|
1
|
Todd NW, Luzina IG and Atamas SP:
Molecular and cellular mechanisms of pulmonary fibrosis.
Fibrogenesis Tissue Repair. 5:112012. View Article : Google Scholar :
|
|
2
|
Fernandez IE and Eickelberg O: New
cellular and molecular mechanisms of lung injury and fibrosis in
idiopathic pulmonary fibrosis. Lancet. 380:680–688. 2012.
View Article : Google Scholar
|
|
3
|
Shi K, Jiang J, Ma T, Xie J, Duan L, Chen
R, Song P, Yu Z, Liu C, Zhu Q and Zheng J: Dexamethasone attenuates
bleomycin-induced lung fibrosis in mice through TGF-β, Smad3 and
JAK-STAT pathway. Int J Clin Exp Med. 7:2645–2650. 2014.
|
|
4
|
Barratt S and Millar A: Vascular
remodelling in the pathogenesis of idiopathic pulmonary fibrosis.
QJM. 107:515–519. 2014. View Article : Google Scholar :
|
|
5
|
Bocchino M, Agnese S, Fagone E, Svegliati
S, Grieco D, Vancheri C, Gabrielli A, Sanduzzi A and Avvedimento
EV: Reactive oxygen species are required for maintenance and
differentiation of primary lung fibroblasts in idiopathic pulmonary
fibrosis. PLoS One. 5:e140032010. View Article : Google Scholar :
|
|
6
|
Kinnula VL and Myllärniemi M:
Oxidant-antioxidant imbalance as a potential contributor to the
progression of human pulmonary fibrosis. Antioxid Redox Signal.
10:727–738. 2008. View Article : Google Scholar
|
|
7
|
Liu RM, Vayalil PK, Ballinger C, Dickinson
DA, Huang WT, Wang S, Kavanagh TJ, Matthews QL and Postlethwait EM:
Transforming growth factor β suppresses glutamate-cysteine ligase
gene expression and induces oxidative stress in a lung fibrosis
model. Free Radic Biol Med. 53:554–563. 2012. View Article : Google Scholar :
|
|
8
|
Felton VM, Borok Z and Willis BC:
N-acetylcysteine inhibits alveolar epithelial-mesenchymal
transition. Am J Physiol Lung Cell Mol Physiol. 297:L805–L812.
2009. View Article : Google Scholar :
|
|
9
|
Odajima N, Betsuyaku T, Nagai K, Moriyama
C, Wang DH, Takigawa T, Ogino K and Nishimura M: The role of
catalase in pulmonary fibrosis. Respir Res. 11:1832010. View Article : Google Scholar :
|
|
10
|
Kinnula VL, Fattman CL, Tan RJ and Oury
TD: Oxidative stress in pulmonary fibrosis: A possible role for
redox modulatory therapy. Am J Respir Crit Care Med. 172:417–422.
2005. View Article : Google Scholar :
|
|
11
|
Sykiotis GP, Habeos IG, Samuelson AV and
Bohmann D: The role of the antioxidant and longevity-promoting Nrf2
pathway in metabolic regulation. Curr Opin Clin Nutr Metab Care.
14:41–48. 2011. View Article : Google Scholar :
|
|
12
|
Nguyen T, Nioi P and Pickett CB: The
Nrf2-antioxidant response element signaling pathway and its
activation by oxidative stress. J Biol Chem. 284:13291–13295. 2009.
View Article : Google Scholar :
|
|
13
|
Pekovic-Vaughan V, Gibbs J, Yoshitane H,
Yang N, Pathiranage D, Guo B, Sagami A, Taguchi K, Bechtold D,
Loudon A, et al: The circadian clock regulates rhythmic activation
of the NRF2/glutathione-mediated antioxidant defense pathway to
modulate pulmonary fibrosis. Genes Dev. 28:548–560. 2014.
View Article : Google Scholar :
|
|
14
|
Kikuchi N, Ishii Y, Morishima Y, Yageta Y,
Haraguchi N, Itoh K, Yamamoto M and Hizawa N: Nrf2 protects against
pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2
balance. Respir Res. 11:312010. View Article : Google Scholar :
|
|
15
|
Kandhare AD, Bodhankar SL, Mohan V and
Thakurdesai PA: Effect of glycosides based standardized fenugreek
seed extract in bleomycin-induced pulmonary fibrosis in rats:
Decisive role of Bax, Nrf2, NF-κB, Muc5ac, TNF-α and IL-1β. Chem
Biol Interact. 237:151–165. 2015. View Article : Google Scholar
|
|
16
|
Mouratis MA and Aidinis V: Modeling
pulmonary fibrosis with bleomycin. Curr Opin Pulm Med. 17:355–361.
