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Article

Cytogenic and molecular studies of male infertility in cases of Y chromosome balanced reciprocal translocation

  • Authors:
    • Ding Wang
    • Rui Chen
    • Shu Kong
    • Qian‑Ying Pan
    • Yu‑Hong Zheng
    • Wen‑Jun Qiu
    • Yong Fan
    • Xiao‑Fang Sun
  • View Affiliations / Copyright

    Affiliations: Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China
  • Pages: 2051-2054
    |
    Published online on: June 21, 2017
       https://doi.org/10.3892/mmr.2017.6835
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Abstract

Y-autosomal translocation has been previously reported in association with male infertility; however, the mechanisms of Y-autosomal translocation and non‑obstructive azoospermia or severe oligospermia remain unclear. G‑banding and fluorescence in situ hybridization (FISH) were performed to analyze the translocation of chromosomes, and a single nucleotide polymorphism (SNP) genotyping assay was used to test mutations. The present study describes three new cases with a de novo balanced translocation t(Y;13), t(Y;9) and t(Y;6). To further explore the genotype‑phenotype correlation, G‑banding and FISH were performed and indicated the presence of a derivative chromosome. The SNP genotyping assay using a microarray revealed no abnormality, especially in the Y chromosome. Molecular deletion analysis demonstrated that no microdeletion was detected in the azoospermia factor region of the Y chromosome in the examined, infertile men. Based on these observations, the authors proposed the hypothesis that a position effect involving unknown spermatogenesis regulatory gene(s) serves a key role in male infertility.
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1 

Giltay JC, Tiemessen CH, van Inzen WG and Scheres JM: One normal child and a chromosomally balanced/normal twin after intracytoplasmic sperm injection in a male with a de-novo t(Y;16) translocation. Hum Reprod. 13:2745–2747. 1998. View Article : Google Scholar : PubMed/NCBI

2 

Barasc H, Mary N, Letron R, Calgaro A, Dudez AM, Bonnet N, Lahbib-Mansais Y, Yerle M, Ducos A and Pinton A: Y-autosome translocation interferes with meiotic sex inactivation and expression of autosomal genes: A case study in the pig. Sex Dev. 6:143–150. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Reijo R, Lee TY, Salo P, Alagappan R, Brown LG, Rosenberg M, Rozen S, Jaffe T, Straus D, Hovatta O, et al: Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene. Nat Genet. 10:383–393. 1995. View Article : Google Scholar : PubMed/NCBI

4 

van der Ven K, Messer L, van der Ven H, Jeyendran RS and Ober C: Cystic fibrosis mutation screening in healthy men with reduced sperm quality. Hum Reprod. 11:513–517. 1996. View Article : Google Scholar : PubMed/NCBI

5 

Jiang YT, Zhang HG, Wang RX, Yu Y, Zhang ZH and Liu RZ: Novel Y chromosome breakpoint in an infertile male with a de novo translocation t(Y;16): A case report. J Assist Reprod Genet. 29:1427–1430. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Martin RH: Cytogenetic determinants of male fertility. Hum Reprod Update. 14:379–390. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Schmid M: Demonstration of Y/autosomal translocations using distamycin A. Hum Genet. 53:107–109. 1979. View Article : Google Scholar : PubMed/NCBI

8 

Nielsen J and Rasmussen K: Y/autosomal translocations. Clin Genet. 9:609–617. 1976. View Article : Google Scholar : PubMed/NCBI

9 

Chen CP, Lin SP, Tsai FJ, Wang TH, Chern SR and Wang W: Characterization of a de novo unbalanced Y;autosome translocation in a 45,X mentally retarded male and literature review. Fertil Steril. 90:1198.e11–e18. 2008. View Article : Google Scholar

10 

Chen CP, Fu CH, Chern SR, Wu PS, Su JW, Lee CC, Lee MS and Wang W: De novo unbalanced translocation resulting in monosomy for distal 5p (5p14.1 → pter) and 14q (14q32.31 → qter) associated with fetal nuchal edema, microcephaly, intrauterine growth restriction and single umbilical artery: Prenatal diagnosis and molecular cytogenetic characterization. Taiwan J Obstet Gynecol. 52:401–406. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Chen-Shtoyerman R, Ben-Yehoshua S Josefsberg, Nissani R, Rosensaft J and Appelman Z: A prevalent Y;15 translocation in the Ethiopian Beta Israel community in Israel. Cytogenet Genome Res. 136:171–174. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Dutrillaux B, Descailleaux J, Viegas-Pequignot E and Couturier J: Y-autosome translocation in Cacajao calvus rubicundus (Platyrrhini). Ann Genet. 24:197–201. 1981.PubMed/NCBI

13 

Sasagawa I, Nakada T, Adachi Y, Kato T, Sawamura T, Ishigooka M and Hashimoto T: Y-autosome translocation associated with azoospermia. Scand J Urol Nephrol. 27:285–268. 1993. View Article : Google Scholar : PubMed/NCBI

