Oncogenic miR-23a-5p is associated with cellular function in RCC

Retraction in: /10.3892/mmr.2024.13202

  • Authors:
    • Jing Quan
    • Lu Jin
    • Xiang Pan
    • Tao He
    • Yulin Lai
    • Peijie Chen
    • Canbin Lin
    • Shangqi Yang
    • Hui Zeng
    • Yongqing Lai
  • View Affiliations

  • Published online on: June 21, 2017     https://doi.org/10.3892/mmr.2017.6829
  • Pages: 2309-2317
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Abstract

In recent years, accumulating evidence has demonstrated that microRNAs (miRs, miRNAs) may serve an important role in the occurrence and development of tumors. miR‑23a‑5p has been confirmed as an oncogene in numerous diseases through gene chip analysis. However, as the most common type of renal tumor, the expression and function of miR‑23a‑5p in renal cell carcinoma (RCC) remains unclear. In the present study, reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) analysis, and Cell Counting Kit‑8 (CCK‑8), wound scratch, Transwell, MTT and flow cytometry assays were performed to investigate the role of miR‑23a‑5p in RCC. The expression of miR‑23a‑5p in RCC tissue samples was significantly higher compared with that in normal tissue samples (P<0.01). Furthermore, the expression of miR‑23a‑5p in RCC cell lines (786O, ACHN and Caki‑1) was significantly higher compared with that in the human embryo kidney 293T cell line, as determined using RT‑qPCR (P<0.001). In addition, the results revealed that the upregulation of miR‑23a‑5p promoted the proliferation, migration and invasion of RCC cells, and inhibited RCC cell apoptosis. The downregulation of miR‑23a‑5p resulted in the reversal of the results described above. Additionally, it was observed that the downregulation of miR‑23a‑5p significantly promoted ACHN and 786O cell viability (P<0.001). The results of the present study suggest that miR-23a-5p is an oncogene in the occurrence and development of RCC and may be a novel therapeutic target for RCC.
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August-2017
Volume 16 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Quan J, Jin L, Pan X, He T, Lai Y, Chen P, Lin C, Yang S, Zeng H, Lai Y, Lai Y, et al: Oncogenic miR-23a-5p is associated with cellular function in RCC Retraction in /10.3892/mmr.2024.13202. Mol Med Rep 16: 2309-2317, 2017
APA
Quan, J., Jin, L., Pan, X., He, T., Lai, Y., Chen, P. ... Lai, Y. (2017). Oncogenic miR-23a-5p is associated with cellular function in RCC Retraction in /10.3892/mmr.2024.13202. Molecular Medicine Reports, 16, 2309-2317. https://doi.org/10.3892/mmr.2017.6829
MLA
Quan, J., Jin, L., Pan, X., He, T., Lai, Y., Chen, P., Lin, C., Yang, S., Zeng, H., Lai, Y."Oncogenic miR-23a-5p is associated with cellular function in RCC Retraction in /10.3892/mmr.2024.13202". Molecular Medicine Reports 16.2 (2017): 2309-2317.
Chicago
Quan, J., Jin, L., Pan, X., He, T., Lai, Y., Chen, P., Lin, C., Yang, S., Zeng, H., Lai, Y."Oncogenic miR-23a-5p is associated with cellular function in RCC Retraction in /10.3892/mmr.2024.13202". Molecular Medicine Reports 16, no. 2 (2017): 2309-2317. https://doi.org/10.3892/mmr.2017.6829