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Article

Epoxyeicosatrienoic acid ameliorates cerebral ischemia-reperfusion injury by inhibiting inflammatory factors and pannexin-1

  • Authors:
    • Zhigang Liu
    • Yongfang Liu
    • Haixiao Zhou
    • Xiangyun Fu
    • Gang Hu
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
  • Pages: 2179-2184
    |
    Published online on: June 21, 2017
       https://doi.org/10.3892/mmr.2017.6831
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Abstract

Epoxyeicosatrienoic acid (EET) has wide applications due to the unique biological effects of anti‑hyperlipidemia, inhibition of platelet aggregation, anti‑inflammation, anti‑cancer, anti‑lipid oxidation and the promotion of brain tissue development. The present study investigated whether EET ameliorates cerebral ischemia‑reperfusion injury (CIRI) by inhibiting inflammatory factors and pannexin. Specific pathogen‑free 7‑week‑old male Sprague‑Dawley rats were randomly divided into three groups: Sham, CIRI and EET. Neurological deficit scores, cerebral infarct volume and cerebral edema were assessed in CIRI rats. Enzyme‑linked immunosorbent assays were performed to detect tumor necrosis factor‑α, interleukin‑6, nuclear factor‑κB and inducible nitric oxide synthase (iNOS) levels, and western blot analysis was performed also used to assess cleaved caspase‑3, phospholipase A2 (PLA2), cyclooxygenase‑2 and prostaglandin E2 (PGE2) protein expression levels. EET ameliorated cerebral injury and CIRI‑induced cleaved caspase‑3 protein expression levels in rats. EET additionally suppressed CIRI‑induced inflammation reactions and iNOS protein expression in rats. Furthermore, the protein expression levels of PLA2, PGE2 and pannexin‑1 in CIRI rats were inhibited by treatment with EET. These results indicated that EET reduces CIRI by inhibiting inflammation and levels of cleaved caspase‑3, PLA2, PGE2 and pannexin-1.
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View References

1 

Nasri H: Renal cell protection of erythropoietin beyond correcting the anemia in chronic kidney disease patients. Cell J. 15:378–380. 2014.PubMed/NCBI

2 

Zager RA, Johnson AC and Becker K: Acute unilateral ischemic renal injury induces progressive renal inflammation, lipid accumulation, histone modification and ‘end-stage’ kidney disease. Am J Physiol Renal Physiol. 301:F1334–F1345. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Liu YF, Zhang Y, Dai D and Xu Z: Expression of NF-κB, MCP-1 and MMP-9 in a cerebral aneurysm rabbit model. Can J Neurol Sci. 41:200–205. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Wang S, Liu K, Seneviratne CJ, Li X, Cheung GS, Jin L, Chu CH and Zhang C: Lipoteichoic acid from an clinical strain promotes TNF-a expression through the NF-kB and p38 MAPK signaling pathways in differentiated THP-1 macrophages. Biomed Rep. 3:697–702. 2015.PubMed/NCBI

5 

Ma XF, Zhang J, Shuai HL, Guan BZ, Luo X and Yan RL: IKKa/NF-kB mediated the low doses of bisphenol A induced migration of cervical cancer cells. Arch Biochem Biophys. 573:52–58. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Li J, Deng Z, Wang Z, Wang D, Zhang L, Su Q, Lai Y, Li B, Luo Z, Chen X, et al: Zipper-interacting protein kinase promotes epithelial-mesenchymal transition, invasion and metastasis through AKT and NF-kB signaling and is associated with metastasis and poor prognosis in gastric cancer patients. Oncotarget. 6:8323–8338. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Kuper C, Beck FX and Neuhofer W: NFAT5 contributes to osmolality-induced MCP-1 expression in mesothelial cells. Mediators Inflamm. 2012:5130152012. View Article : Google Scholar : PubMed/NCBI

8 

Lakkappa N, Krishnamurthy PT, Hammock BD, Velmurugan D and Bharath MM: Possible role of Epoxyeicosatrienoic acid in prevention of oxidative stress mediated neuroinflammation in Parkinson disorders. Med Hypotheses. 93:161–165. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Zhang X, Liang D, Guo L, Liang W, Jiang Y, Li H, Zhao Y, Lu S and Chi ZH: Curcumin protects renal tubular epithelial cells from high glucose-induced epithelial-to-mesenchymal transition through Nrf2-mediated upregulation of heme oxygenase-1. Mol Med Rep. 12:1347–1355. 2015.PubMed/NCBI

