Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
August-2017 Volume 16 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2017 Volume 16 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Protective effect of diethylcarbamazine inhibits NF-κB activation in isoproterenol-induced acute myocardial infarction rat model through the PARP pathway

  • Authors:
    • Guowei Jia
    • Ming Zao
    • Xiaoyu Liu
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Internal Three, Cangzhou Central Hospital, Cangzhou, Hebei 061000, P.R. China
  • Pages: 1596-1602
    |
    Published online on: June 6, 2017
       https://doi.org/10.3892/mmr.2017.6695
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study investigated the protective effect of diethylcarbamazine in inhibiting nuclear factor (NF)-κB activation in isoproterenol‑induced acute myocardial infarction (AMI) rats through the poly ADP ribose polymerase (PARP) pathway. Male albino Wistar rats were injected subcutaneously with isoproterenol (100 mg/kg/day) for 2 days to induce an AMI model. Diethylcarbamazine (50 mg/kg) was administered by gavage for 12 days prior to the isoproterenol-induced AMI. It was noted that diethylcarbamazine significantly inhibited AMI‑induced casein kinase and lactate dehydrogenase levels, and reduced the AMI‑induced wet heart weight to body weight ratio in AMI rats. Diethylcarbamazine treatment significantly weakened reactive oxygen species production and reduced the levels of tumor necrosis factor (TNF)‑α, interleukin‑6 and NF‑κB/p65 in AMI rats. Western blotting demonstrated that diethylcarbamazine significantly suppressed the AMI‑induced inducible nitric oxide synthase (iNOS), transforming growth factor (TGF)‑β1, cyclooxygenase‑2 (COX‑2) and PARP protein expression in AMI rats. The results demonstrated that the protective effect of diethylcarbamazine inhibited isoproterenol‑induced AMI through the suppression of inflammation, iNOS, TGF‑β1, COX‑2 and the PARP pathway, and revealed the clinical potential of diethylcarbamazine for therapeutic and clinical applications.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Ritsinger V, Malmberg K, Mårtensson A, Rydén L, Wedel H and Norhammar A: Intensified insulin-based glycaemic control after myocardial infarction: Mortality during 20 year follow-up of the randomised Diabetes Mellitus Insulin Glucose Infusion in Acute Myocardial Infarction (DIGAMI 1) trial. Lancet Diabetes Endocrinol. 2:627–633. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Suh JW, Yoon YE, Oh IY, Yoon CH, Cho YS, Youn TJ, Chae IH and Choi DJ: A single-center prospective randomized controlled trial evaluating the safety and efficacy of IntraCoronary Erythropoietin delivery BEfore Reperfusion: Gauging infarct size in patients with acute ST-segment elevation myocardial infarction. Study design and rationale of the ‘ICEBERG Trial’. Contemp Clin Trials. 35:145–150. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Peng Y, Fu X, Li W, Geng W, Xing K, Ru L, Sun J and Zhao Y: Effect of intracoronary anisodamine and diltiazem administration during primary percutaneous coronary intervention in acute myocardial infarction. Coron Artery Dis. 25:645–652. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Pellaton C, Cayla G, Silvain J, Zeymer U, Cohen M, Goldstein P, Huber K, Pollack C Jr, Kerneis M, Collet JP, et al: Incidence and consequence of major bleeding in primary percutaneous intervention for ST-elevation myocardial infarction in the era of radial access: An analysis of the international randomized Acute myocardial infarction Treated with primary angioplasty and intravenous enoxaparin or unfractionated heparin to Lower ischemic and bleeding events at short- and Long-term follow-up trial. Am Heart J. 170:778–786. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Yamaguchi A, Adachi H, Kawahito K, Murata S and Ino T: Left ventricular reconstruction benefits patients with dilated ischemic cardiomyopathy. Ann Thorac Surg. 79:456–461. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Manson A, Poyade M and Rea P: A recommended workflow methodology in the creation of an educational and training application incorporating a digital reconstruction of the cerebral ventricular system and cerebrospinal fluid circulation to aid anatomical understanding. BMC Med Imaging. 15:442015. View Article : Google Scholar : PubMed/NCBI

7 

Hu SS, Fan HG, Zheng Z, Feng W, Wang W, Song YH, Wang LQ, Yuan X and Zhang SJ: Left ventricular reconstruction with no-patch technique: Early and late clinical outcomes. Chin Med J (Engl). 123:3412–3416. 2010.PubMed/NCBI

