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Identification and functional analysis of the risk microRNAs associated with cerebral low-grade glioma prognosis

  • Authors:
    • Xinrui Liu
    • Bin Song
    • Shanji Li
    • Nan Wang
    • Hongfa Yang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgical Oncology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Gastrointestinal Colorectal and Anal Surgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Second Department of Neurosurgery, The First People's Hospital of Yibin, Yibin, Sichuan 644000, P.R. China, Department of Neurotrauma, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1173-1179
    |
    Published online on: June 6, 2017
       https://doi.org/10.3892/mmr.2017.6705
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Abstract

Low-grade gliomas (LGGs) are associated with neurological disability. The present study used microRNA (miRNA) expression profiles to identify risk miRNAs for potential prognosis of cerebral LGGs. miRNA expression profiles and clinical data from 408 patients with cerebral LGGs were obtained from the Cancer Genome Atlas database. Risk miRNAs were identified by plotting Kaplan‑Meier curves and Cox proportional hazard regression analysis with the survival and KMsurv packages in R. A regulatory network of miRNA‑targets was constructed, followed by gene ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis using the Database for Annotation, Visualization and Integrated Discovery. A protein‑protein interaction (PPI) network of miRNA targets was built using Search Tool for the Retrieval of Interacting Genes software, and sub‑pathway identification was performed using the iSubpathwayMiner package in R. In total, 39 miRNAs had significant effect on survival curves. Following the Cox analysis and construction of miRNA‑targets regulatory network, hsa‑miRNA (miR)‑326 was identified to regulate 397 target genes. Additionally, targets of miR‑326 were primarily enriched in the GO terms of cell proliferation, epithelial growth factor receptor and nerve growth factor signaling pathways. Additionally, son of sevenless homolog 1 (SOS1), neuroblastoma RAS viral oncogene homolog (NRAS), vitamin D receptor (VDR) and mothers against decapentaplegic family member 3 (SMAD3) were most enriched in the PPI network. Targets of miR‑326 were primarily enriched in sub‑pathways including sphingolipid metabolism and arachidonic acid metabolism, in which sphingomyelin synthase 1 (SGMS1) and hematopoietic prostaglandin D synthase (HPGDS) were screened out. Hsa‑miR‑326 was identified as a risk miRNA for prognosis and may improve the outcome prediction of patients with cerebral LGG. This miRNA may regulate cancer cell proliferation by targeting SOS1, NRAS, VDR, SMAD3, SGMS1 and HPGDS.
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View References

1 

Cavaliere R, Lopes MB and Schiff D: Low-grade gliomas: An update on pathology and therapy. Lancet Neurol. 4:760–770. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Esquela-Kerscher A and Slack FJ: Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer. 6:259–269. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer. 6:857–866. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Giovannetti E, van der Velde A, Funel N, Vasile E, Perrone V, Leon LG, de Lio N, Avan A, Caponi S, Pollina LE, et al: High-throughput microRNA (miRNAs) arrays unravel the prognostic role of MiR-211 in pancreatic cancer. PLoS One. 7:e491452012. View Article : Google Scholar : PubMed/NCBI

7 

Yan LX, Huang XF, Shao Q, Huang MY, Deng L, Wu QL, Zeng YX and Shao JY: MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. RNA. 14:2348–2360. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Markou A, Tsaroucha EG, Kaklamanis L, Fotinou M, Georgoulias V and Lianidou ES: Prognostic value of mature microRNA-21 and microRNA-205 overexpression in non-small cell lung cancer by quantitative real-time RT-PCR. Clin Chem. 54:1696–1704. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Hu X, Macdonald DM, Huettner PC, Feng Z, El Naqa IM, Schwarz JK, Mutch DG, Grigsby PW, Powell SN and Wang X: A miR-200 microRNA cluster as prognostic marker in advanced ovarian cancer. Gynecol Oncol. 114:457–464. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Huse JT, Brennan C, Hambardzumyan D, Wee B, Pena J, Rouhanifard SH, Sohn-Lee C, le Sage C, Agami R, Tuschl T and Holland EC: The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. Genes Dev. 23:1327–1337. 2009. View Article : Google Scholar : PubMed/NCBI