10 

Mawdsley JE, Jenkins DG, Macey MG, Langmead L and Rampton DS: The effect of hypnosis on systemic and rectal mucosal measures of inflammation in ulcerative colitis. Am J Gastroenterol. 103:1460–1469. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Inui Y, Mochida H, Yamairi F, Okada M, Ishida J, Fukamizu A and Arakawa K: Effects of aging and uninephrectomy on renal changes in Tsukuba hypertensive mice. Biomed Rep. 1:359–364. 2013.PubMed/NCBI

12 

Yao L, Lu P, Li Y, Yang L, Feng H, Huang Y, Zhang D, Chen J and Zhu D: Osthole relaxes pulmonary arteries through endothelial phosphatidylinositol 3-kinase/Akt-eNOS-NO signaling pathway in rats. Eur J Pharmacol. 699:23–32. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Hua KF, Yang SM, Kao TY, Chang JM, Chen HL, Tsai YJ, Chen A, Yang SS, Chao LK and Ka SM: Osthole mitigates progressive IgA nephropathy by inhibiting reactive oxygen species generation and NF-kB/NLRP3 pathway. PLoS One. 8:e777942013. View Article : Google Scholar : PubMed/NCBI

14 

Tsai YF, Yu HP, Chung PJ, Leu YL, Kuo LM, Chen CY and Hwang TL: Osthol attenuates neutrophilic oxidative stress and hemorrhagic shock-induced lung injury via inhibition of phosphodiesterase 4. Free Radic Biol Med. 89:387–400. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Mannon PJ, Hornung RL, Yang Z, Yi C, Groden C, Friend J, Yao M, Strober W and Fuss IJ: Suppression of inflammation in ulcerative colitis by interferon-b-1a is accompanied by inhibition of IL-13 production. Gut. 60:449–455. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Yang SK, Jung HY, Kang GH, Kim YM, Myung SJ, Shim KN, Hong WS and Min YI: Appendiceal orifice inflammation as a skip lesion in ulcerative colitis: An analysis in relation to medical therapy and disease extent. Gastrointest Endosc. 49:743–747. 1999. View Article : Google Scholar : PubMed/NCBI

17 

Xia Y, Kong L, Yao Y, Jiao Y, Song J, Tao Z, You Z and Yang J: Osthole confers neuroprotection against cortical stab wound injury and attenuates secondary brain injury. J Neuroinflammation. 12:1552015. View Article : Google Scholar : PubMed/NCBI

18 

Lin VC, Chou CH, Lin YC, Lin JN, Yu CC, Tang CH, Lin HY and Way TD: Osthole suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt/mTOR pathway. J Agric Food Chem. 58:4786–4793. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Yang YZ, Tang YZ and Liu YH: Wogonoside displays anti-inflammatory effects through modulating inflammatory mediator expression using RAW264.7 cells. J Ethnopharmacol. 148:271–276. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Jiang H, McGiff JC, Quilley J, Sacerdoti D, Reddy LM, Falck JR, Zhang F, Lerea KM and Wong PY: Identification of 5,6-trans-epoxyeicosatrienoic acid in the phospholipids of red blood cells. J Biol Chem. 279:36412–36418. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Yang SM, Chan YL, Hua KF, Chang JM, Chen HL, Tsai YJ, Hsu YJ, Chao LK, Feng-Ling Y, Tsai YL, et al: Osthole improves an accelerated focal segmental glomerulosclerosis model in the early stage by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-kB-mediated COX-2 expression and apoptosis. Free Radic Biol Med. 73:260–269. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Lucas AL, Ouellette SP, Kabeiseman EJ, Cichos KH and Rucks EA: The trans-Golgi SNARE syntaxin 10 is required for optimal development of Chlamydia trachomatis. Front Cell Infect Microbiol. 5:682015. View Article : Google Scholar : PubMed/NCBI

23 

Finocchietti S, Cappagli G and Gori M: Encoding audio motion: Spatial impairment in early blind individuals. Front Psychol. 6:13572015. View Article : Google Scholar : PubMed/NCBI

24 

Nordahl H, Osler M, Frederiksen BL, Andersen I, Prescott E, Overvad K, Diderichsen F and Rod NH: Combined effects of socioeconomic position, smoking, and hypertension on risk of ischemic and hemorrhagic stroke. Stroke. 45:2582–2587. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Venturino A, Oda A and Perin P: Hair cell-type dependent expression of basolateral ion channels shapes response dynamics in the frog utricle. Front Cell Neurosci. 9:3382015. View Article : Google Scholar : PubMed/NCBI

