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Small protein A and phospholipase D immunization serves a protective role in a mouse pneumonia model of Acinetobacter baumannii infection

  • Authors:
    • Haitao Li
    • Hongyi Tan
    • Yongbin Hu
    • Pinhua Pan
    • Xiaoli Su
    • Chengpin Hu
  • View Affiliations / Copyright

    Affiliations: Department of Pulmonary and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of Pathological Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1071-1078
    |
    Published online on: June 6, 2017
       https://doi.org/10.3892/mmr.2017.6688
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Abstract

Acinetobacter baumannii is an important pathogen that primarily causes hospital-acquired pneumonia. The present study sought to investigate whether small protein A (SmpA) and phospholipase D (PLD) are potential candidates for protective immunity against infection with A. baumannii. Mice immunized with the fusion proteins histidine (His)‑SmpA and His‑PLD exhibited a specific immunoglobulin G response. In a pneumonia model, active and passive immunization against SmpA and PLD protected mice from A. baumannii infection. The protection was demonstrated by a markedly improved survival rate, and reduced pulmonary bacterial load, infiltration and cytokine levels in the broncho‑alveolar lavage fluid and the serum, although a combination of the two antigens did not provide improved protection compared with immunization with the individual antigens alone. In conclusion, it was identified that SmpA and PLD are highly immunogenic proteins, and potential antigen candidates for the development of effective vaccines or to prepare antisera to mitigate A. baumannii infection.
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Copy and paste a formatted citation
Spandidos Publications style
Li H, Tan H, Hu Y, Pan P, Su X and Hu C: Small protein A and phospholipase D immunization serves a protective role in a mouse pneumonia model of Acinetobacter baumannii infection. Mol Med Rep 16: 1071-1078, 2017.
APA
Li, H., Tan, H., Hu, Y., Pan, P., Su, X., & Hu, C. (2017). Small protein A and phospholipase D immunization serves a protective role in a mouse pneumonia model of Acinetobacter baumannii infection. Molecular Medicine Reports, 16, 1071-1078. https://doi.org/10.3892/mmr.2017.6688
MLA
Li, H., Tan, H., Hu, Y., Pan, P., Su, X., Hu, C."Small protein A and phospholipase D immunization serves a protective role in a mouse pneumonia model of Acinetobacter baumannii infection". Molecular Medicine Reports 16.2 (2017): 1071-1078.
Chicago
Li, H., Tan, H., Hu, Y., Pan, P., Su, X., Hu, C."Small protein A and phospholipase D immunization serves a protective role in a mouse pneumonia model of Acinetobacter baumannii infection". Molecular Medicine Reports 16, no. 2 (2017): 1071-1078. https://doi.org/10.3892/mmr.2017.6688
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Tan H, Hu Y, Pan P, Su X and Hu C: Small protein A and phospholipase D immunization serves a protective role in a mouse pneumonia model of Acinetobacter baumannii infection. Mol Med Rep 16: 1071-1078, 2017.
APA
Li, H., Tan, H., Hu, Y., Pan, P., Su, X., & Hu, C. (2017). Small protein A and phospholipase D immunization serves a protective role in a mouse pneumonia model of Acinetobacter baumannii infection. Molecular Medicine Reports, 16, 1071-1078. https://doi.org/10.3892/mmr.2017.6688
MLA
Li, H., Tan, H., Hu, Y., Pan, P., Su, X., Hu, C."Small protein A and phospholipase D immunization serves a protective role in a mouse pneumonia model of Acinetobacter baumannii infection". Molecular Medicine Reports 16.2 (2017): 1071-1078.
Chicago
Li, H., Tan, H., Hu, Y., Pan, P., Su, X., Hu, C."Small protein A and phospholipase D immunization serves a protective role in a mouse pneumonia model of Acinetobacter baumannii infection". Molecular Medicine Reports 16, no. 2 (2017): 1071-1078. https://doi.org/10.3892/mmr.2017.6688
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