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Article

Scutellaria baicalensis Georgi induces caspase-dependent apoptosis via mitogen activated protein kinase activation and the generation of reactive oxygen species signaling pathways in MCF-7 breast cancer cells

  • Authors:
    • Jin Ryeong Park
    • Min Cheol Lee
    • Seong‑Cheol Moon
    • Junghoon Kim
    • Ki‑Tae Ha
    • Eun Jung Park
    • Chansik Hong
    • Byoung‑Do Seo
    • Byung Joo Kim
  • View Affiliations / Copyright

    Affiliations: Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, Yangsan 50612, Republic of Korea, Healthy Aging Korean Medical Research Center, Pusan National University School of Korean Medicine, Yangsan 50612, Republic of Korea, Department of Physiology, Seoul National University College of Medicine, Seoul 110‑799, Republic of Korea, Department of Physiology, Chosun University College of Medicine, Gwangju 61452, Republic of Korea, Department of Physical Therapy, Kyungwoon University College of Health, Gumi 730‑739, Republic of Korea
  • Pages: 2302-2308
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    Published online on: June 16, 2017
       https://doi.org/10.3892/mmr.2017.6798
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Abstract

Scutellaria baicalensis Georgi extract (SBGE) is used in traditional herbal medicine and has also been used clinically to ameliorate the symptoms of various inflammatory diseases and cancer. In women, breast cancer is one of the most common diseases and numerous women succumb to it. The present study was undertaken to investigate the mechanism responsible for the SBGE‑induced apoptosis of MCF‑7 human breast cancer cells. SBGE was administered to cells at concentrations between 100 and 500 mg/ml, and cell viabilities were identified using an MTT assay. B‑cell lymphoma 2 (Bcl-2) and Bcl-2 X‑associated protein (Bax) family members were identified by western blotting, and the mRNA expression levels of the pro‑apoptosis genes Fas, Fas ligand (FasL) and tumor necrosis factor (TNF)‑α were assessed by reverse transcription‑polymerase chain reaction. It was identified that SBGE treatment for 24 h inhibited MCF‑7 proliferation and increased the sub‑G1 phase ratio. SBGE suppressed mitochondrial membrane potentials and SBGE‑induced apoptotic cell death was identified to be associated with downregulation of Bcl‑2, but upregulation of Bax. SBGE‑activated caspases 3 and 9, and increased reactive oxygen species generation. However, SBGE had no effect on the expression levels of Fas, FasL or TNF‑α. Furthermore, mitogen‑activated protein kinase and C‑Jun N‑terminal kinase inhibitors inhibited SBGE‑induced cell death. These results suggested that SBGE be considered as an agent for the treatment of breast cancer.
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View References

1 

Weigelt B, Peterse JL and van't Veer LJ: Breast cancer metastasis: Markers and models. Nat Rev Cancer. 5:591–602. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Van Pham P: Breast Cancer Stem Cells & Therapy Resistance. Springer; Berlin, Germany: 2015, View Article : Google Scholar

3 

Stewart B and Wild C: World Cancer Report 2014International Agency for Research on Cancer. World Health Organization; Geneva, Switzerland: 2014, View Article : Google Scholar

4 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Bartsch R, Wenzel C and Steger GG: Trastuzumab in the management of early and advanced stage breast cancer. Biologics. 1:19–31. 2007.PubMed/NCBI

6 

Vici P, Colucci G, Gebbia V, Amodio A, Giotta F, Belli F, Conti F, Gebbia N, Pezzella G, Valerio MR, et al: First-line treatment with epirubicin and vinorelbine in metastatic breast cancer. J Clin Oncol. 20:2689–2694. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Li W, Li C, Zheng H, Chen G and Hua B: Therapeutic targets of traditional Chinese medicine for colorectal cancer. J Tradit Chin Med. 36:243–249. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Li HL: Research progress of Scutellaria baicalensis. Chem Eng Equip. 4:100–102. 2008.

