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Hydrogen-containing saline alleviates pressure overload-induced interstitial fibrosis and cardiac dysfunction in rats

  • Authors:
    • Jing Yang
    • Shujing Wu
    • Liqun Zhu
    • Jingjing Cai
    • Lu Fu
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Department of Emergency Internal Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1771-1778
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    Published online on: June 23, 2017
       https://doi.org/10.3892/mmr.2017.6849
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Abstract

Cardiac fibrosis induced by sustained pressure overload contributes to heart failure. Oxidative stress serves an important role in cardiac remodeling and heart failure independent of etiological factors. The application of hydrogen as an antioxidant is a novel concept in disease treatment, however no studies as present have investigated the effects of hydrogen on cardiac fibrosis. In the present study, the effects of hydrogen on pressure overload‑induced cardiac fibrosis and heart failure were investigated in abdominal aortic‑constricted rats. Masson's trichrome staining and echocardiography were used to evaluate the fibrotic area and cardiac function, respectively. Reactive oxygen species (ROS) content was detected by immunofluorescence. Malondialdehyde (MDA) concentration, the activity of superoxide dismutase (SOD) and hydroxyproline content were measured by spectrophotometry. Western blot analysis was used to detect the protein levels of transforming growth factor (TGF)‑β1, connective tissue growth factor (CTGF), NADPH oxidases (NOX)2, NOX4, p38 mitogen‑activated protein kinase (MAPK) and Smad2/3. Reverse transcription‑quantitative polymerase chain reaction was performed to detect the mRNA expression of collagen I (Col I) and fibronectin 1 (FN1). Hydrogen-containing saline (HCS) treatment was observed to improve interstitial fibrosis and cardiac function and to decrease the level of ROS, the oxidative‑stress marker MDA and expression of NOXs, while increasing the activity of the anti‑oxidant enzyme SOD. HCS treatment also decreased the phosphorylation of p38 MAPK and Smad2/3, and the expression of TGF‑β1 and CTGF, which were accompanied by reduced hydroxyproline content, Col I and FN1 mRNA levels. These results indicate that HCS treatment can improve cardiac function by reducing interstitial fibrosis in pressure‑overloaded rats through its anti‑oxidative properties and via suppression of TGF-β1 signaling.
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View References

1 

Braunwald E: The war against heart failure: The Lancet lecture. Lancet. 385:812–824. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Kong P, Christia P and Frangogiannis NG: The pathogenesis of cardiac fibrosis. Cell Mol Life Sci. 71:549–574. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Dobaczewski M, Chen W and Frangogiannis NG: Transforming growth factor (TGF)-β signaling in cardiac remodeling. J Mol Cell Cardiol. 51:600–606. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Lim H and Zhu YZ: Role of transforming growth factor-beta in the progression of heart failure. Cell Mol Life Sci. 63:2584–2596. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Creemers EE and Pinto YM: Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart. Cardiovasc Res. 89:265–272. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Murdoch CE, Zhang M, Cave AC and Shah AM: NADPH oxidase-dependent redox signalling in cardiac hypertrophy, remodelling and failure. Cardiovasc Res. 71:208–215. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Rosenkranz S: TGF-beta1 and angiotensin networking in cardiac remodeling. Cardiovasc Res. 63:423–432. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Yu M, Zheng Y, Sun HX and Yu DJ: Inhibitory effects of enalaprilat on rat cardiac fibroblast proliferation via ROS/P38MAPK/TGF-β1 signaling pathway. Molecules. 17:2738–2751. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S and Ohta S: Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 13:688–694. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Xie K, Yu Y, Pei Y, Hou L, Chen S, Xiong L and Wang G: Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release. Shock. 34:90–97. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Cai J, Kang Z, Liu WW, Luo X, Qiang S, Zhang JH, Ohta S, Sun X, Xu W, Tao H and Li R: Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci Lett. 441:167–172. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Itoh T, Fujita Y and Ito M, Masuda A, Ohno K, Ichihara M, Kojima T, Nozawa Y and Ito M: Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun. 389:651–656. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Kamimura N, Nishimaki K, Ohsawa I and Ohta S: Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. Obesity (Silver Spring). 19:1396–1403. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Yoshida A, Asanuma H, Sasaki H, Sanada S, Yamazaki S, Asano Y, Shinozaki Y, Mori H, Shimouchi A, Sano M, et al: H(2) mediates cardioprotection via involvements of K(ATP) channels and permeability transition pores of mitochondria in dogs. Cardiovasc Drugs Ther. 26:217–226. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Sun Q, Kang Z, Cai J, Liu W, Liu Y, Zhang JH, Denoble PJ, Tao H and Sun X: Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats. Exp Biol Med (Maywood). 234:1212–1219. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Ohsawa I, Nishimaki K, Yamagata K, Ishikawa M and Ohta S: Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. Biochem Biophys Res Commun. 377:1195–1198. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Qian L, Cao F, Cui J, Wang Y, Huang Y, Chuai Y, Zaho L, Jiang H and Cai J: The potential cardioprotective effects of hydrogen in irradiated mice. J Radiat Res. 51:741–747. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Noda K, Shigemura N, Tanaka Y, Kawamura T, Lim S Hyun, Kokubo K, Billiar TR, Bermudez CA, Kobayashi H and Nakao A: A novel method of preserving cardiac grafts using a hydrogen-rich water bath. J Hear Lung Transplant. 32:241–250. 2013. View Article : Google Scholar

