Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
June-2017 Volume 15 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2017 Volume 15 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Expression of reproductive hormone receptors and contraction‑associated genes in porcine uterus during the estrous cycle

  • Authors:
    • Sung‑Min An
    • Sun Suk Kim
    • Jun Kim
    • Mee‑Na Park
    • Jae‑Eon Lee
    • Seong Keun Cho
    • Kyu‑Sup Lee
    • Beum‑Soo An
  • View Affiliations / Copyright

    Affiliations: Department of Biomaterials Science, College of Natural Resources and Life Science, Pusan National University, Miryang, Gyeongsangnam‑do 50463, Republic of Korea, Department of Obstetrics and Gynecology, Biomedical Research Institute, Pusan National University School of Medicine, Pusan, Gyeongsangnam‑do 49241, Republic of Korea, University of Ulsan College of Medicine, Seoul, Gyeonggi‑do 05505, Republic of Korea, Department of Animal Science, College of Natural Resources and Life Science, Pusan National University, Miryang, Gyeongsangnam‑do 50463, Republic of Korea
  • Pages: 4176-4184
    |
    Published online on: April 27, 2017
       https://doi.org/10.3892/mmr.2017.6518
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Contraction of uterus tissue frequently occurs throughout the estrous cycle and is regulated by several endogenous factors, including estradiol, progesterone, luteinizing hormone, follicle‑stimulating hormone, oxytocin (OXT) and contraction‑associated proteins (CAPs). Contraction activity of uterus tissue according to the estrous cycle is important, due to the fact that it is directly associated with balanced implantation and stable pregnancy. However, few studies have examined the mechanism of uterus contraction activity in a porcine model. In the current study, porcine uterus tissue was separated into the follicular and luteal phases by histological analysis. To investigate regulation of contraction‑associated factors according to the estrous cycle, mRNA and protein expression levels of reproductive hormonal receptors, including estrogen receptors, progesterone receptor and luteinizing hormone/choriogonadotropin receptor in addition to CAPs including OXT, OXT receptor (OXTR), hydroxyprostaglandin dehydrogenase 15‑(NAD) and gap junction α‑1 protein, were examined in the porcine uterus according to the follicular and luteal phases. For the results, hormonal receptors and CAPs were dynamically regulated depending on the estrous cycle. In conclusion, genes associated with uterine contraction and its regulatory hormonal receptors in the porcine uterus were differently regulated in the follicular and luteal phases, suggesting that these genes are critically involved in the remodeling and contraction of uterine tissue and may be required to modulate the physiological status of the uterus.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

An BS, Ahn HJ, Kang HS, Jung EM, Yang H, Hong EJ and Jeung EB: Effects of estrogen and estrogenic compounds, 4-tert-octylphenol, and bisphenol A on the uterine contraction and contraction-associated proteins in rats. Mol Cell Endocrinol. 375:27–34. 2013. View Article : Google Scholar

2 

Dawe ST, Husband AJ and Langford CM: Effects of induction of parturition in ewes with dexamethasone or oestrogen on concentrations of immunoglobulins in colostrum, and absorption of immunoglobulins by lambs. Aust J Biol Sci. 35:223–230. 1982. View Article : Google Scholar

3 

Soede N, Langendijk P and Kemp B: Reproductive cycles in pigs. Anim Reprod Sci. 124:251–258. 2011. View Article : Google Scholar

4 

Bullivant SB, Sellergren SA, Stern K, Spencer NA, Jacob S, Mennella JA and McClintock MK: Women's sexual experience during the menstrual cycle: Identification of the sexual phase by noninvasive measurement of luteinizing hormone. J Sex Res. 41:82–93. 2004. View Article : Google Scholar

5 

Rzucidlo S, Weigl R and Tilton J: Myometrial LH/hCG receptors during the estrous cycle and pregnancy in pigs. Anim Reprod Sci. 51:249–257. 1998. View Article : Google Scholar

6 

Krzymowski T and Stefańczyk-Krzymowska S: The oestrous cycle and early pregnancy-a new concept of local endocrine regulation. Vet J. 168:285–296. 2004. View Article : Google Scholar

7 

Rush RW, Keirse MJ, Howat P, Baum JD, Anderson AB and Turnbull AC: Contribution of preterm delivery to perinatal mortality. Br Med J. 2:965–968. 1976. View Article : Google Scholar :

8 

López Bernal A, Rivera J, Europe-Finner GN, Phaneuf S and Asbóth G: Parturition: Activation of stimulatory pathwaysor loss of uterine quiescence? Adv Exp Med Biol. 395:435–451. 1994.

9 

Wu WX, Ma XH, Coksaygan T, Chakrabarty K, Collins V, Rose J and Nathanielsz PW: Prostaglandin mediates premature delivery in pregnant sheep induced by estradiol at 121 days of gestational age. Endocrinology. 145:1444–1452. 2004. View Article : Google Scholar

10 

Csapo AL, Knobil E, Van Der Molen HJ and Wiest WG: Peripheral plasma progesterone levels during human pregnancy and labor. Am J Obstet Gynecol. 110:630–632. 1971. View Article : Google Scholar

11 

Mesiano S and Welsh TN: Steroid hormone control of myometrial contractility and parturition. Seminars in cell & developmental biology. 18:pp. 321–331. 2007; View Article : Google Scholar

12 

Renthal NE, Chen CC, Williams KC, Gerard RD, Prange-Kiel J and Mendelson CR: miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor. Proc Natl Acad Sci USA. 107:pp. 20828–20833. 2010; View Article : Google Scholar :

