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Article

Sodium tanshinone IIA sulfonate suppresses heat stress-induced endothelial cell apoptosis by promoting NO production through upregulating the PI3K/AKT/eNOS pathway

  • Authors:
    • Qing Cheng
    • Yan Zhao
    • Jianguo Li
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China
  • Pages: 1612-1618
    |
    Published online on: June 13, 2017
       https://doi.org/10.3892/mmr.2017.6760
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Abstract

Heat shock is a life-threatening disease involving systematic inflammation that is closely related to endothelial injury and can lead to multiple organ dysfunction syndrome. Sodium tanshinone IIA sulfonate (STS) has various functions in the vascular endothelium. In the present study, STS is presented to suppress heat stress‑induced apoptosis of human umbilical vein endothelial cells (HUVECs) and high ambient temperature‑induced systematic inflammation in Sprague Dawley rats. In addition, the STS apoptosis‑suppression mechanism was explored. The results presented in the present study demonstrated that the PI3K/AKT pathway was stimulated by STS treatment and that eNOS phosphorylation at Ser‑1177 was also upregulated, resulting in increased nitric oxide production in HUVECs under heat stress. Using specific inhibitors, the authors confirmed that STS‑induced endothelial nitric oxide synthase (eNOS) phosphorylation at Ser‑1177 was activated by protein kinase B phosphorylation at Ser‑473, involving activation of phosphatidylinositol‑3 kinase (PI3K). The results suggested that STS suppresses heat stress‑induced apoptosis of HUVECs via the PI3K/AKT/eNOS pathway and may be used in heat shock treatment as a vascular endothelial protection mechanism.
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1 

Bouchama A and Knochel JP: Heat stroke. N Engl J Med. 346:1978–1988. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Geng Y, Ma Q, Liu YN, Peng N, Yuan FF, Li XG, Li M, Wu YS, Li BL, Song WB, et al: Heatstroke induces liver injury via IL-1β and HMGB1-induced pyroptosis. J Hepatol. 63:622–633. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Tang J, Deng P, Jiang Y, Tang Y, Chen B, Su L and Liu Z: Role of HMGB1 in propofol protection of rat intestinal epithelial cells injured by heat shock. Cell Biol Int. 37:262–266. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Leon LR and Bouchama A: Heat stroke. Compr Physiol. 5:611–647. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Epstein Y, Roberts WO, Golan R, Heled Y, Sorkine P and Halpern P: Sepsis, septic shock, and fatal exertional heat stroke. Curr Sports Med Rep. 14:64–69. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Iba T, Gando S, Murata A, Kushimoto S, Saitoh D, Eguchi Y, Ohtomo Y, Okamoto K, Koseki K, Mayumi T, et al: Predicting the severity of systemic inflammatory response syndrome (SIRS)-associated coagulopathy with hemostatic molecular markers and vascular endothelial injury markers. J Trauma. 63:1093–1098. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Gando S: Systemic inflammatory response syndrome (SIRS) and endothelial cell injury. Nihon Rinsho. 62:2244–2250. 2004.(In Japanese). PubMed/NCBI

8 

Sylman JL, Artzer DT, Rana K and Neeves KB: A vascular injury model using focal heat-induced activation of endothelial cells. Integr Biol (Camb). 7:801–814. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Hawiger J, Veach RA and Zienkiewicz J: New paradigms in sepsis: From prevention to protection of failing microcirculation. J Thromb Haemost. 13:1743–1756. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Krau SD: Heat-related illness: A hot topic in critical care. Crit Care Nurs Clin North Am. 25:251–262. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Bruchim Y, Loeb E, Saragusty J and Aroch I: Pathological findings in dogs with fatal heatstroke. J Comp Pathol. 140:97–104. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Liu Y, Zhou G, Wang Z, Guo X, Xu Q, Huang Q and Su L: NF-κB signaling is essential for resistance to heat stress-induced early stage apoptosis in human umbilical vein endothelial cells. Sci Rep. 5:135472015. View Article : Google Scholar : PubMed/NCBI

13 

Li L, Tan H, Gu Z, Liu Z, Geng Y, Liu Y, Tong H, Tang Y, Qiu J and Su L: Heat stress induces apoptosis through a Ca2+-mediated mitochondrial apoptotic pathway in human umbilical vein endothelial cells. PLoS One. 9:e1110832014. View Article : Google Scholar : PubMed/NCBI

