Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
August-2017 Volume 16 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2017 Volume 16 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Degradation and removal of soybean allergen in Japanese soy sauce

  • Authors:
    • Norihiro Magishi
    • Naoya Yuikawa
    • Makio Kobayashi
    • Shoichiro Taniuchi
  • View Affiliations / Copyright

    Affiliations: Research Laboratory, Higashimaru Shoyu Co., Ltd., Tatsuno, Hyogo 679‑4167, Japan, Department of Pediatrics, Takatsuki General Hospital, Takatsuki, Osaka 569-1192, Japan
  • Pages: 2264-2268
    |
    Published online on: June 20, 2017
       https://doi.org/10.3892/mmr.2017.6815
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Soy sauce is a traditional fermented seasoning of Japan and is available throughout the world. The two main raw ingredients of soy sauce are soybean and wheat, both of which are established food allergens. The present study examined the degradation and removal of soybean allergens in soy sauce by immunoblotting with anti‑soybean protein antibody from rabbit and sera from two children with soybean allergy. It was demonstrated that soybean allergens were gradually degraded during the fermentation process, but were not completely degraded in raw soy sauce. During the processes of heat‑treatment and filtration, the soluble soybean allergens in raw soy sauce were denatured to insoluble allergens by heat‑treatment and subsequently completely removed from soy sauce by filtration. Therefore, to reduce the allergenicity of soy sauce, heat‑treatment and filtration are very important processes in addition to the enzymatic degradation during the fermentation of soy sauce.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Ogawa T, Bando N, Tsuji H and Sasaoka K, Nishikawa K and Sasaoka K: Investigation of the IgE-binding proteins in soybeans by immunoblotting with the sera of the soybean-sensitive patients with atopic dermatitis. J Nutr Sci Vitaminol (Tokyo). 37:555–565. 1991. View Article : Google Scholar : PubMed/NCBI

2 

Ogawa T, Bando N, Tsuji H, Nishikawa K and Kitamura K: Alpha-subunit of beta-conglycinin, an allergenic protein recognized by IgE antibodies of soybean-sensitive patients with atopic dermatitis. Biosci Biotechnol Biochem. 59:831–833. 1995. View Article : Google Scholar : PubMed/NCBI

3 

Krishnan HB, Kim WS, Jang S and Kerley MS: All three subunits of soybean beta-conglycinin are potential food allergens. J Agri Food Chem. 57:938–943. 2009. View Article : Google Scholar

4 

Adachi A, Horikawa T, Shimizu H, Sarayama Y, Ogawa T, Sjolander S, Tanaka A and Moriyama T: Soybean beta-conglycinin as the main allergen in a patient with food-dependent exercise-induced anaphylaxis by tofu: Food processing alter pepsin resistance. Clin Exp Allergy. 39:167–173. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Ogawa T, Tsuji H, Bando N, Kitamura K, Zhu YI, Hirano H and Nishikawa K: Identification of the soybean allergenic protein, Gly m Bd 30K, with the soybean seed 34-kDa oil-body-associated protein. Biosci Biotechnol Biochem. 57:1030–1033. 1993. View Article : Google Scholar : PubMed/NCBI

6 

Tsuji H, Bando N, Hiemori M, Yamanishi R, Kimoto M, Nishikawa K and Ogawa T: Purification of characterization of soybean allergen Gly m Bd 28K. Biosci Biotechnol Biochem. 61:942–947. 1997. View Article : Google Scholar : PubMed/NCBI

