Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
August-2017 Volume 16 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2017 Volume 16 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Chinese herbal medicine Xinji pill protects the heart from ischemia/reperfusion injury through the Akt/Nrf2 pathway

  • Authors:
    • Qiuzhen Yuan
    • Ruiming Chen
    • Xu Zheng
    • Maixia Meng
    • Yuping Kao
    • Junfeng Liu
    • Xuefeng Gan
    • Minjuan Shi
    • Junming Fu
    • Shanshan Jiang
    • Huiyao Yu
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Shanxi Hospital of Traditional Chinese Medicine, Xi'an, Shaanxi 710032, P.R. China, Institute of TCM Research, Shaanxi Provincial Academy of Traditional Chinese Medicine, Xianyang, Shaanxi 712046, P.R. China, Department of Pharmacology, Shaanxi Institute for Food and Drug Control, Xi'an, Shaanxi 710000, P.R. China, Scientific Research Department, Shaanxi Hospital of Traditional Chinese Medicine, Xi'an, Shaanxi 710032, P.R. China
  • Pages: 1551-1558
    |
    Published online on: June 8, 2017
       https://doi.org/10.3892/mmr.2017.6732
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The cardioprotective drugs used for treatment against ischemia/reperfusion (MI/R) injury have been well evaluated and are considered inadequate. The Chinese herbal medicine formula, Xinji pill (XJP) has been used traditionally for the prevention and treatment of ischemic heart diseases for decades. In the present study, the cardioprotective effects of XJP against MI/R injury were assessed in vivo and its possible mechanism was examined. Male Sprague‑Dawley rats were selected for establishing an MI/R model, which was induced by ischemia for 30 min followed by 24 h reperfusion. Drugs and saline were administered intragastrically from day 14 prior to MI/R. Blood samples were collected for biochemical detection. The rats were then sacrificed and cardiac muscle tissues were harvested. The mRNA expression levels of antioxidant genes were measured by reverse transcription‑quantitative polymerase chain reaction and the protein levels were measured by western blotting. Pretreatment with XJP for 14 days protected the heart against I/R‑induced myocardial function disorder, protected against heart injury, as demonstrated by normalized serum levels of lactate dehydrogenase and creatine kinase, and suppressed oxidative stress. XJP markedly upregulated the expression of antioxidant genes, including superoxide dismutase, catalase, glutathione reductase and glutathione peroxidase, and promoted the protein expression of heme oxygenase‑1 and NFE2‑related factor 2 (Nrf2) in the heart tissues. Furthermore, Akt kinase was confirmed to be upstream of Nrf2 in the XJP treatment. LY294002, a specific inhibitor of Akt, significantly eliminated the cardioprotective effects of XJP. In conclusion, these results demonstrated that XJP exhibited notable cardioprotective properties, in which the Akt/Nrf2 signaling pathway may be involved.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Zhong X, Li X, Qian L, Xu Y, Lu Y, Zhang J, Li N, Zhu X, Ben J, Yang Q and Chen Q: Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats. J Biomed Res. 26:346–354. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Piper HM, García-Dorado D and Ovize M: A fresh look at reperfusion injury. Cardiovasc Res. 38:291–300. 1998. View Article : Google Scholar : PubMed/NCBI

3 

Jennings RB, Sommers HM, Smyth GA, Flack HA and Linn H: Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog. Arch Pathol. 70:68–78. 1960.PubMed/NCBI

4 

Armstrong SC: Protein kinase activation and myocardial ischemia/reperfusion injury. Cardiovasc Res. 61:427–436. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, et al: Heart disease and stroke statistics-2013 update: A report from the American Heart Association. Circulation. 127:e6–e245. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Murphy E and Steenbergen C: Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. Physiol Rev. 88:581–609. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Becker LB: New concepts in reactive oxygen species and cardiovascular reperfusion physiology. Cardiovasc Res. 61:461–470. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Frangogiannis NG, Smith CW and Entman ML: The inflammatory response in myocardial infarction. Cardiovasc Res. 53:31–47. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Laskowski A, Woodman OL, Cao AH, Drummond GR, Marshall T, Kaye DM and Ritchie RH: Antioxidant actions contribute to the antihypertrophic effects of atrial natriuretic peptide in neonatal rat cardiomyocytes. Cardiovas Resear. 72:112–123. 2006. View Article : Google Scholar

