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Article

Clinical implications of vasohibin-1 in esophageal carcinoma cells: Inhibition of cell growth and migration

  • Authors:
    • Deliang Ma
    • Jingye Li
    • Jinbao Wang
    • Zhigang Sun
    • Kai Wang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Yishui Central Hospital of Linyi, Linyi, Shandong 276400, P.R. China, Department of General Surgery, Yishui Central Hospital of Linyi, Linyi, Shandong 276400, P.R. China, Central Laboratory, Yishui Central Hospital of Linyi, Linyi, Shandong 276400, P.R. China, Department of Breast Surgery, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China
  • Pages: 1479-1485
    |
    Published online on: June 8, 2017
       https://doi.org/10.3892/mmr.2017.6726
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Abstract

As one of the first-established negative feedback regulators of angiogenesis, mesenchymal vasohibin-1 (VASH1) serves important roles in the progression and prognosis of various types of tumor. However, the clinical implications of VASH1 in esophageal carcinoma (EC) cells have not been reported and the direct effects of VASH1 on EC cells remain unknown. In the present study, the expression of VASH1 in EC cells was observed using immunohistochemistry and western blotting; a χ2 test was used to analyze the correlation of VASH1 with clinical parameters, and it was observed that VASH1 was negatively-correlated with tumor size (r=‑0.399; P<0.01) and invasion depth (r=‑0.318; P<0.01). Survival analysis demonstrated that VASH1 was positively‑correlated with increased overall survival (P=0.039) and disease free survival (P=0.012). The direct effects of VASH1 on EC cells were analyzed by altering VASH1 expression, and it was observed that downregulation of VASH1 increased proliferation, clone formation and the migratory ability of EC9706 cells, whereas upregulation of VASH1 inhibited proliferation, clone formation and the migratory ability of EC1 cells. The results of the present study demonstrated that VASH1 in EC cells was negatively‑correlated with progression and poor prognosis of patients with EC. VASH1 was able to directly inhibit the growth and migration of EC cells.
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Copy and paste a formatted citation
Spandidos Publications style
Ma D, Li J, Wang J, Sun Z and Wang K: Clinical implications of vasohibin-1 in esophageal carcinoma cells: Inhibition of cell growth and migration. Mol Med Rep 16: 1479-1485, 2017.
APA
Ma, D., Li, J., Wang, J., Sun, Z., & Wang, K. (2017). Clinical implications of vasohibin-1 in esophageal carcinoma cells: Inhibition of cell growth and migration. Molecular Medicine Reports, 16, 1479-1485. https://doi.org/10.3892/mmr.2017.6726
MLA
Ma, D., Li, J., Wang, J., Sun, Z., Wang, K."Clinical implications of vasohibin-1 in esophageal carcinoma cells: Inhibition of cell growth and migration". Molecular Medicine Reports 16.2 (2017): 1479-1485.
Chicago
Ma, D., Li, J., Wang, J., Sun, Z., Wang, K."Clinical implications of vasohibin-1 in esophageal carcinoma cells: Inhibition of cell growth and migration". Molecular Medicine Reports 16, no. 2 (2017): 1479-1485. https://doi.org/10.3892/mmr.2017.6726
Copy and paste a formatted citation
x
Spandidos Publications style
Ma D, Li J, Wang J, Sun Z and Wang K: Clinical implications of vasohibin-1 in esophageal carcinoma cells: Inhibition of cell growth and migration. Mol Med Rep 16: 1479-1485, 2017.
APA
Ma, D., Li, J., Wang, J., Sun, Z., & Wang, K. (2017). Clinical implications of vasohibin-1 in esophageal carcinoma cells: Inhibition of cell growth and migration. Molecular Medicine Reports, 16, 1479-1485. https://doi.org/10.3892/mmr.2017.6726
MLA
Ma, D., Li, J., Wang, J., Sun, Z., Wang, K."Clinical implications of vasohibin-1 in esophageal carcinoma cells: Inhibition of cell growth and migration". Molecular Medicine Reports 16.2 (2017): 1479-1485.
Chicago
Ma, D., Li, J., Wang, J., Sun, Z., Wang, K."Clinical implications of vasohibin-1 in esophageal carcinoma cells: Inhibition of cell growth and migration". Molecular Medicine Reports 16, no. 2 (2017): 1479-1485. https://doi.org/10.3892/mmr.2017.6726
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