11 

le Sage C, Nagel R, Egan DA, Schrier M, Mesman E, Mangiola A, Anile C, Maira G, Mercatelli N, Ciafrè SA, et al: Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation. EMBO J. 26:3699–3708. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Kefas B, Godlewski J, Comeau L, Li Y, Abounader R, Hawkinson M, Lee J, Fine H, Chiocca EA, Lawler S and Purow B: microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma. Cancer Res. 68:3566–3572. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Hou SX, Ding BJ, Li HZ, Wang L, Xia F, Du F, Liu LJ, Liu YH, Liu XD, Jia JF, et al: Identification of microRNA-205 as a potential prognostic indicator for human glioma. J Clin Neurosci. 20:933–937. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Zhang C, Zhang J, Hao J, Shi Z, Wang Y, Han L, Yu S, You Y, Jiang T, Wang J, et al: High level of miR-221/222 confers increased cell invasion and poor prognosis in glioma. J Transl Med. 10:1192012. View Article : Google Scholar : PubMed/NCBI

15 

Therneau TM and Grambsch PM: Modeling survival data: Extending the Cox model. Springer; 2000, View Article : Google Scholar

16 

Original by Klein, Moeschberger and modifications by. Jun Yan: 2012.KMsurv: Data sets from Klein and Moeschberger (1997), Survival Analysis. R package version 0.1–5.

17 

Xiao F, Zuo Z, Cai G, Kang S, Gao X and Li T: miRecords: An integrated resource for microRNA-target interactions. Nucleic Acids Res. 37:D105–D110. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Dweep H, Sticht C, Pandey P and Gretz N: miRWalk-database: Prediction of possible miRNA binding sites by ‘walking’ the genes of three genomes. J Biomed Inform. 44:839–847. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Enright AJ, John B, Gaul U, Tuschl T, Sander C and Marks DS: MicroRNA targets in drosophila. Genome Biol. 5:R12003. View Article : Google Scholar : PubMed/NCBI

20 

Wang X and El Naqa IM: Prediction of both conserved and nonconserved microRNA targets in animals. Bioinformatics. 24:325–332. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Krek A, Grün D, Poy MN, Wolf R, Rosenberg L, Epstein EJ, MacMenamin P, da Piedade I, Gunsalus KC, Stoffel M and Rajewsky N: Combinatorial microRNA target predictions. Nat Genet. 37:495–500. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Kertesz M, Iovino N, Unnerstall U, Gaul U and Segal E: The role of site accessibility in microRNA target recognition. Nat Genet. 39:1278–1284. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP and Burge CB: Prediction of mammalian microRNA targets. Cell. 115:787–798. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Smoot ME, Ono K, Ruscheinski J, Wang PL and Ideker T: Cytoscape 2.8: New features for data integration and network visualization. Bioinformatics. 27:431–432. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The gene ontology consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar : PubMed/NCBI

27 

Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC and Lempicki RA: DAVID: Database for annotation, visualization, and integrated discovery. Genome Biol. 4:P32003. View Article : Google Scholar : PubMed/NCBI

28 

Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A, Lin J, Minguez P, Bork P, von Mering C and Jensen LJ: STRING v9.1: Protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res. 41:D808–D815. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Li C: iSubpathwayMiner: The package can implement the graph-based reconstruction and analyses of the KEGG pathways. R package version 3.0. 2012.

