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Potential role of autophagy in T‑cell survival in polymyositis and dermatomyositis

  • Authors:
    • Xiaoming Shu
    • Fang Chen
    • Qinglin Peng
    • Xin Lu
    • Xiaolan Tian
    • Yan Wang
    • Guochun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Rheumatology, China‑Japan Friendship Hospital, Chaoyang, Beijing 100029, P.R. China
    Copyright: © Shu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1180-1188
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    Published online on: June 6, 2017
       https://doi.org/10.3892/mmr.2017.6693
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Abstract

Peripheral blood T lymphocytopenia has previously been identified in polymyositis/dermatomyositis (PM/DM) patients. Therefore, the present study aimed to examine the potential role of autophagy in peripheral blood T cell survival in PM/DM patients. Transmission electron microscopy was used to detect the formation of autophagosomes of peripheral blood cluster of differentiation (CD)3+ T cells obtained from 24 patients with PM/DM and 21 healthy controls. Protein and mRNA expression levels of autophagy‑related molecules were examined by western blot analysis and reverse transcription‑quantitative polymerase chain reaction, respectively. The number of peripheral blood CD3+ T cells decreased significantly in PM/DM patients. The median percentage of apoptosis of CD3+ T cells in PM/DM patients was significantly increased compared with healthy controls. Furthermore, the number of autophagosomes and the expression of the autophagy markers microtubule‑associated protein 1A/1B‑light chain 3 (LC3) and Beclin‑1 were significantly reduced in the circulating CD3+ T cells of PM/DM patients compared with those of healthy controls. LC3 and Beclin‑1 protein levels correlated negatively with apoptosis rates in circulating CD3+ T cells in patients with PM/DM. CD3+ T cells from PM/DM patients treated with rapamycin increased autophagy and decreased apoptosis compared with untreated cells (P<0.05). In conclusion, these results suggested that autophagy may serve a potential protective role in the peripheral blood T cells of patients with PM/DM.
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View References

1 

Malmström V, Venalis P and Albrecht I: T cells in myositis. Arthritis Res Ther. 14:2302012. View Article : Google Scholar : PubMed/NCBI

2 

Venalis P and Lundberg IE: Immune mechanisms in polymyositis and dermatomyositis and potential targets for therapy. Rheumatology (Oxford). 53:397–405. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Wang DX, Lu X, Zu N, Lin B, Wang LY, Shu XM, Ma L and Wang GC: Clinical significance of peripheral blood lymphocyte subsets in patients with polymyositis and dermatomyositis. Clin Rheumatol. 31:1691–1697. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Ishii W, Matsuda M, Shimojima Y, Itoh S, Sumida T and Ikeda S: Flow cytometric analysis of lymphocyte subpopulations and TH1/TH2 balance in patients with polymyositis and dermatomyositis. Intern Med. 47:1593–1599. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Aleksza M, Szegedi A, Antal-Szalmás P, Irinyi B, Gergely L, Ponyi A, Hunyadi J, Sipka S, Zeher M, Szegedi G and Dankó K: Altered cytokine expression of peripheral blood lymphocytes in polymyositis and dermatomyositis. Ann Rheum Dis. 64:1485–1489. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Viguier M, Fouéré S, de la Salmonière P, Rabian C, Lebbe C, Dubertret L, Morel P and Bachelez H: Peripheral blood lymphocyte subset counts in patients with dermatomyositis: Clinical correlations and changes following therapy. Medicine (Baltimore). 82:82–86. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Eisenstein DM, O'Gorman MR and Pachman LM: Correlations between change in disease activity and changes in peripheral blood lymphocyte subsets in patients with juvenile dermatomyositis. J Rheumatol. 24:1830–1832. 1997.PubMed/NCBI

8 

Ishida T, Matsumoto Y, Ohashi M and Sasaki R: Analysis of lymphocyte subpopulations in peripheral blood in adult and juvenile cases of dermatomyositis. J Dermatol. 20:30–34. 1993. View Article : Google Scholar : PubMed/NCBI

9 

Cope AP, Schulze-Koops H and Aringer M: The central role of T cells in rheumatoid arthritis. Clin Exp Rhuematol. 25 5 Suppl 46:S4–S11. 2007.