10 

Moens AL, Claeys MJ, Timmermans JP and Vrints CJ: Myocardial ischemia/reperfusion-injury, a clinical view on a complex pathophysiological process. Int J Cardiol. 100:179–190. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Rajak S, Banerjee SK, Sood S, Dinda AK, Gupta YK, Gupta SK and Maulik SK: Emblica officinalis causes myocardial adaptation and protects against oxidative stress in ischemic-reperfusion injury in rats. Phytother Res. 18:54–60. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Li J, Ichikawa T, Villacorta L, Janicki JS, Brower GL, Yamamoto M and Cui T: Nrf2 protects against maladaptive cardiac responses to hemodynamic stress. Arterioscler Thromb Vasc Biol. 29:1843–1850. 2009. View Article : Google Scholar : PubMed/NCBI

13 

McMahon M, Itoh K, Yamamoto M and Hayes JD: Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem. 278:21592–21600. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Boran AD and Iyengar R: Systems approaches to polypharmacology and drug discovery. Curr Opin Drug Discov Devel. 13:297–309. 2010.PubMed/NCBI

15 

Zhang A and Hui A: Inhibition of coxsackie virus and effect on the treatment of viral myocarditis of Xinji Pill in mice. Shanxi Tradit Chin Med. 12:563–564. 1998.(In Chinese).

16 

National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals: Guide for the Care and Use of Laboratory Animals. 8th. National Academies Press (US); Washington, DC: pp. 1072–1073. 2011

17 

China's food and drug administration, . Good laboratory practice. Standards Press of China; Beijing: pp. 54–59. 2003

18 

China's food and drug administration: Good manufacturing practice. Standards Press of China; Beijing: pp. 106–109. 2015

19 

Tao L, Gao E, Bryan NS, Qu Y, Liu HR, Hu A, Christopher TA, Lopez BL, Yodoi J, Koch WJ, et al: Cardioprotective effects of thioredoxin in myocardial ischemia and reperfusion: Role of S-nitrosation (corrected). Proc Natl Acad Sci USA. 101:11471–11476. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Cao Z and Li Y: Protecting against peroxynitrite-mediated cytotoxicity in vascular smooth muscle cells via upregulating endogenous glutathione biosynthesis by 3H-1,2-dithiole-3-thione. Cardiovasc Toxicol. 4:339–353. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Hu W, Zhang P, Gu J, Yu Q and Zhang D: NEDD4-1 protects against ischaemia/reperfusion-induced cardiomyocyte apoptosis via the PI3K/Akt pathway. Apoptosis. 22:437–448. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Cho MH, Niles A, Huang R, Inglese J, Austin CP, Riss T and Xia M: A bioluminescent cytotoxicity assay for assessment of membrane integrity using a proteolytic biomarker. Toxicol In Vitro. 22:1099–1106. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Corey MJ, Kinders RJ, Brown LG and Vessella RL: A very sensitive coupled luminescent assay for cytotoxicity and complement-mediated lysis. J Immunol Methods. 207:43–51. 1997. View Article : Google Scholar : PubMed/NCBI

25 

Kim H, Yoon SC, Lee TY and Jeong D: Discriminative cytotoxicity assessment based on various cellular damages. Toxicol Lett. 184:13–17. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Wu Y and Yuan BX: Effects of Qiangxin capsules on myocardial reperfusion arrhythmias in rats. Northwest Pharmac J. 16:23–24. 2001.

27 

Fu J, Huang H, Liu J, Pi R, Chen J and Liu P: Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis. Eur J Pharmac. 568:213–221. 2007. View Article : Google Scholar

28 

Halliwell B and Gutteridge JMC: Free radicals in biology and medicine. 3rd. Oxford: Clarendon Press; pp. 246–350. 1999

29 

Maxwell SR and Lip GY: Reperfusion injury: A review of the pathophysiology, clinical manifestations and therapeutic options. Int J Cardiol. 58:95–117. 1997. View Article : Google Scholar : PubMed/NCBI

30 

Duranteau J, Chandel NS, Kulisz A, Shao Z and Schumacker PT: Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes. J Biol Chem. 273:11619–11624. 1998. View Article : Google Scholar : PubMed/NCBI

31 

Hensley K, Robinson KA, Gabbita SP, Salsman S and Floyd RA: Reactive oxygen species, cell signaling, and cell injury. Free Radic Biol Med. 28:1456–1462. 2000. View Article : Google Scholar : PubMed/NCBI

32 

Das DK and Maulik N: Antioxidant effectiveness in ischemia reperfusion tissue injury. Methods Enzymol. 233:601–610. 1994. View Article : Google Scholar : PubMed/NCBI

33 

Lefer DJ and Granger DN: Oxidative stress and cardiac disease. Am J Med. 109:315–323. 2000. View Article : Google Scholar : PubMed/NCBI

