Open Access

Identification of the active compounds and significant pathways of yinchenhao decoction based on network pharmacology

  • Authors:
    • Jihan Huang
    • Fan Cheung
    • Hor‑Yue Tan
    • Ming Hong
    • Ning Wang
    • Juan Yang
    • Yibin Feng
    • Qingshan Zheng
  • View Affiliations

  • Published online on: August 2, 2017     https://doi.org/10.3892/mmr.2017.7149
  • Pages: 4583-4592
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Yinchenhao decoction (YCHD) is a traditional Chinese medicine formulation, which has been widely used for the treatment of jaundice for 2,000 years. Currently, YCHD is used to treat various liver disorders and metabolic diseases, however its chemical/pharmacologic profiles remain to be elucidated. The present study identified the active compounds and significant pathways of YCHD based on network pharmacology. All of the chemical ingredients of YCHD were retrieved from the Traditional Chinese Medicine Systems Pharmacology database. Absorption, distribution, metabolism and excretion screening with oral bioavailability (OB) screening, drug‑likeness (DL) and intestinal epithelial permeability (Caco‑2) evaluation were applied to discover the bioactive compounds in YCHD. Following this, target prediction, pathway identification and network construction were employed to clarify the mechanism of action of YCHD. Following OB screening, and evaluation of DL and Caco‑2, 34 compounds in YCHD were identified as potential active ingredients, of which 30 compounds were associated with 217 protein targets. A total of 31 significant pathways were obtained by performing enrichment analyses of 217 proteins using the JEPETTO 3.x plugin, and 16 classes of gene‑associated diseases were revealed by performing enrichment analyses using Database for Annotation, Visualization and Integrated Discovery v6.7. The present study identified potential active compounds and significant pathways in YCHD. In addition, the mechanism of action of YCHD in the treatment of various diseases through multiple pathways was clarified.

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October-2017
Volume 16 Issue 4

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Spandidos Publications style
Huang J, Cheung F, Tan HY, Hong M, Wang N, Yang J, Feng Y and Zheng Q: Identification of the active compounds and significant pathways of yinchenhao decoction based on network pharmacology. Mol Med Rep 16: 4583-4592, 2017.
APA
Huang, J., Cheung, F., Tan, H., Hong, M., Wang, N., Yang, J. ... Zheng, Q. (2017). Identification of the active compounds and significant pathways of yinchenhao decoction based on network pharmacology. Molecular Medicine Reports, 16, 4583-4592. https://doi.org/10.3892/mmr.2017.7149
MLA
Huang, J., Cheung, F., Tan, H., Hong, M., Wang, N., Yang, J., Feng, Y., Zheng, Q."Identification of the active compounds and significant pathways of yinchenhao decoction based on network pharmacology". Molecular Medicine Reports 16.4 (2017): 4583-4592.
Chicago
Huang, J., Cheung, F., Tan, H., Hong, M., Wang, N., Yang, J., Feng, Y., Zheng, Q."Identification of the active compounds and significant pathways of yinchenhao decoction based on network pharmacology". Molecular Medicine Reports 16, no. 4 (2017): 4583-4592. https://doi.org/10.3892/mmr.2017.7149