19 

Yu YS and Zheng H: Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats. Mol Cell Biochem. 365:233–242. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Regulations of People's Republic of China for Administration of Laboratory Animals. State Science and Technology Commission; Beijing: 1988

21 

Oharazawa H, Igarashi T, Yokota T, Fujii H, Suzuki H, Machide M, Takahashi H, Ohta S and Ohsawa I: Protection of the retina by rapid diffusion of hydrogen: Administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury. Investig Ophthalmol Vis Sci. 51:487–492. 2010. View Article : Google Scholar

22 

Ma Y, Chen Y, Yang Y, Chen B, Liu D, Xiong Z, Zhang C and Dong Y: Proteasome inhibition attenuates heart failure during the late stages of pressure overload through alterations in collagen expression. Biochem Pharmacol. 85:223–233. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Ohta S: Recent progress toward hydrogen medicine: Potential of molecular hydrogen for preventive and therapeutic applications. Curr Pharm Des. 17:2241–2252. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Ohta S: Molecular hydrogen as a preventive and therapeutic medical gas: Initiation, development and potential of hydrogen medicine. Pharmacol Ther. 144:1–11. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, Endo J, Katayama T, Kawamura A, Kohsaka S, et al: Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun. 373:30–35. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Hayashida K, Sano M, Kamimura N, Yokota T, Suzuki M, Maekawa Y, Kawamura A, Abe T, Ohta S, Fukuda K and Hori S: H(2) gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model. J Am Heart Assoc. 1:e0034592012. View Article : Google Scholar : PubMed/NCBI

28 

Hayashi T, Yoshioka T, Hasegawa K, Miyamura M, Mori T, Ukimura A, Matsumura Y and Ishizaka N: Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice. Am J Physiol Heart Circ Physiol. 301:H1062–H1069. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK and He J: Global burden of hypertension: Analysis of worldwide data. Lancet. 365:217–223. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Lazzeroni D, Rimoldi O and Camici PG: From left ventricular hypertrophy to dysfunction and failure. Circ J. 80:555–564. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Sawyer DB, Siwik DA, Xiao L, Pimentel DR, Singh K and Colucci WS: Role of oxidative stress in myocardial hypertrophy and failure. J Mol Cell Cardiol. 34:379–388. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Van Kimmenade RR and Januzzi JL Jr: Emerging biomarkers in heart failure. Clin Chem. 58:127–138. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Dhalla AK, Hill MF and Singal PK: Role of oxidative stress in transition of hypertrophy to heart failure. J Am Coll Cardiol. 28:506–514. 1996. View Article : Google Scholar : PubMed/NCBI