9 

Zhang L, Ravipati AS, Koyyalamudi SR, Jeong SC, Reddy N, Smith PT, Bartlett J, Shanmugam K, Münch G and Wu MJ: Antioxidant and anti-inflammatory activities of selected medicinal plants containing phenolic and flavonoid compounds. J Agric Food Chem. 59:12361–12367. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Kim HP, Son KH, Chang HW and Kang SS: Anti-inflammatory plant flavonoids and cellular action mechanisms. J Pharmacol Sci. 96:229–245. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Choi EO, Park C, Hwang HJ, Hong SH, Kim GY, Cho EJ, Kim WJ and Choi YH: Baicalein induces apoptosis via ROS-dependent activation of caspases in human bladder cancer 5637 cells. Int J Oncol. 49:1009–1018. 2016.PubMed/NCBI

12 

Choi EO, Cho EJ, Jeong JW, Park C, Hong SH, Hwang HJ, Moon SK, Son CG, Kim WJ and Choi YH: Baicalein inhibits the migration and invasion of B16F10 mouse melanoma cells through inactivation of the PI3K/Akt signaling pathway. Biomol Ther (Seoul). 25:2013–221. 2017. View Article : Google Scholar

13 

Yan H, Xin S, Wang H, Ma J, Zhang H and Wei H: Baicalein inhibits MMP-2 expression in human ovarian cancer cells by suppressing the p38 MAPK-dependent NF-κB signaling pathway. Anticancer Drugs. 26:649–656. 2015.PubMed/NCBI

14 

Chung H, Choi HS, Seo EK, Kang DH and Oh ES: Baicalin and baicalein inhibit transforming growth factor-β1-mediated epithelial-mesenchymal transition in human breast epithelial cells. Biochem Biophys Res Commun. 458:707–713. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Kim SD, Lee YJ, Baik JS, Han JY, Lee CG, Heo K, Park YS, Kim JS, Ji HD, Park SI, et al: Baicalein inhibits agonist- and tumor cell-induced platelet aggregation while suppressing pulmonary tumor metastasis via cAMP-mediated VASP phosphorylation along with impaired MAPKs and PI3K-Akt activation. Biochem Pharmacol. 92:251–265. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Elmore S: Apoptosis: A review of programmed cell death. Toxicol Pathol. 35:495–516. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Saraste A and Pulkki K: Morphologic and biochemical hallmarks of apoptosis. Cardiovasc Res. 45:528–537. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Wong RS: Apoptosis in cancer: From pathogenesis to treatment. J Exp Clin Cancer Res. 30:872011. View Article : Google Scholar : PubMed/NCBI

19 

Kuno T, Tsukamoto T, Hara A and Tanaka T: Cancer chemoprevention through the induction of apoptosis by natural compounds. J Biophys Chem. 3:156–173. 2012. View Article : Google Scholar

20 

Nicoletti I, Migliorati G, Pagliacci MC, Grignani F and Riccardi C: A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods. 139:271–279. 1991. View Article : Google Scholar : PubMed/NCBI

21 

Wang BJ, Won SJ, Yu ZR and Su CL: Free radical scavenging and apoptotic effects of cordycepin sinensis ractionated by supercritical carbon dioxide. Food Chem Toxicol. 43:543–552. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Gaire BP, Moon SK and Kim H: Scutellaria baicalensis in stroke management: Nature's blessing in traditional Eastern medicine. Chin J Integr Med. 20:712–720. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Chen WP, Xiong Y, Hu PF, Bao JP and Wu LD: Baicalein inhibits MMPs expression via a MAPK-dependent mechanism in chondrocytes. Cell Physiol Biochem. 36:325–333. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Li C, Lin G and Zuo Z: Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones. Biopharm Drug Dispos. 32:427–445. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Lee HZ, Leung HW, Lai MY and Wu CH: Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells. Anticancer Res. 25:959–964. 2005.PubMed/NCBI

26 

Kim SJ, Kim HJ, Kim HR, Lee SH, Cho SD, Choi CS, Nam JS and Jung JY: Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells. Mol Med Rep. 6:1443–1449. 2012.PubMed/NCBI

27 

Li HL, Zhang S, Wang Y, Liang RR, Li J, An P, Wang ZM, Yang J and Li ZF: Baicalein induces apoptosis via a mitochondrial-dependent caspase activation pathway in T24 bladder cancer cells. Mol Med Rep. 7:266–270. 2013.PubMed/NCBI

28 

Wang Z, Jiang C, Chen W, Zhang G, Luo D, Cao Y, Wu J, Ding Y and Liu B: Baicalein induces apoptosis and autophagy via endoplasmic reticulum stress in hepatocellular carcinoma cells. Biomed Res Int. 2014:7325162014.PubMed/NCBI

29 

Liu-Smith F and Meyskens FL: Molecular mechanisms of flavonoids in melanin synthesis and the potential for the prevention and treatment of melanoma. Mol Nutr Food Res. 60:1264–1274. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Mu J, Liu T, Jiang L, Wu X, Cao Y, Li M, Dong Q, Liu Y and Xu H: The traditional Chinese medicine baicalein potently inhibits gastric cancer cells. J Cancer. 7:453–461. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Thompson CB: Apoptosis in the pathogenesis and treatment of disease. Science. 267:1456–1462. 1995. View Article : Google Scholar : PubMed/NCBI