14 

Kim YM, Bombeck CA and Billiar TR: Nitric oxide as a bifunctional regulator of apoptosis. Circ Res. 84:253–256. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Napoli C, Paolisso G, Casamassimi A, Al-Omran M, Barbieri M, Sommese L, Infante T and Ignarro LJ: Effects of nitric oxide on cell proliferation: Novel insights. J Am Coll Cardiol. 62:89–95. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Takahashi K, Ouyang X, Komatsu K, Nakamura N, Hattori M, Baba A and Azuma J: Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells. Biochem Pharmacol. 64:745–749. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Wang C, Li H, Zhou K, Luo C, Li Y, Xie L and Hua Y: Sodium tanshinone IIA sulfonate and sodium danshensu open the placental barrier through down-regulation of placental P-glycoprotein in mice: Implications in the transplacental digoxin treatment for fetal heart failure. Int J Cardiol. 176:1331–1333. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Cirino G, Fiorucci S and Sessa W C: Endothelial nitric oxide synthase: The Cinderella of inflammation? Trends Pharmacol Sci. 24:91–95. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R and Zeiher AM: Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature. 399:601–605. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Gonzalez E, Kou R, Lin AJ, Golan DE and Michel T: Subcellular targeting and agonist-induced site-specific phosphorylation of endothelial nitric-oxide synthase. J Biol Chem. 277:39554–39560. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Zhang Y, Li W, Zhu S, Jundoria A, Li J, Yang H, Fan S, Wang P, Tracey KJ, Sama AE and Wang H: Tanshinone IIA sodium sulfonate facilitates endocytic HMGB1 uptake. Biochem Pharmacol. 84:1492–1500. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Hu Q, Wei B, Wei L, Hua K, Yu X, Li H and Ji H: Sodium tanshinone IIA sulfonate ameliorates ischemia-induced myocardial inflammation and lipid accumulation in Beagle dogs through NLRP3 inflammasome. Int J Cardiol. 196:183–192. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cheng Q, Zhao Y and Li J: Sodium tanshinone IIA sulfonate suppresses heat stress-induced endothelial cell apoptosis by promoting NO production through upregulating the PI3K/AKT/eNOS pathway. Mol Med Rep 16: 1612-1618, 2017.
APA
Cheng, Q., Zhao, Y., & Li, J. (2017). Sodium tanshinone IIA sulfonate suppresses heat stress-induced endothelial cell apoptosis by promoting NO production through upregulating the PI3K/AKT/eNOS pathway. Molecular Medicine Reports, 16, 1612-1618. https://doi.org/10.3892/mmr.2017.6760
MLA
Cheng, Q., Zhao, Y., Li, J."Sodium tanshinone IIA sulfonate suppresses heat stress-induced endothelial cell apoptosis by promoting NO production through upregulating the PI3K/AKT/eNOS pathway". Molecular Medicine Reports 16.2 (2017): 1612-1618.
Chicago
Cheng, Q., Zhao, Y., Li, J."Sodium tanshinone IIA sulfonate suppresses heat stress-induced endothelial cell apoptosis by promoting NO production through upregulating the PI3K/AKT/eNOS pathway". Molecular Medicine Reports 16, no. 2 (2017): 1612-1618. https://doi.org/10.3892/mmr.2017.6760
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng Q, Zhao Y and Li J: Sodium tanshinone IIA sulfonate suppresses heat stress-induced endothelial cell apoptosis by promoting NO production through upregulating the PI3K/AKT/eNOS pathway. Mol Med Rep 16: 1612-1618, 2017.
APA
Cheng, Q., Zhao, Y., & Li, J. (2017). Sodium tanshinone IIA sulfonate suppresses heat stress-induced endothelial cell apoptosis by promoting NO production through upregulating the PI3K/AKT/eNOS pathway. Molecular Medicine Reports, 16, 1612-1618. https://doi.org/10.3892/mmr.2017.6760
MLA
Cheng, Q., Zhao, Y., Li, J."Sodium tanshinone IIA sulfonate suppresses heat stress-induced endothelial cell apoptosis by promoting NO production through upregulating the PI3K/AKT/eNOS pathway". Molecular Medicine Reports 16.2 (2017): 1612-1618.
Chicago
Cheng, Q., Zhao, Y., Li, J."Sodium tanshinone IIA sulfonate suppresses heat stress-induced endothelial cell apoptosis by promoting NO production through upregulating the PI3K/AKT/eNOS pathway". Molecular Medicine Reports 16, no. 2 (2017): 1612-1618. https://doi.org/10.3892/mmr.2017.6760
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