Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
August-2017 Volume 16 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2017 Volume 16 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Resveratrol improves urinary dysfunction in rats with chronic prostatitis and suppresses the activity of the stem cell factor/c-Kit signaling pathway

  • Authors:
    • Yang Yu
    • Jiang Jiang
    • Yi He
    • Wei Wang
    • Chen Shen
    • Bo Yang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116044, P.R. China, Dalian Municipal Food and Drug Administration, Dalian, Liaoning 116000, P.R. China
  • Pages: 1395-1400
    |
    Published online on: June 8, 2017
       https://doi.org/10.3892/mmr.2017.6721
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Chronic prostatitis (CP) is a common urological disorder, with bladder voiding dysfunction being the primary clinical manifestation. Resveratrol is polyphenolic compound isolated from numerous plants, with widely‑reported anti-inflammatory properties. The present study aimed to investigate whether resveratrol may improve overactive bladder in rats with CP and to investigate the underlying molecular mechanisms. Furthermore, the potential pharmacological synergy between resveratrol and solifenacin was also investigated as a potential treatment for CP. Following the successful establishment of a rat model of CP by subcutaneously injecting DPT vaccine, rats were treated with resveratrol or a combination of resveratrol + solifenacin. Bladder pressure and volume tests were performed to investigate the effect of resveratrol and solifenacin on urinary dysfunction in rats with chronic prostatitis. Western blot analysis and immunohistochemical staining were used to examine the expression of c‑Kit receptor, stem cell factor (SCF), AKT and phosphorylated‑AKT (p‑AKT) in the bladder tissue. The results of the bladder pressure and volume test indicated that the maximum capacity of the bladder, residual urine volume and maximum voiding pressure in the control group were 0.57 ml, 0.17 ml and 29.62 cm H2O, respectively. These values were increased by 71, 27 and 206% in rats in the CP group compared with the control group. Following treatment with resveratrol, the results in the resveratrol group were reduced by 25.77, 44.23 and 13.32% compared with the CP group. The results of western blot analysis, immunohistochemical staining and immunofluorescence labeling demonstrate that the protein expression of SCF, c‑Kit and p‑AKT in the bladder of rats in the CP group was 4.32, 6.13 and 6.31 times higher compared with the control group, respectively. Following treatment with resveratrol, protein expression was significantly reduced. However, no significant differences were observed between the protein expression of the SCF, c‑Kit and p‑AKT in the bladder between the resveratrol and combination groups. In conclusion, resveratrol may improve overactive bladder by downregulating the protein expression of SCF, c‑Kit and p‑AKT in the bladder of rats with CP. Furthermore, a combination of resveratrol and solifenacin may have potential pharmacological synergy as a treatment for patients with CP.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Cho DS, Choi JB, Kim YS, Joo KJ, Kim SH, Kim JC and Kim HW: Heart rate variability in assessment of autonomic dysfunction in patients with chronic prostatitis/chronic pelvic pain syndrome. Urology. 78:1369–1372. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Liao LM, Shi BY and Liang CQ: Ambulatory urodynamic monitoring of external urethral sphincter behavior in chronic prostatitis patients. Asian J Androl. 1:215–217. 1999.PubMed/NCBI

3 

Wei J, Li N, Xia X, Chen X, Peng F, Besner GE and Feng J: Effects of lipopolysaccharide-induced inflammation on the interstitial cells of Cajal. Cell Tissue Res. 356:29–37. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Shin DH, Lee MJ, Jiao HY, Choi S, Kim MW, Park CG, Na J, Kim SW, Park IK, So I and Jun JY: Regulatory roles of endogenous mitogen-activated protein kinases and tyrosine kinases in the pacemaker activity of colonic interstitial cells of cajal. Pharmacology. 96:16–24. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Li J, Kong D, He Y, Wang X, Gao L, Li J, Yan M, Liu D, Wang Y, Zhang L and Jin X: The impact of inflammatory cells in malignant ascites on small intestinal ICCs' morphology and function. J Cell Mol Med. 19:2118–2127. 2015.PubMed/NCBI

6 

Sergeant GP, Hollywood MA, McCloskey KD, Thornbury KD and McHale NG: Specialised pacemaking cells in the rabbit urethra. J Physiol. 526:359–366. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Faussone-Pellegrini MS, Serni S and Carini M: Distribution of ICC and motor response characteristics in urinary bladders reconstructed from human ileum. Am J Physiol. 273:G147–G157. 1997.PubMed/NCBI

