Open Access

Targeted inhibition of endoplasmic reticulum stress: New hope for renal fibrosis (Review)

  • Authors:
    • Ben Ke
    • Na Zhu
    • Fuli Luo
    • Yang Xu
    • Xiangdong Fang
  • View Affiliations

  • Published online on: June 13, 2017     https://doi.org/10.3892/mmr.2017.6762
  • Pages: 1014-1020
  • Copyright: © Ke et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Chronic kidney disease (CKD) has a very high mortality rate and remains a global health challenge. Inhibiting renal fibrosis is one of the most promising therapeutic strategies for CKD. Recent studies have indicated that endoplasmic reticulum stress (ERS) serves an active role in the development of acute and chronic kidney disease, especially with regards to renal fibrosis. In the current review, the authors summarize the latest understanding of the role of ERS during the onset of renal fibrosis. ERS promotes renal fibrosis through multiple signaling pathways, such as transforming growth factor‑β, epithelial‑mesenchymal transition and oxidative stress. In addition, ERS also causes podocyte damage, leading to increased proteinuria and the development of renal fibrosis in rat models. In conclusion, targeted inhibition of ERS may become a promising therapeutic strategy for renal fibrosis.
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August-2017
Volume 16 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Ke B, Zhu N, Luo F, Xu Y and Fang X: Targeted inhibition of endoplasmic reticulum stress: New hope for renal fibrosis (Review). Mol Med Rep 16: 1014-1020, 2017.
APA
Ke, B., Zhu, N., Luo, F., Xu, Y., & Fang, X. (2017). Targeted inhibition of endoplasmic reticulum stress: New hope for renal fibrosis (Review). Molecular Medicine Reports, 16, 1014-1020. https://doi.org/10.3892/mmr.2017.6762
MLA
Ke, B., Zhu, N., Luo, F., Xu, Y., Fang, X."Targeted inhibition of endoplasmic reticulum stress: New hope for renal fibrosis (Review)". Molecular Medicine Reports 16.2 (2017): 1014-1020.
Chicago
Ke, B., Zhu, N., Luo, F., Xu, Y., Fang, X."Targeted inhibition of endoplasmic reticulum stress: New hope for renal fibrosis (Review)". Molecular Medicine Reports 16, no. 2 (2017): 1014-1020. https://doi.org/10.3892/mmr.2017.6762