34 

Ferrari R, Ceconi C, Curello S, Cargnoni A, Alfieri O, Pardini A, Marzollo P and Visioli O: Oxygen free radicals and myocardial damage: Protective role of thiolcontaining agents. Am J Med. 91 Suppl:95–105. 1991. View Article : Google Scholar

35 

Frei B: On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction. Proc Soc Exp Biol Med. 222:196–204. 1999. View Article : Google Scholar : PubMed/NCBI

36 

Valko M, Rhodes CJ, Moncol J, Izakovic M and Mazur M: Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact. 160:1–40. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Tengattini S, Reiter RJ, Tan DX, Terron MP, Rodella LF and Rezzani R: Cardiovascular diseases: Protective effects of melatonin. J Pineal Res. 44:16–25. 2008.PubMed/NCBI

38 

Ma Q, Kinneer K, Bi Y, Chan JY and Kan YW: Induction of murine NAD(P)H:quinine oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap ‘n’ collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2): Cross-interaction between AhR (aryl hydrocarbon receptor) and Nrf2 signal transduction. Biochem J. 377:205–213. 2004. View Article : Google Scholar : PubMed/NCBI

39 

He X, Chen MG, Lin GX and Ma Q: Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 × Keap1 x·Cul3 complex and recruiting Nrf2 x·Maf to the antioxidant response element enhancer. J Biol Chem. 281:23620–23631. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Su JD, Yen JH, Li S, Weng CY, Lin MH, Ho CT and Wu MJ: 3′,4′-didemethylnobiletin induces phase II detoxification gene expression and modulates PI3K/Akt signaling in PC12 cells. Free Radic Biol Med. 52:126–141. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yuan Q, Chen R, Zheng X, Meng M, Kao Y, Liu J, Gan X, Shi M, Fu J, Jiang S, Jiang S, et al: Chinese herbal medicine Xinji pill protects the heart from ischemia/reperfusion injury through the Akt/Nrf2 pathway. Mol Med Rep 16: 1551-1558, 2017.
APA
Yuan, Q., Chen, R., Zheng, X., Meng, M., Kao, Y., Liu, J. ... Yu, H. (2017). Chinese herbal medicine Xinji pill protects the heart from ischemia/reperfusion injury through the Akt/Nrf2 pathway. Molecular Medicine Reports, 16, 1551-1558. https://doi.org/10.3892/mmr.2017.6732
MLA
Yuan, Q., Chen, R., Zheng, X., Meng, M., Kao, Y., Liu, J., Gan, X., Shi, M., Fu, J., Jiang, S., Yu, H."Chinese herbal medicine Xinji pill protects the heart from ischemia/reperfusion injury through the Akt/Nrf2 pathway". Molecular Medicine Reports 16.2 (2017): 1551-1558.
Chicago
Yuan, Q., Chen, R., Zheng, X., Meng, M., Kao, Y., Liu, J., Gan, X., Shi, M., Fu, J., Jiang, S., Yu, H."Chinese herbal medicine Xinji pill protects the heart from ischemia/reperfusion injury through the Akt/Nrf2 pathway". Molecular Medicine Reports 16, no. 2 (2017): 1551-1558. https://doi.org/10.3892/mmr.2017.6732
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan Q, Chen R, Zheng X, Meng M, Kao Y, Liu J, Gan X, Shi M, Fu J, Jiang S, Jiang S, et al: Chinese herbal medicine Xinji pill protects the heart from ischemia/reperfusion injury through the Akt/Nrf2 pathway. Mol Med Rep 16: 1551-1558, 2017.
APA
Yuan, Q., Chen, R., Zheng, X., Meng, M., Kao, Y., Liu, J. ... Yu, H. (2017). Chinese herbal medicine Xinji pill protects the heart from ischemia/reperfusion injury through the Akt/Nrf2 pathway. Molecular Medicine Reports, 16, 1551-1558. https://doi.org/10.3892/mmr.2017.6732
MLA
Yuan, Q., Chen, R., Zheng, X., Meng, M., Kao, Y., Liu, J., Gan, X., Shi, M., Fu, J., Jiang, S., Yu, H."Chinese herbal medicine Xinji pill protects the heart from ischemia/reperfusion injury through the Akt/Nrf2 pathway". Molecular Medicine Reports 16.2 (2017): 1551-1558.
Chicago
Yuan, Q., Chen, R., Zheng, X., Meng, M., Kao, Y., Liu, J., Gan, X., Shi, M., Fu, J., Jiang, S., Yu, H."Chinese herbal medicine Xinji pill protects the heart from ischemia/reperfusion injury through the Akt/Nrf2 pathway". Molecular Medicine Reports 16, no. 2 (2017): 1551-1558. https://doi.org/10.3892/mmr.2017.6732
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team