Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
August-2017 Volume 16 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2017 Volume 16 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Associations of common IL-4 gene polymorphisms with cancer risk: A meta-analysis

  • Authors:
    • Yingxian Jia
    • Xiaochuan Xie
    • Xiaohan Shi
    • Shangwei Li
  • View Affiliations / Copyright

    Affiliations: Division of Reproductive Medical Center, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China , Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Jia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1927-1945
    |
    Published online on: June 20, 2017
       https://doi.org/10.3892/mmr.2017.6822
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cancer incidence is dramatically increasing worldwide, therefore improved prediction and therapeutic methods are needed. Single nucleotide polymorphisms in cytokine genes may contribute to carcinogenesis. Interleukin (IL)‑4 gene polymorphisms have been intensively studied with regard to their associations with cancer. However, the results of these previous studies remain inconclusive. The present study, therefore, aimed to conduct a meta‑analysis of previously published studies in order to clarify the association of IL‑4 with cancer risk. Eligible published articles were searched in Medline, PubMed, Embase and China National Knowledge Infrastructure databases up to March 2016. Odds ratios and 95% confidence intervals were used to identify potential associations between IL‑4 genetic polymorphisms and the risk of cancer. A meta‑analysis was then performed on 10,873 patients and 14,328 controls for IL‑4 rs2243250 polymorphism, 3,970 patients and 5,686 controls for IL‑4 rs2070874 polymorphism, and 1,896 patients and 2,526 controls for IL‑4 rs79071878 polymorphism. A significant association with cancer risk was observed for rs2243250 and rs79071878 polymorphisms. In the subgroup analysis by cancer type, rs2243250 polymorphism was demonstrated to be associated with an increased risk of gastric cancer and breast cancer, rs2070874 polymorphism was correlated with leukemia and oral carcinoma, and rs79071878 polymorphism was relevant to bladder carcinoma risk. In the subgroup analysis by ethnicity, IL‑4 rs2243250 polymorphism was demonstrated to be associated with cancer risk in both Caucasian and Asian populations, rs2070874 was associated with cancer risk in Asian populations, while rs79071878 polymorphism was associated with cancer risk in Caucasian populations. In conclusion, the present results suggested that the IL‑4 rs2243250 and rs79071878 polymorphisms were associated with cancer susceptibility. Further subgroup analyses revealed that the effects of IL‑4 gene polymorphisms on cancer risk may vary by cancer type and by ethnicity.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Knox SS: From ‘omics’ to complex disease: A systems biology approach to gene-environment interactions in cancer. Cancer Cell Int. 10:112010. View Article : Google Scholar : PubMed/NCBI

3 

Jang JP, Baek IC, Choi EJ and Kim TG: Multiplex genotyping of cytokine gene SNPs using fluorescence bead array. PLoS One. 10:e01180082015. View Article : Google Scholar : PubMed/NCBI

4 

Balkwill F and Mantovani A: Inflammation and cancer: Back to Virchow? Lancet. 357:539–545. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Leibovici D, Grossman HB, Dinney CP, Millikan RE, Lerner S, Wang Y, Gu J, Dong Q and Wu X: Polymorphisms in inflammation genes and bladder cancer: From initiation to recurrence, progression, and survival. J Clin Oncol. 23:5746–5756. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Baniyash M: Chronic inflammation, immunosuppression and cancer: New insights and outlook. Semin Cancer Biol. 16:80–88. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Aggarwal BB, Vijayalekshmi RV and Sung B: Targeting inflammatory pathways for prevention and therapy of cancer: Short-term friend, long-term foe. Clin Cancer Res. 15:425–430. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Bidwell J, Keen L, Gallagher G, Kimberly R, Huizinga T, McDermott MF, Oksenberg J, McNicholl J, Pociot F, Hardt C and D'Alfonso S: Cytokine gene polymorphism in human disease: On-line databases, supplement 1. Genes Immun. 2:61–70. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Wang HW and Joyce JA: Alternative activation of tumor-associated macrophages by IL-4: Priming for protumoral functions. Cell Cycle. 9:4824–4835. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Stang A: Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 25:603–605. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Crusius JB, Canzian F, Capellá G, Peña AS, Pera G, Sala N, Agudo A, Rico F, Del Giudice G, Palli D, et al: Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). Ann Oncol. 19:1894–1902. 2008. View Article : Google Scholar : PubMed/NCBI

12 

El-Omar EM, Rabkin CS, Gammon MD, Vaughan TL, Risch HA, Schoenberg JB, Stanford JL, Mayne ST, Goedert J, Blot WJ, et al: Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology. 124:1193–1201. 2003. View Article : Google Scholar : PubMed/NCBI