8 

Shafik A, El Sibai O and Ahmed I: The identification of specialized pacemaking cells in the anal sphincters. Int J Colorectal Dis. 21:453–457. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Thornbury KD, Hollywood MA, McHale NG and Sergeant GP: Cajal beyond the gut: Interstitial cells in the urinary system-towards general regulatory mechanisms of smooth muscle contractility? Acta Gastroenterol Belg. 74:536–542. 2011.PubMed/NCBI

10 

Hashitani H and Lang RJ: Functions of ICC-like cells in the urinary tract and male genital organs. J Cell Mol Med. 14:1199–1211. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Lang RJ and Klemm MF: Interstitial cell of Cajal-like cells in the upper urinary tract. J Cell Mol Med. 9:543–556. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Lennartsson J and Rönnstrand L: Stem cell factor receptor/c-Kit: From basic science to clinical implications. Physiol Rev. 92:1619–1649. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Abu-Duhier FM, Goodeve AC, Care RS, Gari M, Wilson GA, Peake IR and Reilly JT: Mutational analysis of class III receptor tyrosine kinases (C-KIT, C-FMS, FLT3) in idiopathic myelofibrosis. Br J Haematol. 120:464–470. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Biers SM, Reynard JM, Doore T and Brading AF: The functional effects of a c-kit tyrosine inhibitor on guinea-pig and human detrusor. BJU Int. 97:612–616. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Roskoski R Jr: Structure and regulation of Kit protein-tyrosine kinase-the stem cell factor receptor. Biochem Biophys Res Commun. 338:1307–1315. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Yuksel O Haki, Urkmez A and Verit A: The role of Cajal cells in chronic prostatitis. Arch Ital UrolAndrol. 88:133–135. 2016. View Article : Google Scholar

17 

Torres P, Poveda A, Jimenez-Barbero J, Ballesteros A and Plou FJ: Regioselective lipase-catalyzed synthesis of 3-o-acyl derivatives of resveratrol and study of their antioxidant properties. J Agric Food Chem. 58:807–813. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Sharma S, Anjaneyulu M, Kulkarni SK and Chopra K: Resveratrol, a polyphenolic phytoalexin, attenuates diabetic nephropathy in rats. Pharmacology. 76:69–75. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Csiszar A: Anti-inflammatory effects of resveratrol: Possible role in prevention of age-related cardiovascular disease. Ann N Y Acad Sci. 1215:117–122. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Huang F, Wu XN, Chen J, Wang WX and Lu ZF: Resveratrol reverses multidrug resistance in human breast cancer doxorubicin-resistant cells. Exp Ther Med. 7:1611–1616. 2014.PubMed/NCBI

21 

Poolman TM, Ng LL, Farmer PB and Manson MM: Inhibition of the respiratory burst by resveratrol in human monocytes: Correlation with inhibition of PI3K signaling. Free Radic Biol Med. 39:118–132. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Vajravelu BN, Hong KU, Al-Maqtari T, Cao P, Keith MC, Wysoczynski M, Zhao J, JB IV Moore and Bolli R: C-Kit promotes growth and migration of human cardiac progenitor cells via the PI3K-AKT and MEK-ERK pathways. PloS One. 10:e01407982015. View Article : Google Scholar : PubMed/NCBI

23 

Lee SH, Byun SS, Lee SJ, Kim KH and Lee JY: Effects of initial combined tamsulosin and solifenacin therapy for overactive bladder and bladder outlet obstruction secondary to benign prostatic hyperplasia: A prospective, randomized, multicenter study. Int Urol Nephrol. 46:523–529. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Guohong S, Qiumei Z, Baozhen P, Lijuan H, Julaiti S, Aisikeer T, Xuan G, Lina Y, Reyihan W, Wentao Z and Qingyang P: Effects of different Chinese herbal prescriptions on cytokines in au- toimmune prostatitis rats. J Tradit Chin Med. 35:211–217. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Cheng PW, Ho WY, Su YT, Lu PJ, Chen BZ, Cheng WH, Lu WH, Sun GC, Yeh TC, Hsiao M and Tseng CJ: Resveratrol decreases fructose-induced oxidative stress, mediated by NADPH oxidase via an AMPK-dependent mechanism. Br J Pharmacol. 171:2739–2750. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Suzuki M, Ohtake A, Yoshino T, Yuyama H, Hayashi A, Ukai M, Okutsu H, Noguchi Y, Sato S and Sasamata M: Effects of solifenacin succinate (YM905) on detrusor overactivity in conscious cerebral infarcted rats. Eur J Pharmacol. 512:61–66. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Yang X, Yuan L, Chen J, Xiong C and Ruan J: Multitargeted protective effect of Abacopteris penangiana against carrageenan-induced chronic prostatitis in rats. J Ethnopharmacol. 151:343–351. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Rivera RS, Nagatsuka H, Gunduz M, Cengiz B, Gunduz E, Siar CH, Tsujigiwa H, Tamamura R, Han KN and Nagai N: C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma. Virchows Arch. 452:27–32. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Metzger R, Schuster T, Till H, Franke FE and Dietz HG: Cajal-like cells in the upper urinary tract: Comparative study in various species. Pediatr Surg Int. 21:169–174. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Johnston L, Woolsey S, Cunningham RM, O'Kane H, Duggan B, Keane P and McCloskey KD: Morphological expression of KIT positive interstitial cells of Cajal in human bladder. J Urol. 184:370–377. 2010. View Article : Google Scholar : PubMed/NCBI