7 

Tsuji H, Hiemori M, Kimoto M, Yamashita H, Kobatake R, Adachi M, Fukuda T, Bando N, Okita M and Utsumi S: Cloning of cDNA encoding a soybean allergen, Gly m Bd 28K. Biochim Biophys Acta. 1518:178–182. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Kleine-Tebbe J, Vogel L, Crowell DN, Haustein UF and Vieths S: Severe oral allergy syndrome and anaphylactic reactions caused by a Bet v 1- related PR-10 protein in soybean, SAM2. J Allergy Clin Immunol. 110:797–804. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Morisset M, Moneret-Vautrin DA, Kanny G, Guénard L, Beaudouin E, Flabbée J and Hatahet R: Thresholds of clinical reactivity to milk, egg, peanut and sesame in immunoglobulin E-dependent allergies: Evaluation by double-blind or single-blind placebo-controlled oral challenges. Clin Exp Allergy. 33:1046–1051. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Chen JC, Lin RH, Huang HC and Tzen JT: Cloning, expression and isoform classification of a minor oleosin in sesame oil bodies. J Biochem. 122:819–824. 1997. View Article : Google Scholar : PubMed/NCBI

11 

Leduc V, Moneret-Vautrin DA, Tzen JT, Morisset M, Guerin L and Kanny G: Identification of oleosins as major allergens in sesame seed allergic patients. Allergy. 61:349–356. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Pons L, Olszewski A and Guéant JL: Characterization of the oligomeric behavior of a 16.5 kDa peanut oleosin by chromatography and electrophoresis of the iodinated form. J Chromatogr B Biomed Sci Appl. 706:131–140. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Huang AHC: Oil bodies and oleosins in seeds. Ann Rev Plant Physiol Plant Mol Biol. 43:177–200. 1992. View Article : Google Scholar

14 

Pons L, Chery C, Romano A, Namour F, Artesani MC and Guéant JL: The 18 kDa peanut oleosin is a candidate allergen for IgE-mediated reactions to peanuts. Allergy. 57 Suppl 72:S88–S93. 2002. View Article : Google Scholar

15 

Yokotsuka T: Soy sauce biochemistry. Adv Food Res. 30:195–329. 1986. View Article : Google Scholar : PubMed/NCBI

16 

Kobayashi M and Hayashi S: Modeling combined effects of temperature and pH on growth of Zygosaccharomyces rouxii in soy sauce mash. J Ferment Bioeng. 85:638–641. 1998. View Article : Google Scholar

17 

Kobayashi M and Hayashi S: Supplementation of NaCl to starter culture of the soy yeast Zygosaccharomyces rouxii. J Ferment Bioeng. 85:642–644. 1998. View Article : Google Scholar

18 

Nagai H, Kobayashi M, Tsuji Y, Nakashimada Y, Kakizono T and Nishio N: Biological and chemical treatment of solid waste from soy sauce manufacture. Water Sci Technol. 45:335–338. 2002.PubMed/NCBI

19 

Kobayashi M, Hashimoto Y, Taniuchi S and Tanabe S: Degradation of wheat allergen in Japanese soy sauce. Int J Mol Med. 13:821–827. 2004.PubMed/NCBI

20 

Tsuji H, Okada N, Yamanishi R, Bando N, Kimoto M and Ogawa T: Measurement of Gly m Bd 30K, a major soybean allergen, in soybean products by a sandwich enzyme-linked immunosorbent assay. Biosci Biotechnol Biochem. 59:150–151. 1995. View Article : Google Scholar : PubMed/NCBI

21 

Ogawa T, Samoto M and Takahashi K: Soybean allergens and hypoallergenic soybean products. J Nutr Sci Vitaminol (Tokyo). 46:271–279. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Bando N, Tsuji H, Hiemori M, Yoshimizu K, Yamanishi R, Kimoto M and Ogawa T: Quantitative analysis of Gly m Bd 28K in soybean products by a sandwich enzyme-linked immunosorbent assay. J Nutr Sci Vitaminol (Tokyo). 44:655–664. 1998. View Article : Google Scholar : PubMed/NCBI

23 

Kobayashi M, Matsushita H, Yoshida K, Tsukiyama R, Sugimura T and Yamamoto K: In vitro and in vivo anti-allergic activity of soy sauce. Int J Mol Med. 14:879–884. 2004.PubMed/NCBI