10 

La Cava A: Lupus and T cells. Lupus. 18:196–201. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Wehrens EJ, Prakken BJ and van Wijk F: T cells out of control-impaired immune regulation in the inflame joint. Nat Rev Rheumatol. 9:34–42. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Klionsky DJ and Emr SD: Autophagy as a regulated pathway of cellular degradation. Science. 290:1717–1721. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Pope RM: Apoptosis as a therapeutic tool in rheumatoid arthritis. Nat Rev Immunol. 2:527–535. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Citro A, Barnaba V and Martini H: From T cell apoptosis to chronic immune activation in inflammatory diseases. Int Arch Allergy Immunol. 164:140–146. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Choi AM, Ryter SW and Levine B: Autophagy in human health and disease. N Engl J Med. 368:651–662. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Lleo A, Invernizzi P, Selmi C, Coppel RL, Alpini G, Podda M, Mackay IR and Gershwin ME: Autophagy: Highlighting a novel player in the autoimmunity scenario. J Autoimmun. 29:61–68. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Bhattacharya A and Eissa NT: Autophagy and autoimmunity crosstalks. Front Immunol. 4:882013. View Article : Google Scholar : PubMed/NCBI

18 

Kuballa P, Nolte WM, Castoreno AB and Xavier RJ: Autophagy and the immune system. Annu Rev Immunol. 30:611–646. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Ma Y, Galluzzi L, Zitvogel L and Kroemer G: Autohagy and cellular immune responses. Immunity. 39:211–227. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Han JW, Zheng HF, Cui Y, Sun LD, Ye DQ, Hu Z, Xu JH, Cai ZM, Huang W, Zhao GP, et al: Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet. 41:1234–1237. 2009. View Article : Google Scholar : PubMed/NCBI

21 

International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN), ; Harley JB, Alarcón-Riquelme ME, Criswell LA, Jacob CO, Kimberly RP, Moser KL, Tsao BP, Vyse TJ, Langefeld CD, et al: Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet. 40:204–210. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Zhou XJ, Lu XL, Lv JC, Yang HZ, Qin LX, Zhao MH, Su Y, Li ZG and Zhang H: Genetic association of PRDM1-ATG5 intergenic region and autophagy with systemic lupus erythematosus in a Chinese population. Ann Rheum Dis. 70:1330–1337. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, Guiducci C, Catanese JJ, Xie G, Stahl EA, Chen R, et al: Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. Nat Genet. 41:1313–1318. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Parkes M, Barrett JC, Prescott NJ, Tremelling M, Anderson CA, Fisher SA, Roberts RG, Nimmo ER, Cummings FR, Soars D, et al: Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet. 39:830–832. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Temiz P, Weihl CC and Pestronk A: Inflammatory myopathies with mitochondrial pathology and protein aggregates. J Neurol Sci. 278:25–29. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Nogalska A, D'Agostino C, Terracciano C, Engel WK and Askanas V: Impaired autophagy in sporadic inclusion-body myositis and in endoplasmic reticulum stress-provoked cultured human muscle fibers. Am J Pathol. 177:1377–1387. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Alger HM, Raben N, Pistilli E, Francia DL, Rawat R, Getnet D, Ghimbovschi S, Chen YW, Lundberg IE and Nagaraju K: The role of TRAIL in mediating autophagy in myositis skeletal muscle: A potential nonimmune mechanism of muscle damage. Arthritis Rheum. 63:3448–3457. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Jia W and He YW: Temporal regulation of intracellular organelle homeostasis in T lymphocytes by autophagy. J Immunol. 186:5313–5322. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Bohan A and Peter JB: Polymyositis and dermatomyositis (first of two parts). N Engl J Med. 292:344–347. 1975. View Article : Google Scholar : PubMed/NCBI

30 

Bohan A and Peter JB: Polymyositis and dermatomyositis (second of two parts). N Engl J Med. 292:403–407. 1975. View Article : Google Scholar : PubMed/NCBI

31 

Hoogendijk JE, Amato AA, Lecky BR, Choy EH, Lundberg IE, Rose MR, Vencovsky J, de Visser M and Hughes RA: 119th ENMC international workshop: Trial design in adult idiopathic inflammatory myopathies, with the exception of inclusion body myositis, 10–12 October 2003, Naarden, The Netherlands. Neuromuscul Disord. 14:337–345. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Findlay AR, Goyal NA and Mozaffar T: An overview of polymyositis and dermatomyositis. Muscle Nerve. 51:638–656. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Mammen AL: Autoimmune myopathies: Autoantibodies, phenotypes and pathogenesis. Nat Rev Neurol. 7:343–354. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Amato AA and Greenberg SA: Inflammatory myopathies. Continuum (Minneap Minn). 19(6 Muscle Disease): 1615–1633. 2013.PubMed/NCBI

