Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
August-2017 Volume 16 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2017 Volume 16 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Quercetin protects neuronal cells from oxidative stress and cognitive degradation induced by amyloid β-peptide treatment

  • Authors:
    • Yan‑Ling Li
    • Hua Guo
    • Yong‑Qiang Zhao
    • Ai‑Fan Li
    • Yue‑Qin Ren
    • Jie‑Wen Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Zhengzhou First People's Hospital, Zhengzhou, Henan 450004, P.R. China, Department of Medicine Imaging, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China, Department of Endocrinology, Anyang District Hospital, Anyang, Henan 455000, P.R. China, Department of Radiology Magnetic Resonance, The Second Affiliated Hospital of Henan Traditional Chinese Medicine University, Zhengzhou, Henan 450000, P.R. China, Department of Neurology, The People's Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China
  • Pages: 1573-1577
    |
    Published online on: June 6, 2017
       https://doi.org/10.3892/mmr.2017.6704
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to investigate the effect of quercetin on cytotoxicity and cognitive degradation induced by amyloid β(Aβ)‑peptide in mice. Using the 1,1-diphenyl-2‑picrylhydrazyl (DPPH) method and a Y‑maze assay, the radical quenching ability and effect on working memory were determined, respectively, of quercetin treatment following 4 days of Aβ administration. The acute oral toxicity was assessed used to determine the concentration of quercetin at which 50% lethality of the neuronal cells was induced. For determination of the effect of quercetin on degradation of learning and memory loss induced by Aβ, a passive avoidance test was used. The results revealed that quercetin was involved in the inhibition of DPPH radical activity and was found to reduce radical activity by 76.5%. Quercetin significantly protected PC12 neuronal cells from death induced by Aβ treatment. Treatment of mice with daily doses of 100 mg/kg body weight quercetin for 30 days significantly improved the degradation of learning and memory loss induced by Aβ. The acute oral dose of quercetin in mice was determined to be 575 mg/kg body weight. Therefore, quercetin was found to be of therapeutic value for the treatment of neurological disorders, including AD, although further investigations are required.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Zhu Y, Li C, Sun A, Wang Y and Zhou S: Quantification of microRNA-210 in the cerebrospinal fluid and serum: Implications for Alzheimer's disease. Exp Ther Med. 9:1013–1017. 2015.PubMed/NCBI

2 

Chambers JK, Uchida K, Harada T, Tsuboi M, Sato M, Kubo M, Kawaguchi H, Miyoshi N, Tsujimoto H and Nakayama H: Neurofibrillary tangles and the deposition of a beta amyloid peptide with a novel-N-terminal epitope in the brains of wild Tsushima leopard cats. PLoS One. 7:e464522012. View Article : Google Scholar : PubMed/NCBI

3 

Guo J, Chang L, Zhang X, Pei S, Yu M and Gao J: Ginsenoside compound K promotes β-amyloid peptide clearance in primary astrocytes via autophagy enhancement. Exp Ther Med. 8:1271–1274. 2014.PubMed/NCBI

4 

Floyd RA and Hensley K: Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases. Neurobiol Aging. 23:795–807. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Mattson MP, Chan SL and Duan W: Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior. Physiol Rev. 82:637–672. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Huang X, Atwood CS, Hartshorn MA, Multhaup G, Goldstein LE, Scarpa RC, Cuajungco MP, Gray DN, Lim J, Moir RD, et al: The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry. 38:7609–7616. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Christen Y: Oxidative stress and Alzheimer disease. Am J Clin Nutr. 71:621s–629s. 2000.PubMed/NCBI

8 

Sultana R, Perluigi M and Butterfield DA: Oxidatively modified proteins in Alzheimer's disease (AD), mild cognitive impairment and animal models of AD: Role of Abeta in pathogenesis. Acta Neuropathol. 118:131–150. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Zhu X, Su B, Wang X, Smith MA and Perry G: Causes of oxidative stress in Alzheimer disease. Cell Mol Life Sci. 64:2202–2210. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Mark RJ, Lovell MA, Markesbery WR, Uchida K and Mattson MP: A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide. J Neurochem. 68:255–264. 1997. View Article : Google Scholar : PubMed/NCBI

11 

Butterfield DA, Hensley K, Harris M, Mattson M and Carney J: beta-amyloid peptide free radical fragments initiates synaptosomal lipoperoxidation in a sequence-specific fashion: Implications to Alzheimer's disease. Biochem Biophys Res Commun. 200:710–715. 1994. View Article : Google Scholar : PubMed/NCBI

