Open Access

BMP‑7 suppresses excessive scar formation by activating the BMP‑7/Smad1/5/8 signaling pathway

  • Authors:
    • Jingdong Guo
    • Quan Lin
    • Ying Shao
    • Li Rong
    • Duo Zhang
  • View Affiliations

  • Published online on: June 14, 2017     https://doi.org/10.3892/mmr.2017.6779
  • Pages: 1957-1963
  • Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Scarring is the inevitable consequence of wound repair, which may cause significant physical and mental pain to patients when excessive. Bone morphogenetic protein‑7 (BMP‑7) has been proved to inhibit TGF‑β‑induced fibrosis in various tissues including dermal papilla cells. However, the effect of BMP‑7 on hypertrophic scarring, a common proliferative disorder of dermal fibroblasts, has not been determined. To overcome this problem, the present study established a mouse model of thermal injury to investigate the inhibitory effects of BMP‑7 on scar formation. The histological analysis of scar tissues was performed by H&E and Masson's trichrome staining. Western blot assay was used to determine the level changes of related proteins and TUNEL assay was performed to assess the apoptosis of scar tissues. The results demonstrated that BMP‑7 promoted wound healing and inhibited scar formation when compared with untreated mice. Collagen deposition and the expression of fibrotic proteins were suppressed in the scar tissues of mice treated with BMP‑7. In addition, BMP‑7 induced fibroblast apoptosis in scar tissues. Furthermore, activation of the BMP‑7/Smad1/5/8 signaling pathway may have been involved in the inhibitory effects of BMP‑7 on scar formation. In conclusion, the results of the present study indicate that BMP‑7 may inhibit excessive scar formation via activation of the BMP‑7/Smad1/5/8 signaling pathway. The results present a potential alternative therapeutic strategy for the treatment of hypertrophic scarring.
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August-2017
Volume 16 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Guo J, Lin Q, Shao Y, Rong L and Zhang D: BMP‑7 suppresses excessive scar formation by activating the BMP‑7/Smad1/5/8 signaling pathway. Mol Med Rep 16: 1957-1963, 2017.
APA
Guo, J., Lin, Q., Shao, Y., Rong, L., & Zhang, D. (2017). BMP‑7 suppresses excessive scar formation by activating the BMP‑7/Smad1/5/8 signaling pathway. Molecular Medicine Reports, 16, 1957-1963. https://doi.org/10.3892/mmr.2017.6779
MLA
Guo, J., Lin, Q., Shao, Y., Rong, L., Zhang, D."BMP‑7 suppresses excessive scar formation by activating the BMP‑7/Smad1/5/8 signaling pathway". Molecular Medicine Reports 16.2 (2017): 1957-1963.
Chicago
Guo, J., Lin, Q., Shao, Y., Rong, L., Zhang, D."BMP‑7 suppresses excessive scar formation by activating the BMP‑7/Smad1/5/8 signaling pathway". Molecular Medicine Reports 16, no. 2 (2017): 1957-1963. https://doi.org/10.3892/mmr.2017.6779