24 

Kobayashi M, Matsushita H, Shioya I, Nagai M, Tsukiyama R, Saito M, Sugita T, Sugimura T and Yamamoto K: Quality of life improvement with soy sauce ingredients, shoyu polysaccharides, in perennial allergic rhinitis: A double-blind placebo-controlled clinical study. Int J Mol Med. 14:885–889. 2004.PubMed/NCBI

25 

Kobayashi M, Matsushita H, Tsukiyama R, Saito M and Sugita T: Shoyu polysaccharides from soy sauce improve quality of life for patients with seasonal allergic rhinitis: A double-blind placebo-controlled clinical study. Int J Mol Med. 15:463–467. 2005.PubMed/NCBI

26 

Matsushita H, Kobayashi M, Tsukiyama R and Yamamoto K: In vitro and in vivo immunomodulating activities of Shoyu polysaccharides from soy sauce. Int J Mol Med. 17:905–909. 2006.PubMed/NCBI

27 

Kobayashi M, Nagatani Y, Magishi N, Tokuriki N, Nakata Y, Tsukiyama R, Imai H, Suzuki M, Saito M and Tsuji K: Promotive effect of Shoyu polysaccharides from soy sauce on iron absorption in animals and humans. Int J Mol Med. 18:1159–1163. 2006.PubMed/NCBI

28 

Kobayashi M, Magishi N, Matsushita H, Hashimoto T, Fujimoto M, Suzuki M, Tsuji K, Saito M, Inoue E, Yoshikawa Y and Matsuura T: Hypolimidemic effect of Shoyu polysaccharides from soy sauce in animals and humans. Int J Mol Med. 22:565–570. 2008.PubMed/NCBI

29 

Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:680–685. 1970. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Magishi N, Yuikawa N, Kobayashi M and Taniuchi S: Degradation and removal of soybean allergen in Japanese soy sauce. Mol Med Rep 16: 2264-2268, 2017.
APA
Magishi, N., Yuikawa, N., Kobayashi, M., & Taniuchi, S. (2017). Degradation and removal of soybean allergen in Japanese soy sauce. Molecular Medicine Reports, 16, 2264-2268. https://doi.org/10.3892/mmr.2017.6815
MLA
Magishi, N., Yuikawa, N., Kobayashi, M., Taniuchi, S."Degradation and removal of soybean allergen in Japanese soy sauce". Molecular Medicine Reports 16.2 (2017): 2264-2268.
Chicago
Magishi, N., Yuikawa, N., Kobayashi, M., Taniuchi, S."Degradation and removal of soybean allergen in Japanese soy sauce". Molecular Medicine Reports 16, no. 2 (2017): 2264-2268. https://doi.org/10.3892/mmr.2017.6815
Copy and paste a formatted citation
x
Spandidos Publications style
Magishi N, Yuikawa N, Kobayashi M and Taniuchi S: Degradation and removal of soybean allergen in Japanese soy sauce. Mol Med Rep 16: 2264-2268, 2017.
APA
Magishi, N., Yuikawa, N., Kobayashi, M., & Taniuchi, S. (2017). Degradation and removal of soybean allergen in Japanese soy sauce. Molecular Medicine Reports, 16, 2264-2268. https://doi.org/10.3892/mmr.2017.6815
MLA
Magishi, N., Yuikawa, N., Kobayashi, M., Taniuchi, S."Degradation and removal of soybean allergen in Japanese soy sauce". Molecular Medicine Reports 16.2 (2017): 2264-2268.
Chicago
Magishi, N., Yuikawa, N., Kobayashi, M., Taniuchi, S."Degradation and removal of soybean allergen in Japanese soy sauce". Molecular Medicine Reports 16, no. 2 (2017): 2264-2268. https://doi.org/10.3892/mmr.2017.6815
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team