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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Gold nanoparticles promote osteogenic differentiation of human periodontal ligament stem cells via the p38 MAPK signaling pathway

  • Authors:
    • Chenguang Niu
    • Keyong Yuan
    • Rui Ma
    • Li Gao
    • Wenxin Jiang
    • Xuchen Hu
    • Wenzhen Lin
    • Xiaoling Zhang
    • Zhengwei Huang

  • View Affiliations / Copyright

    Affiliations: Department of Endodontics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, P.R. China, Department of Orthopedic Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai 200092, P.R. China
  • Pages: 4879-4886
    |
    Published online on: August 4, 2017
       https://doi.org/10.3892/mmr.2017.7170
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Abstract

Gold nanoparticles (AuNPs) are a promising material for use in regenerative medicine due to their biocompatibility and easy functionalization with biomolecules including growth factors, DNA and peptides. In the present study, transmission electron microscopy indicated that the AuNPs were monodisperse and spherical in shape, with an estimated average diameter of 13 nm. And the cellular effects of AuNPs on the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) and the associated signaling pathways in cell differentiation were investigated based on histochemical analysis of alkaline phosphatase activity and mineralization, quantitative polymerase chain reaction, and western blotting. The results indicated that AuNPs enhanced the differentiation of hPDLSCs into osteoblasts, increasing their osteogenic transcriptional profile including alkaline phosphatase, osterix, collagen type I and runt‑related transcription factor 2 (RUNX2) and activating the p38 mitogen‑activated protein kinase (MAPK) signaling pathway. Furthermore, AuNPs increased the protein level of RUNX2, which is crucial for osteogenic differentiation. These results suggested that AuNPs stimulate the osteogenesis of hPDLSCs partially via activation of the p38 MAPK signaling pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Niu C, Yuan K, Ma R, Gao L, Jiang W, Hu X, Lin W, Zhang X and Huang Z: Gold nanoparticles promote osteogenic differentiation of human periodontal ligament stem cells via the p38 MAPK signaling pathway. Mol Med Rep 16: 4879-4886, 2017.
APA
Niu, C., Yuan, K., Ma, R., Gao, L., Jiang, W., Hu, X. ... Huang, Z. (2017). Gold nanoparticles promote osteogenic differentiation of human periodontal ligament stem cells via the p38 MAPK signaling pathway. Molecular Medicine Reports, 16, 4879-4886. https://doi.org/10.3892/mmr.2017.7170
MLA
Niu, C., Yuan, K., Ma, R., Gao, L., Jiang, W., Hu, X., Lin, W., Zhang, X., Huang, Z."Gold nanoparticles promote osteogenic differentiation of human periodontal ligament stem cells via the p38 MAPK signaling pathway". Molecular Medicine Reports 16.4 (2017): 4879-4886.
Chicago
Niu, C., Yuan, K., Ma, R., Gao, L., Jiang, W., Hu, X., Lin, W., Zhang, X., Huang, Z."Gold nanoparticles promote osteogenic differentiation of human periodontal ligament stem cells via the p38 MAPK signaling pathway". Molecular Medicine Reports 16, no. 4 (2017): 4879-4886. https://doi.org/10.3892/mmr.2017.7170
Copy and paste a formatted citation
x
Spandidos Publications style
Niu C, Yuan K, Ma R, Gao L, Jiang W, Hu X, Lin W, Zhang X and Huang Z: Gold nanoparticles promote osteogenic differentiation of human periodontal ligament stem cells via the p38 MAPK signaling pathway. Mol Med Rep 16: 4879-4886, 2017.
APA
Niu, C., Yuan, K., Ma, R., Gao, L., Jiang, W., Hu, X. ... Huang, Z. (2017). Gold nanoparticles promote osteogenic differentiation of human periodontal ligament stem cells via the p38 MAPK signaling pathway. Molecular Medicine Reports, 16, 4879-4886. https://doi.org/10.3892/mmr.2017.7170
MLA
Niu, C., Yuan, K., Ma, R., Gao, L., Jiang, W., Hu, X., Lin, W., Zhang, X., Huang, Z."Gold nanoparticles promote osteogenic differentiation of human periodontal ligament stem cells via the p38 MAPK signaling pathway". Molecular Medicine Reports 16.4 (2017): 4879-4886.
Chicago
Niu, C., Yuan, K., Ma, R., Gao, L., Jiang, W., Hu, X., Lin, W., Zhang, X., Huang, Z."Gold nanoparticles promote osteogenic differentiation of human periodontal ligament stem cells via the p38 MAPK signaling pathway". Molecular Medicine Reports 16, no. 4 (2017): 4879-4886. https://doi.org/10.3892/mmr.2017.7170
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