13 

Yun SM, Choi KC, Kim IH, An BS, Lee GS, Hong EJ, Oh GT and Jeung EB: Dominant expression of porcine Calbindin-D9k in the uterus during a luteal phase. Mol Reprod Dev. 67:251–256. 2004. View Article : Google Scholar

14 

Knox R: Recruitment and selection of ovarian follicles for determination of ovulation rate in the pig. Domest Anim Endocrinol. 29:385–397. 2005. View Article : Google Scholar

15 

Sukjumlong S, Kaeoket K, Dalin AM and Persson E: Immunohistochemical Studies on Oestrogen Receptor Alpha (ER Alpha) and the Proliferative Marker Ki-67 in the Sow Uterus at Different Stages of the Oestrous Cycle. Reprod Domest Anim. 38:5–12. 2003. View Article : Google Scholar

16 

Ribeiro LA, Bacci ML, Seren E, Tamanini C and Forni M: Characterization and differential expression of vascular endothelial growth factor isoforms and receptors in swine corpus luteum throughout estrous cycle. Mol Reprod Dev. 74:163–171. 2007. View Article : Google Scholar

17 

Cassidy A, Bingham S and Setchell KD: Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women. Am J Clin Nutr. 60:333–340. 1994.

18 

Sukjumlong S, Persson E, Dalin AM, Janson V and Sahlin L: Messenger RNA levels of estrogen receptors alpha and beta and progesterone receptors in the cyclic and inseminated/early pregnant sow uterus. Anim Reprod Sci. 112:215–228. 2009. View Article : Google Scholar

19 

Murata T, Narita K, Honda K and Higuchi T: Changes of receptor mRNAs for oxytocin and estrogen during the estrous cycle in rat uterus. J Vet Med Sci. 65:707–712. 2003. View Article : Google Scholar

20 

Murata T, Narita K, Honda K, Matsukawa S and Higuchi T: Differential regulation of estrogen receptor alpha and beta mRNAs in the rat uterus during pregnancy and labor: Possible involvement of estrogen receptors in oxytocin receptor regulation. Endocr J. 50:579–587. 2003. View Article : Google Scholar

21 

Murata T, Murata E, Liu C, Narita K, Honda K and Higuchi T: Oxytocin receptor gene expression in rat uterus: Regulation by ovarian steroids. J Endocrinol. 166:45–52. 2000. View Article : Google Scholar

22 

Matsuo M, Ensor CM and Tai HH: Characterization of the genomic structure and promoter of the mouse NAD+-dependent 15-hydroxyprostaglandin dehydrogenase gene. Biochem Biophys Res Commun. 235:582–586. 1997. View Article : Google Scholar

23 

Kelly RW, Linan C, Thong J, Yong EL and Baird DT: Prostaglandin inactivation is increased in endometrium after exposure to clomiphene. Prostaglandins Leukot Essent Fatty Acids. 50:235–238. 1994. View Article : Google Scholar

24 

Grazul-Bilska AT, Redmer DA, Johnson ML, Jablonka-Shariff A, Bilski JJ and Reynolds LP: Gap junctional protein connexin 43 in bovine corpora lutea throughout the estrous cycle. Biol Rep. 54:1279–1287. 1996. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
An SM, Kim SS, Kim J, Park MN, Lee JE, Cho SK, Lee KS and An BS: Expression of reproductive hormone receptors and contraction‑associated genes in porcine uterus during the estrous cycle. Mol Med Rep 15: 4176-4184, 2017.
APA
An, S., Kim, S.S., Kim, J., Park, M., Lee, J., Cho, S.K. ... An, B. (2017). Expression of reproductive hormone receptors and contraction‑associated genes in porcine uterus during the estrous cycle. Molecular Medicine Reports, 15, 4176-4184. https://doi.org/10.3892/mmr.2017.6518
MLA
An, S., Kim, S. S., Kim, J., Park, M., Lee, J., Cho, S. K., Lee, K., An, B."Expression of reproductive hormone receptors and contraction‑associated genes in porcine uterus during the estrous cycle". Molecular Medicine Reports 15.6 (2017): 4176-4184.
Chicago
An, S., Kim, S. S., Kim, J., Park, M., Lee, J., Cho, S. K., Lee, K., An, B."Expression of reproductive hormone receptors and contraction‑associated genes in porcine uterus during the estrous cycle". Molecular Medicine Reports 15, no. 6 (2017): 4176-4184. https://doi.org/10.3892/mmr.2017.6518
Copy and paste a formatted citation
x
Spandidos Publications style
An SM, Kim SS, Kim J, Park MN, Lee JE, Cho SK, Lee KS and An BS: Expression of reproductive hormone receptors and contraction‑associated genes in porcine uterus during the estrous cycle. Mol Med Rep 15: 4176-4184, 2017.
APA
An, S., Kim, S.S., Kim, J., Park, M., Lee, J., Cho, S.K. ... An, B. (2017). Expression of reproductive hormone receptors and contraction‑associated genes in porcine uterus during the estrous cycle. Molecular Medicine Reports, 15, 4176-4184. https://doi.org/10.3892/mmr.2017.6518
MLA
An, S., Kim, S. S., Kim, J., Park, M., Lee, J., Cho, S. K., Lee, K., An, B."Expression of reproductive hormone receptors and contraction‑associated genes in porcine uterus during the estrous cycle". Molecular Medicine Reports 15.6 (2017): 4176-4184.
Chicago
An, S., Kim, S. S., Kim, J., Park, M., Lee, J., Cho, S. K., Lee, K., An, B."Expression of reproductive hormone receptors and contraction‑associated genes in porcine uterus during the estrous cycle". Molecular Medicine Reports 15, no. 6 (2017): 4176-4184. https://doi.org/10.3892/mmr.2017.6518
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team