8 

Vargas-Barron J, Antunez-Montes OY, Roldán FJ, Aranda-Frausto A, González-Pacheco H, Romero-Cardenas Á and Zabalgoitia M: Myocardial rupture in acute myocardial infarction: Mechanistic explanation based on the ventricular myocardial band hypothesis. Rev Invest Clin. 67:318–322. 2015.PubMed/NCBI

9 

Yao L, Huang K, Huang D, Wang J, Guo H and Liao Y: Acute myocardial infarction induced increases in plasma tumor necrosis factor-alpha and interleukin-10 are associated with the activation of poly (ADP-ribose) polymerase of circulating mononuclear cell. Int J Cardiol. 123:366–368. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Graziani G and Szabó C: Clinical perspectives of PARP inhibitors. Pharmacol Res. 52:109–118. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Szabó C: Pharmacological inhibition of poly(ADP-ribose) polymerase in cardiovascular disorders: Future directions. Curr Vasc Pharmacol. 3:301–303. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Boerma M, Wang J, Sridharan V, Herbert JM and Hauer-Jensen M: Pharmacological induction of transforming growth factor-beta1 in rat models enhances radiation injury in the intestine and the heart. PLoS One. 8:e704792013. View Article : Google Scholar : PubMed/NCBI

13 

Santos LA, Ribeiro EL, Barbosa KP, Fragoso IT, Gomes FO, Donato MA, Silva BS, Silva AK, Rocha SW, França ME, et al: Diethylcarbamazine inhibits NF-kB activation in acute lung injury induced by carrageenan in mice. Int Immunopharmacol. 23:153–162. 2014. View Article : Google Scholar : PubMed/NCBI

14 

da Silva BS, Rodrigues GB, Rocha SW, Ribeiro EL, Gomes FO, E Silva AK and Peixoto CA: Inhibition of NF-kB activation by diethylcarbamazine prevents alcohol-induced liver injury in C57BL/6 mice. Tissue Cell. 46:363–371. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Lai D, Sun J, Li Y and He B: Usefulness of ventricular endocardial electric reconstruction from body surface potential maps to noninvasively localize ventricular ectopic activity in patients. Phys Med Biol. 58:3897–3909. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Menon SC, Cetta F, Dearani JA, Burkhart HA, Cabalka AK and Hagler DJ: Hybrid intraoperative pulmonary artery stent placement for congenital heart disease. Am J Cardiol. 102:1737–1741. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Ka SM, Chao L Kuoping, Lin JC, Chen ST, Li WT, Lin CN, Cheng JC, Jheng HL, Chen A and Hua KF: A low toxicity synthetic cinnamaldehyde derivative ameliorates renal inflammation in mice by inhibiting NLRP3 inflammasome and its related signaling pathways. Free Radic Biol Med. 91:10–24. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Mezzaroma E, Toldo S, Farkas D, Seropian IM, van Tassell BW, Salloum FN, Kannan HR, Menna AC, Voelkel NF and Abbate A: The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse. Proc Natl Acad Sci USA. 108:19725–19730. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Mezzaroma E, Toldo S and Abbate A: Role of NLRP3 (cryopyrin) in acute myocardial infarction. Cardiovasc Res. 99:225–226. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Altaf A, Qu P, Zhao Y, Wang H, Lou D and Niu N: NLRP3 inflammasome in peripheral blood monocytes of acute coronary syndrome patients and its relationship with statins. Coron Artery Dis. 26:409–421. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Alestalo K, Miettinen JA, Vuolteenaho O, Huikuri H and Lehenkari P: Bone marrow mononuclear cell transplantation restores inflammatory balance of cytokines after ST segment elevation myocardial infarction. PLoS One. 10:e01450942015. View Article : Google Scholar : PubMed/NCBI

22 

Ruparelia N, Digby JE, Jefferson A, Medway DJ, Neubauer S, Lygate CA and Choudhury RP: Myocardial infarction causes inflammation and leukocyte recruitment at remote sites in the myocardium and in the renal glomerulus. Inflamm Res. 62:515–525. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Zaitone SA and Abo-Gresha NM: Rosuvastatin promotes angiogenesis and reverses isoproterenol-induced acute myocardial infarction in rats: Role of iNOS and VEGF. Eur J Pharmacol. 691:134–142. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Das B and Sarkar C: Is preconditioning by oxytocin administration mediated by iNOS and/or mitochondrial K(ATP) channel activation in the in vivo anesthetized rabbit heart? Life Sci. 90:763–769. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Ørn S, Ueland T, Manhenke C, Sandanger Ø, Godang K, Yndestad A, Mollnes TE, Dickstein K and Aukrust P: Increased interleukin-1b levels are associated with left ventricular hypertrophy and remodelling following acute ST segment elevation myocardial infarction treated by primary percutaneous coronary intervention. J Intern Med. 272:267–276. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Li S, Fan Q, He S, Tang T, Liao Y and Xie J: MicroRNA-21 negatively regulates Treg cells through a TGF-β1/Smad-independent pathway in patients with coronary heart disease. Cell Physiol Biochem. 37:866–878. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Rocha SW, de França ME, Rodrigues GB, Barbosa KP, Nunes AK, Pastor AF, Oliveira AG, Oliveira WH, Luna RL and Peixoto CA: Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl4-) induced liver injury in mice. Mediators Inflamm. 2014:6963832014. View Article : Google Scholar : PubMed/NCBI