2011. View Article : Google Scholar
|
|
17
|
Fahey JW and Talalay P: Antioxidant
functions of sulforaphane: A potent inducer of Phase II
detoxication enzymes. Food Chem Toxicol. 37:973–979. 1999.
View Article : Google Scholar
|
|
18
|
Cui W, Bai Y, Miao X, Luo P, Chen Q, Tan
Y, Rane MJ, Miao L and Cai L: Prevention of diabetic nephropathy by
sulforaphane: Possible role of Nrf2 upregulation and activation.
Oxid Med Cell Longev. 2012:8219362012. View Article : Google Scholar :
|
|
19
|
Noh JR, Kim YH, Hwang JH, Choi DH, Kim KS,
Oh WK and Lee CH: Sulforaphane protects against
acetaminophen-induced hepatotoxicity. Food Chem Toxicol.
80:193–200. 2015. View Article : Google Scholar
|
|
20
|
Szapiel SV, Elson NA, Fulmer JD,
Hunninghake GW and Crystal RG: Bleomycin-induced interstitial
pulmonary disease in the nude, athymic mouse. Am Rev Respir Dis.
120:893–899. 1979.
|
|
21
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
22
|
Cheresh P, Kim SJ, Tulasiram S and Kamp
DW: Oxidative stress and pulmonary fibrosis. Biochim Biophys Acta.
1832:1028–1040. 2013. View Article : Google Scholar
|
|
23
|
Walters DM and Kleeberger SR: Mouse models
of bleomycin-induced pulmonary fibrosis. Curr Protoc Pharmacol
Chapter. 5:Unit 5 462008.
|
|
24
|
Cho HY, Reddy SP, Yamamoto M and
Kleeberger SR: The transcription factor NRF2 protects against
pulmonary fibrosis. FASEB J. 18:1258–1260. 2004.
|
|
25
|
Walters DM, Cho HY and Kleeberger SR:
Oxidative stress and antioxidants in the pathogenesis of pulmonary
fibrosis: A potential role for Nrf2. Antioxid Redox Signal.
10:321–332. 2008. View Article : Google Scholar
|
|
26
|
Jiang X, Bai Y, Zhang Z, Xin Y and Cai L:
Protection by sulforaphane from type 1 diabetes-induced testicular
apoptosis is associated with the up-regulation of Nrf2 expression
and function. Toxicol Appl Pharmacol. 279:198–210. 2014. View Article : Google Scholar
|
|
27
|
Wang Y, Zhang Z, Sun W, Tan Y, Liu Y,
Zheng Y, Liu Q, Cai L and Sun J: Sulforaphane attenuation of type 2
diabetes-induced aortic damage was associated with the upregulation
of Nrf2 expression and function. Oxid Med Cell Longev.
2014:1239632014. View Article : Google Scholar :
|
|
28
|
Artaud-Macari E, Goven D, Brayer S, Hamimi
A, Besnard V, Marchal-Somme J, Ali ZE, Crestani B, Kerdine-Römer S,
Boutten A and Bonay M: Nuclear factor erythroid 2-related factor 2
nuclear translocation induces myofibroblastic dedifferentiation in
idiopathic pulmonary fibrosis. Antioxid Redox Signal. 18:66–79.
2013. View Article : Google Scholar
|
|
29
|
Higgins LG, Kelleher MO, Eggleston IM,
Itoh K, Yamamoto M and Hayes JD: Transcription factor Nrf2 mediates
an adaptive response to sulforaphane that protects fibroblasts in
vitro against the cytotoxic effects of electrophiles, peroxides and
redox-cycling agents. Toxicol Appl Pharmacol. 237:267–280. 2009.
View Article : Google Scholar
|
|
30
|
Miao X, Bai Y, Sun W, Cui W, Xin Y, Wang
Y, Tan Y, Miao L, Fu Y, Su G and Cai L: Sulforaphane prevention of
diabetes-induced aortic damage was associated with the
up-regulation of Nrf2 and its down-stream antioxidants. Nutr Metab
(Lond). 9:842012. View Article : Google Scholar :
|
|
31
|
Bai Y, Cui W, Xin Y, Miao X, Barati MT,
Zhang C, Chen Q, Tan Y, Cui T, Zheng Y and Cai L: Prevention by
sulforaphane of diabetic cardiomyopathy is associated with
up-regulation of Nrf2 expression and transcription activation. J
Mol Cell Cardiol. 57:82–95. 2013. View Article : Google Scholar
|
|
32
|
Oh CJ, Kim JY, Min AK, Park KG, Harris RA,
Kim HJ and Lee IK: Sulforaphane attenuates hepatic fibrosis via
NF-E2-related factor 2-mediated inhibition of transforming growth
factor-β/Smad signaling. Free Radic Biol Med. 52:671–682. 2012.
View Article : Google Scholar
|
