Open Access

Structural and evolutionary divergence of aquaporins in parasites (Review)

  • Authors:
    • Zi‑Xin Ni
    • Jian‑Min Cui
    • Nian‑Zhang Zhang
    • Bao‑Quan Fu
  • View Affiliations

  • Published online on: April 25, 2017     https://doi.org/10.3892/mmr.2017.6505
  • Pages: 3943-3948
  • Copyright: © Ni et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Aquaporins are ubiquitous proteins that belong to the major intrinsic protein family. Previous studies have indicated that aquaporins are involved in multiple physiological processes in parasites, such as nutrient absorption and end product efflux, and thus, would be promising pharmacological agents in the fight against parasite infection. In the present paper, the authors analyzed the evolutionary relationship of parasitic aquaporins by re‑constructing of a phylogenic tree using neighbor‑joining and maximum likelihood methods. In addition, the authors discussed the variation of the conserved functional sites impacting on the transportation of water molecules. The protein was concluded to be a potential drug target in parasites.
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June-2017
Volume 15 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Ni ZX, Cui JM, Zhang NZ and Fu BQ: Structural and evolutionary divergence of aquaporins in parasites (Review). Mol Med Rep 15: 3943-3948, 2017
APA
Ni, Z., Cui, J., Zhang, N., & Fu, B. (2017). Structural and evolutionary divergence of aquaporins in parasites (Review). Molecular Medicine Reports, 15, 3943-3948. https://doi.org/10.3892/mmr.2017.6505
MLA
Ni, Z., Cui, J., Zhang, N., Fu, B."Structural and evolutionary divergence of aquaporins in parasites (Review)". Molecular Medicine Reports 15.6 (2017): 3943-3948.
Chicago
Ni, Z., Cui, J., Zhang, N., Fu, B."Structural and evolutionary divergence of aquaporins in parasites (Review)". Molecular Medicine Reports 15, no. 6 (2017): 3943-3948. https://doi.org/10.3892/mmr.2017.6505