32 

Adams JM and Cory S: The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene. 26:1324–1337. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Wajant H: The Fas signaling pathway: More than a paradigm. Science. 296:1635–1636. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Cory S and Adams JM: The Bcl2 family: Regulators of the cellular life-or-death switch. Nat Rev Cancer. 2:647–656. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Moldoveanu T, Liu Q, Tocilj A, Watson M, Shore G and Gehring K: The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site. Mol Cell. 24:677–688. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Suzuki M, Youle RJ and Tjandra N: Structure of Bax: Coregulation of dimer formation and intracellular localization. Cell. 103:645–654. 2000. View Article : Google Scholar : PubMed/NCBI

37 

Green SR and Reed JC: Mitochondria and apoptosis. Science. 281:1309–1312. 1998. View Article : Google Scholar : PubMed/NCBI

38 

Jeong SY and Seol DW: The role of mitochondria in apoptosis. BMB Rep. 41:11–22. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Spierings D, McStay G, Saleh M, Bender C, Chipuk J, Maurer U and Green DR: Connected to death: The (unexpurgated) mitochondrial pathway of apoptosis. Science. 310:66–67. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Earnshaw WC, Martins LM and Kaufmann SH: Mammalian caspases: Structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem. 68:383–424. 1999. View Article : Google Scholar : PubMed/NCBI

41 

Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, Clark L, Bayani N, Coppe JP, Tong F, et al: A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell. 10:515–527. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Kim HJ, Wie J, So I, Jung MH, Ha KT and Kim BJ: Menthol modulates pacemaker potentials through TRPA1 channels in cultured interstitial cells of cajal from murine small intestine. Cell Physiol Biochem. 38:1869–1882. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Kim BJ, Lee GS and Kim HW: Involvement of transient receptor potential melastatin type 7 channels on Poncirus fructus-induced depolarizations of pacemaking activity in interstitial cells of Cajal from murine small intestine. Integr Med Res. 2:62–69. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Guilbert A, Gautier M, Dhennin-Duthille I, Haren N, Sevestre H and Ouadid-Ahidouch H: Evidence that TRPM7 is required for breast cancer cell proliferation. Am J Physiol Cell Physiol. 297:C493–C502. 2009. View Article : Google Scholar : PubMed/NCBI

45 

Dhillon AS, Hagan S, Rath O and Kolch W: MAP kinase signalling pathways in cancer. Oncogene. 26:3279–3290. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Boutros T, Chevet E and Metrakos P: Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: Roles in cell growth, death, and cancer. Pharmacol Rev. 60:261–310. 2008. View Article : Google Scholar : PubMed/NCBI

47 

Sebolt-Leopold JS: Development of anticancer drugs targeting the MAP kinase pathway. Oncogene. 19:6594–6599. 2000. View Article : Google Scholar : PubMed/NCBI

48 

Chakraborti S, Mandal M, Das S, Mandal A and Chakraborti T: Regulation of matrix metalloproteinases: an overview. Mol Cell Biochem. 253:269–285. 2003. View Article : Google Scholar : PubMed/NCBI

49 

Kim EK and Choi EJ: Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta. 1802:396–405. 2010. View Article : Google Scholar : PubMed/NCBI

50 

Cheng YL, Chang WL, Lee SC, Liu YG, Lin HC, Chen CJ, Yen CY, Yu DS, Lin SZ and Harn HJ: Acetone extract of Bupleurum scorzonerifolium inhibits proliferation of A549 human lung cancer cells via inducing apoptosis and suppressing telomerase activity. Life Sci. 73:2383–2394. 2003. View Article : Google Scholar : PubMed/NCBI

51 

Wartenberg M, Budde P, de Mareés M, Grünheck F, Tsang SY, Huang Y, Chen ZY, Hescheler J and Sauer H: Inhibition of tumor-induced angiogenesis and matrix-metalloproteinase expression in confrontation cultures of embryoid bodies and tumor spheroids by plant ingredients used in traditional chinese medicine. Lab Invest. 83:87–98. 2003. View Article : Google Scholar : PubMed/NCBI

52 

Ruan WJ, Lai MD and Zhou JG: Anticancer effects of Chinese herbal medicine, science or myth? J Zhejiang Univ Sci B. 7:1006–1014. 2006. View Article : Google Scholar : PubMed/NCBI

53 

Mabed M, El-Helw L and Shamaa S: Phase II study of viscum fraxini-2 in patients with advanced hepatocellular carcinoma. Br J Cancer. 90:65–69. 2004. View Article : Google Scholar : PubMed/NCBI