26 

Michaelis UR and Fleming I: From endothelium-derived hyperpolarizing factor (EDHF) to angiogenesis: Epoxyeicosatrienoic acids (EETs) and cell signaling. Pharmacol Ther. 111:584–595. 2006. View Article : Google Scholar : PubMed/NCBI

27 

de Groote RP, Budinčević I, Billowes J, Bissell ML, Cocolios TE, Farooq-Smith GJ, Fedosseev VN, Flanagan KT, Franchoo S, Ruiz RF Garcia, et al: Use of a continuous wave laser and pockels cell for sensitive high-resolution collinear resonance ionization spectroscopy. Phys Rev Lett. 115:1325012015. View Article : Google Scholar : PubMed/NCBI

28 

Shen Y, Qiao H, Fan Q, Zhang S and Tang T: Potentiated osteoinductivity via cotransfection with BMP-2 and VEGF genes in microencapsulated C2C12 cells. Biomed Res Int. 2015:4352532015. View Article : Google Scholar : PubMed/NCBI

29 

Rodriguez DA, de Lima RF, Campos MS, Costa JR, Biancardi MF, Marques MR, Taboga SR and Santos FC: Intrauterine exposure to bisphenol A promotes different effects in both neonatal and adult prostate of male and female gerbils (Meriones unguiculatus). Environ Toxicol. Oct 7–2015.(Epub ahead of print) doi: 10.1002/tox.22176. PubMed/NCBI

30 

Nusing RM, Schweer H, Fleming I, Zeldin DC and Wegmann M: Epoxyeicosatrienoic acids affect electrolyte transport in renal tubular epithelial cells: Dependence on cyclooxygenase and cell polarity. Am J Physiol Renal Physiol. 293:F288–F298. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu Z, Liu Y, Zhou H, Fu X and Hu G: Epoxyeicosatrienoic acid ameliorates cerebral ischemia-reperfusion injury by inhibiting inflammatory factors and pannexin-1. Mol Med Rep 16: 2179-2184, 2017.
APA
Liu, Z., Liu, Y., Zhou, H., Fu, X., & Hu, G. (2017). Epoxyeicosatrienoic acid ameliorates cerebral ischemia-reperfusion injury by inhibiting inflammatory factors and pannexin-1. Molecular Medicine Reports, 16, 2179-2184. https://doi.org/10.3892/mmr.2017.6831
MLA
Liu, Z., Liu, Y., Zhou, H., Fu, X., Hu, G."Epoxyeicosatrienoic acid ameliorates cerebral ischemia-reperfusion injury by inhibiting inflammatory factors and pannexin-1". Molecular Medicine Reports 16.2 (2017): 2179-2184.
Chicago
Liu, Z., Liu, Y., Zhou, H., Fu, X., Hu, G."Epoxyeicosatrienoic acid ameliorates cerebral ischemia-reperfusion injury by inhibiting inflammatory factors and pannexin-1". Molecular Medicine Reports 16, no. 2 (2017): 2179-2184. https://doi.org/10.3892/mmr.2017.6831
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Z, Liu Y, Zhou H, Fu X and Hu G: Epoxyeicosatrienoic acid ameliorates cerebral ischemia-reperfusion injury by inhibiting inflammatory factors and pannexin-1. Mol Med Rep 16: 2179-2184, 2017.
APA
Liu, Z., Liu, Y., Zhou, H., Fu, X., & Hu, G. (2017). Epoxyeicosatrienoic acid ameliorates cerebral ischemia-reperfusion injury by inhibiting inflammatory factors and pannexin-1. Molecular Medicine Reports, 16, 2179-2184. https://doi.org/10.3892/mmr.2017.6831
MLA
Liu, Z., Liu, Y., Zhou, H., Fu, X., Hu, G."Epoxyeicosatrienoic acid ameliorates cerebral ischemia-reperfusion injury by inhibiting inflammatory factors and pannexin-1". Molecular Medicine Reports 16.2 (2017): 2179-2184.
Chicago
Liu, Z., Liu, Y., Zhou, H., Fu, X., Hu, G."Epoxyeicosatrienoic acid ameliorates cerebral ischemia-reperfusion injury by inhibiting inflammatory factors and pannexin-1". Molecular Medicine Reports 16, no. 2 (2017): 2179-2184. https://doi.org/10.3892/mmr.2017.6831
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