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Article

Role of ADAMTS13 in diet-induced liver steatosis

  • Authors:
    • Lotte Geys
    • Elien Roose
    • Karen Vanhoorelbeke
    • Pierre Bedossa
    • Ilse Scroyen
    • H. Roger Lijnen
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, B‑3000 Leuven, Belgium, Laboratory for Thrombosis Research, Department of Chemistry, University of Leuven Kulak Campus Kortrijk, B‑8500 Kortrijk, Belgium, Department of Pathology, Physiology and Imaging, Université Paris Diderot, 75013 Paris, France
  • Pages: 1451-1458
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    Published online on: June 7, 2017
       https://doi.org/10.3892/mmr.2017.6714
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Abstract

Previous studies, predominantly based on increased or decreased plasma levels, have reported conflicting data on a potential functional role of ADAMTS13 in the pathogenesis of liver diseases, including non‑alcoholic steatohepatitis (NASH). The aim of the current study was to evaluate whether ADAMTS13 deficiency affects development of NASH. Therefore, male wild‑type (WT) and Adamts13 deficient (Adamts13‑/‑) mice were kept on a steatosis‑inducing diet devoid of methionine and choline (MCD) or a control diet (MCC) for 4 weeks. Induction of NASH did not affect plasma ADAMTS13 antigen levels of WT mice. MCD as compared with MCC feeding resulted in reduced body and liver weight with no differences between the genotypes. Plasma levels of the liver enzymes AST and ALT were significantly higher for MCD vs. MCC fed Adamts13‑/‑ and WT mice, however were not different between the genotypes. Liver triglyceride levels were also higher after MCD feeding, but were not different between WT and Adamts13‑/‑ mice. Adamts13‑/‑ mice on the two diets exhibited higher insulin sensitivity when compared with WT mice. On the MCC diet, the genotype did not show clear histological abnormalities in the liver, whereas severe steatosis and fibrosis were observed on MCD diet, however were comparable for both genotypes. This was supported by comparably enhanced hepatic expression in the two genotypes on MCD diet of the steatosis marker CD36 and of the fibrosis marker tissue inhibitor of metalloproteinase 1. Thus, the results of the current study do not support a functional role of ADAMTS13 in this murine model of NASH.
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View References

1 

Cassiman D and Jaeken J: NASH may be trash. Gut. 57:141–144. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Powell EE, Cooksley WG, Hanson R, Searle J, Halliday JW and Powell LW: The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years. Hepatology. 11:74–80. 1990. View Article : Google Scholar : PubMed/NCBI

3 

Harrison SA, Torgerson S and Hayashi PH: The natural history of nonalcoholic fatty liver disease: A clinical histopathological study. Am J Gastroenterol. 98:2042–2047. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Cohen JC, Horton JD and Hobbs HH: Human fatty liver disease: Old questions and new insights. Science. 332:1519–1523. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Bedogni G, Miglioli L, Masutti F, Tiribelli C, Marchesini G and Bellentani S: Prevalence of and risk factors for nonalcoholic fatty liver disease: The Dionysos nutrition and liver study. Hepatology. 42:44–52. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Blachier M, Leleu H, Peck-Radosavljevic M, Valla DC and Roudot-Thoraval F: The burden of liver disease in Europe: A review of available epidemiological data. J Hepatol. 58:593–608. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Sanyal AJ; American Gastroenterological Association, : AGA technical review on nonalcoholic fatty liver disease. Gastroenterology. 123:1705–1725. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Neuschwander-Tetri BA: Nonalcoholic steatohepatitis and the metabolic syndrome. Am J Med Sci. 330:326–335. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Le Goff C and Cormier-Daire V: The ADAMTS(L) family and human genetic disorders. Hum Mol Genet. 20:R163–R167. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Uemura M, Tatsumi K, Matsumoto M, Fujimoto M, Matsuyama T, Ishikawa M, Iwamoto TA, Mori T, Wanaka A, Fukui H and Fujimura Y: Localization of ADAMTS13 to the stellate cells of human liver. Blood. 106:922–924. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Watanabe N, Ikeda H, Kume Y, Satoh Y, Kaneko M, Takai D, Tejima K, Nagamine M, Mashima H, Tomiya T, et al: Increased production of ADAMTS13 in hepatic stellate cells contributes to enhanced plasma ADAMTS13 activity in rat models of cholestasis and steatohepatitis. Thromb Haemost. 102:389–396. 2009.PubMed/NCBI