31 

McCloskey KD: Interstitial cells in the urinary bladder-localization and function. Neurourol Urodyn. 29:82–87. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Bashamboo A, Taylor AH, Samuel K, Panthier JJ, Whetton AD and Forrester LM: The survival of differentiating embryonic stem cells is dependent on the SCF-KIT pathway. J Cell Sci. 119:3039–3046. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Fraser L, Taylor AH and Forrester LM: SCF/KIT inhibition has a cumulative but reversible effect on the self-renewal of embryonic stem cells and on the survival of differentiating cells. Cell Reprogram. 15:259–268. 2013.PubMed/NCBI

34 

Lorincz A, Redelman D, Horvath VJ, Bardsley MR, Chen H and Ordog T: Progenitors of interstitial cells of cajal in the postnatal murine stomach. Gastroenterology. 134:1083–1093. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Taylor ML and Metcalfe DD: Kit signal transduction. Hematol Oncol Clin North Am. 14:517–535. 2000. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yu Y, Jiang J, He Y, Wang W, Shen C and Yang B: Resveratrol improves urinary dysfunction in rats with chronic prostatitis and suppresses the activity of the stem cell factor/c-Kit signaling pathway. Mol Med Rep 16: 1395-1400, 2017.
APA
Yu, Y., Jiang, J., He, Y., Wang, W., Shen, C., & Yang, B. (2017). Resveratrol improves urinary dysfunction in rats with chronic prostatitis and suppresses the activity of the stem cell factor/c-Kit signaling pathway. Molecular Medicine Reports, 16, 1395-1400. https://doi.org/10.3892/mmr.2017.6721
MLA
Yu, Y., Jiang, J., He, Y., Wang, W., Shen, C., Yang, B."Resveratrol improves urinary dysfunction in rats with chronic prostatitis and suppresses the activity of the stem cell factor/c-Kit signaling pathway". Molecular Medicine Reports 16.2 (2017): 1395-1400.
Chicago
Yu, Y., Jiang, J., He, Y., Wang, W., Shen, C., Yang, B."Resveratrol improves urinary dysfunction in rats with chronic prostatitis and suppresses the activity of the stem cell factor/c-Kit signaling pathway". Molecular Medicine Reports 16, no. 2 (2017): 1395-1400. https://doi.org/10.3892/mmr.2017.6721
Copy and paste a formatted citation
x
Spandidos Publications style
Yu Y, Jiang J, He Y, Wang W, Shen C and Yang B: Resveratrol improves urinary dysfunction in rats with chronic prostatitis and suppresses the activity of the stem cell factor/c-Kit signaling pathway. Mol Med Rep 16: 1395-1400, 2017.
APA
Yu, Y., Jiang, J., He, Y., Wang, W., Shen, C., & Yang, B. (2017). Resveratrol improves urinary dysfunction in rats with chronic prostatitis and suppresses the activity of the stem cell factor/c-Kit signaling pathway. Molecular Medicine Reports, 16, 1395-1400. https://doi.org/10.3892/mmr.2017.6721
MLA
Yu, Y., Jiang, J., He, Y., Wang, W., Shen, C., Yang, B."Resveratrol improves urinary dysfunction in rats with chronic prostatitis and suppresses the activity of the stem cell factor/c-Kit signaling pathway". Molecular Medicine Reports 16.2 (2017): 1395-1400.
Chicago
Yu, Y., Jiang, J., He, Y., Wang, W., Shen, C., Yang, B."Resveratrol improves urinary dysfunction in rats with chronic prostatitis and suppresses the activity of the stem cell factor/c-Kit signaling pathway". Molecular Medicine Reports 16, no. 2 (2017): 1395-1400. https://doi.org/10.3892/mmr.2017.6721
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team