54 

Shen ZX, Shi ZZ, Fang J, Gu BW, Li JM, Zhu YM, Shi JY, Zheng PZ, Yan H, Liu YF, et al: All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. Proc Natl Acad Sci USA. 101:5328–5335. 2004. View Article : Google Scholar : PubMed/NCBI

55 

Piao BK, Wang YX, Xie GR, Mansmann U, Matthes H, Beuth J and Lin HS: Impact of complementary mistletoe extract treatment on quality of life in breast, ovarian and non-small cell lung cancer patients. A prospective randomized controlled clinical trial. Anticancer Res. 24:303–309. 2004.PubMed/NCBI

56 

Yan X, Shen H, Jiang H, Hu D, Zhang C, Wang J and Wu X: External Qi of Yan Xin Qigong Induces apoptosis and inhibits migration and invasion of estrogen-independent breast cancer cells through suppression of Akt/NF-kB signaling. Cell Physiol Biochem. 25:263–270. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Park JR, Lee MC, Moon SC, Kim J, Ha KT, Park EJ, Hong C, Seo BD and Kim BJ: Scutellaria baicalensis Georgi induces caspase-dependent apoptosis via mitogen activated protein kinase activation and the generation of reactive oxygen species signaling pathways in MCF-7 breast cancer cells. Mol Med Rep 16: 2302-2308, 2017.
APA
Park, J.R., Lee, M.C., Moon, S., Kim, J., Ha, K., Park, E.J. ... Kim, B.J. (2017). Scutellaria baicalensis Georgi induces caspase-dependent apoptosis via mitogen activated protein kinase activation and the generation of reactive oxygen species signaling pathways in MCF-7 breast cancer cells. Molecular Medicine Reports, 16, 2302-2308. https://doi.org/10.3892/mmr.2017.6798
MLA
Park, J. R., Lee, M. C., Moon, S., Kim, J., Ha, K., Park, E. J., Hong, C., Seo, B., Kim, B. J."Scutellaria baicalensis Georgi induces caspase-dependent apoptosis via mitogen activated protein kinase activation and the generation of reactive oxygen species signaling pathways in MCF-7 breast cancer cells". Molecular Medicine Reports 16.2 (2017): 2302-2308.
Chicago
Park, J. R., Lee, M. C., Moon, S., Kim, J., Ha, K., Park, E. J., Hong, C., Seo, B., Kim, B. J."Scutellaria baicalensis Georgi induces caspase-dependent apoptosis via mitogen activated protein kinase activation and the generation of reactive oxygen species signaling pathways in MCF-7 breast cancer cells". Molecular Medicine Reports 16, no. 2 (2017): 2302-2308. https://doi.org/10.3892/mmr.2017.6798
Copy and paste a formatted citation
x
Spandidos Publications style
Park JR, Lee MC, Moon SC, Kim J, Ha KT, Park EJ, Hong C, Seo BD and Kim BJ: Scutellaria baicalensis Georgi induces caspase-dependent apoptosis via mitogen activated protein kinase activation and the generation of reactive oxygen species signaling pathways in MCF-7 breast cancer cells. Mol Med Rep 16: 2302-2308, 2017.
APA
Park, J.R., Lee, M.C., Moon, S., Kim, J., Ha, K., Park, E.J. ... Kim, B.J. (2017). Scutellaria baicalensis Georgi induces caspase-dependent apoptosis via mitogen activated protein kinase activation and the generation of reactive oxygen species signaling pathways in MCF-7 breast cancer cells. Molecular Medicine Reports, 16, 2302-2308. https://doi.org/10.3892/mmr.2017.6798
MLA
Park, J. R., Lee, M. C., Moon, S., Kim, J., Ha, K., Park, E. J., Hong, C., Seo, B., Kim, B. J."Scutellaria baicalensis Georgi induces caspase-dependent apoptosis via mitogen activated protein kinase activation and the generation of reactive oxygen species signaling pathways in MCF-7 breast cancer cells". Molecular Medicine Reports 16.2 (2017): 2302-2308.
Chicago
Park, J. R., Lee, M. C., Moon, S., Kim, J., Ha, K., Park, E. J., Hong, C., Seo, B., Kim, B. J."Scutellaria baicalensis Georgi induces caspase-dependent apoptosis via mitogen activated protein kinase activation and the generation of reactive oxygen species signaling pathways in MCF-7 breast cancer cells". Molecular Medicine Reports 16, no. 2 (2017): 2302-2308. https://doi.org/10.3892/mmr.2017.6798
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