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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Long non‑coding RNA HOXA11‑AS promotes cell proliferation and metastasis in human breast cancer

  • Authors:
    • Jian‑Chun Su
    • Xue‑Feng Hu
  • View Affiliations / Copyright

    Affiliations: Department of Head and Neck Radiotherapy, The First People's Hospital of Foshan, Foshan, Guangdong 528000, P.R. China
  • Pages: 4887-4894
    |
    Published online on: August 3, 2017
       https://doi.org/10.3892/mmr.2017.7163
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Abstract

Breast cancer is one of the most frequently occurring malignancies in female cancers worldwide, however, its detailed mechanism of tumorigenesis remains to be elucidated. Long non-coding RNAs (LncRNAs) have previously been demonstrated to be important in multiple cancers, including breast cancer. The present study aimed to elucidate the molecular mechanism of the effects of the novel Lnc RNA HOXA11‑AS, on cell proliferation and metastasis in breast cancer. The data revealed that the relative transcript level of HOXA11‑AS was upregulated in vivo and in vitro in models of breast cancer. Knockdown of HOXA11‑AS in MDA‑MB‑231 and MDA‑MB‑436 breast cancer cell lines inhibited the formation of cell colonies and arrested the cell cycle at the G0/G1 phase. Depletion of HOXA11‑AS using two specific short interfering (si)RNAs against HOXA11‑AS (siHOXA11‑AS‑1 and siHOXA11‑AS‑2) additionally suppressed the cell proliferative rate. Furthermore, transwell assays and wound‑healing analysis revealed that siRNA transfection inhibited cell migration and invasion by ~50% in the two cell lines. The results of the present study demonstrated the oncogenic role of HOXA11‑AS in breast cancer, providing novel clues for the future clinical diagnosis and treatment of early stage breast cancer patients.

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Copy and paste a formatted citation
Spandidos Publications style
Su JC and Hu XF: Long non‑coding RNA HOXA11‑AS promotes cell proliferation and metastasis in human breast cancer. Mol Med Rep 16: 4887-4894, 2017.
APA
Su, J., & Hu, X. (2017). Long non‑coding RNA HOXA11‑AS promotes cell proliferation and metastasis in human breast cancer. Molecular Medicine Reports, 16, 4887-4894. https://doi.org/10.3892/mmr.2017.7163
MLA
Su, J., Hu, X."Long non‑coding RNA HOXA11‑AS promotes cell proliferation and metastasis in human breast cancer". Molecular Medicine Reports 16.4 (2017): 4887-4894.
Chicago
Su, J., Hu, X."Long non‑coding RNA HOXA11‑AS promotes cell proliferation and metastasis in human breast cancer". Molecular Medicine Reports 16, no. 4 (2017): 4887-4894. https://doi.org/10.3892/mmr.2017.7163
Copy and paste a formatted citation
x
Spandidos Publications style
Su JC and Hu XF: Long non‑coding RNA HOXA11‑AS promotes cell proliferation and metastasis in human breast cancer. Mol Med Rep 16: 4887-4894, 2017.
APA
Su, J., & Hu, X. (2017). Long non‑coding RNA HOXA11‑AS promotes cell proliferation and metastasis in human breast cancer. Molecular Medicine Reports, 16, 4887-4894. https://doi.org/10.3892/mmr.2017.7163
MLA
Su, J., Hu, X."Long non‑coding RNA HOXA11‑AS promotes cell proliferation and metastasis in human breast cancer". Molecular Medicine Reports 16.4 (2017): 4887-4894.
Chicago
Su, J., Hu, X."Long non‑coding RNA HOXA11‑AS promotes cell proliferation and metastasis in human breast cancer". Molecular Medicine Reports 16, no. 4 (2017): 4887-4894. https://doi.org/10.3892/mmr.2017.7163
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