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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

miR-127 contributes to ventilator-induced lung injury

  • Authors:
    • Qian Li
    • Ya‑Li Ge
    • Min Li
    • Xiang‑Zhi Fang
    • Yan‑Ping Yuan
    • Lei Liang
    • Shao‑Qiang Huang

  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200433, P.R. China, Department of Anesthesiology, Subei People's Hospital of Jiangsu, Yangzhou, Jiangsu 225001, P.R. China, Department of Anesthesiology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, P.R. China, Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China
  • Pages: 4119-4126
    |
    Published online on: July 27, 2017
       https://doi.org/10.3892/mmr.2017.7109
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Abstract

Although it is essential in critical care medicine, mechanical ventilation often results in ventilator‑induced lung injury (VILI). Treating mice with lipopolysaccharide has been reported to upregulate the expression of miR‑127, which has been implicated in the modulation of immune responses. However, the putative roles of miR‑127 during the development of VILI have yet to be elucidated. The present study demonstrated that challenging mice with mechanical ventilation for 6 h significantly upregulated the expression of miR‑127 in bronchoalveolar lavage fluid, serum and lung tissue samples. Conversely, following the downregulation of miR‑127 expression in vivo using an adenovirus delivery system, VILI‑associated pathologies, including alterations in the pulmonary wet/dry ratio, pulmonary permeability, lung neutrophil infiltration and levels of pro‑inflammatory cytokines, were significantly attenuated. In addition, miR‑127 knockdown inhibited the ventilation‑induced activation of nuclear factor (NF)‑κB and p38 mitogen‑activated protein kinase (MAPK). These findings suggested that the upregulation of miR‑127 expression may contribute to the development of VILI, through the modulation of pulmonary permeability, the induction of histopathological alterations, and the potentiation of inflammatory responses involving NF‑κB and p38 MAPK‑associated signaling pathways.

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Copy and paste a formatted citation
Spandidos Publications style
Li Q, Ge YL, Li M, Fang XZ, Yuan YP, Liang L and Huang SQ: miR-127 contributes to ventilator-induced lung injury. Mol Med Rep 16: 4119-4126, 2017.
APA
Li, Q., Ge, Y., Li, M., Fang, X., Yuan, Y., Liang, L., & Huang, S. (2017). miR-127 contributes to ventilator-induced lung injury. Molecular Medicine Reports, 16, 4119-4126. https://doi.org/10.3892/mmr.2017.7109
MLA
Li, Q., Ge, Y., Li, M., Fang, X., Yuan, Y., Liang, L., Huang, S."miR-127 contributes to ventilator-induced lung injury". Molecular Medicine Reports 16.4 (2017): 4119-4126.
Chicago
Li, Q., Ge, Y., Li, M., Fang, X., Yuan, Y., Liang, L., Huang, S."miR-127 contributes to ventilator-induced lung injury". Molecular Medicine Reports 16, no. 4 (2017): 4119-4126. https://doi.org/10.3892/mmr.2017.7109
Copy and paste a formatted citation
x
Spandidos Publications style
Li Q, Ge YL, Li M, Fang XZ, Yuan YP, Liang L and Huang SQ: miR-127 contributes to ventilator-induced lung injury. Mol Med Rep 16: 4119-4126, 2017.
APA
Li, Q., Ge, Y., Li, M., Fang, X., Yuan, Y., Liang, L., & Huang, S. (2017). miR-127 contributes to ventilator-induced lung injury. Molecular Medicine Reports, 16, 4119-4126. https://doi.org/10.3892/mmr.2017.7109
MLA
Li, Q., Ge, Y., Li, M., Fang, X., Yuan, Y., Liang, L., Huang, S."miR-127 contributes to ventilator-induced lung injury". Molecular Medicine Reports 16.4 (2017): 4119-4126.
Chicago
Li, Q., Ge, Y., Li, M., Fang, X., Yuan, Y., Liang, L., Huang, S."miR-127 contributes to ventilator-induced lung injury". Molecular Medicine Reports 16, no. 4 (2017): 4119-4126. https://doi.org/10.3892/mmr.2017.7109
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