Open Access

Differences in cell death and cell cycle following fucoidan treatment in high-density HT-29 colon cancer cells

  • Authors:
    • In‑Hye Kim
    • Mi‑Jin Kwon
    • Taek‑Jeong Nam
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  • Published online on: April 27, 2017     https://doi.org/10.3892/mmr.2017.6520
  • Pages: 4116-4122
  • Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Fucoidan, a sulfated polysaccharide present in marine brown seaweed, has been demonstrated to inhibit in vivo and in vitro growth of cells. The present study was conducted in HT‑29 human colon cancer cells cultured at a high density, and examined the potential underlying mechanisms by which fucoidan exerts its anti‑proliferative effects, which remain poorly understood. Fucoidan treatment of high‑density HT‑29 cells resulted in the inhibition of cell growth and increased apoptotic cell death. Flow cytometric analysis revealed that fucoidan treatment led to sub‑G1 phase cell cycle arrest. This was associated with decreased protein expression levels of Retinoblastoma protein and E2 factor protein. In conclusion, the results of the present study demonstrated that fucoidan possesses anticancer activity against high density HT‑29 cells by inhibiting cell growth and cell cycle progression.
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June-2017
Volume 15 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Kim IH, Kwon MJ and Nam TJ: Differences in cell death and cell cycle following fucoidan treatment in high-density HT-29 colon cancer cells. Mol Med Rep 15: 4116-4122, 2017
APA
Kim, I., Kwon, M., & Nam, T. (2017). Differences in cell death and cell cycle following fucoidan treatment in high-density HT-29 colon cancer cells. Molecular Medicine Reports, 15, 4116-4122. https://doi.org/10.3892/mmr.2017.6520
MLA
Kim, I., Kwon, M., Nam, T."Differences in cell death and cell cycle following fucoidan treatment in high-density HT-29 colon cancer cells". Molecular Medicine Reports 15.6 (2017): 4116-4122.
Chicago
Kim, I., Kwon, M., Nam, T."Differences in cell death and cell cycle following fucoidan treatment in high-density HT-29 colon cancer cells". Molecular Medicine Reports 15, no. 6 (2017): 4116-4122. https://doi.org/10.3892/mmr.2017.6520