34 

Wu S, Zhu L, Yang J, Fan Z, Dong Y, Luan R, Cai J and Fu L: Hydrogen-containing saline attenuates doxorubicin-induced heart failure in rats. Pharmazie. 69:633–636. 2014.PubMed/NCBI

35 

Takimoto E and Kass DA: Role of oxidative stress in cardiac hypertrophy and remodeling. Hypertension. 49:241–248. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Tsutsui H, Kinugawa S and Matsushima S: Oxidative stress and heart failure. Am J Physiol Heart Circ Physiol. 301:H2181–H2190. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Barcellos-Hoff MH and Dix TA: Redox-mediated activation of latent transforming growth factor-beta 1. Mol Endocrinol. 10:1077–1083. 1996. View Article : Google Scholar : PubMed/NCBI

38 

Kuwahara F, Kai H, Tokuda K, Kai M, Takeshita A, Egashira K and Imaizumi T: Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats. Circulation. 106:130–135. 2002. View Article : Google Scholar : PubMed/NCBI

39 

Wang Y: Mitogen-activated protein kinases in heart development and diseases. Circulation. 116:1413–1423. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Chen CH, Manaenko A, Zhan Y, Liu WW, Ostrowki RP, Tang J and Zhang JH: Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model. Neuroscience. 169:402–414. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Cardinal JS, Zhan J, Wang Y, Sugimoto R, Tsung A, McCurry KR, Billiar TR and Nakao A: Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney Int. 77:101–109. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang J, Wu S, Zhu L, Cai J and Fu L: Hydrogen-containing saline alleviates pressure overload-induced interstitial fibrosis and cardiac dysfunction in rats. Mol Med Rep 16: 1771-1778, 2017.
APA
Yang, J., Wu, S., Zhu, L., Cai, J., & Fu, L. (2017). Hydrogen-containing saline alleviates pressure overload-induced interstitial fibrosis and cardiac dysfunction in rats. Molecular Medicine Reports, 16, 1771-1778. https://doi.org/10.3892/mmr.2017.6849
MLA
Yang, J., Wu, S., Zhu, L., Cai, J., Fu, L."Hydrogen-containing saline alleviates pressure overload-induced interstitial fibrosis and cardiac dysfunction in rats". Molecular Medicine Reports 16.2 (2017): 1771-1778.
Chicago
Yang, J., Wu, S., Zhu, L., Cai, J., Fu, L."Hydrogen-containing saline alleviates pressure overload-induced interstitial fibrosis and cardiac dysfunction in rats". Molecular Medicine Reports 16, no. 2 (2017): 1771-1778. https://doi.org/10.3892/mmr.2017.6849
Copy and paste a formatted citation
x
Spandidos Publications style
Yang J, Wu S, Zhu L, Cai J and Fu L: Hydrogen-containing saline alleviates pressure overload-induced interstitial fibrosis and cardiac dysfunction in rats. Mol Med Rep 16: 1771-1778, 2017.
APA
Yang, J., Wu, S., Zhu, L., Cai, J., & Fu, L. (2017). Hydrogen-containing saline alleviates pressure overload-induced interstitial fibrosis and cardiac dysfunction in rats. Molecular Medicine Reports, 16, 1771-1778. https://doi.org/10.3892/mmr.2017.6849
MLA
Yang, J., Wu, S., Zhu, L., Cai, J., Fu, L."Hydrogen-containing saline alleviates pressure overload-induced interstitial fibrosis and cardiac dysfunction in rats". Molecular Medicine Reports 16.2 (2017): 1771-1778.
Chicago
Yang, J., Wu, S., Zhu, L., Cai, J., Fu, L."Hydrogen-containing saline alleviates pressure overload-induced interstitial fibrosis and cardiac dysfunction in rats". Molecular Medicine Reports 16, no. 2 (2017): 1771-1778. https://doi.org/10.3892/mmr.2017.6849
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