13 

García-González MA, Lanas A, Quintero E, Nicolás D, Parra-Blanco A, Strunk M, Benito R, Simón M Angel, Santolaria S, Sopeña F, et al: Gastric cancer susceptibility is not linked to pro-and anti-inflammatory cytokine gene polymorphisms in whites: A Nationwide Multicenter Study in Spain. Am J Gastroenterol. 102:1878–1892. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Lai KC, Chen WC, Jeng LB, Li SY, Chou MC and Tsai FJ: Association of genetic polymorphisms of MK, IL-4, p16, p21, p53 genes and human gastric cancer in Taiwan. Eur J Surg Oncol. 31:1135–1140. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Pan XF, Wen Y, Loh M, Wen YY, Yang SJ, Zhao ZM, Tian Z, Huang H, Lan H, Chen F, et al: Interleukin-4 and −8 gene polymorphisms and risk of gastric cancer in a population in Southwestern China. Asian Pac J Cancer Prev. 15:2951–2957. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Zambon CF, Basso D, Marchet A, Fasolo M, Stranges A, Schiavon S, Navaglia F, Greco E, Fogar P, Falda A, et al: IL-4-588C>T polymorphism and IL-4 receptor alpha [Ex5+14A>G; Ex11+828A>G] haplotype concur in selecting H. pylori cagA subtype infections. Clin Chim Acta. 389:139–145. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Liang XL, Hu HB, Jia AP and Liu ZP: Association of PTPN11 and interleukin-4 gene polymorphisms and helicobacter pylori infection with susceptibility to gastric cancer. Hai Nan Yi Xue. 2010:1–5. 2010.(In Chinese).

18 

Chu H, Wang M, Yan F, Zhong D, Shi D, Ma L, Pan X, Qin C, Yin C and Zhang Z: Polymorphisms in the IL-13 and IL-4R genes are associated with the development of renal cell carcinoma. Ann Oncol. 23:2114–2121. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Cozar JM, Romero JM, Aptsiauri N, Vazquez F, Vilchez JR, Tallada M, Garrido F and Ruiz-Cabello F: High incidence of CTLA-4 AA (CT60) polymorphism in renal cell cancer. Hum Immunol. 68:698–704. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Joshi NN, Bhat S, Hake S, Kale M and Kannan S: Opposing effects of pro- and anti-inflammatory cytokine gene polymorphisms on the risk for breast cancer in western Indian women: A pilot study. Int J Immunogenet. 41:242–249. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Schonfeld SJ, Bhatti P, Brown EE, Linet MS, Simon SL, Weinstock RM, Hutchinson AA, Stovall M, Preston DL, Alexander BH, et al: Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologists. Cancer Causes Control. 21:1857–1866. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Chen J, Ying XM, Huang XM, Huang P and Yan SC: Association between polymorphisms in selected inflammatory response genes and the risk of prostate cancer. Onco Targets Ther. 9:223–229. 2016.PubMed/NCBI

23 

Olson SH, Orlow I, Simon J, Tommasi D, Roy P, Bayuga S, Ludwig E, Zauber AG and Kurtz RC: Allergies, variants in IL-4 and IL-4R alpha genes, and risk of pancreatic cancer. Cancer Detect Prev. 31:345–351. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Welsh MM, Karagas MR, Kuriger JK, Houseman A, Spencer SK, Perry AE and Nelson HH: Genetic determinants of UV-susceptibility in non-melanoma skin cancer. PLoS One. 6:e200192011. View Article : Google Scholar : PubMed/NCBI

25 

Howell WM, Turner SJ, Theaker JM and Bateman AC: Cytokine gene single nucleotide polymorphisms and susceptibility to and prognosis in cutaneous malignant melanoma. Eur J Immunogenet. 30:409–414. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Andrie E, Michos A, Kalampoki V, Pourtsidis A, Moschovi M, Polychronopoulou S, Athanasiadou-Piperopoulou F, Kalmanti M, Hatzakis A, Paraskevis D, et al: Genetic variants in immunoregulatory genes and risk for childhood lymphomas. Eur J Haematol. 83:334–342. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Monroy CM, Cortes AC, Lopez MS, D'Amelio AM Jr, Etzel CJ, Younes A, Strom SS and El-Zein RA: Hodgkin disease risk: Role of genetic polymorphisms and gene-gene interactions in inflammation pathway genes. Mol Carcinog. 50:36–46. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Gaur P, Mittal M, Mohanti B and Das S: Functional variants of IL4 and IL6 genes and risk of tobacco-related oral carcinoma in high-risk Asian Indians. Oral Dis. 17:720–726. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Tsai MH, Chen WC, Tsai CH, Hang LW and Tsai FJ: Interleukin-4 gene, but not the interleukin-1 beta gene polymorphism, is associated with oral cancer. J Clin Lab Anal. 19:93–98. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Vairaktaris E, Yapijakis C, Serefoglou Z, Avgoustidis D, Critselis E, Spyridonidou S, Vylliotis A, Derka S, Vassiliou S, Nkenke E and Patsouris E: Gene expression polymorphisms of interleukins-1 beta, −4, −6, −8, −10, and tumor necrosis factors-alpha, -beta: Regression analysis of their effect upon oral squamous cell carcinoma. J Cancer Res Clin Oncol. 134:821–832. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Lu Y, Wu Z, Peng Q, Ma L, Zhang X, Zhao J, Qin X and Li S: Role of IL-4 gene polymorphisms in HBV-related hepatocellular carcinoma in a Chinese population. PLoS One. 9:e1100612014. View Article : Google Scholar : PubMed/NCBI

