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Article Open Access

ATM mediates DAB2IP-deficient bladder cancer cell resistance to ionizing radiation through the p38MAPK and NF-κB signaling pathway

  • Authors:
    • Hui He
    • Rulve Chang
    • Tingting Zhang
    • Chen Yang
    • Zhaolu Kong
  • View Affiliations / Copyright

    Affiliations: Department of Radiobiology, Institute of Radiation Medicine, Fudan University, Shanghai 200032, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1216-1222
    |
    Published online on: June 6, 2017
       https://doi.org/10.3892/mmr.2017.6689
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Abstract

Although surgery remains the standard therapy for the treatment of bladder cancer (BCa), the data from previous clinical studies suggest that there is an increase in the number of patients with a preference for bladder preservation strategies, including radiotherapy, to improve their life quality. Our preliminary results showed that disabled homolog 2 interactive protein (DAB2IP), a putative tumor suppressor gene, is often downregulated in BCa with a radioresistant phenotype. Subsequent investigations revealed that elevated expression of ataxia‑telangiectasia mutated (ATM) induced by DAB2IP‑knockdown may be the key event in BCa cell resistance to ionizing radiation (IR). However, how ATM is involved in the survival of DAB2IP‑deficient cells exposed to IR remains to be fully elucidated. The present study knocked down the expression of ATM in DAB2IP‑deficient BCa cells using RNA interference technology. Activation of mitogen‑activated protein kinase (MAPK) and nuclear factor‑κB (NF‑κB) signaling pathways were detected by western blot analysis and immunofluorescence assay, respectively. It was demonstrated that knockdown of ATM enhanced the response of DAB2IP‑deficient BCa cells to IR, which may have resulted from delayed DNA double‑strand break repair kinetics, compromised nuclear factor‑κB translocation, inhibited phosphorylation of p38 and the induced activation of c‑Jun N‑terminal kinase. Taken together, these findings suggested that ATM may be an effective target in the radiotherapy of patients with DAB2IP-deficient BCa.
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1 

Han SJ, Zhang SW, Chen WQ and Li CL: Analysis of the status and trends of bladder cancer incidence in China. Oncology Progress. 11:89–95. 2013.

2 

Eapen L: A review of the 2014 English Language publications pertinent to the treatment of invasive bladder cancer by radiotherapy. Curr Opin Support Palliat Care. 9:245–248. 2015. View Article : Google Scholar : PubMed/NCBI

3 

James ND, Hussain SA, Hall E, Jenkins P, Tremlett J, Rawlings C, Crundwell M, Sizer B, Sreenivasan T, Hendron C, et al: Radiotherapy with or without chemotherapy in muscle-invasive bladder cancer. N Engl J Med. 366:1477–1488. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Zehnder P, Studer UE, Skinner EC, Dorin RP, Cai J, Roth B, Miranda G, Birkhäuser F, Stein J, Burkhard FC, et al: Super extended versus extended pelvic lymph node dissection in patients undergoing radical cystectomy for bladder cancer: A comparative study. J Urol. 186:1261–1268. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Kotwal S, Choudhury A, Johnston C, Paul AB, Whelan P and Kiltie AE: Similar treatment outcomes for radical cystectomy and radical radiotherapy in invasive bladder cancer treated at a united kingdom specialist treatment center. Int J Radiat Oncol Biol Phys. 70:456–463. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Chen H, Pong R, Wang Z and Hsieh JT: Differential regulation of the human gene DAB2IP in normal and malignant prostatic epithelia: Cloning and characterization. Genomics. 79:573–581. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Shen YJ, Kong ZL, Wan FN, Wang HK, Bian XJ, Gan HL, Wang CF and Ye DW: Downregulation of DAB2IP results in cell proliferation and invasion and contributes to unfavorable outcomes in bladder cancer. Cancer Sci. 105:704–712. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Zhang T, Shen Y, Chen Y, Hsieh JT and Kong Z: The ATM inhibitor KU55933 sensitizes radioresistant bladder cancer cells with DAB2IP gene defect. Int J Radiat Biol. 91:368–378. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Wu K, Wang B, Chen Y, Zhou J, Huang J, Hui K, Zeng J, Zhu J, Zhang K, Li L, et al: DAB2IP regulates the chemoresistance to pirarubicin and tumor recurrence of non-muscle invasive bladder cancer through STAT3/Twist1/P-glycoprotein signaling. Cell Signal. 27:2515–2523. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Guleria A and Chandna S: ATM kinase: Much more than a DNA damage responsive protein. DNA Repair (Amst). 39:1–20. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Kong Z, Xie D, Boike T, Raghavan P, Burma S, Chen DJ, Habib AA, Chakraborty A, Hsieh JT and Saha D: Downregulation of Human DAB2IP gene expression in prostate cancer cells results in resistance to ionizing radiation. Cancer Res. 70:2829–2839. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Otterson MF, Nie L, Schmidt JL, Link BJ, Jovanovic N, Lyros O and Rafiee P: EUK-207 protects human intestinal microvascular endothelial cells (HIMEC) against irradiation-induced apoptosis through the Bcl2 pathway. Life Sci. 91:771–782. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Shrivastav M, Miller CA, de Haro LP, Durant ST, Chen BP, Chen DJ and Nickoloff JA: DNA-PKcs and ATM co-regulate DNA double-strand break repair. DNA Repair (Amst). 8:920–929. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Juvekar A, Burga LN, Hu H, Lunsford EP, Ibrahim YH, Balmañà J, Rajendran A, Papa A, Spencer K, Lyssiotis CA, et al: Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer. Cancer Discov. 2:1048–1063. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Dent P, Yacoub A, Contessa J, Caron R, Amorino G, Valerie K, Hagan MP, Grant S and Schmidt-Ullrich R: Stress and radiation-induced activation of multiple intracellular signaling pathways. Radiat Res. 159:283–300. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Bai M, Ma X, Li X, Mei Q, Li X, Wu Z and Han W: The Accomplices of NF-κB Lead to Radioresistance. Curr Protein Pept Sci. 16:279–294. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Hadian K and Krappmann D: Signals from the nucleus: Activation of NF-kappaB by cytosolic ATM in the DNA damage response. Sci Signal. 4:pe22011. View Article : Google Scholar : PubMed/NCBI

