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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

In silico design of colchicine-based bioisosteric inhibitors of tubulin for the treatment of rheumatoid arthritis

  • Authors:
    • Li Wang
    • Hao‑Jie Yang
    • Ran Tu
    • Min Shen
    • Dan Liu

  • View Affiliations / Copyright

    Affiliations: Department of Rheumatology and Immunology, Rheumatology Institute, The Fifth Hospital of Xi'an, Xi'an, Shaanxi 710082, P.R. China, Department of Prevention and Health Care, Xi'an Jiaotong University Hospital, Xi'an, Shaanxi 710049, P.R. China, College of Life Sciences, Shaanxi Normal University College of Life Sciences, Xi'an, Shaanxi 710119, P.R. China, Department of Respiratory Medicine, Northwest Petroleum Pipeline Hospital, Xi'an, Shaanxi 710082, P.R. China
  • Pages: 4823-4828
    |
    Published online on: August 9, 2017
       https://doi.org/10.3892/mmr.2017.7202
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Abstract

The super-saturation of serum with monosodium urate due to hyperuricemia is the core metabolic disorder of rheumatoid arthritis. When the serum urate concentration is ≥7 mg/dl, this results in the crystallization of monosodium urate in serum at body temperature (37˚C/98.6˚F). Colchicine (COL) is considered to be a first‑line medication for acute arthritis when NSAIDs are contraindicated. COL causes severe side effects, including diarrhea, nausea, cramping, abdominal pain and vomiting, in humans. Experimental studies have additionally demonstrated the presence of mutagenic and reproductive effects in humans. In the present study, molecular docking simulation techniqueswere used to design COL‑derived bioisosteric inhibitors, with the aim of designing an alternative treatment that exhibitedpotent anti‑arthritic activity and was free from the side effects associated with COL.

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Copy and paste a formatted citation
Spandidos Publications style
Wang L, Yang HJ, Tu R, Shen M and Liu D: In silico design of colchicine-based bioisosteric inhibitors of tubulin for the treatment of rheumatoid arthritis. Mol Med Rep 16: 4823-4828, 2017.
APA
Wang, L., Yang, H., Tu, R., Shen, M., & Liu, D. (2017). In silico design of colchicine-based bioisosteric inhibitors of tubulin for the treatment of rheumatoid arthritis. Molecular Medicine Reports, 16, 4823-4828. https://doi.org/10.3892/mmr.2017.7202
MLA
Wang, L., Yang, H., Tu, R., Shen, M., Liu, D."In silico design of colchicine-based bioisosteric inhibitors of tubulin for the treatment of rheumatoid arthritis". Molecular Medicine Reports 16.4 (2017): 4823-4828.
Chicago
Wang, L., Yang, H., Tu, R., Shen, M., Liu, D."In silico design of colchicine-based bioisosteric inhibitors of tubulin for the treatment of rheumatoid arthritis". Molecular Medicine Reports 16, no. 4 (2017): 4823-4828. https://doi.org/10.3892/mmr.2017.7202
Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Yang HJ, Tu R, Shen M and Liu D: In silico design of colchicine-based bioisosteric inhibitors of tubulin for the treatment of rheumatoid arthritis. Mol Med Rep 16: 4823-4828, 2017.
APA
Wang, L., Yang, H., Tu, R., Shen, M., & Liu, D. (2017). In silico design of colchicine-based bioisosteric inhibitors of tubulin for the treatment of rheumatoid arthritis. Molecular Medicine Reports, 16, 4823-4828. https://doi.org/10.3892/mmr.2017.7202
MLA
Wang, L., Yang, H., Tu, R., Shen, M., Liu, D."In silico design of colchicine-based bioisosteric inhibitors of tubulin for the treatment of rheumatoid arthritis". Molecular Medicine Reports 16.4 (2017): 4823-4828.
Chicago
Wang, L., Yang, H., Tu, R., Shen, M., Liu, D."In silico design of colchicine-based bioisosteric inhibitors of tubulin for the treatment of rheumatoid arthritis". Molecular Medicine Reports 16, no. 4 (2017): 4823-4828. https://doi.org/10.3892/mmr.2017.7202
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