32 

Saxena R, Chawla YK, Verma I and Kaur J: Effect of IL-12B, IL-2, TGF-β1, and IL-4 polymorphism and expression on hepatitis B progression. J Interferon Cytokine Res. 34:117–128. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Li X, Shi W, Yu G, Lin L, Yang B, Li J, Guo W, Tang C, Wang H, Gao H, et al: Interleukin-4 −590T/C polymorphism influences the susceptibility to nonsmall cell lung cancer. DNA Cell Biol. 31:797–800. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Gu J, Shen Y and Zhang Y: Association between interleukin-4 polymorphisms and environment and nonsmall cell lung cancer in Chinese population. J Cancer Res Ther. 10 Suppl:C135–C139. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Chang WS, Wang SC, Chuang CL, Ji HX, Hsiao CL, Hsu CM, Tsai CW, Liu SP, Hsu PC, Lo YL and Bau DT: Contribution of interleukin-4 genotypes to lung cancer risk in Taiwan. Anticancer Res. 35:6297–6301. 2015.PubMed/NCBI

36 

Suchy J, Kłujszo-Grabowska E, Kładny J, Cybulski C, Wokołorczyk D, Szymańska-Pasternak J, Kurzawski G, Scott RJ and Lubiński J: Inflammatory response gene polymorphisms and their relationship with colorectal cancer risk. BMC Cancer. 8:1122008. View Article : Google Scholar : PubMed/NCBI

37 

Wilkening S, Tavelin B, Canzian F, Enquist K, Palmqvist R, Altieri A, Hallmans G, Hemminki K, Lenner P and Försti A: Interleukin promoter polymorphisms and prognosis in colorectal cancer. Carcinogenesis. 29:1202–1206. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Yannopoulos A, Nikiteas N, Chatzitheofylaktou A and Tsigris C: The (−590 C/T) polymorphism in the interleukin-4 gene is associated with increased risk for early stages of corolectal adenocarcinoma. In Vivo. 21:1031–1035. 2007.PubMed/NCBI

39 

Wiemels JL, Wiencke JK, Kelsey KT, Moghadassi M, Rice T, Urayama KY, Miike R and Wrensch M: Allergy-related polymorphisms influence glioma status and serum IgE levels. Cancer Epidemiol Biomarkers Prev. 16:1229–1235. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Purdue MP, Sakoda LC, Graubard BI, Welch R, Chanock SJ, Sesterhenn IA, Rubertone MV, Erickson RL and McGlynn KA: A case-control investigation of immune function gene polymorphisms and risk of testicular germ cell tumors. Cancer Epidemiol Biomarkers Prev. 16:77–83. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Chu H, Ma L, Wang M, Shi D, Qin C, Yuan L, Yin C and Zhang Z: The polymorphisms of IL-4, IL-4R and IL-13 genes and bladder cancer risk in a Chinese population: A case-control study. Mol Biol Rep. 39:5349–5357. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Amirzargar AA, Bagheri M, Ghavamzadeh A, Alimoghadam K, Khosravi F, Rezaei N, Moheydin M, Ansaripour B, Moradi B and Nikbin B: Cytokine gene polymorphism in Iranian patients with chronic myelogenous leukaemia. Int J Immunogenet. 32:167–171. 2005. View Article : Google Scholar : PubMed/NCBI

43 

Shamran HA, Hamza SJ, Yaseen NY, Al-Juboory AA, Taub DD, Price RL, Nagarkatti M, Nagarkatti PS and Singh UP: Impact of single nucleotide polymorphism in IL-4, IL-4R genes and systemic concentration of IL-4 on the incidence of glioma in Iraqi patients. Int J Med Sci. 11:1147–1153. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Lu Y: Association of variants of inflammation and immunity genes with susceptibility to gastric cancer. Nanjing Medical University; 2010, (In Chinese).

45 

Gu F, Qureshi AA, Niu T, Kraft P, Guo Q, Hunter DJ and Han J: Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma. Melanoma Res. 18:330–335. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Chen XL: TNF-β IL-4 genes polymorphisms and Helicobacter pylori in gastric cancer and duodenal ulcer in the Chinese. Fujian Medical University; 2006, (In Chinese).