12 

Uemura M, Fujimura Y, Ko S, Matsumoto M, Nakajima Y and Fukui H: Pivotal role of ADAMTS13 function in liver diseases. Int J Hematol. 91:20–29. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Takaya H, Uemura M, Fujimura Y, Matsumoto M, Matsuyama T, Kato S, Morioka C, Ishizashi H, Hori Y, Fujimoto M, et al: ADAMTS13 activity may predict the cumulative survival of patients with liver cirrhosis in comparison with the Child-Turcotte-Pugh score and the model for end-stage liver disease score. Hepatol Res. 42:459–472. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Uemura M, Matsuyama T, Ishikawa M, Fujimoto M, Kojima H, Sakurai S, Ishii S, Toyohara M, Yamazaki M, Yoshiji H, et al: Decreased activity of plasma ADAMTS13 may contribute to the development of liver disturbance and multiorgan failure in patients with alcoholic hepatitis. Alcohol Clin Exp Res. 29 12 Suppl:264S–271S. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Matsumoto M, Kawa K, Uemura M, Kato S, Ishizashi H, Isonishi A, Yagi H, Park YD, Takeshima Y, Kosaka Y, et al: Prophylactic fresh frozen plasma may prevent development of hepatic VOD after stem cell transplantation via ADAMTS13-mediated restoration of von Willebrand factor plasma levels. Bone Marrow Transplant. 40:251–259. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Ikeda H, Tateishi R, Enooku K, Yoshida H, Nakagawa H, Masuzaki R, Kondo Y, Goto T, Shiina S, Kume Y, et al: Prediction of hepatocellular carcinoma development by plasma ADAMTS13 in chronic hepatitis B and C. Cancer Epidemiol Biomarkers Prev. 20:2204–2211. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Motto DG, Chauhan AK, Zhu G, Homeister J, Lamb CB, Desch KC, Zhang W, Tsai HM, Wagner DD and Ginsburg D: Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice. J Clin Invest. 115:2752–2761. 2005. View Article : Google Scholar : PubMed/NCBI

18 

de Maeyer B, de Meyer SF, Feys HB, Pareyn I, Vandeputte N, Deckmyn H and Vanhoorelbeke K: The distal carboxyterminal domains of murine ADAMTS13 influence proteolysis of platelet-decorated VWF strings in vivo. J Thromb Haemost. 8:2305–2312. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Council NR: Guide for the Care and Use Laboratoy Animals. 7th. Washington, DC: National Academy Press; 1996

20 

Kleiner DE, Brunt EM, van Natta M, Behling C, Contos MJ, Cummings OW, Ferrell LD, Liu YC, Torbenson MS, Unalp-Arida A, et al: Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 41:1313–1321. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Verbeek J, Lannoo M, Pirinen E, Ryu D, Spincemaille P, Elst I Vander, Windmolders P, Thevissen K, Cammue BP, van Pelt J, et al: Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis. Gut. 64:673–683. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Bedossa P, Poitou C, Veyrie N, Bouillot JL, Basdevant A, Paradis V, Tordjman J and Clement K: Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients. Hepatology. 56:1751–1759. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Bedossa P, Dargère D and Paradis V: Sampling variability of liver fibrosis in chronic hepatitis C. Hepatology. 38:1449–1457. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2 (−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Verhenne S, Denorme F, Libbrecht S, Vandenbulcke A, Pareyn I, Deckmyn H, Lambrecht A, Nieswandt B, Kleinschnitz C, Vanhoorelbeke K and De Meyer SF: Platelet-derived VWF is not essential for normal thrombosis and hemostasis but fosters ischemic stroke injury in mice. Blood. 126:1715–1722. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Deforche L, Tersteeg C, Roose E, Vandenbulcke A, Vandeputte N, Pareyn I, de Cock E, Rottensteiner H, Deckmyn H, De Meyer SF and Vanhoorelbeke K: Generation of anti-murine ADAMTS13 antibodies and their application in a mouse model for acquired thrombotic thrombocytopenic purpura. PLoS One. 11:e01603882016. View Article : Google Scholar : PubMed/NCBI

27 

Murrin RJ and Murray JA: Thrombotic thrombocytopenic purpura: Aetiology, pathophysiology and treatment. Blood Rev. 20:51–60. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Geys L, Scroyen I, Roose E, Vanhoorelbeke K and Lijnen HR: ADAMTS13 deficiency in mice does not affect adipose tissue development. Biochim Biophys Acta. 1850:1368–1374. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Geys L, Bauters D, Roose E, Tersteeg C, Vanhoorelbeke K, Hoylaerts MF, Lijnen RH and Scroyen I: ADAMTS13 deficiency promotes microthrombosis in a murine model of diet-induced liver steatosis. Thromb Haemost. 117:19–26. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Lombardi AM, Fabris R, de Marinis G Berti, Marson P, Navaglia F, Plebani M, Vettor R and Fabris F: Defective ADAMTS13 synthesis as a possible consequence of NASH in an obese patient with recurrent thrombotic thrombocytopenic purpura. Eur J Haematol. 92:497–501. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Hugenholtz GC, Adelmeijer J, Meijers JC, Porte RJ, Stravitz RT and Lisman T: An unbalance between von Willebrand factor and ADAMTS13 in acute liver failure: Implications for hemostasis and clinical outcome. Hepatology. 58:752–761. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Takahashi Y, Soejima Y and Fukusato T: Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. World J Gastroenterol. 18:2300–2308. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Machado MV, Michelotti GA, Xie G, Pereira T Almeida, Boursier J, Bohnic B, Guy CD and Diehl AM: Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease. PLoS One. 10:e01279912015. View Article : Google Scholar : PubMed/NCBI