30 

Kefas B, Comeau L, Floyd DH, Seleverstov O, Godlewski J, Schmittgen T, Jiang J, diPierro CG, Li Y, Chiocca EA, et al: The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors. J Neurosci. 29:15161–15168. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Wong JW: MicroRNA-induced silencing of glioma progression. J Neurosci. 30:3868–3869. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Gureasko J, Galush WJ, Boykevisch S, Sondermann H, Bar-Sagi D, Groves JT and Kuriyan J: Membrane-dependent signal integration by the Ras activator Son of sevenless. Nat Struct Mol Biol. 15:452–461. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Downward J: Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer. 3:11–22. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Goffin JR and Zbuk K: Epidermal growth factor receptor: Pathway, therapies, and pipeline. Clin Ther. 35:1282–1303. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Nico B, Mangieri D, Benagiano V, Crivellato E and Ribatti D: Nerve growth factor as an angiogenic factor. Microvasc Res. 75:135–141. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Eyles DW, Smith S, Kinobe R, Hewison M and McGrath JJ: Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat. 29:21–30. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Hansen CM, Binderup L, Hamberg KJ and Carlberg C: Vitamin D and cancer: Effects of 1,25(OH)2D3 and its analogs on growth control and tumorigenesis. Front Biosci. 6:D820–D848. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Conery AR, Cao Y, Thompson EA, Townsend CM Jr, Ko TC and Luo K: Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis. Nat Cell Biol. 6:366–372. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Hjelmeland AB, Hjelmeland MD, Shi Q, Hart JL, Bigner DD, Wang XF, Kontos CD and Rich JN: Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity. Cancer Res. 65:11276–11281. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Tafesse FG, Ternes P and Holthuis JC: The multigenic sphingomyelin synthase family. J Biol Chem. 281:29421–29425. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Zeidan YH and Hannun YA: Translational aspects of sphingolipid metabolism. Trends Mol Med. 13:327–336. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Oskouian B and Saba JD: Cancer treatment strategies targeting sphingolipid metabolismSphingolipids as Signaling and Regulatory Molecules. Springer; pp. 185–205. 2010, View Article : Google Scholar

43 

Pidgeon GP, Lysaght J, Krishnamoorthy S, Reynolds JV, O'Byrne K, Nie D and Honn KV: Lipoxygenase metabolism: Roles in tumor progression and survival. Cancer Metastasis Rev. 26:503–524. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Jiang WG, Douglas-Jones A and Mansel RE: Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer. Prostaglandins Leukot Essent Fatty Acids. 69:275–281. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Hoque A, Lippman SM, Wu TT, Xu Y, Liang ZD, Swisher S, Zhang H, Cao L, Ajani JA and Xu XC: Increased 5-lipoxygenase expression and induction of apoptosis by its inhibitors in esophageal cancer: A potential target for prevention. Carcinogenesis. 26:785–791. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Leung HW, Yang WH, Lai MY, Lin CJ and Lee HZ: Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis. Food Chem Toxicol. 45:403–411. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu X, Song B, Li S, Wang N and Yang H: Identification and functional analysis of the risk microRNAs associated with cerebral low-grade glioma prognosis. Mol Med Rep 16: 1173-1179, 2017.
APA
Liu, X., Song, B., Li, S., Wang, N., & Yang, H. (2017). Identification and functional analysis of the risk microRNAs associated with cerebral low-grade glioma prognosis. Molecular Medicine Reports, 16, 1173-1179. https://doi.org/10.3892/mmr.2017.6705
MLA
Liu, X., Song, B., Li, S., Wang, N., Yang, H."Identification and functional analysis of the risk microRNAs associated with cerebral low-grade glioma prognosis". Molecular Medicine Reports 16.2 (2017): 1173-1179.
Chicago
Liu, X., Song, B., Li, S., Wang, N., Yang, H."Identification and functional analysis of the risk microRNAs associated with cerebral low-grade glioma prognosis". Molecular Medicine Reports 16, no. 2 (2017): 1173-1179. https://doi.org/10.3892/mmr.2017.6705
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Song B, Li S, Wang N and Yang H: Identification and functional analysis of the risk microRNAs associated with cerebral low-grade glioma prognosis. Mol Med Rep 16: 1173-1179, 2017.
APA
Liu, X., Song, B., Li, S., Wang, N., & Yang, H. (2017). Identification and functional analysis of the risk microRNAs associated with cerebral low-grade glioma prognosis. Molecular Medicine Reports, 16, 1173-1179. https://doi.org/10.3892/mmr.2017.6705
MLA
Liu, X., Song, B., Li, S., Wang, N., Yang, H."Identification and functional analysis of the risk microRNAs associated with cerebral low-grade glioma prognosis". Molecular Medicine Reports 16.2 (2017): 1173-1179.
Chicago
Liu, X., Song, B., Li, S., Wang, N., Yang, H."Identification and functional analysis of the risk microRNAs associated with cerebral low-grade glioma prognosis". Molecular Medicine Reports 16, no. 2 (2017): 1173-1179. https://doi.org/10.3892/mmr.2017.6705
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