12 

Kelly GS: Quercetin. Monograph. Altern Med Rev. 16:172–194. 2011.PubMed/NCBI

13 

Heim KE, Tagliaferro AR and Bobilya DJ: Flavonoid antioxidants: Chemistry, metabolism and structure-activity relationships. J Nutr Biochem. 13:572–584. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Heijnen CG, Haenen GR, Oostveen RM, Stalpers EM and Bast A: Protection of flavonoids against lipid peroxidation: The structure activity relationship revisited. Free Radic Res. 36:575–581. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Cai Q, Rahn RO and Zhang R: Dietary flavonoids, quercetin, luteolin and genistein, reduce oxidative DNA damage and lipid peroxidation and quench free radicals. Cancer Lett. 119:99–107. 1997. View Article : Google Scholar : PubMed/NCBI

16 

Meyers KJ, Rudolf JL and Mitchell AE: Influence of dietary quercetin on glutathione redox status in mice. J Agric Food Chem. 56:830–836. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Rivera L, Morón R, Sánchez M, Zarzuelo A and Galisteo M: Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats. Obesity (Silver Spring). 16:2081–2087. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Phan TT, Lim IJ, Chan SY, Tan EK, Lee ST and Longaker MT: Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: Implications for the treatment of excessive scars. J Trauma. 57:1032–1037. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Jung JC, Jang S, Lee Y, Min D, Lim E, Jung H, Oh M, Oh S and Jung M: Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones. J Med Chem. 51:4054–4058. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Heneka MT, O'Banion MK, Terwel D and Kummer MP: Neuroinflammatory processes in Alzheimer's disease. J Neural Transm (Vienna). 117:919–947. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Kim MJ, Seung AR, Yoo JY, Jin CH, Lee YH, Kim YJ, Lee J, Jun WJ and Yoon HG: Gallic acid, a histone acetyltransferase inhibitor, suppresses β-amyloid neurotoxicity by inhibiting microglial-mediated neuroinflammation. Mol Nutr Food Res. 55:1798–1808. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Varadarajan S, Yatin S, Aksenova M and Butterfield DA: Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity. J Struct Biol. 130:184–208. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Kadowaki H, Nishitoh H, Urano F, Sadamitsu C, Matsuzawa A, Takeda K, Masutani H, Yodoi J, Urano Y, Nagano T and Ichijo H: Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation. Cell Death Differ. 12:19–24. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Park SY, Kim HS, Cho EK, Kwon BY, Phark S, Hwang KW and Sul D: Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation. Food Chem Toxicol. 46:2881–2887. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Bonda DJ, Wang X, Perry G, Numonura A, Tabaton M, Zhu X and Smith MA: Oxidative stress in Alzheimer disease: A possibility for prevention. Neuropharmacololgy. 59:290–294. 2010. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li YL, Guo H, Zhao YQ, Li AF, Ren YQ and Zhang JW: Quercetin protects neuronal cells from oxidative stress and cognitive degradation induced by amyloid β-peptide treatment. Mol Med Rep 16: 1573-1577, 2017.
APA
Li, Y., Guo, H., Zhao, Y., Li, A., Ren, Y., & Zhang, J. (2017). Quercetin protects neuronal cells from oxidative stress and cognitive degradation induced by amyloid β-peptide treatment. Molecular Medicine Reports, 16, 1573-1577. https://doi.org/10.3892/mmr.2017.6704
MLA
Li, Y., Guo, H., Zhao, Y., Li, A., Ren, Y., Zhang, J."Quercetin protects neuronal cells from oxidative stress and cognitive degradation induced by amyloid β-peptide treatment". Molecular Medicine Reports 16.2 (2017): 1573-1577.
Chicago
Li, Y., Guo, H., Zhao, Y., Li, A., Ren, Y., Zhang, J."Quercetin protects neuronal cells from oxidative stress and cognitive degradation induced by amyloid β-peptide treatment". Molecular Medicine Reports 16, no. 2 (2017): 1573-1577. https://doi.org/10.3892/mmr.2017.6704
Copy and paste a formatted citation
x
Spandidos Publications style
Li YL, Guo H, Zhao YQ, Li AF, Ren YQ and Zhang JW: Quercetin protects neuronal cells from oxidative stress and cognitive degradation induced by amyloid β-peptide treatment. Mol Med Rep 16: 1573-1577, 2017.
APA
Li, Y., Guo, H., Zhao, Y., Li, A., Ren, Y., & Zhang, J. (2017). Quercetin protects neuronal cells from oxidative stress and cognitive degradation induced by amyloid β-peptide treatment. Molecular Medicine Reports, 16, 1573-1577. https://doi.org/10.3892/mmr.2017.6704
MLA
Li, Y., Guo, H., Zhao, Y., Li, A., Ren, Y., Zhang, J."Quercetin protects neuronal cells from oxidative stress and cognitive degradation induced by amyloid β-peptide treatment". Molecular Medicine Reports 16.2 (2017): 1573-1577.
Chicago
Li, Y., Guo, H., Zhao, Y., Li, A., Ren, Y., Zhang, J."Quercetin protects neuronal cells from oxidative stress and cognitive degradation induced by amyloid β-peptide treatment". Molecular Medicine Reports 16, no. 2 (2017): 1573-1577. https://doi.org/10.3892/mmr.2017.6704
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team