34 

Caballero F, Fernández A, Matías N, Martínez L, Fucho R, Elena M, Caballeria J, Morales A, Fernández-Checa JC and García-Ruiz C: Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: Impact on mitochondrial S-adenosyl-L-methionine and glutathione. J Biol Chem. 285:18528–18536. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Rinella ME, Elias MS, Smolak RR, Fu T, Borensztajn J and Green RM: Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet. J Lipid Res. 49:1068–1076. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Weltman MD, Farrell GC and Liddle C: Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation. Gastroenterology. 111:1645–1653. 1996. View Article : Google Scholar : PubMed/NCBI

37 

Weltman MD, Farrell GC, Hall P, Ingelman-Sundberg M and Liddle C: Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology. 27:128–133. 1998. View Article : Google Scholar : PubMed/NCBI

38 

Rinella ME and Green RM: The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance. J Hepatol. 40:47–51. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Fan JG and Qiao L: Commonly used animal models of non-alcoholic steatohepatitis. Hepatobiliary Pancreat Dis Int. 8:233–240. 2009.PubMed/NCBI

40 

Kirsch R, Clarkson V, Shephard EG, Marais DA, Jaffer MA, Woodburne VE, Kirsch RE and Pde L Hall: Rodent nutritional model of non-alcoholic steatohepatitis: Species, strain and sex difference studies. J Gastroenterol Hepatol. 18:1272–1282. 2003. View Article : Google Scholar : PubMed/NCBI

41 

Bauters D, Spincemaille P, Geys L, Cassiman D, Vermeersch P, Bedossa P, Scroyen I and Lijnen RH: ADAMTS5 deficiency protects against non-alcoholic steatohepatitis (NASH) in obesity. Liver Int. 36:1848–1859. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Pena A Dela, Leclercq I, Field J, George J, Jones B and Farrell G: NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis. Gastroenterology. 129:1663–1674. 2005. View Article : Google Scholar : PubMed/NCBI

43 

Leclercq IA, Farrell GC, Field J, Bell DR, Gonzalez FJ and Robertson GR: CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. J Clin Invest. 105:1067–1075. 2000. View Article : Google Scholar : PubMed/NCBI

44 

Ip E, Farrell G, Hall P, Robertson G and Leclercq I: Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice. Hepatology. 39:1286–1296. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Potze W, Siddiqui MS, Boyett SL, Adelmeijer J, Daita K, Sanyal AJ and Lisman T: Preserved hemostatic status in patients with non-alcoholic fatty liver disease. J Hepatol. 65:980–987. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Geys L, Roose E, Vanhoorelbeke K, Bedossa P, Scroyen I and Lijnen HR: Role of ADAMTS13 in diet-induced liver steatosis. Mol Med Rep 16: 1451-1458, 2017.
APA
Geys, L., Roose, E., Vanhoorelbeke, K., Bedossa, P., Scroyen, I., & Lijnen, H.R. (2017). Role of ADAMTS13 in diet-induced liver steatosis. Molecular Medicine Reports, 16, 1451-1458. https://doi.org/10.3892/mmr.2017.6714
MLA
Geys, L., Roose, E., Vanhoorelbeke, K., Bedossa, P., Scroyen, I., Lijnen, H. R."Role of ADAMTS13 in diet-induced liver steatosis". Molecular Medicine Reports 16.2 (2017): 1451-1458.
Chicago
Geys, L., Roose, E., Vanhoorelbeke, K., Bedossa, P., Scroyen, I., Lijnen, H. R."Role of ADAMTS13 in diet-induced liver steatosis". Molecular Medicine Reports 16, no. 2 (2017): 1451-1458. https://doi.org/10.3892/mmr.2017.6714
Copy and paste a formatted citation
x
Spandidos Publications style
Geys L, Roose E, Vanhoorelbeke K, Bedossa P, Scroyen I and Lijnen HR: Role of ADAMTS13 in diet-induced liver steatosis. Mol Med Rep 16: 1451-1458, 2017.
APA
Geys, L., Roose, E., Vanhoorelbeke, K., Bedossa, P., Scroyen, I., & Lijnen, H.R. (2017). Role of ADAMTS13 in diet-induced liver steatosis. Molecular Medicine Reports, 16, 1451-1458. https://doi.org/10.3892/mmr.2017.6714
MLA
Geys, L., Roose, E., Vanhoorelbeke, K., Bedossa, P., Scroyen, I., Lijnen, H. R."Role of ADAMTS13 in diet-induced liver steatosis". Molecular Medicine Reports 16.2 (2017): 1451-1458.
Chicago
Geys, L., Roose, E., Vanhoorelbeke, K., Bedossa, P., Scroyen, I., Lijnen, H. R."Role of ADAMTS13 in diet-induced liver steatosis". Molecular Medicine Reports 16, no. 2 (2017): 1451-1458. https://doi.org/10.3892/mmr.2017.6714
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