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October-2017 Volume 16 Issue 4

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In vitro reconstitution of interactions in the CARD9 signalosome

  • Authors:
    • Jin Hee Park
    • Jae Young Choi
    • Mir Faisal Mustafa
    • Hyun Ho Park

  • View Affiliations / Copyright

    Affiliations: School of Chemistry and Biochemistry and Graduate School of Biochemistry, Yeungnam University, Gyeongsangnam 38541, Republic of Korea
    Copyright: © Park et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3910-3916
    |
    Published online on: July 31, 2017
       https://doi.org/10.3892/mmr.2017.7116
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Abstract

The caspase-associated recruitment domain (CARD)‑containing protein 9 (CARD9) signalosome is composed of CARD9, B‑cell CLL/lymphoma 10 (BCL10) and mucosa‑associated lymphoid tissue lymphoma translocation protein 1 (MALT1). The CARD9 signalosome has been reported to exert critical functions in the immunoreceptor tyrosine‑based activation motif‑coupled receptor‑mediated activation of myeloid cells, through nuclear factor‑κB pathways during innate immunity processes. During CARD9 signalosome assembly, BCL10 has been revealed to function as an adaptor protein and to interact with CARD9 via CARD‑CARD interactions; BCL10 also interacts with MALT1 via its C‑terminal Ser/Thr‑rich region and the first immunoglobulin domain of MALT1. The CARD9 signalosome is implicated in critical biological processes; however, its structural and biochemical characteristics have yet to be elucidated. In the present study, CARD9 and BCL10 CARDs were successfully purified and characterized, and their biochemical properties were investigated. In addition, CARD9‑BCL10 complexes were reconstituted in vitro under low salt and pH conditions. Furthermore, based on structural modeling data, a scheme was proposed to describe the interactions between CARD9 and BCL10. This provides a further understanding of the mechanism of how the CARD9 signalosome may be assembled.

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Copy and paste a formatted citation
Spandidos Publications style
Park JH, Choi JY, Mustafa MF and Park HH: In vitro reconstitution of interactions in the CARD9 signalosome. Mol Med Rep 16: 3910-3916, 2017.
APA
Park, J.H., Choi, J.Y., Mustafa, M.F., & Park, H.H. (2017). In vitro reconstitution of interactions in the CARD9 signalosome. Molecular Medicine Reports, 16, 3910-3916. https://doi.org/10.3892/mmr.2017.7116
MLA
Park, J. H., Choi, J. Y., Mustafa, M. F., Park, H. H."In vitro reconstitution of interactions in the CARD9 signalosome". Molecular Medicine Reports 16.4 (2017): 3910-3916.
Chicago
Park, J. H., Choi, J. Y., Mustafa, M. F., Park, H. H."In vitro reconstitution of interactions in the CARD9 signalosome". Molecular Medicine Reports 16, no. 4 (2017): 3910-3916. https://doi.org/10.3892/mmr.2017.7116
Copy and paste a formatted citation
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Spandidos Publications style
Park JH, Choi JY, Mustafa MF and Park HH: In vitro reconstitution of interactions in the CARD9 signalosome. Mol Med Rep 16: 3910-3916, 2017.
APA
Park, J.H., Choi, J.Y., Mustafa, M.F., & Park, H.H. (2017). In vitro reconstitution of interactions in the CARD9 signalosome. Molecular Medicine Reports, 16, 3910-3916. https://doi.org/10.3892/mmr.2017.7116
MLA
Park, J. H., Choi, J. Y., Mustafa, M. F., Park, H. H."In vitro reconstitution of interactions in the CARD9 signalosome". Molecular Medicine Reports 16.4 (2017): 3910-3916.
Chicago
Park, J. H., Choi, J. Y., Mustafa, M. F., Park, H. H."In vitro reconstitution of interactions in the CARD9 signalosome". Molecular Medicine Reports 16, no. 4 (2017): 3910-3916. https://doi.org/10.3892/mmr.2017.7116
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