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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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Article Open Access

Proteomic profiling of human HepG2 cells treated with hesperidin using antibody array

  • Authors:
    • Silvia Yumnam
    • Venu Venkatarame Gowda Saralamma
    • Suchismita Raha
    • Ho Jeong Lee
    • Won Sup Lee
    • Eun Kim Kim
    • Sang Joon Lee
    • Jeong Doo Heo
    • Gon Sup Kim

  • View Affiliations / Copyright

    Affiliations: Research Institute of Life Science, College of Veterinary Medicine, Gyeongsang National University, Jinju, Gyeongsang 52828, Republic of Korea, Department of Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Gyeongsang 52727, Republic of Korea, Department of Nursing Science, International University of Korea, Jinju, Gyeongsang 52833, Republic of Korea, Gyeongnam Department of Environment Toxicology and Chemistry, Gyeongnam Biological Resource Research Center, Korea Institute of Toxicology, Jinju, Gyeongsang 52834, Republic of Korea
    Copyright: © Yumnam et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5386-5392
    |
    Published online on: August 11, 2017
       https://doi.org/10.3892/mmr.2017.7232
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Abstract

Protein array technology not only identifies a large number of proteins but also determines their expression levels. In the present study, antibody array analysis is used to decipher the proteins involved in hesperidin-induced cell death in HepG2 cells. Altered proteins in hesperidin treated cells were compared with that of untreated control cells by using a RayBio® Label‑based (L series) human antibody array kit. The identified proteins were further confirmed using western blot analysis. STRING software based analysis was used to determine the protein‑protein interactions. Many proteins related to signal transduction, cellular mechanisms, cell growth and proliferation regulatory proteins were identified. Among the proteins identified Hsp90, Smac/DIABLO, Prdx6 and FRK were significantly reduced in hesperidin treated cells. To the best of the authors' knowledge, the present study is the first to use antibody array for identifying proteins marker in hesperidin‑induced cell death in HepG2 cells. The present study provides a novel insight into the anticancer mechanism of hesperidin.

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Copy and paste a formatted citation
Spandidos Publications style
Yumnam S, Venkatarame Gowda Saralamma V, Raha S, Lee HJ, Lee WS, Kim EK, Lee SJ, Heo JD and Kim GS: Proteomic profiling of human HepG2 cells treated with hesperidin using antibody array. Mol Med Rep 16: 5386-5392, 2017.
APA
Yumnam, S., Venkatarame Gowda Saralamma, V., Raha, S., Lee, H.J., Lee, W.S., Kim, E.K. ... Kim, G.S. (2017). Proteomic profiling of human HepG2 cells treated with hesperidin using antibody array. Molecular Medicine Reports, 16, 5386-5392. https://doi.org/10.3892/mmr.2017.7232
MLA
Yumnam, S., Venkatarame Gowda Saralamma, V., Raha, S., Lee, H. J., Lee, W. S., Kim, E. K., Lee, S. J., Heo, J. D., Kim, G. S."Proteomic profiling of human HepG2 cells treated with hesperidin using antibody array". Molecular Medicine Reports 16.4 (2017): 5386-5392.
Chicago
Yumnam, S., Venkatarame Gowda Saralamma, V., Raha, S., Lee, H. J., Lee, W. S., Kim, E. K., Lee, S. J., Heo, J. D., Kim, G. S."Proteomic profiling of human HepG2 cells treated with hesperidin using antibody array". Molecular Medicine Reports 16, no. 4 (2017): 5386-5392. https://doi.org/10.3892/mmr.2017.7232
Copy and paste a formatted citation
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Spandidos Publications style
Yumnam S, Venkatarame Gowda Saralamma V, Raha S, Lee HJ, Lee WS, Kim EK, Lee SJ, Heo JD and Kim GS: Proteomic profiling of human HepG2 cells treated with hesperidin using antibody array. Mol Med Rep 16: 5386-5392, 2017.
APA
Yumnam, S., Venkatarame Gowda Saralamma, V., Raha, S., Lee, H.J., Lee, W.S., Kim, E.K. ... Kim, G.S. (2017). Proteomic profiling of human HepG2 cells treated with hesperidin using antibody array. Molecular Medicine Reports, 16, 5386-5392. https://doi.org/10.3892/mmr.2017.7232
MLA
Yumnam, S., Venkatarame Gowda Saralamma, V., Raha, S., Lee, H. J., Lee, W. S., Kim, E. K., Lee, S. J., Heo, J. D., Kim, G. S."Proteomic profiling of human HepG2 cells treated with hesperidin using antibody array". Molecular Medicine Reports 16.4 (2017): 5386-5392.
Chicago
Yumnam, S., Venkatarame Gowda Saralamma, V., Raha, S., Lee, H. J., Lee, W. S., Kim, E. K., Lee, S. J., Heo, J. D., Kim, G. S."Proteomic profiling of human HepG2 cells treated with hesperidin using antibody array". Molecular Medicine Reports 16, no. 4 (2017): 5386-5392. https://doi.org/10.3892/mmr.2017.7232
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