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Molecular Medicine Reports
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October-2017 Volume 16 Issue 4

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Article Open Access

Two novel cross‑protective antigens for bovine Pasteurella multocida

  • Authors:
    • Huihui Du
    • Chenlu Wu
    • Chunming Li
    • Rendong Fang
    • Jianwei Ma
    • Jiale Ji
    • Zhihong Li
    • Nengzhang Li
    • Yuanyi Peng
    • Zeyang Zhou

  • View Affiliations / Copyright

    Affiliations: The State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, P.R. China, College of Animal Science and Technology, Southwest University, Chongqing 400716, P.R. China
    Copyright: © Du et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4627-4633
    |
    Published online on: August 3, 2017
       https://doi.org/10.3892/mmr.2017.7153
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Abstract

Pasteurella multocida is an important pathogen that leads to a range of diseases that have severe economic consequences on cattle production. In order to develop an effective cross‑protective component vaccine, an immunoproteomics approach was used to analyze outer membrane proteins (OMPs) of the P. multocida serotype A, B and F strains. Candidate antigen molecules from the whole genome were screened via linear trap quadrupole mass spectrometry and bioinformatics analysis, and the reactogenicity of the candidate antigen molecules was analyzed via cloning, expression, and ELISA or protein immunoblotting, and the vaccine efficacy of the candidate molecules was determined in infective animal models and cross‑protective antigens may be obtained. rPmCQ2_2g0128, rPmCQ2_1g0327 and rPmCQ2_1g0020 proteins were selected. Their protective rates were 40/30/20% (rPmCQ2_2g0128), 50/40/0% (rPmCQ2_1g0327) and 0/40/30% (rPmCQ2_1g0020) against ten‑fold median lethal dose (10LD50) of the P. multocida serotypes A, B and F in a mouse model, respectively. The results suggested that the two proteins rPmCQ2_2g0128 and rPmCQ2_1g0327 may be used as vaccine candidates against bovine P. multocida serotypes A, B. To the best of our knowledge, the present study was the first to identify cross‑protective antigens, extracted OMPs from bovine P. multocida.

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Copy and paste a formatted citation
Spandidos Publications style
Du H, Wu C, Li C, Fang R, Ma J, Ji J, Li Z, Li N, Peng Y, Zhou Z, Zhou Z, et al: Two novel cross‑protective antigens for bovine Pasteurella multocida. Mol Med Rep 16: 4627-4633, 2017.
APA
Du, H., Wu, C., Li, C., Fang, R., Ma, J., Ji, J. ... Zhou, Z. (2017). Two novel cross‑protective antigens for bovine Pasteurella multocida. Molecular Medicine Reports, 16, 4627-4633. https://doi.org/10.3892/mmr.2017.7153
MLA
Du, H., Wu, C., Li, C., Fang, R., Ma, J., Ji, J., Li, Z., Li, N., Peng, Y., Zhou, Z."Two novel cross‑protective antigens for bovine Pasteurella multocida". Molecular Medicine Reports 16.4 (2017): 4627-4633.
Chicago
Du, H., Wu, C., Li, C., Fang, R., Ma, J., Ji, J., Li, Z., Li, N., Peng, Y., Zhou, Z."Two novel cross‑protective antigens for bovine Pasteurella multocida". Molecular Medicine Reports 16, no. 4 (2017): 4627-4633. https://doi.org/10.3892/mmr.2017.7153
Copy and paste a formatted citation
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Spandidos Publications style
Du H, Wu C, Li C, Fang R, Ma J, Ji J, Li Z, Li N, Peng Y, Zhou Z, Zhou Z, et al: Two novel cross‑protective antigens for bovine Pasteurella multocida. Mol Med Rep 16: 4627-4633, 2017.
APA
Du, H., Wu, C., Li, C., Fang, R., Ma, J., Ji, J. ... Zhou, Z. (2017). Two novel cross‑protective antigens for bovine Pasteurella multocida. Molecular Medicine Reports, 16, 4627-4633. https://doi.org/10.3892/mmr.2017.7153
MLA
Du, H., Wu, C., Li, C., Fang, R., Ma, J., Ji, J., Li, Z., Li, N., Peng, Y., Zhou, Z."Two novel cross‑protective antigens for bovine Pasteurella multocida". Molecular Medicine Reports 16.4 (2017): 4627-4633.
Chicago
Du, H., Wu, C., Li, C., Fang, R., Ma, J., Ji, J., Li, Z., Li, N., Peng, Y., Zhou, Z."Two novel cross‑protective antigens for bovine Pasteurella multocida". Molecular Medicine Reports 16, no. 4 (2017): 4627-4633. https://doi.org/10.3892/mmr.2017.7153
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