The surface aqp SmAQP is a lactate transporter. Plos One. 5:e104512010. View Article : Google Scholar :

40 

Mitani-Ueno N, Yamaji N, Zhao FJ and Ma JF: The aromatic/arginine selectivity filter of NIP aquaporins plays a critical role in substrate selectivity for silicon, boron, and arsenic. J Exper Bot. 62:4391–4398. 2011. View Article : Google Scholar

41 

Figarella K, Uzcategui NL, Zhou Y, LeFurgey A, Ouellette M, Bhattacharjee H and Mukhopadhyay R: Biochemical characterization of Leishmania major aquaglyceroporin LmAQP1: Possible role in volume regulation and osmotaxis. Mol Microbiol. 65:1006–1017. 2007. View Article : Google Scholar

42 

Mukhopadhyay R, Mandal G, Atluri VS, Figarella K, Uzcategui NL, Zhou Y, Beitz E, Ajees AA and Bhattacharjee H: The role of alanine 163 in solute permeability of Leishmania major aquaglyceroporin LmAQP1. Mol Biochem Parasitol. 175:83–90. 2011. View Article : Google Scholar

43 

Kuwahara M, Asai T, Sato K, Shinbo I, Terada Y, Marumo F and Sasaki S: Functional characterization of a water channel of the nematode Caenorhabditis elegans. Biochim Biophys Acta. 1517:107–112. 2000. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Ni ZX, Cui JM, Zhang NZ and Fu BQ: Structural and evolutionary divergence of aquaporins in parasites (Review). Mol Med Rep 15: 3943-3948, 2017.
APA
Ni, Z., Cui, J., Zhang, N., & Fu, B. (2017). Structural and evolutionary divergence of aquaporins in parasites (Review). Molecular Medicine Reports, 15, 3943-3948. https://doi.org/10.3892/mmr.2017.6505
MLA
Ni, Z., Cui, J., Zhang, N., Fu, B."Structural and evolutionary divergence of aquaporins in parasites (Review)". Molecular Medicine Reports 15.6 (2017): 3943-3948.
Chicago
Ni, Z., Cui, J., Zhang, N., Fu, B."Structural and evolutionary divergence of aquaporins in parasites (Review)". Molecular Medicine Reports 15, no. 6 (2017): 3943-3948. https://doi.org/10.3892/mmr.2017.6505
Copy and paste a formatted citation
x
Spandidos Publications style
Ni ZX, Cui JM, Zhang NZ and Fu BQ: Structural and evolutionary divergence of aquaporins in parasites (Review). Mol Med Rep 15: 3943-3948, 2017.
APA
Ni, Z., Cui, J., Zhang, N., & Fu, B. (2017). Structural and evolutionary divergence of aquaporins in parasites (Review). Molecular Medicine Reports, 15, 3943-3948. https://doi.org/10.3892/mmr.2017.6505
MLA
Ni, Z., Cui, J., Zhang, N., Fu, B."Structural and evolutionary divergence of aquaporins in parasites (Review)". Molecular Medicine Reports 15.6 (2017): 3943-3948.
Chicago
Ni, Z., Cui, J., Zhang, N., Fu, B."Structural and evolutionary divergence of aquaporins in parasites (Review)". Molecular Medicine Reports 15, no. 6 (2017): 3943-3948. https://doi.org/10.3892/mmr.2017.6505
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