47 

Tsai FJ, Chang CH, Chen CC, Hsia TC, Chen HY and Chen WC: Interleukin-4 gene intron-3 polymorphism is associated with transitional cell carcinoma of the urinary bladder. BJU Int. 95:432–435. 2005. View Article : Google Scholar : PubMed/NCBI

48 

Bozdoğan ST, Erol B, Dursun A, Bozdoğan G, Dönmez I, Mungan NA and Seydaoglu G: The IL-1RN and IL-4 gene polymorphisms are potential genetic markers of susceptibility to bladder cancer: A case-control study. World J Urol. 33:389–395. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Hsieh YY, Chang CC, Tsai CH, Lin CC and Tsai FJ: Interleukin (IL)-12 receptor beta1 codon 378 G homozygote and allele, but not IL-1 (beta-511 promoter, 3953 exon 5, receptor antagonist), IL-2 114, IL-4-590 intron 3, IL-8 3′-UTR2767, and IL-18 105, are associated with higher susceptibility to leiomyoma. Fertil Steril. 87:886–895. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Shekari M, Kordi-Tamandani DM, MalekZadeh K, Sobti RC, Karimi S and Suri V: Effect of anti-inflammatory (IL-4, IL-10) cytokine genes in relation to risk of cervical carcinoma. Am J Clin Oncol. 35:514–519. 2012. View Article : Google Scholar : PubMed/NCBI

51 

Konwar R, Chaudhary P, Kumar S, Mishra D, Chattopadhyay N and Bid HK: Breast cancer risk associated with polymorphisms of IL-1RN and IL-4 gene in Indian women. Oncol Res. 17:367–372. 2009. View Article : Google Scholar : PubMed/NCBI

52 

Kesarwani P, Ahirwar DK, Mandhani A and Mittal RD: Association between-174 G/C promoter polymorphism of the interleukin-6 gene and progression of prostate cancer in North Indian population. DNA Cell Biol. 27:505–510. 2008. View Article : Google Scholar : PubMed/NCBI

53 

Yang CM, Chen HC, Hou YY, Lee MC, Liou HH, Huang SJ, Yen LM, Eng DM, Hsieh YD and Ger LP: A high IL-4 production diplotype is associated with an increased risk but better prognosis of oral and pharyngeal carcinomas. Arch Oral Biol. 59:35–46. 2014. View Article : Google Scholar : PubMed/NCBI

54 

Salimi S, Mohammadoo-Khorasani M, Yaghmaei M, Mokhtari M and Moossavi M: Possible association of IL-4 VNTR polymorphism with susceptibility to preeclampsia. Biomed Res Int. 2014:4970312014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Jia Y, Xie X, Shi X and Li S: Associations of common IL-4 gene polymorphisms with cancer risk: A meta-analysis. Mol Med Rep 16: 1927-1945, 2017.
APA
Jia, Y., Xie, X., Shi, X., & Li, S. (2017). Associations of common IL-4 gene polymorphisms with cancer risk: A meta-analysis. Molecular Medicine Reports, 16, 1927-1945. https://doi.org/10.3892/mmr.2017.6822
MLA
Jia, Y., Xie, X., Shi, X., Li, S."Associations of common IL-4 gene polymorphisms with cancer risk: A meta-analysis". Molecular Medicine Reports 16.2 (2017): 1927-1945.
Chicago
Jia, Y., Xie, X., Shi, X., Li, S."Associations of common IL-4 gene polymorphisms with cancer risk: A meta-analysis". Molecular Medicine Reports 16, no. 2 (2017): 1927-1945. https://doi.org/10.3892/mmr.2017.6822
Copy and paste a formatted citation
x
Spandidos Publications style
Jia Y, Xie X, Shi X and Li S: Associations of common IL-4 gene polymorphisms with cancer risk: A meta-analysis. Mol Med Rep 16: 1927-1945, 2017.
APA
Jia, Y., Xie, X., Shi, X., & Li, S. (2017). Associations of common IL-4 gene polymorphisms with cancer risk: A meta-analysis. Molecular Medicine Reports, 16, 1927-1945. https://doi.org/10.3892/mmr.2017.6822
MLA
Jia, Y., Xie, X., Shi, X., Li, S."Associations of common IL-4 gene polymorphisms with cancer risk: A meta-analysis". Molecular Medicine Reports 16.2 (2017): 1927-1945.
Chicago
Jia, Y., Xie, X., Shi, X., Li, S."Associations of common IL-4 gene polymorphisms with cancer risk: A meta-analysis". Molecular Medicine Reports 16, no. 2 (2017): 1927-1945. https://doi.org/10.3892/mmr.2017.6822
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team