18 

Di Minin G, Bellazzo A, Dal Ferro M, Chiaruttini G, Nuzzo S, Bicciato S, Piazza S, Rami D, Bulla R, Sommaggio R, et al: Mutant p53 reprograms TNF signaling in cancer cells through interaction with the tumor suppressor DAB2IP. Mol Cell. 56:617–629. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Zhu HB, Yang K, Xie YQ, Lin YW, Mao QQ and Xie LP: Silencing of mutant p53 by siRNA induces cell cycle arrest and apoptosis in human bladder cancer cells. World J Surg Oncol. 11:222013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
He H, Chang R, Zhang T, Yang C and Kong Z: ATM mediates DAB2IP-deficient bladder cancer cell resistance to ionizing radiation through the p38MAPK and NF-κB signaling pathway. Mol Med Rep 16: 1216-1222, 2017.
APA
He, H., Chang, R., Zhang, T., Yang, C., & Kong, Z. (2017). ATM mediates DAB2IP-deficient bladder cancer cell resistance to ionizing radiation through the p38MAPK and NF-κB signaling pathway. Molecular Medicine Reports, 16, 1216-1222. https://doi.org/10.3892/mmr.2017.6689
MLA
He, H., Chang, R., Zhang, T., Yang, C., Kong, Z."ATM mediates DAB2IP-deficient bladder cancer cell resistance to ionizing radiation through the p38MAPK and NF-κB signaling pathway". Molecular Medicine Reports 16.2 (2017): 1216-1222.
Chicago
He, H., Chang, R., Zhang, T., Yang, C., Kong, Z."ATM mediates DAB2IP-deficient bladder cancer cell resistance to ionizing radiation through the p38MAPK and NF-κB signaling pathway". Molecular Medicine Reports 16, no. 2 (2017): 1216-1222. https://doi.org/10.3892/mmr.2017.6689
Copy and paste a formatted citation
x
Spandidos Publications style
He H, Chang R, Zhang T, Yang C and Kong Z: ATM mediates DAB2IP-deficient bladder cancer cell resistance to ionizing radiation through the p38MAPK and NF-κB signaling pathway. Mol Med Rep 16: 1216-1222, 2017.
APA
He, H., Chang, R., Zhang, T., Yang, C., & Kong, Z. (2017). ATM mediates DAB2IP-deficient bladder cancer cell resistance to ionizing radiation through the p38MAPK and NF-κB signaling pathway. Molecular Medicine Reports, 16, 1216-1222. https://doi.org/10.3892/mmr.2017.6689
MLA
He, H., Chang, R., Zhang, T., Yang, C., Kong, Z."ATM mediates DAB2IP-deficient bladder cancer cell resistance to ionizing radiation through the p38MAPK and NF-κB signaling pathway". Molecular Medicine Reports 16.2 (2017): 1216-1222.
Chicago
He, H., Chang, R., Zhang, T., Yang, C., Kong, Z."ATM mediates DAB2IP-deficient bladder cancer cell resistance to ionizing radiation through the p38MAPK and NF-κB signaling pathway". Molecular Medicine Reports 16, no. 2 (2017): 1216-1222. https://doi.org/10.3892/mmr.2017.6689
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