36 

Suárez-Fueyo A, Bradley SJ and Tsokos GC: T cells in systemic lupus erythematosus. Curr Opin Immunol. 43:32–38. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Wu DJ and Adamopoulos IE: Autophagy and autoimmunity. Clin Immunol. 176:55–62. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Peng QL, Zhang YL, Shu XM, Yang HB, Zhang L, Chen F, Lu X and Wang GC: Elevated serum levels of soluble CD163 in polymyositis and dermatomyositis: Associated with macrophage infiltration in muscle tissue. J Rheumatol. 42:979–987. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Fasth AE, Dastmalchi M, Rahbar A, Salomonsson S, Pandya JM, Lindroos E, Nennesmo I, Malmberg KJ, Söderberg-Nauclér C, Trollmo C, et al: T cell infiltrates in the muscles of patients with dermatomyositis and polymyositis are dominated by CD28null T cells. J Immunol. 183:4792–4799. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Sugihara T, Sekine C, Nakae T, Kohyama K, Harigai M, Iwakura Y, Matsumoto Y, Miyasaka N and Kohsaka H: A new murine model to define the critical pathologic and therapeutic mediators of polymyositis. Arthritis Rheum. 56:1304–1314. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Espinosa-Ortega F, Gómez-Martin D, Santana-de Anda K, Romo-Tena J, Villaseñor-Ovies P and Alcocer-Varela J: Quantitative T cell subsets profile in peripheral blood from patients with idiopathic inflammatory myopathies: Tilting the balance towards proinflammatory and pro-apoptotic subsets. Clin Exp Immunol. 179:520–528. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Dhir V, Singh AP, Aggarwal A, Naik S and Misra R: Increased T-lymphocyte apoptosis in lupus correlates with disease activity and may be responsible for reduced T-cell frequency: A cross-sectional and longitudinal study. Lupus. 18:785–791. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Gros F, Arnold J, Page N, Décossas M, Korganow AS, Martin T and Muller S: Macroautophagy is deregulated in murine and human lupus T lymphocytes. Autophagy. 8:1113–1123. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Alessandri C, Barbati C, Vacirca D, Piscopo P, Confaloni A, Sanchez M, Maselli A, Colasanti T, Conti F, Truglia S, et al: T lymphocytes from patients with systemic lupus eythematosus are resistant to induction of autophagy. FASEB J. 26:4722–4732. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Emlen W, Niebur J and Kadera R: Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus. J Immunol. 152:3685–3692. 1994.PubMed/NCBI

46 

Thorburn A: Apoptosis and autophagy: regulatory connections between two supposedly different processes. Apoptosis. 13:1–9. 2008. View Article : Google Scholar : PubMed/NCBI

47 

Pua HH, Guo J, Komatsu M and He YW: Autophagy is essential for mitochondrial clearance in mature T lymphocytes. J Immunol. 182:4046–4055. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Kovacs JR, Li C, Yang Q, Li G, Garcia IG, Ju S, Roodman DG, Windle JJ, Zhang X and Lu B: Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery. Cell Death Differ. 19:144–152. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Valdor R and Macian F: Autophagy and the regulation of the immune response. Pharmacol Res. 66:475–483. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Shu X, Chen F, Peng Q, Lu X, Tian X, Wang Y and Wang G: Potential role of autophagy in T‑cell survival in polymyositis and dermatomyositis. Mol Med Rep 16: 1180-1188, 2017.
APA
Shu, X., Chen, F., Peng, Q., Lu, X., Tian, X., Wang, Y., & Wang, G. (2017). Potential role of autophagy in T‑cell survival in polymyositis and dermatomyositis. Molecular Medicine Reports, 16, 1180-1188. https://doi.org/10.3892/mmr.2017.6693
MLA
Shu, X., Chen, F., Peng, Q., Lu, X., Tian, X., Wang, Y., Wang, G."Potential role of autophagy in T‑cell survival in polymyositis and dermatomyositis". Molecular Medicine Reports 16.2 (2017): 1180-1188.
Chicago
Shu, X., Chen, F., Peng, Q., Lu, X., Tian, X., Wang, Y., Wang, G."Potential role of autophagy in T‑cell survival in polymyositis and dermatomyositis". Molecular Medicine Reports 16, no. 2 (2017): 1180-1188. https://doi.org/10.3892/mmr.2017.6693
Copy and paste a formatted citation
x
Spandidos Publications style
Shu X, Chen F, Peng Q, Lu X, Tian X, Wang Y and Wang G: Potential role of autophagy in T‑cell survival in polymyositis and dermatomyositis. Mol Med Rep 16: 1180-1188, 2017.
APA
Shu, X., Chen, F., Peng, Q., Lu, X., Tian, X., Wang, Y., & Wang, G. (2017). Potential role of autophagy in T‑cell survival in polymyositis and dermatomyositis. Molecular Medicine Reports, 16, 1180-1188. https://doi.org/10.3892/mmr.2017.6693
MLA
Shu, X., Chen, F., Peng, Q., Lu, X., Tian, X., Wang, Y., Wang, G."Potential role of autophagy in T‑cell survival in polymyositis and dermatomyositis". Molecular Medicine Reports 16.2 (2017): 1180-1188.
Chicago
Shu, X., Chen, F., Peng, Q., Lu, X., Tian, X., Wang, Y., Wang, G."Potential role of autophagy in T‑cell survival in polymyositis and dermatomyositis". Molecular Medicine Reports 16, no. 2 (2017): 1180-1188. https://doi.org/10.3892/mmr.2017.6693
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