28 

Davies NM, Smith GD, Windmeijer F and Martin RM: COX-2 selective nonsteroidal anti-inflammatory drugs and risk of gastrointestinal tract complications and myocardial infarction: An instrumental variable analysis. Epidemiology. 24:352–362. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Varas-Lorenzo C, Castellsague J, Stang MR, Perez-Gutthann S, Aguado J and Rodriguez LA: The use of selective cyclooxygenase-2 inhibitors and the risk of acute myocardial infarction in Saskatchewan, Canada. Pharmacoepidemiol Drug Saf. 18:1016–1025. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Metcalfe C, Wheeler BW, Gunnell D and Martin RM: International regulatory activity restricting COX-2 inhibitor use and deaths due to gastrointestinal haemorrhage and myocardial infarction. Pharmacoepidemiol Drug Saf. 19:778–785. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Ribeiro EL, Barbosa KP, Fragoso IT, Donato MA, Gomes FO, da Silva BS, e Silva AK Soares, Rocha SW, da Silva Junior VA and Peixoto CA: Diethylcarbamazine attenuates the development of carrageenan-induced lung injury in mice. Mediators Inflamm. 2014:1051202014. View Article : Google Scholar : PubMed/NCBI

32 

Dong F, Yang XJ, Jiang TB and Chen Y: Ischemia triggered ATP release through Pannexin-1 channel by myocardial cells activates sympathetic fibers. Microvasc Res. 104:32–37. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Jia G, Zao M and Liu X: Protective effect of diethylcarbamazine inhibits NF-κB activation in isoproterenol-induced acute myocardial infarction rat model through the PARP pathway. Mol Med Rep 16: 1596-1602, 2017.
APA
Jia, G., Zao, M., & Liu, X. (2017). Protective effect of diethylcarbamazine inhibits NF-κB activation in isoproterenol-induced acute myocardial infarction rat model through the PARP pathway. Molecular Medicine Reports, 16, 1596-1602. https://doi.org/10.3892/mmr.2017.6695
MLA
Jia, G., Zao, M., Liu, X."Protective effect of diethylcarbamazine inhibits NF-κB activation in isoproterenol-induced acute myocardial infarction rat model through the PARP pathway". Molecular Medicine Reports 16.2 (2017): 1596-1602.
Chicago
Jia, G., Zao, M., Liu, X."Protective effect of diethylcarbamazine inhibits NF-κB activation in isoproterenol-induced acute myocardial infarction rat model through the PARP pathway". Molecular Medicine Reports 16, no. 2 (2017): 1596-1602. https://doi.org/10.3892/mmr.2017.6695
Copy and paste a formatted citation
x
Spandidos Publications style
Jia G, Zao M and Liu X: Protective effect of diethylcarbamazine inhibits NF-κB activation in isoproterenol-induced acute myocardial infarction rat model through the PARP pathway. Mol Med Rep 16: 1596-1602, 2017.
APA
Jia, G., Zao, M., & Liu, X. (2017). Protective effect of diethylcarbamazine inhibits NF-κB activation in isoproterenol-induced acute myocardial infarction rat model through the PARP pathway. Molecular Medicine Reports, 16, 1596-1602. https://doi.org/10.3892/mmr.2017.6695
MLA
Jia, G., Zao, M., Liu, X."Protective effect of diethylcarbamazine inhibits NF-κB activation in isoproterenol-induced acute myocardial infarction rat model through the PARP pathway". Molecular Medicine Reports 16.2 (2017): 1596-1602.
Chicago
Jia, G., Zao, M., Liu, X."Protective effect of diethylcarbamazine inhibits NF-κB activation in isoproterenol-induced acute myocardial infarction rat model through the PARP pathway". Molecular Medicine Reports 16, no. 2 (2017): 1596-1602. https://doi.org/10.3892/mmr.2017.6695
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team