14 

Cui YX, Xia XY, Pan LJ, Wang YH, Yao B and Huang YF: An infertile male with apparent 45,X turned out to have 45,X,der(Y)t(Y;13) (q11.2;q12),-13: Clinicopathologic and cytogenomic studies. Fertil Steril. 88:1676.e7–e11. 2007. View Article : Google Scholar

15 

Alves C, Carvalho F, Cremades N, Sousa M and Barros A: Unique (Y;13) translocation in a male with oligozoospermia: Cytogenetic and molecular studies. Eur J Hum Genet. 10:467–474. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Viguie F, Romani F and Dadoune JP: Male infertility in a case of (Y;6) balanced reciprocal translocation. Mitotic and meiotic study. Hum Genet. 62:225–227. 1982. View Article : Google Scholar : PubMed/NCBI

17 

Delobel B, Djlelati R, Gabriel-Robez O, Croquette MF, Rousseaux-Prevost R, Rousseaux J, Rigot JM and Rumpler Y: Y-autosome translocation and infertility: Usefulness of molecular, cytogenetic and meiotic studies. Hum Genet. 102:98–102. 1998. View Article : Google Scholar : PubMed/NCBI

18 

Moreau N, Teyssier M and Rollet J: A new case of (Y;1) balanced reciprocal translocation in an infertile man with Hodgkin's disease. J Med Genet. 24:379–380. 1987. View Article : Google Scholar : PubMed/NCBI

19 

Yumura Y, Murase M, Katayama K, Segino M, Aizawa Y, Kuroda SN and Noguchi K: Y-autosome translocation associated with male infertility: A case report. Hinyokika Kiyo. 58:307–310. 2012.PubMed/NCBI

20 

Vogt PH, Edelmann A, Kirsch S, Henegariu O, Hirschmann P, Kiesewetter F, Köhn FM, Schill WB, Farah S, Ramos C, et al: Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11. Hum Mol Genet. 5:933–943. 1996. View Article : Google Scholar : PubMed/NCBI

21 

Krausz C, Forti G and McElreavey K: The Y chromosome and male fertility and infertility. Int J Androl. 26:70–75. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Krausz C, Chianese C, Giachini C, Guarducci E, Laface I and Forti G: The Y chromosome-linked copy number variations and male fertility. J Endocrinol Invest. 34:376–382. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Vogt PH: Genomic heterogeneity and instability of the AZF locus on the human Y chromosome. Mol Cell Endocrinol. 224:1–9. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang D, Chen R, Kong S, Pan QY, Zheng YH, Qiu WJ, Fan Y and Sun XF: Cytogenic and molecular studies of male infertility in cases of Y chromosome balanced reciprocal translocation. Mol Med Rep 16: 2051-2054, 2017.
APA
Wang, D., Chen, R., Kong, S., Pan, Q., Zheng, Y., Qiu, W. ... Sun, X. (2017). Cytogenic and molecular studies of male infertility in cases of Y chromosome balanced reciprocal translocation. Molecular Medicine Reports, 16, 2051-2054. https://doi.org/10.3892/mmr.2017.6835
MLA
Wang, D., Chen, R., Kong, S., Pan, Q., Zheng, Y., Qiu, W., Fan, Y., Sun, X."Cytogenic and molecular studies of male infertility in cases of Y chromosome balanced reciprocal translocation". Molecular Medicine Reports 16.2 (2017): 2051-2054.
Chicago
Wang, D., Chen, R., Kong, S., Pan, Q., Zheng, Y., Qiu, W., Fan, Y., Sun, X."Cytogenic and molecular studies of male infertility in cases of Y chromosome balanced reciprocal translocation". Molecular Medicine Reports 16, no. 2 (2017): 2051-2054. https://doi.org/10.3892/mmr.2017.6835
Copy and paste a formatted citation
x
Spandidos Publications style
Wang D, Chen R, Kong S, Pan QY, Zheng YH, Qiu WJ, Fan Y and Sun XF: Cytogenic and molecular studies of male infertility in cases of Y chromosome balanced reciprocal translocation. Mol Med Rep 16: 2051-2054, 2017.
APA
Wang, D., Chen, R., Kong, S., Pan, Q., Zheng, Y., Qiu, W. ... Sun, X. (2017). Cytogenic and molecular studies of male infertility in cases of Y chromosome balanced reciprocal translocation. Molecular Medicine Reports, 16, 2051-2054. https://doi.org/10.3892/mmr.2017.6835
MLA
Wang, D., Chen, R., Kong, S., Pan, Q., Zheng, Y., Qiu, W., Fan, Y., Sun, X."Cytogenic and molecular studies of male infertility in cases of Y chromosome balanced reciprocal translocation". Molecular Medicine Reports 16.2 (2017): 2051-2054.
Chicago
Wang, D., Chen, R., Kong, S., Pan, Q., Zheng, Y., Qiu, W., Fan, Y., Sun, X."Cytogenic and molecular studies of male infertility in cases of Y chromosome balanced reciprocal translocation". Molecular Medicine Reports 16, no. 2 (2017): 2051-2054. https://doi.org/10.3892/mmr.2017.6835
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