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Review

Roles of gangliosides in the differentiation of mouse pluripotent stem cells to neural stem cells and neural cells (Review)

  • Authors:
    • Jae‑Sung Ryu
    • Kinarm Ko
    • Kisung Ko
    • Ji‑Su Kim
    • Sun‑Uk Kim
    • Kyu‑Tae Chang
    • Young‑Kug Choo
  • View Affiliations / Copyright

    Affiliations: Stem Cell Research Center, Korea Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea, Department of Stem Cell Biology, School of Medicine, Konkuk University, Seoul 05029, Republic of Korea, Department of Medicine, College of Medicine, Chung‑Ang University, Seoul 06974, Republic of Korea, National Primate Research Center, Korea Institute of Bioscience and Biotechnology, Cheongju, Chungcheongbuk 28116, Republic of Korea, Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeollabuk 54538, Republic of Korea
  • Pages: 987-993
    |
    Published online on: June 8, 2017
       https://doi.org/10.3892/mmr.2017.6719
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Abstract

Glycosphingolipids are important components of the outer layer of the plasma membrane in the majority of eukaryotic cells. Specifically, gangliosides are sialic acid‑containing glycosphingolipids that participate in cell‑cell recognition, adhesion, proliferation, differentiation and signal transduction, and are integral components of cell surface microdomains and lipid rafts. Stem cells are defined functionally as cells that have the capacity to self‑renewal and differentiate to generate various cell types. Due to different synthesis patterns and locations of gangliosides, they have been used as molecular markers of stem cells. The current review describes the presence of gangliosides in various types of mouse stem cells, including pluripotent stem cells (embryonic stem cells and induced pluripotent stem cells) and neural stem cells, and the functional roles of gangliosides in various processes, including cell proliferation and neural differentiation. Thus, this review will aid the understanding of gangliosides patterns and functions in mouse stem cells, and outline markers for the identification of stem cells.
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Copy and paste a formatted citation
Spandidos Publications style
Ryu JS, Ko K, Ko K, Kim JS, Kim SU, Chang KT and Choo YK: Roles of gangliosides in the differentiation of mouse pluripotent stem cells to neural stem cells and neural cells (Review). Mol Med Rep 16: 987-993, 2017.
APA
Ryu, J., Ko, K., Ko, K., Kim, J., Kim, S., Chang, K., & Choo, Y. (2017). Roles of gangliosides in the differentiation of mouse pluripotent stem cells to neural stem cells and neural cells (Review). Molecular Medicine Reports, 16, 987-993. https://doi.org/10.3892/mmr.2017.6719
MLA
Ryu, J., Ko, K., Ko, K., Kim, J., Kim, S., Chang, K., Choo, Y."Roles of gangliosides in the differentiation of mouse pluripotent stem cells to neural stem cells and neural cells (Review)". Molecular Medicine Reports 16.2 (2017): 987-993.
Chicago
Ryu, J., Ko, K., Ko, K., Kim, J., Kim, S., Chang, K., Choo, Y."Roles of gangliosides in the differentiation of mouse pluripotent stem cells to neural stem cells and neural cells (Review)". Molecular Medicine Reports 16, no. 2 (2017): 987-993. https://doi.org/10.3892/mmr.2017.6719
Copy and paste a formatted citation
x
Spandidos Publications style
Ryu JS, Ko K, Ko K, Kim JS, Kim SU, Chang KT and Choo YK: Roles of gangliosides in the differentiation of mouse pluripotent stem cells to neural stem cells and neural cells (Review). Mol Med Rep 16: 987-993, 2017.
APA
Ryu, J., Ko, K., Ko, K., Kim, J., Kim, S., Chang, K., & Choo, Y. (2017). Roles of gangliosides in the differentiation of mouse pluripotent stem cells to neural stem cells and neural cells (Review). Molecular Medicine Reports, 16, 987-993. https://doi.org/10.3892/mmr.2017.6719
MLA
Ryu, J., Ko, K., Ko, K., Kim, J., Kim, S., Chang, K., Choo, Y."Roles of gangliosides in the differentiation of mouse pluripotent stem cells to neural stem cells and neural cells (Review)". Molecular Medicine Reports 16.2 (2017): 987-993.
Chicago
Ryu, J., Ko, K., Ko, K., Kim, J., Kim, S., Chang, K., Choo, Y."Roles of gangliosides in the differentiation of mouse pluripotent stem cells to neural stem cells and neural cells (Review)". Molecular Medicine Reports 16, no. 2 (2017): 987-993. https://doi.org/10.3892/mmr.2017.6719
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