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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Inhibitory effects of FKBP14 on human cervical cancer cells

  • Authors:
    • Lian‑Yi Sun
    • Jiu‑Zhi Tao
    • Bing Yan
    • Jian‑Shu Lin

  • View Affiliations / Copyright

    Affiliations: Department of Medical Imaging, Jiading Maternal and Child Health Hospital, Shanghai 201821, P.R. China
  • Pages: 4265-4272
    |
    Published online on: July 21, 2017
       https://doi.org/10.3892/mmr.2017.7043
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Abstract

The FK506-binding protein 14 (FKBP14), which belongs to a subfamily of immunophilins, has been implicated in various biochemical processes. However, its effects on human cervical cancer remain to be elucidated. The present study aimed to determine the exact role of FKBP14 in human cervical cancer cell proliferation, cell cycle progression, apoptosis, invasion and migration. Cell proliferation was measured by Cell Counting Kit‑8 assay. Flow cytometry was conducted to determine the effects of FKBP14 on cell cycle progression and apoptosis. Cell invasion and migration were determined by Transwell assay. The results of the present study demonstrated that silencing FKBP14 expression using short hairpin (sh)RNA suppressed proliferation, invasion and migration of HeLa and C‑33A cells, and also induced apoptosis and cell cycle arrest. Furthermore, silencing FKBP14 expression decreased the protein expression levels of B‑cell lymphoma 2 (Bcl‑2), matrix metalloproteinase (MMP)2 and MMP9, and increased the levels of caspase‑3 and Bcl‑2‑associated X protein in FKBP14 shRNA‑infected HeLa and C‑33A cells. In conclusion, FKBP14 may act as an oncogene through suppressing apoptosis and promoting motility in human cervical carcinogenesis; therefore, it may be considered a potential therapeutic target for the treatment of cervical cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Sun LY, Tao JZ, Yan B and Lin JS: Inhibitory effects of FKBP14 on human cervical cancer cells. Mol Med Rep 16: 4265-4272, 2017.
APA
Sun, L., Tao, J., Yan, B., & Lin, J. (2017). Inhibitory effects of FKBP14 on human cervical cancer cells. Molecular Medicine Reports, 16, 4265-4272. https://doi.org/10.3892/mmr.2017.7043
MLA
Sun, L., Tao, J., Yan, B., Lin, J."Inhibitory effects of FKBP14 on human cervical cancer cells". Molecular Medicine Reports 16.4 (2017): 4265-4272.
Chicago
Sun, L., Tao, J., Yan, B., Lin, J."Inhibitory effects of FKBP14 on human cervical cancer cells". Molecular Medicine Reports 16, no. 4 (2017): 4265-4272. https://doi.org/10.3892/mmr.2017.7043
Copy and paste a formatted citation
x
Spandidos Publications style
Sun LY, Tao JZ, Yan B and Lin JS: Inhibitory effects of FKBP14 on human cervical cancer cells. Mol Med Rep 16: 4265-4272, 2017.
APA
Sun, L., Tao, J., Yan, B., & Lin, J. (2017). Inhibitory effects of FKBP14 on human cervical cancer cells. Molecular Medicine Reports, 16, 4265-4272. https://doi.org/10.3892/mmr.2017.7043
MLA
Sun, L., Tao, J., Yan, B., Lin, J."Inhibitory effects of FKBP14 on human cervical cancer cells". Molecular Medicine Reports 16.4 (2017): 4265-4272.
Chicago
Sun, L., Tao, J., Yan, B., Lin, J."Inhibitory effects of FKBP14 on human cervical cancer cells". Molecular Medicine Reports 16, no. 4 (2017): 4265-4272. https://doi.org/10.3892/mmr.2017.7043
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