Protein kinase C isozyme expression in right ventricular hypertrophy induced by pulmonary hypertension in chronically hypoxic rats

Zeng,Chao; Liang,Bin; Jiang,Rui; Shi,Yiwei; Du,Yongcheng

doi:10.3892/mmr.2017.7098

October-2017 Volume 16 Issue 4

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October-2017 Volume 16 Issue 4

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Article Open Access

Protein kinase C isozyme expression in right ventricular hypertrophy induced by pulmonary hypertension in chronically hypoxic rats

Authors:
- Chao Zeng
- Bin Liang
- Rui Jiang
- Yiwei Shi
- Yongcheng Du
View Affiliations / Copyright

Affiliations: Department of Pediatrics, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China, Department of Cardiology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China, Department of Respiratory Medicine, The Affiliated People's Hospital of Shanxi Medical University, Taiyuan, Shanxi 030012, P.R. China, Department of Respiratory Medicine, First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China

Copyright: © Zeng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 3833-3840
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Published online on: July 27, 2017

https://doi.org/10.3892/mmr.2017.7098
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Abstract

In chronic hypoxia, pulmonary hypertension (PH) induces right ventricular hypertrophy (RVH). Evidence indicates that protein kinase C (PKC) serves a crucial role in hypoxia‑induced RVH. The present study investigated PKC isoform-specific expression and its involvement in RVH. Rats were exposed to normobaric hypoxia for a number of days to induce PH. PKC isoform‑specific membrane translocation and protein expression in the myocardium were evaluated by western blotting and immunostaining. A total of six isoforms of conventional PKC (cPKC; α, βI and βII) and of novel PKC (nPKC; δ, ε and η), were detected in the rat myocardium. Hypoxic exposure (1‑21 days) induced PH with RVH and vascular remodeling. nPKCδ membrane translocation at 3‑7 days and cPKCβI expression at 1‑21 days in the RV following hypoxic exposure were significantly decreased as compared with the normoxia control group. Membrane translocation of cPKCβII at 14‑21 days and of nPKCη at 7‑21 days in the left ventricle following hypoxic exposure was significantly increased when compared with the control. The results of the present study suggested that the alterations in membrane translocation, and nPKCδ and cPKCβI expression, are associated with RVH following PH, and the upregulation of cPKCβII membrane translocation is involved in left‑sided heart failure.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Protein kinase C isozyme expression in right ventricular hypertrophy induced by pulmonary hypertension in chronically hypoxic rats

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Abstract

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