Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters

  • Authors:
    • Chungang Liu
    • Juan Wang
    • Shiqi Xu
    • Shengshu An
    • Siying Tang
    • Jian He
    • Yang Liu
    • Robert J. Lee
    • Di Wang
  • View Affiliations

  • Published online on: June 20, 2017     https://doi.org/10.3892/mmr.2017.6807
  • Pages: 2172-2178
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Abstract

The medicinal fungus Paecilomyces tenuipes exhibits a variety of pharmacological effects, including antidepressive effects. The chronic unpredictable mild stress (CUMS)‑induced rat model has served an important role in studies involving antidepressants screening. The aim of the present study was to evaluate the antidepressant‑like activity of P. tenuipes N45 aqueous extract (PTNE) in a CUMS‑induced rat model of behavioral despair depression. Following 4 weeks of PTNE treatment, behavioral tests were conducted to investigate the antidepressant‑like activities, and the levels of neurotransmitters and hormones in blood and hypothalamus were measured. The results demonstrated that PTNE treatment significantly increased movement in the forced running test, whereas the immobility time was reduced in the hotplate test and the forced swim test in depression‑model rats. PTNE treatment was able to normalize the levels of hormones and neurotransmitters in serum and hypothalamus of CUMS rats. The data demonstrated that PTNE treatment may be a potential pharmaceutical agent in treatment‑resistant depression, and the effects of PTNE may be partly mediated through normalizing the levels of neurotransmitters.
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August-2017
Volume 16 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Liu C, Wang J, Xu S, An S, Tang S, He J, Liu Y, Lee RJ and Wang D: Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters. Mol Med Rep 16: 2172-2178, 2017.
APA
Liu, C., Wang, J., Xu, S., An, S., Tang, S., He, J. ... Wang, D. (2017). Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters. Molecular Medicine Reports, 16, 2172-2178. https://doi.org/10.3892/mmr.2017.6807
MLA
Liu, C., Wang, J., Xu, S., An, S., Tang, S., He, J., Liu, Y., Lee, R. J., Wang, D."Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters". Molecular Medicine Reports 16.2 (2017): 2172-2178.
Chicago
Liu, C., Wang, J., Xu, S., An, S., Tang, S., He, J., Liu, Y., Lee, R. J., Wang, D."Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters". Molecular Medicine Reports 16, no. 2 (2017): 2172-2178. https://doi.org/10.3892/mmr.2017.6807