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Article Open Access

Renal denervation attenuates cardiac hypertrophy in spontaneously hypertensive rats via regulation of autophagy

Retraction in: /10.3892/mmr.2025.13663
  • Authors:
    • Jionghua Huang
    • He Huang
    • Wei Pan
    • Dejin Ou
    • Wenjun Dai
    • Yuhui Lin
    • Jinlei Wu
    • Wenjie Xie
    • Ximing Chen
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China, Department of Cardiology, The First Affiliated Hospital of Gannan Medical College, Ganzhou, Jiangxi 341000, P.R. China, Department of Cardiology, Nanhai Hospital Affiliated to Southern Medical University, Foshan, Guangdong 528200, P.R. China, Department of Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2023-2029
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    Published online on: June 15, 2017
       https://doi.org/10.3892/mmr.2017.6790
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Abstract

It has been suggested that renal denervation (RD) may attenuate left ventricular (LV) hypertrophy. However, the role that autophagy serves in this process is currently unclear. In the present study, utilizing a model of hypertension‑induced cardiac hypertrophy in spontaneous hypertensive rats, it was demonstrated that RD was significantly associated with a reduction in LV hypertrophy. Furthermore, a decrease in the myocardial mRNA of hypertrophy‑associated genes was demonstrated in RD rats compared with sham controls. In addition, RD in hypertension‑induced LV hypertrophy rats was associated with the attenuation of cellular autophagic response over activation at a physiological level. This was indicated by a reduction in the expression of Beclin‑1, autophagy related 9A and microtubule‑associated protein 1A/1B-light chain 3 II/I in RD rats to physiological levels that are observed in control rats. Furthermore, the number of autophagosomes was restored to physiological levels in the cardiomyocytes of RD rats. The results of the current study suggest that RD may attenuate LV hypertrophy via the regulation of autophagic responses.
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Copy and paste a formatted citation
Spandidos Publications style
Huang J, Huang H, Pan W, Ou D, Dai W, Lin Y, Wu J, Xie W and Chen X: Renal denervation attenuates cardiac hypertrophy in spontaneously hypertensive rats via regulation of autophagy Retraction in /10.3892/mmr.2025.13663. Mol Med Rep 16: 2023-2029, 2017.
APA
Huang, J., Huang, H., Pan, W., Ou, D., Dai, W., Lin, Y. ... Chen, X. (2017). Renal denervation attenuates cardiac hypertrophy in spontaneously hypertensive rats via regulation of autophagy Retraction in /10.3892/mmr.2025.13663. Molecular Medicine Reports, 16, 2023-2029. https://doi.org/10.3892/mmr.2017.6790
MLA
Huang, J., Huang, H., Pan, W., Ou, D., Dai, W., Lin, Y., Wu, J., Xie, W., Chen, X."Renal denervation attenuates cardiac hypertrophy in spontaneously hypertensive rats via regulation of autophagy Retraction in /10.3892/mmr.2025.13663". Molecular Medicine Reports 16.2 (2017): 2023-2029.
Chicago
Huang, J., Huang, H., Pan, W., Ou, D., Dai, W., Lin, Y., Wu, J., Xie, W., Chen, X."Renal denervation attenuates cardiac hypertrophy in spontaneously hypertensive rats via regulation of autophagy Retraction in /10.3892/mmr.2025.13663". Molecular Medicine Reports 16, no. 2 (2017): 2023-2029. https://doi.org/10.3892/mmr.2017.6790
Copy and paste a formatted citation
x
Spandidos Publications style
Huang J, Huang H, Pan W, Ou D, Dai W, Lin Y, Wu J, Xie W and Chen X: Renal denervation attenuates cardiac hypertrophy in spontaneously hypertensive rats via regulation of autophagy Retraction in /10.3892/mmr.2025.13663. Mol Med Rep 16: 2023-2029, 2017.
APA
Huang, J., Huang, H., Pan, W., Ou, D., Dai, W., Lin, Y. ... Chen, X. (2017). Renal denervation attenuates cardiac hypertrophy in spontaneously hypertensive rats via regulation of autophagy Retraction in /10.3892/mmr.2025.13663. Molecular Medicine Reports, 16, 2023-2029. https://doi.org/10.3892/mmr.2017.6790
MLA
Huang, J., Huang, H., Pan, W., Ou, D., Dai, W., Lin, Y., Wu, J., Xie, W., Chen, X."Renal denervation attenuates cardiac hypertrophy in spontaneously hypertensive rats via regulation of autophagy Retraction in /10.3892/mmr.2025.13663". Molecular Medicine Reports 16.2 (2017): 2023-2029.
Chicago
Huang, J., Huang, H., Pan, W., Ou, D., Dai, W., Lin, Y., Wu, J., Xie, W., Chen, X."Renal denervation attenuates cardiac hypertrophy in spontaneously hypertensive rats via regulation of autophagy Retraction in /10.3892/mmr.2025.13663". Molecular Medicine Reports 16, no. 2 (2017): 2023-2029. https://doi.org/10.3892/mmr.2017.6790
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