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Article

Nifedipine stimulates proliferation and migration of different breast cancer cells by distinct pathways

  • Authors:
    • Tao Zhao
    • Dongqing Guo
    • Yuchun Gu
    • Yang Ling
  • View Affiliations / Copyright

    Affiliations: Changzhou Tumor Hospital Affiliated of Suzhou University, Changzhou, Jiangsu 213000, P.R. China, School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, P.R. China, Laboratory of Molecular Pharmacology, Institute of Molecular Medicine, Peking University, Beijing 100871, P.R. China
  • Pages: 2259-2263
    |
    Published online on: June 20, 2017
       https://doi.org/10.3892/mmr.2017.6818
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Abstract

Nifedipine is widely used to treat high blood pressure and angina. Were nifedipine able to promote the proliferation and migration of breast cancer, it would pose a significant threat for patients. Thus, it is important to determine the effects of nifedipine on breast cancer and the mechanism involved. The present study identified that nifedipine significantly promoted the proliferation and migration of breast cancer cells in vitro. The mechanism of nifedipine on different breast cancer cells was investigated and it was identified that the effects of nifedipine on MCF‑7 cells were via the protein kinase B‑endothelial constitutive nitric oxide synthase‑nitric oxide axis, and on MDA‑MB‑231 cells via activation of the extracellular signal‑regulated kinase pathway. These results identified the distinct pathways in the activation of cell proliferation and migration presented in different cell lines by nifedipine. The present study advises that nifedipine can promote breast cancer and should be avoided for women who suffer from breast cancer and hypertension.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao T, Guo D, Gu Y and Ling Y: Nifedipine stimulates proliferation and migration of different breast cancer cells by distinct pathways. Mol Med Rep 16: 2259-2263, 2017.
APA
Zhao, T., Guo, D., Gu, Y., & Ling, Y. (2017). Nifedipine stimulates proliferation and migration of different breast cancer cells by distinct pathways. Molecular Medicine Reports, 16, 2259-2263. https://doi.org/10.3892/mmr.2017.6818
MLA
Zhao, T., Guo, D., Gu, Y., Ling, Y."Nifedipine stimulates proliferation and migration of different breast cancer cells by distinct pathways". Molecular Medicine Reports 16.2 (2017): 2259-2263.
Chicago
Zhao, T., Guo, D., Gu, Y., Ling, Y."Nifedipine stimulates proliferation and migration of different breast cancer cells by distinct pathways". Molecular Medicine Reports 16, no. 2 (2017): 2259-2263. https://doi.org/10.3892/mmr.2017.6818
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao T, Guo D, Gu Y and Ling Y: Nifedipine stimulates proliferation and migration of different breast cancer cells by distinct pathways. Mol Med Rep 16: 2259-2263, 2017.
APA
Zhao, T., Guo, D., Gu, Y., & Ling, Y. (2017). Nifedipine stimulates proliferation and migration of different breast cancer cells by distinct pathways. Molecular Medicine Reports, 16, 2259-2263. https://doi.org/10.3892/mmr.2017.6818
MLA
Zhao, T., Guo, D., Gu, Y., Ling, Y."Nifedipine stimulates proliferation and migration of different breast cancer cells by distinct pathways". Molecular Medicine Reports 16.2 (2017): 2259-2263.
Chicago
Zhao, T., Guo, D., Gu, Y., Ling, Y."Nifedipine stimulates proliferation and migration of different breast cancer cells by distinct pathways". Molecular Medicine Reports 16, no. 2 (2017): 2259-2263. https://doi.org/10.3892/mmr.2017.6818
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